No effective preemergence or postemergence herbicides are currently available to use on sugar beets for managing kochia and Palmer amaranth that are resistant to glyphosate and acetolactate synthase. To evaluate a new herbicide option, field experiments were conducted to assess the efficacy of a preemergence application of metamitron to sugar beet crops. Studies were carried out in Lingle, Wyoming, and Scottsbluff, Nebraska, in 2019. Studies were repeated in 2020 at the Scottsbluff location, and two locations in Oregon, Nyssa and Ontario. Cycloate (4.03 kg ai ha−1), ethofumesate (1.58 kg ai ha−1), metamitron (2.82, 5.63, and 7 kg ai ha−1), and metamitron + ethofumesate (5.63 + 1.58 kg ai ha−1) were applied preemergence. Metamitron (5.63 kg ai ha−1) + ethofumesate (1.58 kg ai ha−1) was applied preemergence followed by (fb) ethofumesate (1.58 kg ai ha−1) or acetochlor (1.26 kg ai ha−1) applied at the 2 to 4 true-leaf (TL) stage of sugar beet, ethofumesate or acetochlor at the 2 to 4 TL and 6 to 8 TL stages, and ethofumesate fb acetochlor at the 2 to 4 TL and 6 to 8 TL stages, respectively. A nontreated control and weed-free check (glyphosate applied at 2 to 4 TL and 6 to 8 TL stages of sugar beet) were included for treatment comparison. Ethofumesate applied alone preemergence provided ≤65% control of Palmer amaranth, common lambsquarters, and redroot pigweed relative to ≥95% control when metamitron (5.63 kg ai ha−1) was applied as a tank mixture partner. Any treatment containing metamitron (≥5.63 kg ai ha−1) provided ≥80% control of common lambsquarters, redroot pigweed, and Palmer amaranth, but not kochia. When kochia was not present, any herbicide combination that contained metamitron (≥5.63 kg ai ha−1) provided similar sugar beet root yield and recoverable sugar as glyphosate-based treatments. Based on the findings of this research, metamitron (≥5.63 kg ai ha−1) applied preemergence will control Palmer amaranth, common lambsquarters, and redroot pigweed until other herbicides, such as those that inhibit very-long-chain fatty acids, can be applied at the 2 TL stage of sugar beet.