Rates of common mental disorders (CMD), such as anxiety and depression, treated in primary care have increased among young adults in the UK. However, it remains unclear whether this increase reflects a greater tendency to seek help for CMD or a rise in CMD symptoms over time. Additionally, it is not clear if these increases are more pronounced in specific sociodemographic groups. This research examined the temporal trends of primary care-recorded CMD and self-reported CMD symptoms in young adults.

We included participants born between 1980 and 2003 in two datasets: UK primary care records from the Clinical Practice Research Datalink, and longitudinal cohort data from Understanding Society. We estimated the annual incidence of primary care-recorded CMD overall and by sex, age, birth cohort, ethnicity, country, region, and deprivation from 2009 to 2019, and explored changes over time using incidence rate ratios. We compared these trends to annual estimates of self-reported CMD symptoms from longitudinal cohort data between 2009-10 and 2019-20, calculating ratios to explore changes in CMD symptoms over time by sociodemographic group.

Between 2009 and 2019, the incidence of recorded CMD increased by 9·90% and CMD symptoms increased by 19·33%. The sharpest increases for both recorded CMD and CMD symptoms were observed in older adolescents (ages 16-19) and those born after 1995. Recorded CMD increased more in males (20·61%, increase) than in females (7·65%), despite similar increases in CMD symptoms. Recorded CMD increased the most in the least deprived areas of England (16·34%) compared to the most deprived areas (3·55%), despite similar increases in CMD symptoms across all levels of deprivation.

Both primary care-recorded CMD and self-reported CMD symptoms in young adults increased between 2009-19, suggesting that the rising rates of CMD treated in primary care may reflect heightened symptoms of CMD. However, differences in the patterns of recorded CMD and CMD symptoms across sociodemographic groups highlight potential misalignment between mental health care provision and underlying population need, suggesting that the groups with the highest burden of CMD symptoms may not be the groups most likely to receive care.

None Declared

Background and relevance

Addictive behaviours have for the first time been included within the addiction spectrum. The transition to ICD-11 is a critical step in advancing mental health and addiction medicine.

The implementation of ICD-11 is expected to improve Health Records, facilitate Better Treatment, reduce Stigma, and enhance Public Health Surveillance.Testing the practical implications of these changes is key to ensure preparedness and smooth and effective implementation.

We conducted a comprehensive evaluation to assess the practical implications of these changes in Switzerland, determining the ease of implementation in clinical and public health settings.

Assessment consisted in:

Gathering Feedback through collecting insights from health professionals to identify potential challenges and areas for improvement.

Informing Training Needs by identifying the training requirements for health professionals to effectively use the new system.

The field testing involved multiple components: online survey, focus groups, expert reviews, key informant interviews, and a consensus conference.

The testinginvolved 64 health professionals and covered diverse professional backgrounds and geographical locations). Respondents had a median of 15.25 years of experience in addiction medicine, 75% of them were Clinicians and 25% were Public Health Professionals.

Key findings of the diffrernt survey components included: High approval rates for the utility (89%), feasibility (92%) and ease of use (86%) of the ICD-11.

Strong support (90%) for the inclusion of Addictive behaviors, particularly Gaming disorder and Gambling disorder, In contrast, the broader clinical spectrum of Gaming disorder (hazardous gaming and harmful gaming) received limited support (5%).

The national consensus conference concluded that ICD-11 is mainly perceived to have a positive impact on Swiss health records, to enable better documentation of emerging health conditions, and to reduce stigma. Divergent views were represented and expressed their acceptance or reluctance towards including addictive behaviours.

Careful transition and preparedness at the national level, training health professionals along with effective communication to public audience, were reported to be essential to mitigate risks of stigma and over-pathologizing addictive behaviours.

The implementation of ICD-11 in Switzerland is anticipated to enhance the understanding of the societal and economic impacts of new categories such as Gaming disorder. The field-testing data collected from a wide variety of experts and care professionals underscores the need for investment in training, communication, and preparedness to ensure a smooth transition and maximize the benefits of the new classification system.

None Declared

Suicidality is a critical concern in individuals with affective disorders, and environmental and biological factors may influence its risk. In recent years, seasonal variations and systemic inflammation, as indicated by high-sensitivity C-reactive protein (hsCRP), have garnered interest as potential contributors.

