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Inference is considered for the marginal distribution of X, when (X, Y) has a truncated bivariate normal distribution. The Y variable is truncated, but only the X values are observed. The relationship of this distribution to Azzalini's “skew-normal” distribution is obtained. Method of moments and maximum likelihood estimation are compared for the three-parameter Azzalini distribution. Samples that are uniformative about the skewness of this distribution may occur, even for large n. Profile likelihood methods are employed to describe the uncertainty involved in parameter estimation. A sample of 87 Otis test scores is shown to be well-described by this model.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
Head and neck squamous cell carcinomas (HNSCCs) are aggressive tumours lacking a standardised timeline for treatment initiation post-diagnosis. Delays beyond 60 days are linked to poorer outcomes and higher recurrence risk.
Methods:
A retrospective review was conducted on patients over 18 with HNSCC treated with (chemo)radiation at a rural tertiary care centre (September 2020–2022). Data on patient demographics, oncologic characteristics, treatment details and delay causes were analysed using SPSS.
Results:
Out of 93 patients, 35.5% experienced treatment initiation delays (TTIs) over 60 days. Median TTI was 73 days for delayed cases, compared to 41.5 days otherwise. No significant differences in demographics or cancer characteristics were observed between groups. The primary reasons for the delay were care coordination (69.7%) and patient factors (18.2%). AJCC cancer stage showed a trend towards longer delays in advanced stages.
Conclusion:
One-third of patients faced delayed TTI, primarily due to care coordination and lack of social support. These findings highlight the need for improved multidisciplinary communication and patient support mechanisms, suggesting potential areas for quality improvement in HNSCC treatment management.
Inflammation may contribute to the high prevalence of depressive symptoms seen in lung cancer. “Sickness behavior” is a cluster of symptoms induced by inflammation that are similar but distinct from depressive symptoms. The Sickness Behavior Inventory-Revised (SBI-R) was developed to measure sickness behavior. We hypothesized that the SBI-R would demonstrate adequate psychometric properties in association with inflammation.
Method
Participants with stage IV lung cancer (n = 92) were evaluated for sickness behavior using the SBI-R. Concomitant assessments were made of depression (Patient Hospital Questionniare-9, Hospital Anxiety and Depression Scale) and inflammation [C-reactive protein (CRP)]. Classical test theory (CTT) was applied and multivariate models were created to explain SBI-R associations with depression and inflammation. Factor Analysis was also used to identify the underlying factor structure of the hypothesized construct of sickness behavior. A longitudinal analysis was conducted for a subset of participants.
Results
The sample mean for the 12-item SBI-R was 8.3 (6.7) with a range from 0 to 33. The SBI-R demonstrated adequate internal consistency with a Cronbach's coefficient of 0.85, which did not increase by more than 0.01 with any single-item removal. This analysis examined factor loadings onto a single factor extracted using the principle components method. Eleven items had factor loadings that exceeded 0.40. SBI-R total scores were significantly correlated with depressive symptoms (r = 0.78, p < 0.001) and CRP (r = 0.47, p < 0.001). Multivariate analyses revealed that inflammation and depressive symptoms explained 67% of SBI-R variance.
Significance of results
The SBI-R demonstrated adequate reliability and construct validity in this patient population with metastatic lung cancer. The observed findings suggest that the SBI-R can meaningfully capture the presence of sickness behavior and may facilitate a greater understanding of inflammatory depression.
To investigate changes in socio-economic inequalities in growth in height, weight, BMI and grip strength in children born during 1955–1993 in Guatemala, a period of marked socio-economic-political change.
Design:
We modelled longitudinal data on height, weight, BMI and hand grip strength using Super-Imposition by Translation and Rotation (SITAR). Internal Z-scores summarising growth size, timing and intensity (peak growth velocity, e.g. cm/year) were created to investigate inequalities by socio-economic position (SEP; measured by school attended). Interactions of SEP with date of birth were investigated to capture secular changes in inequalities.
Setting:
Urban and peri-urban schools in the region of Guatemala City, Guatemala.
Participants:
Participants were 40 484 children and adolescents aged 3–19 years of Ladino and Maya ancestry (nobservations 157 067).
Results:
The difference in height (SITAR size) between lowest and highest SEP decreased from −2·0 (95 % CI −2·2, −1·9) sd to −1·4 (95 % CI −1·5, −1·3) sd in males, and from −2·0 (95 % CI −2·1, −1·9) sd to −1·2 (95 % CI −1·3, −1·2) sd in females over the study period. Inequalities also reduced for weight, BMI and grip strength, due to greater secular increases in lowest-SEP groups. The puberty period was earlier and shorter in higher-SEP individuals (earlier SITAR timing and higher SITAR intensity). All SEP groups showed increases in BMI intensity over time.
Conclusions:
Inequality narrowed between the 1960s and 1990s. The lowest-SEP groups were still >1 sd shorter than the highest. Risks remain for reduced human capital and poorer population health for urban Guatemalans.
