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Intermittent swimming behaviour is commonly observed in larval zebrafish, often attributed to energy-saving mechanisms. In this study, we utilize a hybrid approach combining deep reinforcement learning and the immersed boundary–lattice Boltzmann method to train a larval zebrafish-like swimmer to reach a target with minimized energy expenditure. We find that when the tail-beat period is fixed, continuous swimming emerges as the optimal strategy. However, when the tail-beat period is allowed to vary, intermittent swimming proves superior in energy performance, achieved through reductions in tail-beat amplitude and frequency. Our detailed analysis reveals that intermittent swimmers employ rapid backward tail flicks to attain high speeds, coupled with slower forward tail flicks and coasting phases to conserve energy. Furthermore, we derive scaling laws governing the swimming performance of trained fish. These results offer valuable insights into the intermittent swimming patterns of fish, with implications for understanding bio-inspired locomotion and informing the design of energy-efficient aquatic systems.
The Early-Middle Jurassic impression/compression macroflora and the palynoflora from the Qaidam Basin in the northeastern Qinghai-Xizang (Tibetan) Plateau have been well studied; however, fossil wood from this region has not been previously documented systematically. Here, we describe an anatomically well-preserved fossil wood specimen from the Lower Jurassic Huoshaoshan Formation at the Dameigou section in northern Qinghai Province, northwestern China. This fossil exhibits typical Metapodocarpoxylon Dupéron-Laudoueneix et Pons anatomy with usually araucarian radial tracheid pits and variable cross-field pits, representing a new record for Metapodocarpoxylon in the Qaidam Basin. This discovery indicates that trees with this type of wood anatomy were not confined to northern Gondwana but also grew in more northerly regions in Laurasia. The wood displays distinct growth rings, with abundant, well-formed earlywood and narrow latewood. This observation, along with previous interpretations based on macroflora, palynoflora and sedimentological data, suggests that a warm and humid climate with mild seasonality prevailed in the region during the Early Jurassic.
The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.
Methods
A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed. Using a seed-based FC approach, we first investigated the group differences in whole-brain resting-state FC of the 14 ERN seeds between participants with and without MDD. Furthermore, an independent sample (45 MDD patients) was used to evaluate the relationship between the aforementioned abnormal FC in the ERN and symptom improvement after 8 weeks of antidepressant monotherapy.
Results
Compared to the HCs, patients with MDD exhibited aberrant FC between 7 ERN seeds and several cortical and subcortical areas, including the bilateral middle temporal gyrus, bilateral occipital gyrus, right thalamus, calcarine cortex, middle frontal gyrus, and the bilateral superior temporal gyrus. In an independent sample, these aberrant FCs in the ERN were negatively correlated with the reduction rate of the HAMD17 score among MDD patients.
Conclusions
These results might extend our understanding of the neurobiological underpinnings underlying unadaptable or inflexible emotional processing in MDD patients and help to elucidate the mechanisms of therapeutic response.
The three-dimensional flow field past an I-shaped dual-step cylinder has been obtained by numerical integration of the Navier–Stokes equations at Reynolds number ($Re_D$) 150. The I-shaped cylinder consisted of two large-diameter (D) cylinders with a small-diameter (d) cylinder in between. With a view to exploring the vortex dynamics and structural loads, simulations were performed for eight different lengths $l$ of the small cylinder, varied from $l/D=10$ to 0.2 for a fixed diameter ratio $D/d=2$. When the length of the small cylinder is sufficiently large, the wake behind the I-shaped cylinder is similar to the wake behind the single-step cylinder (Tian et al., J. Fluid Mech., vol. 891, 2020, A24). As the small cylinder length decreases, the enhanced interactions between the two steps make the present wake deviate from the wake of the single-step cylinder, leading to four different wake modes distinguished by different combinations of vortex cells. The physical formation mechanisms were analysed in terms of the vortex dynamics. Besides the wake flow, the streamwise vortices around the I-shaped step cylinder were also investigated. A pair of edge vortices and a junction vortex were identified for $l/D \geq ~1$. When the gap between the two steps becomes too small, $l/D \leq ~0.2$, the junction vortex disappears, and only a pair of edge vortices exists. Varying the distance between the two steps strongly affects the structural loads (drag and lift) along the I-shaped cylinder. The dependence of the loads on $l/D$ was readily explained by the different wake modes.