To assess the risk of suicidality in affective disorders among seasonality correlated with hsCRP.

A naturalistic, observational, cross-sectional study was carried out by retrospectively recruiting 353 adult inpatients affected by severe mental illness (SMI) consecutively hospitalized in the Psychiatry Clinic of the Ospedali Riuniti of Ancona, Italy. Patients affected by inflammatory pathology, alcohol/substance use disorders or treated by anti-inflammatory/immunosuppressive therapy were excluded. Only patients suffering from mood disorders were considered for this analysis (n=246). We administered a checklist for socio-demographic and clinical features (diagnosis, age of onset, disease duration, number of episodes, number of episodes per year, suicidal attempts and comorbidities). Subscale 5 of the Mini International Neuropsychiatric Interview (MINI-5-s) was administered to all the patients involved to assess suicidality risk. To normalize hs-CRP, a logarithmic transformation was performed (log-hsCRP). At the same time, season were codified as dummy variables. T-test for independent groups and multivariate linear regression were conducted.

47.2% (n=116) of the sample were male. The mean value of hsCRP was 5.7mg/L (SD=15.8). The mean score of MINI-5-s total score was 13.3 (SD=11.6). Patients admitted to our psychiatric ward in meteorological (p=0.013) and astronomical (p=0.049) autumn had a lower log-hsCRP compared to other seasons. A multivariate linear regression was observed between MINI-5-s total score (R² =0.74, F=9.639, Durbin-Watson=1.915, p<0.001) and hsCRP (B=0.94, p=0.041) and the meteorological autumn (B=-7.436; p<0.001).

This study highlights a significant association between seasonality, systemic inflammation (as measured by hsCRP), and suicidality risk in patients with mood disorders. Our results focus on the importance of considering biological and environmental factors in assessing and managing suicidality risk in affective disorders. Further studies are essential to link seasonal and inflammatory mechanisms.

None Declared

As a neurodevelopmental disorder characterized by symptoms such as inattention, hyperactivity, and impulsivity, ADHD was once predominantly associated with Western medical discourse. However, recent years have seen a notable rise in self-diagnoses of ADHD among young people in Kyrgyzstan.

This research aims to explore the myths surrounding ADHD in the Kyrgyz Republic, focusing on how these misconceptions contribute to the destigmatization of mental health disorders and create challenges for mental health professionals. The research also seeks to examine the gap between public awareness of ADHD and the actual resources available for diagnosis and treatment in Kyrgyzstan.

This analysis is qualitative and is based on, (1) observations of self-diagnosis trends among young people in Kyrgyzstan, and (2) anecdotal evidence from mental health professionals working in the country. In-depth interviews were conducted with 15 adolescents, self-diagnosed with ADHD, and 15 mental health care specialists working in Bishkek. Informed consent was presented before the interviews and both patients and specialists were rewarded by 15 dollars after the interview.

Three key myths emerged from the analysis: (1) ADHD as a Temporary Condition: A prevalent belief in Kyrgyzstan is that ADHD can be easily cured by a few visits to a “good” psychologist. It reflects the unrealistic expectations of therapy and the lack of understanding that ADHD often requires long-term management. (2)ADHD as a Fashionable Disorder: There is a growing trend, particularly among urban youth, to romanticize ADHD as a “cool” or “fashionable” diagnosis. While this has contributed to greater awareness of ADHD, it also trivializes the disorder, promoting self-diagnosis and diluting the seriousness of the condition. (3) ADHD as a Childhood Disorder: Another widespread misconception is that ADHD primarily affects children and that individuals grow out of it with age. This myth prevents many from seeking early intervention.

The growing awareness of ADHD in the Kyrgyz Republic is a double-edged sword. On one side, it is helping to reduce the stigma associated with mental health disorders, providing people with a socially acceptable way to discuss and understand their struggles. Conversely, the myths accompanying this awareness hinder effective diagnosis and treatment, making it difficult for individuals to access proper care. Mental health professionals must not only treat ADHD but also work to correct these societal misconceptions, a task made more difficult by limited resources in Kyrgyzstan. A more nuanced public understanding of ADHD, supported by accurate information and improved mental health infrastructure, is essential for addressing these challenges

None Declared

Given the high rates of disengagement of psychological and/or psychopharmacological treatment in individuals with severe mental illness (SMI), building a strong therapeutic alliance (TA) in treatment is crucial. Despite the awareness of a favorable role of the TA in mental health care for people with SMI, there is a paucity of research that contributes to the formulation of concrete guidelines for establishing a strong TA.