We apply two methods to estimate the 21-cm bispectrum from data taken within the Epoch of Reionisation (EoR) project of the Murchison Widefield Array (MWA). Using data acquired with the Phase II compact array allows a direct bispectrum estimate to be undertaken on the multiple redundantly spaced triangles of antenna tiles, as well as an estimate based on data gridded to the uv-plane. The direct and gridded bispectrum estimators are applied to 21 h of high-band (167–197 MHz; z = 6.2–7.5) data from the 2016 and 2017 observing seasons. Analytic predictions for the bispectrum bias and variance for point-source foregrounds are derived. We compare the output of these approaches, the foreground contribution to the signal, and future prospects for measuring the bispectra with redundant and non-redundant arrays. We find that some triangle configurations yield bispectrum estimates that are consistent with the expected noise level after 10 h, while equilateral configurations are strongly foreground-dominated. Careful choice of triangle configurations may be made to reduce foreground bias that hinders power spectrum estimators, and the 21-cm bispectrum may be accessible in less time than the 21-cm power spectrum for some wave modes, with detections in hundreds of hours.
The Rockefeller Clinical Scholars (KL2) program began in 1976 and transitioned into a 3-year Master’s degree program in 2006 when Rockefeller joined the National Institute of Health Clinical and Translational Science Award program. The program consists of ∼15 trainees supported by the Clinical and Translational Science Award KL2 award and University funds. It is designed to provide an optimal environment for junior translational investigators to develop team science and leadership skills by designing and performing a human subjects protocol under the supervision of a distinguished senior investigator mentor and a team of content expert educators. This is complemented by a tutorial focused on important translational skills.
Results
Since 2006, 40 Clinical Scholars have graduated from the programs and gone on to careers in academia (72%), government service (5%), industry (15%), and private medical practice (3%); 2 (5%) remain in training programs; 39/40 remain in translational research careers with 23 National Institute of Health awards totaling $23 million, foundation and philanthropic support of $20.3 million, and foreign government and foundation support of $6 million. They have made wide ranging scientific discoveries and have endeavored to translate those discoveries into improved human health.
Conclusion
The Rockefeller Clinical Scholars (KL2) program provides one model for translational science training.
Field studies were conducted at three sites in Missouri in 1986 and 1987 to evaluate the performance of below-label rates of bentazon, acifluorfen, and chlorimuron tank mixed with sethoxydim and applied to soybeans 7 and 14 days after planting to evaluate broadleaf and grass weed control and weed seed production. Sequential applications of 0.25X-labeled rates of all three broadleaf herbicides tank mixed with 0.5X sethoxydim rates controlled giant foxtail, velvetleaf, and common cocklebur equivalent to one application of standard-labeled rates of the same tank mixes. Single applications of below-labeled rates of the postemergence herbicides did not control weeds, and soybean yields were not equal to sequential 0.25X or single full-rate treatments. A preemergence treatment of clomazone plus imazaquin applied at labeled rates controlled weeds, and soybean yields were equal to a handweeded check in both years at all test locations. Weeds survived and produced seed to reinfest the plots the following year unless nearly 100% control was achieved.
A fossil assemblage containing molluscs, mammals, insects, ostracodes, and plants has been recovered from a silt-filled depression near Lima, in west-central Illinois. The reversed remanent magnetic signature of the sediments and the temporal ranges of two mammals, Microtus paroperarius and Lasiopodomys deceitensis, constrain the age of the assemblage to between 730,000 and 830,000 yr B.P. The extent of isoleucine epimerization in the molluscan shell is consistent with this age interpretation. The fauna includes at least 43 taxa of beetles from 11 families, 35 nominal species of molluscs, and two genera of ostracodes. The mammals include two shrews, three rodents, and a rabbit. The plant macrofossils (no pollen recovered) include 25 species of seed plants and four kinds of terrestrial or wetland mosses. Most of the plant species identified still occur in the upper Midwest, although a few of the taxa are found mainly to the north of the site. The fauna is characterized by an almost total absence of true aquatic taxa. The association of both boreal and thermophilous faunal and floral elements suggest that summer temperatures were not greatly different from present ones, but cooler, moist areas must have been available to support the boreal elements. Local conditions were probably similar to those now found in northeastern Iowa, where rains blocks, fissures, and joints in carbonate bedrock serve as traps for debris accumulations, provide shade, and are kept cool and moist during the hot summer months by cold-air drainage and groundwater seepage. Summer mean temperature in these microhabitats was probably between 18 and 20°C, similar to temperatures that now occur near the northern hardwood spruce-fir transition in the eastern United States.