The multi-colour complete light curves and low-resolution spectra of two short period eclipsing Am binaries V404 Aur and GW Gem are presented. The stellar atmospheric parameters of the primary stars were derived through the spectra fitting. The observed and TESS-based light curves of them were analysed by using the Wilson-Devinney code. The photometric solutions suggest that both V404 Aur and GW Gem are semi-detached systems with the secondary component filling its critical Roche Lobe, while the former should be a marginal contact binary. The $O-C$ analysis found that the period of V404 Aur is decreasing at a rate of $dP/dt=-1.06(\pm0.01)\times 10^{-7}\,\mathrm{d}\,\mathrm{ yr}^{-1}$, while the period of GW Gem is increasing at $dP/dt=+2.41(\pm0.01)\times 10^{-8} \mathrm{d}\,\mathrm{yr}^{-1}$. The period decrease of V404 Aur may mainly be caused by the combined effects of the angular momentum loss (AML) via an enhanced stellar wind of the more evolved secondary star and mass transfer between two components. The period increase of GW Gem supports the mass transfer from the secondary to the primary. Both targets may be in the broken contact stage predicted by the thermal relaxation oscillations theory and will eventually evolve to the contact stage. We have collected about 54 well-known eclipsing Am binaries with absolute parameters from the literature. The relations of these parameters are summarised. There are some components that have a higher degree of evolution. The majority of their hydrogen shell may have been stripped away and the stellar internal layer exposed. The accretion processes from such evolved components may be very important for the formation of Am peculiarity in binaries.
Femtosecond oscillators with gigahertz (GHz) repetition rate are appealing sources for spectroscopic applications benefiting from the individually accessible and high-power comb line. The mode mismatch between the potent pump laser diode (LD) and the incredibly small laser cavity, however, limits the average output power of existing GHz Kerr-lens mode-locked (KLM) oscillators to tens of milliwatts. Here, we present a novel method that solves the difficulty and permits high average power LD-pumped KLM oscillators at GHz repetition rate. We propose a numerical simulation method to guide the realization of Kerr-lens mode-locking and comprehend the dynamics of the Kerr-lens mode-locking process. As a proof-of-principle demonstration, an LD-pumped Yb:KGW oscillator with up to 6.17-W average power and 184-fs pulse duration at 1.6-GHz repetition rate is conducted. The simulation had a good agreement with the experimental results. The cost-effective, compact and powerful laser source opens up new possibilities for research and industrial applications.
Digitaria ciliaris var. chrysoblephara (Fig. & De Not.) R.R. Stewart is an annual xeromorphic weed that severely infests direct-seeded rice fields in China. Herbicide resistance is emerging in D. ciliaris var. chrysoblephara owing to extensive and recurrent use of the acetyl-CoA carboxylase (ACCase)-inhibiting herbicide metamifop. In this study, a total of 53 D. ciliaris var. chrysoblephara populations randomly sampled from direct-seeded rice fields across Jiangsu Province were investigated for metamifop resistance and potential resistance-endowing mutations. Single-dose assays revealed that 17 (32.1%) populations evolved resistance to metamifop and 5 (9.4%) populations were in the process of developing resistance. The resistance index (RI) of metamifop-resistant populations ranged from 2.7 to 32.1. Amino acid substitutions (Ile-1781-Leu, Trp-2027-Cys/Ser, and Ile-2041-Asn) in ACCase genes were detected in resistant D. ciliaris var. chrysoblephara plants and caused various cross-resistance patterns to ACCase-inhibiting herbicides. All of four resistant populations (YC07, YZ09, SQ03, and HA06), with different ACCase mutations, exhibited cross-resistance to the aryloxyphenoxypropionate (APP) herbicides cyhalofop-butyl (RI values: 10.0 to 19.9), fenoxaprop-P-ethyl (RI values: 53.7 to 132.8), and haloxyfop-P-methyl (RI values: 6.2 to 62.6), and the phenylpyrazoline (DEN) pinoxaden (RI values: 2.3 to 5.4), but responded differently to the cyclohexanedione (CHD) herbicides clethodim and sethoxydim. It is noteworthy that four postemergence herbicides used for rice cropping, including bispyribac-sodium, pyraclonil, quinclorac, and anilofos, showed poor control effect against D. ciliaris var. chrysoblephara, suggesting few alternations for managing this weed in rice fields except ACCase inhibitors. In conclusion, this work demonstrated that the D. ciliaris var. chrysoblephara had developed resistance to ACCase-inhibiting herbicides in rice cultivation of China, and target-site amino acid substitutions in ACCase were primarily responsible for metamifop resistance.