This review aims to systematically synthesize existing literature of associated factors of the TA across six domains: client, mental health professionals (MHPs), clinical, social, care, and other. These include the views of clients with SMI, MHP, and independent raters of the TA.

Parallel literature searches in PsycInfo, Medline, and PubMed between 2000-2022 identified 2699 possible articles, of which n=53 met inclusion criteria.

Associated factors of better client-rated TA were: high insight, secure attachment, higher outcome expectancy at baseline, specific personality traits, less internalized stigma, more therapists’ empathy and frequent use of supportive techniques by MHP. MHP-rated and/or independent observer-rated TA was significantly related to: more insight, sex of client (female), MHP without anxious attachment, and less severe symptomatology of client.

Clinical symptom severity only affected TA when rated by MHP, but not when rated by clients. Attachment style affects the TA bidirectionally: clients’ secure attachment to the MHPs may help modify maladaptive attachment patterns, and anxious/insecure attachment style from either client or MHP affects the TA negatively. Furthermore, having an early positive click with the client builds the foundation for a later stable and supportive relationship, making the client more likely to continue perceiving the alliance as positively as treatment progresses. It is therefore crucial to provide a warm and supporting environment from the start of treatment, where clients have the opportunity to overcome perceived (self-)stigma and develop a positive mindset towards outcome expectations. Focusing on supportive techniques like providing feedback or shared agenda setting instead on the clients clinical symptomatology solely might result in a more favorable perception of the TA. Notably, current TA measurements assume a one-on-one relationship between clients and MHP, while nowadays multiple MHPs are involved. We recommend re-evaluating the assessment of TA within SMI care.

None Declared

In clinical studies on psychosis prediction, small sample sizes have been a persistent issue. Most studies rely on limited data, lack cross-validation, and use poor model strategies, leading to overfitting and overestimated accuracy. This challenge also affects traditional studies, where recruiting few participants introduces biases. Data harmonization is another hurdle, especially in speech analysis, which is crucial in psychiatry for conditions like psychosis, aphasia, and PTSD, but suffers from inconsistent methodologies across databases.

Our goal was to develop an method using Large Language Models (LLMs) to create diverse, synthetic speech datasets, addressing these challenges: 1. Develop an evolutionary system for optimizing high-quality speech data generation. 2. Incorporate contrastive learning for improved model decision boundaries. 3. Provide a methodology for training classification models and conducting cross-cultural studies. 4. Create a large-scale, diverse database of synthetic psychiatric speech samples.

Our findings suggest that this approach could significantly benefit psychiatric research by addressing the challenges of small sample sizes and data inconsistency. The method shows promise for creating more reliable and generalizable predictive models, which could lead to advancements in mental health care practices. The system’s flexibility indicates potential applications beyond our case study, possibly extending to other areas where data scarcity has impeded progress.

None Declared

The concept “mild cognitive impairment” (MCI) means a decline in executive functions (such as memory, attention, language or thought) that does not correspond to what is expected for a person’s age group. It is estimated that this diagnosis may affect a fifth of the population over 65 years and 50-80% of them will develop dementia. This pathology is related to a loss of autonomy and an increase in dependence. In addition, there are therapeutic limitations, so it is a flagrant health and social problem. In this context of difficulties, various non-pharmacological therapies are emerging with the aim of improving various aspects of this disease, among which we can found music therapy (MT).

The aim of this study is to review the most recent findings of the scientific community regarding the validity of MT as an intervention in patients with MCI. Specifically, its efficacy on cognition and its power to stop the progression of dementia are evaluated, as well as its effects on other areas of the patient.

A systematic review was carried out in the “WOS-Web of Science”, “Scopus” and “Psycoinfo” databases following PRISMA guidelines. The keywords were “MT” and “MCI”. We included clinical trials, systematic reviews and meta-analyses in english or spanish whose study population had MCI, excluding those published before 2017.

