To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
L’année 2024 est marquée à la fois par la passivité de la pratique conventionnelle du Canada et l’hyperactivité de sa pratique contentieuse. L’apurement de l’arriéré des réclamations fondées sur le régime de règlement des différends entre investisseurs et États (RDIE) de l’Accord de libre-échange nord-américain entre le gouvernement du Canada, le gouvernement des États-Unis et le gouvernement du Mexique (ALÉNA) se poursuit.1 De nombreuses sentences sont aussi rendues dans des affaires portées par des investisseurs canadiens à l’étranger, des sociétés minières pour l’essentiel. Ces affaires permettent de tester les innovations juridiques visant à renforcer le droit de légiférer de l’État dans les traités plus récents du Canada. Une première sentence très attendue sur la question hautement controversée de la portée temporelle du régime transitoire de RDIE de l’Accord entre le Canada, les États-Unis et le Mexique (ACÉUM)2 est rendue dans l’affaire TC Energy et TransCanada c États-Unis (II)3 et se solde en faveur de l’État. La controverse sur la portée temporelle de ce régime transitoire fait l’objet d’une analyse détaillée dans la chronique cette année. Un tour d’horizon des principaux autres faits marquants de 2024 est d’abord effectué en ce qui concerne la pratique conventionnelle et la pratique contentieuse du Canada.
Since the setting for Antoninus Liberalis, Metamorphoses 4 has been misinterpreted by commentators and historians, a review of the evidence for the toponym Dryopis is warranted. The narrative logic of the account demands that it be set in Ambracia, but most have interpreted Dryopis as the area near Mt Oeta. A close review of the first lines show that Antoninus’ account is indeed set in Ambracia, which was also called Dryopis.
This study investigates the impact of patent ductus arteriosus (PDA) status and treatment response on myocardial adaptation in preterm infants by comparing serial echocardiographic trajectories across three groups: high-risk infants with treatment success, high-risk infants with treatment failure, and low-risk infants not requiring treatment.
Methods:
In this prospective cohort study, preterm infants born < 29 weeks’ gestation were stratified using the EL-Khuffash PDA Severity Score and subsequent response to medical therapy. Echocardiographic assessments were performed at three timepoints: day 2, 2 weeks, and 36 weeks corrected gestational age. A range of structural and functional parameters was analysed.
Results:
Of 184 included infants, 58 were high risk with treatment success, 52 were high risk with treatment failure, and 74 were low risk. High-risk infants with treatment failure had persistent myocardial and haemodynamic alterations, including higher left ventricular wall thickness and lower coeliac artery velocities at follow-up. Treatment success was associated with improvements in strain metrics, systemic perfusion, and structural indices. Low-risk infants demonstrated spontaneous PDA closure and overall stable haemodynamics. Distinct differences in the evolution of myocardial trajectories between groups were apparent between day 2 and week 2 echocardiograms.
Conclusions:
Serial echocardiographic assessments highlight the dynamic impact of PDA treatment response on myocardial adaptation. Persistent ductal patency despite treatment is associated with sustained structural and functional changes. Early definitive ductal closure may promote haemodynamic stability and mitigate maladaptive remodelling in a subgroup of high-risk infants.
We consider two-person zero-sum semi-Markov games with incomplete reward information on one side under the expected discount criterion. First, we prove that the value function exists and satisfies the Shapley equation. From the Shapley equation, we construct an optimal policy for the informed player. Second, to show the existence of an optimal policy for the uninformed player, we introduce an auxiliary dual game and establish the relationship between the primal game and the dual game. By this relationship, we also prove the existence of the value function of the dual game, and then construct an optimal policy for the uninformed player in the primal game. Finally, we develop two iterative algorithms to compute $\varepsilon$-optimal policies for the informed player and the uninformed player, respectively.
A random variable $\xi$ has a light-tailed distribution (for short, is light-tailed) if it possesses a finite exponential moment, ${\mathbb{E}} \, {\exp}{(\lambda \xi)} <\infty$ for some $\lambda >0$, and has a heavy-tailed distribution (is heavy-tailed) if ${\mathbb{E}} \, {\exp}{(\lambda\xi)} = \infty$ for all $\lambda>0$. Leipus et al. (2023 AIMS Math.8, 13066–13072) presented a particular example of a light-tailed random variable that is the minimum of two independent heavy-tailed random variables. We show that this phenomenon is universal: any light-tailed random variable with right-unbounded support may be represented as the minimum of two independent heavy-tailed random variables. Moreover, a more general fact holds: these two independent random variables may have as heavy-tailed distributions as we wish. Further, we extend the latter result to the minimum of any finite number of independent random variables. We also comment on possible generalizations of our result to the case of dependent random variables.
This study sought to obtain the views of doctors associated with the Royal College of Psychiatrists on the use of outcome measures in mental health services. An online survey was developed by the College’s working group on outcome measures and widely disseminated to psychiatrists through College channels.
Results
In total, 339 completed responses were received. Respondents were mostly consultant psychiatrists; based in England; and working in the National Health Service with working-age adults. Almost half said they used outcome measures routinely, with almost half finding outcome measures clinically useful. Lack of time and inadequate information technology systems were identified as the top barriers to using outcome measures.
Clinical implications
Based on our results, psychiatrists are generally keen to use outcome measures, but are often prevented from doing so effectively by pressures on services and lack of appropriate support. The Royal College of Psychiatrists and other relevant organisations could enhance the use of outcome measures in mental health services through improved guidance, providing additional resources and integration of measures into electronic patient records.
Recent palaeobiological studies have emphasized the need for interpretations of the fossil record to consider spatial changes in environmental conditions (e.g. topography, climate). Establishing the role the environment plays in determining the distributions of extinct and existing organisms is complicated by biological evolution. Using available observations to ‘see through’ the randomness of biological evolution to determine contributions from environmental change is not trivial because of the sparsity of the fossil record, lack of precise information about rates of evolution, and because we obviously cannot physically re-run the evolutionary history that resulted in modern biodiversity or the fossil record. To address these issues, we establish scales and scenarios in which spatial environmental change is manifested in records of the number of species in a given area (richness) generated by eco-evolutionary simulation. Evolutionary processes that are likely to be random on the timescales of environmental change are included. Signals of environmental change that are likely to be hidden by the effects of ‘noisy’ evolutionary processes and those likely to emerge are identified. The ‘experiment of life’ is simulated many times, producing statistical insights. Results show that the spatial rate of environmental change is strongly correlated with species richness when the ability of organisms to disperse is high. Interaction between scale, dispersal and environmental structure is shown to determine both statistical and spatial distributions of richness. As a proof-of-concept, we compare predictions to bird species richness. The results emphasize the need to consider the randomness of evolution when interpreting the observations of extinct or present life on Earth.
It is a privilege to write a preface to this Symposium on Canada before International Courts and Tribunals, which includes many stimulating and insightful contributions. In this preface, I go back to the beginning and focus on Canada’s first cases at the International Court of Justice (ICJ) and before international arbitral tribunals.