Model spent cetyltrimethylammonium bromide (CTMAB)-bentonite, and cetyl pyridinium chloride (CPC)-bentonite used for sorbing p-nitrophenol (PNP) from wastewater, as well as virgin CTMAB-bentonite and CPC-bentonite, were employed as the starting materials to prepare porous clay heterostructures (PCHs). The BET surface areas and total pore volumes of the PCHs based on these spent and virgin organobentonites (PNP-CTMAB-PCH, CTMAB-PCH, PNP-CPC-PCH and CPC-PCH) are 661.5 m2/g and 0.25 cm3/g, 690.4 m2/g and 0.27 cm3/g, 506.3 m2/g and 0.30 cm3/g, and 525.4 m2/g and 0.30 cm3/g, respectively. These values approximate those of activated carbon (AC), at 731.4 m2/g and 0.23 cm3/g, and are much larger than those of bentonite and CTMAB-bentonite, at 60.9 m2/g and 0.12 cm3/g, and 3.7 m2/g and 0.0055 m2/g, respectively. The PCHs have slightly higher adsorption capacities for benzene and CC14 than AC at higher relative pressures despite their comparatively lower benzene and CC14 adsorption capacity at lower relative pressures. The existence of PNP in organobentonites also enhances the volatile organic compounds (VOCs) adsorption capacity of PCHs at lower adsorbate concentrations, although some adsorption capacity is lost at higher concentrations. The hydrophobicity order of the adsorbents is: CTMAB-bentonite > AC > PCHs > bentonite. The micro- to mesoporous pore sizes, superior VOC adsorption properties, thermal stability to 750°C and hydrophobicity and negligible influences of PNP on PCHs make spent PNP-containing organobentonites ideal starting materials for synthesis of PCHs and especially attractive adsorbents for VOC sorption control.
In order to establish a compact all-optical Thomson scattering source, experimental studies were conducted on the 45 TW Ti: sapphire laser facility. By including a steel wafer, mixed gas, and plasma mirror into a double-exit jet, several mechanisms, such as shock-assisted ionization injection, ionization injection, and driving laser reflection, were integrated into one source. So, the source of complexity was remarkably reduced. Electron bunches with central energy fluctuating from 90 to 160 MeV can be produced. Plasma mirrors were used to reflect the driving laser. The scattering of the reflected laser on the electron bunches led to the generation of X-ray photons. Through comparing the X-ray spots under different experimental conditions, it is confirmed that the X-ray photons are generated by Thomson scattering. For further application, the energy spectra and source size of the Thomson scattering source were measured. The unfolded spectrum contains a large amount of low-energy photons besides a peak near 67 keV. Through importing the electron energy spectrum into the Monte Carlo simulation code, the different contributions of the photons with small and large emitting angles can be used to explain the origin of the unfolded spectrum. The maximum photon energy extended to about 500 keV. The total photon production was 107/pulse. The FWHM source size was about 12 μm.
Montmorillonite (Mnt)-based solid acids have a wide range of applications in catalysis and adsorption of pollutants. For such solid acids, the acidic characteristic often plays a significant role in these applications. The objective of the current study was to examine the effects of H3PO4-activation and supporting WO3 on the textural structure and surface acidic properties of Mnt. The Mnt-based solid acid materials were prepared by H3PO4 treatment and an impregnation method with a solution of ammonium metatungstate (AMT) and were examined as catalysts in the dehydration of glycerol to acrolein. The catalysts were characterized by nitrogen adsorption-desorption, powder X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electronic microscopy (SEM), X-ray photoelectron spectroscopy (XPS), diffuse reflectance ultraviolet-visible (DR UV-Vis) spectroscopy, temperature programmed desorption of NH3 (NH3-TPD), diffuse reflectance Fourier-transform infrared (DR FTIR) spectroscopy of adsorbed pyridine, and thermogravimetric (TG) analyses. The phosphoric acid treatment of Mnt created Brönsted and Lewis acid sites and led to increases in specific surface areas, porosity, and acidity. WO3 species influenced total acidity, acid strength, the numbers of Brönsted and Lewis acid sites, and catalytic performances. A high turnover frequency (TOF) value (31.2 h−1) based on a maximal 60.7% yield of acrolein was reached. The correlation of acrolein yield with acidic properties indicated that the cooperative role of Brönsted and Lewis acid sites was beneficial to the formation of acrolein and a little coke deposition (<3.3 wt.%). This work provides a new idea for the design of solid acid catalysts with cooperative Brönsted and Lewis acidity for the dehydration of glycerol.
Exploring the neural basis related to different mood states is a critical issue for understanding the pathophysiology underlying mood switching in bipolar disorder (BD), but research has been scarce and inconsistent.