15 studies were selected, all with high quality evidence designs measured by Scotish Intercollegiate Guidelines Network scale. Among all the types of MT evaluated, various studies agree that Active MT (which includes activities that involve active participation of the patient such as singing or dancing) stands out as one of the best options, showing post-intervention improvements in MMEE scores and, secondarily, in emotional well-being (specially depression and anxiety). Instrumental practice has an important protective effect on cognitive function. On the other hand, MT with movement, in addition to being effective on cognition (it increases activity in prefrontal cortex), also causes an improvement in physical conditions. However, musical reminiscence (which consists of listening to music with an emotional component for patients with simultaneus display of images to favor memories), although it shows postive effects in several articles, these are not statistically significant. Finally, multimodal therapy (which is a combination of training and cognitive stimulations based on reminiscence and MT) did not show statistically significant changes in either mood or executive functions.

MT is a valid intervention to improve cognitive function, some neuropsychiatric symptoms and the quality of life of patients with MCI. If we also take into account its economic accessibility, the organizational simplicity and null adverse effects, it is easily concluded to be one of the most attractive therapeutic options for treating MCI today.

None Declared

Mental health literacy (MHL) plays a crucial role in promoting help-seeking behavior. However, negative attitudes toward mental illness still pose a substantial barrier. Social media platforms provide a valuable opportunity to explore the relationship between stigma, help-seeking attitudes, and behaviors through the application of natural language processing (NLP) and machine learning (ML) techniques.

This study aims to investigate how attitudes toward reducing mental illness stigma and help-seeking influence actual help-seeking behavior among social media users.

We analyzed 1,506,333 posts from mental health-related Post Text Table (PTT) forums between January 2018 and January 2024. Posts were preprocessed and categorized into three categories: reducing mental illness stigma, help-seeking attitudes, and help-seeking behaviors. Using Bidirectional Encoder Representations from Transformers (BERT) for scoring, the model achieved a precision of 0.81 and accuracy of 0.89. Logistic regression was then applied to assess the predictive value of stigma reduction and help-seeking attitudes on help-seeking behavior.

The study found that for each one-unit increase in score measuring attitudes toward reducing mental illness stigma, he likelihood of help-seeking behavior increased by 1.35 times (95% CI: 1.21–1.50, p < 0.001). Similarly, stronger help-seeking attitudes were associated with a 1.41 times higher likelihood of help-seeking behavior (95% CI: 1.16–1.71, p < 0.05). Binary logistic regression analysis further demonstrated that users with more pronounced stigma-reducing attitudes and positive help-seeking attitudes were 1.76 times (95% CI: 1.43–2.17, p < 0.001) and 2.62 times (95% CI: 1.48–4.65, p < 0.05) more likely to engage in help-seeking behavior, respectively.

This study highlights that stronger attitudes toward reducing mental illness stigma, along with more positive help-seeking attitudes, significantly predict help-seeking behavior. By leveraging machine learning and natural language processing, it offers novel insights into how social media discussions influence mental health behaviors, providing a valuable foundation for future interventions aimed at reducing stigma, fostering positive attitudes toward help-seeking, and encouraging actual help-seeking behaviors.

None Declared

Paediatric patients with severe diseases awaiting solid organ or haematopoietic stem cell transplantation are known to experience cognitive impairments, particularly in executive functioning. Neuropsychological pre-transplant evaluation serves as a baseline for identifying executive functioning deficits that may affect the medical and psychosocial aspects of care. This is clinically relevant because patients with poorer executive functioning may show decreased adherence to medical treatments, face greater challenges in coping with their illness, and be more likely to require educational adaptations, including curricular or methodological adjustments based on pedagogical criteria.

This study aimed to assess everyday executive functioning in paediatric patients awaiting transplantation using an ecologically valid measure.

A total of 49 patients (59.2% male) aged between 6 and 18 years (M = 11.4, S.D. = 3.5) were recruited from La Paz University Hospital (Madrid, Spain). Patients were awaiting for various types of organ transplants (kidney: 26, heart: 4, lung: 4, hepato-renal: 3, or liver: 2 patients) or haematopoietic stem cells (10 patients). Patients were assessed using the Spanish parent-reported version of the Behavior Rating Inventory of Executive Function, Second Edition (BRIEF-2) with age- and sex-adjusted norms from the Spanish general population. The three BRIEF-2 composite scores were analysed (the Cognitive, Emotional and Behavioral Regulation Indexes), and clinically relevant scores were set at T ≥ 65 points.

