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To deconstruct the multiple levels of risk factors for Clostridioides difficile infection, using multilevel models (MLMs) accounting for patient movement.
Study Design and Setting:
Case-control study of patients hospitalized in three acute care Delaware hospitals, December 2019–December 2023.
Patients:
Cases were patients aged ≥18 years who tested positive for hospital-onset C. difficile infection. Controls were patients aged ≥18 years hospitalized more than 72 hours, who did not test positive for C. difficile infection.
Methods:
Hierarchical and cross-classified MLMs were used to calculate odds of C. difficile infection based on patient-level risk factors and to evaluate the variation in odds of infection attributable to environmental risk factors using the hospital unit(s) a patient was assigned to during hospitalization.
Results:
Our study included 1,223 patients (249 cases, 974 controls). In both models, greater odds of infection were associated with antibiotic exposure [adjusted odds ratio (aOR) = 11.20, 95% confidence interval (CI) = 7.19, 17.40; aOR = 12.80, 95% CI = 8.46, 19.40 for hierarchical and cross-classified models respectively] and health insurance (aOR = 1.74, 95% CI = 1.12, 2.68; aOR = 1.62, 95% CI = 1.03, 2.53; public vs. private). Median odds ratios (MOR) for both models indicated greater relevance of between-unit heterogeneity in the outcome than health insurance but less than antibiotic exposure (MOR = 1.83, 95% CI = 1.56, 2.30 and 2.71 95% CI = 2.10, 4.06).
Conclusion:
Using multilevel methods accounting for patient movement, we found that while antibiotic use is the most important risk factor in patients that developed C. difficile infection, environmental risk factors are additionally important and should be considered in research involving hospitalized patients and healthcare-associated infections.
Wolff-Parkinson-White syndrome, characterised by accessory pathways, is rarely seen with dextrocardia. We present a case of situs inversus-dextrocardia with Wolff-Parkinson-White syndrome successfully treated via catheter ablation using 3D mapping (EnSite Precision®). Adjustments included reversed electrocardiogram (ECG) electrode placement, EnSite patch positioning, and fluoroscopic views. Coronary sinus access required counterclockwise manoeuvers. Mapping identified a left-sided accessory pathway, necessitating transseptal puncture with mirror-image adjustments. Ablation at the optimal site resulted in success. This case highlights the feasibility of catheter ablation in dextrocardia with tailored procedural modifications.
Children are uniquely vulnerable to chemical, biological, radiological, and nuclear (CBRN) events due to anatomical, physiological, and psychological differences. Current decontamination practices are adapted from adult protocols.
Objective
To evaluate current practices, challenges, and special considerations in pediatric decontamination during CBRN events.
Method
A scoping review was conducted using six databases in accordance with PRISMA-ScR framework. Studies were eligible if they evaluated decontamination methods involving children (0-18 years) in real or simulated CBRN scenarios. Fourteen studies met the inclusion criteria, and data were thematically analyzed into four domains.
Results
Disrobing is widely recognized as a critical first step in the decontamination process, and 43% of the studies reviewed identified it as such. When done immediately and appropriately, it can remove a significant amount of contaminants. Although its effectiveness varies based on how much of the body is covered and the nature of the exposure. Dry decontamination was discussed in 21% of studies, and wet decontamination was the most commonly reported approach, appearing in 93%. Key pediatric challenges included hypothermia, psychological distress, separation from caregivers, and difficulties managing non-ambulatory or special needs populations. Few studies addressed age-specific protocols or long-term psychological impacts. The results are presented in procedural order to reflect the typical sequence of decontamination in CBRN response.
Conclusions
Current decontamination guidelines inadequately address pediatric-specific needs. There is a critical need for standardized, age-appropriate guidelines that integrate caregiver support and psychosocial considerations. A pediatric decontamination algorithm was developed to consolidate current evidence into a practical framework for CBRN mass casualty incidents.