Methods
Resting-state functional magnetic resonance imaging data were acquired from 162 patients with BD: 33 (hypo)manic, 64 euthymic, and 65 depressive, and 80 healthy controls (HCs). The differences of large-scale brain network functional connectivity (FC) between the four groups were compared and correlated with clinical characteristics. To validate the generalizability of our findings, we recruited a small longitudinal independent sample of BD patients (n = 11). In addition, we examined topological nodal properties across four groups as exploratory analysis.
Results
A specific strengthened pattern of network FC, predominantly involving the default mode network (DMN), was observed in (hypo)manic patients when compared with HCs and bipolar patients in other mood states. Longitudinal observation revealed an increase in several network FCs in patients during (hypo)manic episode. Both samples evidenced an increase in the FC between the DMN and ventral attention network, and between the DMN and limbic network (LN) related to (hypo)mania. The altered network connections were correlated with mania severity and positive affect. Bipolar depressive patients exhibited decreased FC within the LN compared with HCs. The exploratory analysis also revealed an increase in degree in (hypo)manic patients.
Conclusions
Our findings identify a distributed pattern of large-scale network disturbances in the unique context of (hypo)mania and thus provide new evidence for our understanding of the neural mechanism of BD.
Aerospace represents the development of national science and technology. It is an important foundation for exploring space and an important guarantee for the construction of aerospace power. There are many large workpieces in the aerospace field. The box insulation layer of large workpieces is an important processing problem. A new thick processing equipment is proposed to process the box insulation layer of large workpieces. The thick processing equipment consists of the XYZ shaft long guide rail and five degrees of freedom (5-DOF) RAPA. The mechanical structure of the 5-DOF RAPA is a redundantly actuated parallel mechanism (RAPM). Meanwhile, this paper proposes a new method to design 5-DOF redundantly actuated parallel mechanisms (RAPMs) with large output rotational angles. Based on configuration evolution and Li group, two articulated moving platforms (AMPs) and four kinds of limbs are designed, and a series of 3T2R (T represents translation, R represents rotation) RAPMs and 2T3R RAPMs are synthesized. To verify the designed RAPMs with large angle, an example of RAPMs, 4UPS-{2UPR}-R is analyzed. To ensure that the RAPM has no mechanism vibration impact in movement, this paper represents the RAPM adopts a newly proposed trajectory planning method. The results show that the 4SPU-(2UPR)R mechanism possesses large angles and verifies the efficiency of the new proposed trajectory planning method in simplified trajectories. This work lays the foundation for processing the box insulation layer of large workpieces with straight lines and arcs paths.
The vortex dynamics and the structural load in a step cylinder (consisting of a small, d, and a large, D, cylinder) flow are investigated numerically at Reynolds number ($Re_D$) 150 for diameter ratios $D/d=2.0, 2.4$ and 2.8. First, the formation mechanism of a non-uniform oblique vortex shedding (the vortex shedding frequency remains unchanged as the oblique shedding angle varies) behind the small cylinder is explained: an increase in the production rate of the vortex strength and a farther downstream movement of the vortex formation position occur simultaneously as the vicinity of the step is approached along the small cylinder. Second, the structural load (the drag and lift) along the step cylinder is investigated, where four local extremes (two local minima and two local maxima) are observed. An in-depth investigation of the vortex dislocation effects on the structural load is provided, showing that the decreased circulation in the near wake and the weakened staggered Kármán vortex shedding pattern cause a major reduction (90 %) of the sectional lift amplitude and a relatively modest reduction (5.7 %) of the sectional drag amplitude, compared with the corresponding sectional force when no vortex dislocation occurs. This new knowledge combined with the three-dimensional effect of the step cylinder wake (caused by the blending of the small and larger cylinder wakes around the step) explain the formation of the four local extremes and the distribution of the structural load between them. Finally, it is found that the increasing $D/d$ amplifies the structural load variation along the step cylinder.