Clinically significant levels of executive deficits were observed in 33.3% of patients regarding cognitive regulation problems, in 32.7% regarding emotional regulation difficulties and in 26.5% regarding behavioural regulation problems.

Between 1 in 4 and 1 in 3 patients have shown some type of executive regulation difficulties. The early identification of executive functioning deficits in paediatric transplant candidates is crucial. Incorporating standardised ecologically valid measures, such as the BRIEF-2, into routine assessments can help detect neuropsychological impairments at an early stage, allowing timely therapeutic or preventive interventions (e.g., psychological prehabilitation). This approach can improve medical outcomes and quality of life and guide educational adaptations to support academic performance.

None Declared

Vladimir Chizh, who replaced Emil Kraepelin in the Department of Psychiatry at the University of Dorpat in 1891, counted no fewer than 30 characters with psychoneurological disorders in Dostoevsky’s works, beginning with the main character of “The Double,” written in 1846.

Try to answer the following questions: (1) Should a psychopathological analysis of a literary work include elements of the author’s psychobiography, psychopathological components of the author’s language, and can such work be carried out by one psychiatrist without the participation of a literary scholar? (2) What goals should such an analysis pursue? (3) Should the accuracy of the author’s description of the mental disorders present in the characters of his work be considered as a criterion for assessing the author’s artistic skill and the significance of the work as a literary and cultural phenomenon?

Taking Dostoevsky’s “The Double” as a starting point, the authors analyzed professional literature on the topic and conducted their own psychopathological and literary analysis of this literary work.

(1) psychopathological analysis without the participation of a literary scholar is always incomplete, since everything we learn about the hero of the work we learn through the language of the work. (2) the assessment of the quality of a work of art by a psychiatrist from the point of view of the accuracy of the description of psychopathological symptoms in a particular character leads to the fact that the ideal work of art becomes a well-written case history.

It is hardly correct to give a precise psychiatric categorization to persons whose behavior in a work of art is depicted as pathological. The author’s depiction of his hero’s pathological experiences has goals other than psychiatric ones and is conditioned by the general concept of the work.

None Declared

Maniform symptoms for the first time after the age of 50 are not common, although we can find it in our clinical practice due to the increasing aging of the world’s population.

We present a clinical case of a patient with manifest behavioral symptoms where a differential diagnosis is made between Late-onset bipolar disorder vs Frontotemporal dementia with a behavioral profile (FTD)

62-year-old male with a history of type II diabetes, hypertension and L4-L5 disc herniation. Psychiatric history of recurrent depressive disorder and dysfunctional personality. Treated with venlafaxine 150 mg and gabapentin 600 mg DMD. He was on sick leave from his company due to lower back pain. Married with two children, dysfunctional relationship with them. He was admitted to Psychiatry for the first time in February 2024 due to behavioral disturbances of 5 days’ duration. He was verbose, irritable and described “being better than ever”. A few days earlier he took a Tadalafil tablet, an event that he related to the onset of the condition. Since then, there has been an increase in psychomotor activity, disinhibition and exalted mood. He reported having contact with high-ranking political figures. Upon discharge from hospital, he was diagnosed with an Unspecified Manic Episode and was prescribed Lithium 800mg DMD and Risperidone extended release 75 mg monthly. The symptoms did not improve, he abandoned the treatment and was admitted for the second time in April 2024 where Valproic 1000 mg DMD, Olanzapine 20mg DMD and Risperidone 6 DMD were prescribed.

He has a poor outpatient evolution with loss of autonomy, physical deterioration, hyperfamiliarity, behavioral disinhibition and no awareness of the disease. Given the suspicion of an organic condition, he was referred to Neurology consultations where a cranial magnetic resonance imaging was performed. with results of punctate and hyperintense images in T2 localized in subcortical white matter of nonspecific character and Mini-ACEII test: 22/30. Waiting for PET-CT and with a diagnosis of possible Frontal Release Syndrome to rule out behavioral variant FTD.