An isolate of the fungus Dactylaria higginsii obtained from purple nutsedge in Florida was highly pathogenic to Cyperus spp. The potential of this isolate as a bioherbicide was field tested in natural populations of purple nutsedge in Gainesville and Jay, FL. The fungus was applied in 0.5% Metamucil® as a carrier, and the treatments were: carrier only, 105 conidia/ml + carrier, and 106 conidia/ml + carrier. Treatments were applied as single, double, or triple postemergence (POST) sprays at biweekly intervals. The disease and secondary infections developed in about 5 and 15 d after inoculation, respectively, killing most of the infected leaves. All weed growth parameters and disease progress rates were affected by inoculum dosage and inoculation frequencies. Three inoculations, each at 106 conidia/ml, provided effective control of purple nutsedge compared to a single inoculation, as measured by shoot dry weight, tuber numbers, and tuber dry weight. Higher rates of disease progress and disease levels, defined by the area under the disease progress curve (AUDPC), occurred with three inoculations at 106 conidia/ml. Disease progress was slower and the level of weed control was lower at 105 conidia/ml compared to the higher inoculum level. Three applications of 106 conidia/ml provided >90% nutsedge control. Dactylaria higginsii appears to be an effective bioherbicide candidate deserving further development for commercial use.
A fossil assemblage containing molluscs, ostracodes, and fish has been recovered from lacustrine sediments from near Connersville, southeastern Indiana. The reversed remanent magnetic signature of the sediments and the extent of isoleucine epimerization in molluscan shell protein indicate a pre-Illinoian age for the fossils. The fauna includes four taxa of fish, Coregonus sp., cf. Prosopium sp., cf. Thymallus arcticus, and Catostomus sp.; four taxa of ostracodes, Cytherissa lacustris, Candona caudata, Cyclocypris ampla, and Candona sp.; and 28 taxa of molluscs. Elements of the aquatic molluscs, fish, and ostracodes suggest a cool-water lake (8° to 16°C). The terrestrial molluscs include boreal species that now reach the southern limits of their range in the Great Lakes region near the north shore of Lake Superior and imply average summer temperatures of about 15°C near the lake margins. The lake may have been formed when West Lebanon ice advanced into the Anderson-New Castle Buried Valley system which drained northwest as a tributary of the Lafayette Bedrock Valley System.
Field studies were conducted at Yoakum and Stephenville, TX; Jay, FL; and Midville and Plains, GA, to determine the persistence of imazapic applied to peanuts at 0, 70, 140, and 210 g ai/ha. The following year, cotton, sorghum, and corn were planted in the treated plots in Texas, cotton was planted in Florida, and corn and cotton were planted in Georgia and evaluated for carryover injury. Data collected to determine injury included plant heights and weights. In 1999 in Texas and in Florida and Georgia, there was no significant carryover injury to rotational crops from any of the imazapic rates. Data on cotton and sorghum plant height from Texas in 2000 showed height reductions for the 210-g/ha rate on cotton and the 140- and 210-g/ha rates on sorghum. These data showed no significant carryover effects to rotational crops from the 70-g/ha rate of imazapic applied to peanuts the previous year.
Herbicide soil/solution distribution coefficients (Kd) are used in mathematical models to predict the movement of herbicides in soil and groundwater. Herbicides bind to various soil constituents to differing degrees. The universal soil colloid that binds most herbicides is organic matter (OM), however clay minerals (CM) and metallic hydrous oxides are more retentive for cationic, phosphoric, and arsenic acid compounds. Weakly basic herbicides bind to both organic and inorganic soil colloids. The soil organic carbon (OC) affinity coefficient (Koc) has become a common parameter for comparing herbicide binding in soil; however, because OM and OC determinations vary greatly between methods and laboratories, Koc values may vary greatly. This proposal discusses this issue and offers suggestions for obtaining the most accurate Kd, Freundlich constant (Kf), and Koc values for herbicides listed in the WSSA Herbicide Handbook and Supplement.
Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.
Farm level risk analyses have used price and yield variability almost exclusively to represent risk. Results from a survey of 149 agricultural producers in 12 states indicate that producers consider a broader range of sources of variability in their operations. Significant differences exist among categories with respect to the importance of the sources of variability in crop and livestock production. Producers also used a variety of management responses to variability. There were significant difference among categories in the importance given to particular responses and their use of them. These results have implications for research, extension, and policy programs.
The Murchison Widefield Array is a new low-frequency interferometric radio telescope built in Western Australia at one of the locations of the future Square Kilometre Array. We describe the automated radio-frequency interference detection strategy implemented for the Murchison Widefield Array, which is based on the aoflagger platform, and present 72–231 MHz radio-frequency interference statistics from 10 observing nights. Radio-frequency interference detection removes 1.1% of the data. Radio-frequency interference from digital TV is observed 3% of the time due to occasional ionospheric or atmospheric propagation. After radio-frequency interference detection and excision, almost all data can be calibrated and imaged without further radio-frequency interference mitigation efforts, including observations within the FM and digital TV bands. The results are compared to a previously published Low-Frequency Array radio-frequency interference survey. The remote location of the Murchison Widefield Array results in a substantially cleaner radio-frequency interference environment compared to Low-Frequency Array’s radio environment, but adequate detection of radio-frequency interference is still required before data can be analysed. We include specific recommendations designed to make the Square Kilometre Array more robust to radio-frequency interference, including: the availability of sufficient computing power for radio-frequency interference detection; accounting for radio-frequency interference in the receiver design; a smooth band-pass response; and the capability of radio-frequency interference detection at high time and frequency resolution (second and kHz-scale respectively).