Fat deposition and lipid metabolism are closely related to the morphology, structure and function of mitochondria. The morphology of mitochondria between fusion and fission processes is mainly regulated by protein posttranslational modification. Intermittent fasting (IF) promotes high expression of Sirtuin 3 (Sirt3) and induces mitochondrial fusion in high-fat diet (HFD)-fed mice. However, the mechanism by which Sirt3 participates in mitochondrial protein acetylation during IF to regulate mitochondrial fusion and fission dynamics remains unclear. This article demonstrates that IF promotes mitochondrial fusion and improves mitochondrial function in HFD mouse inguinal white adipose tissue. Proteomic sequencing revealed that IF increased protein deacetylation levels in HFD mice and significantly increased Sirt3 mRNA and protein expression. After transfecting with Sirt3 overexpression or interference vectors into adipocytes, we found that Sirt3 promoted adipocyte mitochondrial fusion and improved mitochondrial function. Furthermore, Sirt3 regulates the JNK-FIS1 pathway by deacetylating malate dehydrogenase 2 (MDH2) to promote mitochondrial fusion. In summary, our study indicates that IF promotes mitochondrial fusion and improves mitochondrial function by upregulating the high expression of Sirt3 in HFD mice, promoting deacetylation of MDH2 and inhibiting the JNK-FIS1 pathway. This research provides theoretical support for studies related to energy limitation and animal lipid metabolism.
Steinernema populi n. sp. was recovered by baiting from beneath poplar trees in China. Morphological and molecular features provided evidence for placing the new species into the Kushidai clade. The new species is characterized by the following morphological features: third-stage infective juveniles (IJ) with a body length of 1095 (973–1172) μm, a distance from the anterior end to excretory pore of 77 (70–86) μm and a tail length of 64 (55–72) μm. The Body length/Tail length (c) ratio and Anterior end to Excretory pore/ Tail length × 100 (E%) of S. populi n. sp. are substantially greater than those of all other ‘Feltiae–Kushidai–Monticolum’ group members. The first-generation males can be recognized by a spicule length of 66 (57–77) μm and a gubernaculum length of 46 (38–60) μm. The new species is further characterized by sequences of the internal transcribed spacer and partial 28S regions of the ribosomal DNA. Phylogenetic analyses show that Steinernema akhursti and Steinernema kushidai are the closest relatives to S. populi n. sp.
The inertial parameters of payloads attached to the end effector of robots benefit to several robotics applications, such as the model-based control, the task optimization, and so on. These applications require the accurate estimation of the inertial parameters. In the existing payload estimation approaches, however, the data weighting technique, which can reduce the adverse effects of outliers and significantly improve the final results, has not been applied yet. In this article, an accurate identification method based on double weighting for inertial parameters of robot payloads is proposed. In order to obtain the weighting matrices, a modified dynamic parameter identification method with two loops is firstly proposed. Then, based on the identified results of dynamic parameters, a payload identification model based on double weighting is constructed. In addition, the variations of both nonlinear friction parameters and linear friction parameters caused by the payload are considered in this model. Finally, experimental comparisons between our method and another four methods are conducted. The results confirm that our method shows the best performance, especially on improving the identification accuracy of mass and center of mass of the payload.
A droplet impinging on a superhydrophobic substrate in an electric field is an important process in droplet manipulation and electrostatic spraying. Here, the entire impinging dynamic of the droplet in a vertical electric field is studied by a visualization experiment and numerical simulation with OpenFOAM. We investigate the effect of an electrostatic force on droplet impact in depth, where four ejection modes and three rebound modes are found experimentally. In particular, the filamentous ejecting phenomenon occurs after a droplet impinging on a superhydrophobic substrate is first discovered. In the numerical simulation, the strong coupling between the dynamic distribution of the interface electric charge and the evolution of the droplet profile can lead to different ejection modes, and the different ejection behaviours are caused by the combined effects of electrostatic pressure, capillary pressure, dynamic pressure and static pressure on the droplet apex. A charge scaling law for the ejection droplets is proposed. Furthermore, a set of theoretical models is established, which can successfully predict the threshold electric capillary number for different droplet ejection modes. The results reveal some important characteristics for a droplet impinging on a superhydrophobic surface in an electric field, which could facilitate the design of electrically operated droplet equipment and guide the safe and stable operation of the device.
Chapter 5 evaluates the role of education in China’s rapid growth. In 1980, China was one of the poorest countries in the world, but the average years of schooling of its adult population was already near that of a middle-income country. This relatively high educational level was an advantage for China’s economic development. However, this advantage all but disappeared by 2005. China’s greatest advantage turns out to be in the quality rather than quantity of education. According to the cognitive skills index produced by Eric Hanushek and his coauthors, who use it as a measure of a country’s educational quality, China ranks the best among all developing nations. This factor alone may explain a very significant 4 percentage point difference in GDP per capita growth between China and developing countries such as Peru and South Africa. It is shown that China’s advantage in the quality of schooling is not due to more investment in education by the government. Instead, it is the traditional Confucian culture that has made people in China and other East Asian economies influenced by the culture value of education more than people in most other developing countries.