Within the differential diagnosis of the condition we find Late-onset bipolar affective disorder and behavioral variant FTD. The first presents with inappropriate, repetitive and stereotyped behavior, as well as a progressive and gradual deterioration. While late bipolar disorder presents with self-limiting episodes and more manifest symptoms. In a PET-CT suggestive of FTD it is likely to find areas of hypoperfusion in frontal and temporal regions. The differential diagnosis between both is a challenge in clinical practice.

None Declared

Sexual dysfunction is a multifaced issue that significantly affects women’s physical and psychological health, contributing to broader emotional challenges such as dissatisfaction and inadequacy. In Tunisia, cultural and social factors, including gender roles and societal expectations, further shape women’s perceptions and experiences of their sexual well-being. Self-esteem, a core component of psychological health, plays a crucial role in how women view and experience their sexuality, with lower self-esteem often intensifying sexual dysfunction.

This study aims to explore the relationship between sexual dysfunction and self-esteem among Tunisian women within this cultural context.

a cross-sectional study was conducted online using a Google Forms questionnaire between July and August 2024.The inclusion criteria were sexually active women aged 18 years or older who provided informed consent to participate. Participants completed a self-administered questionnaire that included sociodemographic information, personal medical history, lifestyle habits, and psychometric assessments.

The Female Sexual Function Index (FSFI) was used to evaluate sexual function and self-esteem was assessed using the Rosenberg Self-Esteem Scale (RSE).

A total of 180 women participated in the study. The average age of the sample was 32.79, with ages ranging from 21 to 60 years. In our study, 97.78% of the women were from urban areas 94.44% had a university degree 80% were employed and 62.78% were married. Regarding medical history, 21.11% reported organic issues, while 27.22% had a psychiatric history.

Lifestyle habits indicated that 18.9% of women smoked, and 21.1% consumed alcohol, while only 1.1% reported using psychoactive substances. . The majority, 93.89%, had a single partner, and 93.89% identified as heterosexual.

The evaluation of sexual function using the Female Sexual Function Index (FSFI) showed an average score of 23.37 ± 9.64, with 43.33% of participants experiencing sexual dysfunction. Specifically, 75.6% had issues with sexual desire, 83.3% reported pain during intercourse, and 71.7% experienced problems with sexual arousal.

The average self-esteem score, was 32.25 ± 5.75. A significant correlation was found between sexual dysfunction and self-esteem (p < 10^-3). Among the women with very low self-esteem, 80% experienced sexual dysfunction, while only 20% of those with very high self-esteem reported dysfunction.

Addressing both sexual health and self-esteem is essential for improving the emotional and psychological well-being of women in Tunisia. These findings underscore the importance of comprehensive sexual health interventions that promote positive self-esteem, ultimately enhancing the overall quality of life and fostering psychological resilience among Tunisian women.

None Declared

Decedents without known mental disorders constitute 5%-40% of suicides and epidemiologic studies show that 20% of those with a history of suicidal behavior (SB) may be free of psychiatric disorders. This implies that suicide ideation (SI) may occur in the psychiatrically healthy volunteers (HVs), providing an opportunity for preventing suicide and SB. Yet, studies of HVs have not focused on the occurrence of SI, nor has SI in HVs been characterized, especially in relation to the occurrence of stress. If SI is not rare in HVs, current approaches to managing suicide risk in medical settings may be too limited to identify psychiatrically healthy individuals at risk for suicide.

We recruited HVs and major depressive disorder (MDD) patients to test two hypotheses: (1) some HVs, screened to exclude those meeting lifetime criteria for Axis I or II disorders and with no personal or family history of SB, would endorse SI on Ecological Momentary Assessment (EMA); and (2) HVs’ SI scores would be lower than those of MDD patients. In addition, we investigated whether HV and MDD groups had different responses to stressors in terms of SI.

HVs and MDD patients were recruited through advertisements: some patients were recruited in the emergency department. Participants provided 7 days of ecological momentary assessment (EMA) data about SI and stressors. EMA data was collected in six 2-hour epochs during a 12-hour period selected to match participant wake hours. Longitudinal mixed effects logistic regression models compared HV and patient SI scores and frequency of stressors. Mixed effects linear regression models compared HVs’ and patients’ SI score change from the previous epoch’s SI score when each stressor occurred.