After Dobbs v. Jackson Women’s Health Organization, the United States Supreme Court decision that overturned Roe v. Wade in 2022, OB/GYN residents’ access to abortion training, which is required in all accredited programs, has come under pressure. To receive the foundational training doctors in the field need, many residents in ban states travel to out-of-state programs where abortion is legal. But demand is high, travel for multiple weeks is expensive, and the capacity to train at host sites is limited.
Training by travel could have ripple effects for the quality of patient care. As the number of OB/GYNs continues to decrease, newly-trained providers will have different, and arguably diminished, skills in delivering not just elective but also medically necessary abortion care. And as exceptions for life and health become how legal, procedural terminations take place in one-third of the United States, there is no guarantee that the doctors in those states will feel comfortable providing that care.
This article explores the residency training provided today, providers’ and institutions’ navigation of abortion bans, and what changes in residency programs might mean for patient care in the coming years. Part I surveys the landscape of abortion law after Dobbs; even the strictest bans contemplate instances when abortion is medically required and legally permitted. Part II summarizes the pre- and post-Dobbs expectations for abortion training for OB/GYN residents, describing how graduate medical education has changed for residents in ban states. Part III assesses shorter and longer-term effects of a system that relies on travel and simulation (the use of models) or is out of compliance with national accreditation standards. Part IV concludes with potential paths forward that depend on state and national organizations supporting and funding the networks of health care professionals that facilitate training across the country.
The genus Apharyngostrigea comprises a group of diplostomoidean digeneans that parasitize birds of the family Ardeidae (herons), with approximately 20 species described worldwide. Despite numerous efforts, a robust phylogenetic framework to delimit species within the genus is still lacking, mainly due to the limited morphological variation among its members. This study employed an integrative taxonomic approach, combining nuclear and mitochondrial DNA sequences with morphological data to assess species boundaries within Apharyngostrigea based on specimens collected from southeastern Mexico. Using a combination of species discovery (Automatic Barcode Gap Discovery, Assemble Species by Automatic Partition, General Mixed Yule Coalescent and Poisson Tree Processes) and validation methods based on Bayesian gene tree topologies (BPP and PHRAPL). We found high diversity within this genus in southeastern Mexico. Our analyses supported the delimitation of four nominal species that were previously described and validated in this study, along with the redescription of three of them. In addition, through species delimitation methods and morphological examination, we identified two candidate species and/or lineages that require further evidence to be formally described. This study demonstrates that an integrative taxonomic approach provides a robust framework for species delimitation in taxonomically complex groups such as Apharyngostrigea.
Farman Saeed Sedeeq and Percem Arman’s article aims to develop a framework of AI governance that avoids shortcomings in existing models such as limited enforceability and rigid data-sharing rules. The goal of the weighty undertaking is to develop a “structured yet flexible approach” to balancing AI advancements in public health with ethical imperatives. Three core “pillars” are used for evaluation: ethical accountability, regulatory adaptability, and transparency. The concept of ethical accountability is explored briefly in this commentary.
This paper addresses the comprehensive regulation of artificial intelligence (“AI”) across its entire lifecycle in the health care sector. It builds on a proposal for a True Lifecycle Approach (“TLA”) to address governance gaps across three phases of AI and expands the framework with detailed practical insights for governing health care AI, drawing on pioneering examples from Qatar, Saudi Arabia, and the United Arab Emirates (“UAE”) as models for global implementation. Beginning with the research and development phase, it highlights the urgent need for robust guidelines and certification processes to ensure that AI technologies are developed in compliance with ethical and safety standards. Moving into the approval stage, the discussion explores how AI systems can be effectively regulated under existing medical device frameworks, emphasizing the need for tailored regulations that consider the unique challenges posed by AI. Finally, the paper delves into the deployment of AI in clinical practice, examining the gaps in current laws and the need for a coherent and consistent regulatory framework that can adapt to AI advancements. The paper argues that the existing legal structures are inadequate, often inconsistent, and fail to address the complexities of AI in health care. It argues for a broader regulatory approach focused on patient safety throughout the AI lifecycle.
