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This study assessed neonatal visual maturity in infants with congenital heart disease (CHD) and its predictive value for neurodevelopmental outcomes. Neonates with CHD underwent a standardized visual assessment before and after cardiopulmonary bypass surgery. Visual maturity was rated as normal versus abnormal by means of normative reference data. Twelve-month neurodevelopment was assessed with the Bayley-III. Twenty-five healthy controls served as the reference group. Neonatal visual assessment was performed in five neonates with CHD preoperatively and in 24 postoperatively. Only postoperative assessments were considered for further analysis. Median [IQR] age at assessment was 27.0 [21.5, 42.0] days of life in postoperative neonates with CHD and 24.0 [15.0, 32.0] in controls. Visual performance was within reference values in 87.5% in postoperative CHD versus 90.5% in healthy controls (p = 1.0). Visual maturity was not predictive of neurodevelopment at 12 months. These results demonstrate the limited feasibility and predictive value of neonatal visual assessments in CHD.
We consider a collection of statistically identical two-state continuous time Markov chains (channels). A controller continuously selects a channel with the view of maximizing infinite horizon average reward. A switching cost is paid upon channel changes. We consider two cases: full observation (all channels observed simultaneously) and partial observation (only the current channel observed). We analyze the difference in performance between these cases for various policies. For the partial observation case with two channels or an infinite number of channels, we explicitly characterize an optimal threshold for two sensible policies which we name “call-gapping” and “cool-off.” Our results present a qualitative view on the interaction of the number of channels, the available information, and the switching costs.
Stochastic processes model experiments whose outcomes are collections of variables organized in some fashion. We focus here on Markov processes, which include random walks (think of the fortune of a person gambling on black/red at the roulette over time) and branching processes (think of the behavior of a population of an asexual species where each individual gives birth to a number of otherwise identical offsprings according to a given probability distribution) .
In this chapter we consider distributions on the real line that have a discrete support. It is indeed common to count certain occurrences in an experiment, and the corresponding counts are invariably integer-valued. In fact, all the major distributions of this type are supported on the (non-negative) integers. We introduce the main ones here.
We consider an experiment resulting in two paired numerical variables. The general goal addressed in this chapter is that of quantifying the strength of association between these two variables. By association we mean dependence. Contrary to the previous chapter, here the two variables can be measurements of completely different kinds (e.g., height and weight). Several measures of association are introduced, and used to test for independence.
In some areas of mathematics, physics, and elsewhere, continuous objects and structures are often motivated, or even defined, as limits of discrete objects. For example, in mathematics, the real numbers are defined as the limit of sequences of rational numbers, and in physics, the laws of thermodynamics arise as the number of particles in a system tends to infinity (the so-called thermodynamic or macroscopic limit). Taking certain discrete distributions (discussed in the previous chapter) to their continuous limits, which is done by letting their support size increase to infinity in a controlled manner, gives rise to continuous distributions on the real line. We introduce and discuss such distributions in this chapter, including the normal (aka Gaussian) family of distributions, and in the process cover probability densities.
We consider in this chapter experiments where the variables of interest are paired. Importantly, we assume that these variables are directly comparable (in contrast with the following two chapters). Crossover trials are important examples of such experiments. The main question of interest here is that of exchangeability, which reduces to testing for symmetry when there are only two variables.
When a die (with 3 or more faces) is rolled, the result of each trial can take one of as many possible values. The same is true in the context of an urn experiment, when the balls in the urn are of multiple different colors. Such models are broadly applicable. Indeed, even `yes/no’ polls almost always include at least one other option like `not sure’ or `no opinion’. Another situation where discrete variables arise is when two or more coins are compared in terms of their chances of landing heads, or more generally, when two or more (otherwise identical) dice are compared in terms of their chances of landing on a particular face. In terms of urn experiments, the analog is a situation where balls are drawn from multiple urns. This sort of experiments can be used to model clinical trials where several treatments are compared and the outcome is dichotomous. When the coins are tossed together, or when the dice are rolled together, we might want to test for independence. We thus introduce some classical tests for comparing multiple discrete distributions and for testing for the independence of two or more discrete variables that are observed together.
A prototypical (although somewhat idealized) workflow in any scientific investigation starts with the design of the experiment to probe a question or hypothesis of interest. The experiment is modeled using several plausible mechanisms. The experiment is conducted and the data are collected. These data are finally analyzed to identify the most adequate mechanism, meaning the one among those considered that best explains the data. Although an experiment is supposed to be repeatable, this is not always possible, particularly if the system under study is chaotic or random in nature. When this is the case, the mechanisms above are expressed as probability distributions. We then talk about probabilistic modeling --- albeit with not one but several probability distributions. It is as if we contemplate several probability experiments, and the goal of statistical inference is to decide on the most plausible one in view of the collected data. We introduce core concepts such as estimators, confidence intervals, and tests.
The chapter focuses on discrete probability spaces, where probability calculations are combinatorial in nature. Urn models are presented as the quintessential discrete experiments.