HVs (n=42) reported less frequent (p<0.001) and less intense SI (p<0.003) than patients (n=80). HVs did endorse SI and/or SI-related items in 44% of EMA epochs, endorsing actual SI items, as opposed to SI related items (lack of wish to live) in 25% of epochs with non-zero SI scores. For 7 of 8 stressors, patients reported stressors more often than HVs (all p<0.001) and responded to them with greater SI (0.0001<p<0.0472). HVs reported statistically significant SI increases only in response to neglect (p<0.0147), indicating HVs were relatively resilient to other stressors.

The occurrence of SI and SB among psychiatrically healthy individuals has been relatively neglected. However, SI does occur in this population. Although HVs demonstrated more modest SI increases than patients in response to stressors, the reports of SI in 44% of epochs by HVs suggest that focusing solely on individuals with mental disorders when screening for suicide risk may be too narrow an approach.

M. Oquendo, MD, PhD earned royalties from: Research Foundation for Mental Hygiene, Inc. - Columbia Suicide Scale, Conflict with: Honoraria - Alkermes - Grant Reviews, Honorarium.

Cyberchondria, defined as excessive and anxiety-driven health-related internet searching, has become an increasingly significant issue in the digital age, where easy access to online health information can contribute to heightened health anxiety. Recent studies suggest that cognitive avoidance strategies, such as thought suppression, may worsen anxiety-related behaviors, including health-related internet searching.

The objective of this study was to investigate how the tendency to suppress thoughts (thought suppression) influences the development and intensity of cyberchondria in a sample of medical students.

A cross-sectional study design was employed, involving a sample of 213 medical students. The White Bear Suppression Inventory (WBSI) was used to assess participants’ tendency to suppress health-related thoughts. The Cyberchondria Severity Scale (CSS) was used to measure the extent and severity of health-related internet searching behaviors. Participants also provided information about their medical history, family medical history, and psychiatric background.

The sample consisted predominantly of females (74.2%), with a mean age of 22.11 ± 2 years. Among the 213 participants, 22.1% reported a personal medical history, and 20.2% had a documented history of psychiatric disorders. Regarding family medical history, 59.6% of participants reported a familial history of medical conditions, and 21.6% reported a familial history of psychiatric disorders. Additionally, 39% of participants reported that family members had been hospitalized for serious illness.

The levels of cyberchondria among participants were as follows: 36.6% of participants reported low levels of cyberchondria, 41.8% reported moderate levels, 20.7% reported high levels, and 0.9% reported very high levels of cyberchondria.

A significant positive correlation was found between WBSI scores (measuring thought suppression) and Cyberchondria Severity Scale (CSS) scores (measuring health-related internet searching) (r = 0.4, p=0.02). This suggests that medical students who engaged in higher levels of thought suppression were more likely to experience intrusive health-related thoughts and engage in heightened online health searching behaviors.

The findings of this study suggest that there is a positive relationship between thought suppression and the intensity of cyberchondria among medical students. These results highlight the importance of addressing cognitive avoidance strategies, such as thought suppression, in the management of health anxiety. Future research could explore interventions that aim to reduce thought suppression, such as cognitive-behavioral therapy (CBT) or mindfulness-based techniques, as potential strategies for alleviating cyberchondria and its associated health anxiety.

None Declared

Strength training has long been linked to several physical and mental health advantages, ranging from increased muscle strength and endurance to higher mood and self-esteem. However, the potential link between strength training intensity and sexual satisfaction is a relatively unexplored area of research.

This study’s objective is to evaluate the potential relationship between the intensity of strength training and an individual’s degree of sexual satisfaction among people who exercise at the gym in Tunisia.

This is a cross-sectional study, conducted from February to March 2024. Participants were recruited online through social media platforms (Tunisian facebook groups and fitness forums) using a posted survey link. We’ve included respondents who are 18 years of age or older who have been active in strength training with a gym membership for 1 month or more. The respondents were required to answer a questionnaire that included socio-demographic data and to provide strength training intensity related details (sessions frequency, duration, perceived overall intensity using likert scale)

Sexual satisfaction was measured using the Sexual Satisfaction Index (SSI), validated psychometric tool developed by Leth-Nissen et al. in 2021. The sum score of the SSI can range from 0 to 36. A higher sum score indicates a higher level of sexual satisfaction.

The total number of participants was 72, with 86% being male. The majority of responders (n=65, 90.2%) indicated that they performed strength training exercises at least three times per week, with an average session length of 45 minutes. In terms of strength training intensity, 38.8% (n= 28) of participants reported high-intensity sessions, 48.6% (n=35) moderate-intensity sessions, and the remaining participants reported low-intensity sessions.

Analysis of the Sexual Satisfaction Index scores revealed a mean score of 23.6 (SD = 6.2), indicating that individuals had moderate to high sexual satisfaction. A significant association was found between strength training intensity and sexual satisfaction scores (r = 0.42, p < 0.01), indicating that higher intensity exercises are associated with higher sexual satisfaction.

Our findings aim to shed light on the link between fitness habits and sexual well-being, emphasising the potential value of including exercise interventions in talks about sexual health and satisfaction. The findings could indicate that the benefits of strength training go beyond physical fitness, potentially contributing to improved overall well-being. More research is needed to delve deeper into the underlying mechanisms causing this link and to investigate its broader implications for overall health and quality of life.

None Declared

Psychotic depression is a severe mental disorder that can cause severe suffering and dysfunctionality in the patient. It is characterised by the presence of major affective symptoms together with the presence of psychotic symptoms in the form of delusions and/or sensory-perceptual alterations. Psychotic depression is particularly severe when it becomes resistant to pharmacological treatment, often requiring the combination of antipsychotics with antidepressants and even the use of electroconvulsive therapy. Lifetime prevalence of psychotic depression ranges from 0.35% to 1%, being more frequent in the elderly. Previous studies have shown positive experience with intravenous ketamine in the treatment of psychotic depression, improving psychotic symptomatology and showing a good safety and tolerability profile. The present study shows the response in a series of cases with psychotic depression treated with inhaled esketamine, showing their evolution through the Montgomery-Asberg Depression Rating Scale (MADRS) as well as their safety and tolerability profile.

The main objective of this study is to describe the use of inhaled esketamine in patients with psychotic depression in real clinical practice, using the MADRS as main outcomes to show the evolution.

Retrospective descriptive study with a sample selected by non-probabilistic consecutive sampling, retrospective type, in a time interval of 2 years. The patients selected were those who completed treatment with inhaled esketamine and had a diagnosis of psychotic depression at Hospital Universitario Infanta Elena. A descriptive analysis was performed. Mean and standard deviation were calculated for quantitative variables and N and percentage for categorical variables.

A total of 5 patients with a diagnosis of psychotic depression (n: 5) all treated with inhaled esketamine were included in the study. The efficacy of inhaled esketamine was very high in the treatment of patients with psychotic depression, achieving a 100% response rate (MADRS<10). All 5 patients showed a rapid improvement in psychotic symptomatology, with cessation of psychotic symptoms in the initial phases of treatment, showing a rapid response. No worsening of psychotic symptoms was observed at any time with the administration of inhaled esketamine. Tolerability was excellent, with no serious adverse effects occurring during treatment administration.

The present study shows a high efficacy of esketamine in the treatment of psychotic depression, with a high response rate and an excellent tolerability profile. Inhaled esketamine could be a useful tool in the treatment of psychotic depression, helping to rapidly restore patients’ functionality. Longitudinal studies must be carried out to confirm this hypothesis.

None Declared

Computational psychiatry uses computer models to improve the understanding, diagnosis, and treatment of mental health disorders. These models can integrate large datasets from various sources, including genetic, neurobiological, and environmental factors, to predict the likelihood of developing depression.

The aim of the study is to explore the potential of computational psychiatry methods in identifying risk factors for the development of depressive disorders.

A review of relevant studies was conducted using the PubMed database. The search focused on articles examining computational psychiatry approaches, particularly those assessing risk factors associated with the onset of depressive disorders.

The study highlights computational models that show potential in identifying risk factors for depressive disorders.

Computational psychiatry offers new insights into identifying risk factors for psychiatric disorders and has the potential to contribute to the prevention and treatment of depressive disorders. However, further research is needed to improve the generalizability and applicability of the models.

None Declared