Reflections on Claire O’Callaghan and Brendan Parent’s article “Withdrawal of Life-Sustaining Treatment and Organ Donation After Circulatory Death: Consequences of Legislative Separation.”
Financialization of healthcare drains our current system of resources it needs to provide care. It occurs when money is siphoned off for private profit through mechanisms such as rent seeking, gamesmanship, and exploitative price setting. This is not an ethically neutral activity, and the people profiting in this way ought to justify why they are entitled to this money, given the foreseeable negative effects what they are doing has on people’s health. This important problem is masked by current accounting methods and healthcare billing methods, which need to be changed to allow for a more transparent assessment of what is really occurring.
Pulmonary artery sling with complete tracheal rings represents a rare and challenging congenital anomaly, particularly in premature infants. We present a case of successful repair in an extremely low-weight premature infant.
Case Presentation:
A male premature infant (34 weeks of gestation, birth weight 1820 g) was diagnosed prenatally with pulmonary artery sling, perimembranous ventricular septal defect, and patent ductus arteriosus. At one month of age, bronchoscopy revealed severe tracheal stenosis with complete tracheal rings (3.1 mm external diameter). Despite the high surgical risk due to low body weight, complete surgical repair was performed at 2.7 kg through median sternotomy under cardiopulmonary bypass. The procedure included pulmonary artery sling repair with autologous pericardial augmentation, slide tracheoplasty using interrupted everted 6-0 PDS sutures, ventricular septal defect closure, and patent ductus arteriosus ligation. Intraoperative bronchoscopy confirmed adequate airway patency.
Conclusion:
This case demonstrates that successful complete repair of complex cardiac and airway anomalies can be achieved in premature, low-weight infants when conventional weight gain thresholds cannot be met. Key factors for success include meticulous surgical technique, precise cardiopulmonary bypass management, careful perioperative care optimisation, and a multidisciplinary approach. While body weight alone should not be an absolute contraindication for surgical intervention, careful patient selection and appropriate institutional expertise are essential.
This article assesses a 10-month co-created universal school-based mental health (SBMH) promotion initiative for adolescents (10–19). The study combined quantitative and qualitative components. Pre- and post-intervention surveys were conducted in four schools in Tanzania (n = 400 baseline, 488 endline, with 100 intervention participants at both) and eight schools in Vietnam (n = 1,036 baseline, 893 endline and 436 in panel). In each country, ~90 qualitative interactions (interviews and focus groups) were held at baseline and endline with adolescents, parents, teachers and service providers (total = ~180). In Tanzania, multivariate analysis indicated significant gains among intervention participants relative to peers. Emotional literacy rose 9.5% (p = 0.007; d = 0.57). Attitudes toward help-seeking (p = 0.021; d = 0.50) and prosocial behaviors (p = 0.043, d = 0.38) also improved Active coping increased 15.6% (p = 0.006; d = 0.55). In Vietnam, emotional literacy increased 5.3% (p = 0.012, η2 = .019), and positively, emotion-focused coping declined 14.4% (p = 0.032, η2 = .015). Qualitative evidence reinforces these findings, and suggested spillover effects for nonparticipants. Overall results indicate that co-created universal SBMH initiatives can improve adolescent well-being and offer viable alternatives to limited adolescent-focused mental health services in LMICs.
Hydatid cyst is an infectious disease that occurs in humans due to infection of Echinococcus granulosus larvae. Although cardiac hydatid cysts are rare, right atrial localisation is even rarer. The aim of this article is to emphasise the importance of always being alert and prepared for the risk of anaphylaxis developing due to cyst rupture in paediatric patients with isolated cardiac hydatid cysts, to initiate oral albendazole treatment immediately upon diagnosis, to underline the importance of surgical timing, and to discuss the role of clinical assessment and imaging methods in predicting of cyst rupture.
This study aimed to determine the prevalence and associated factors of depressive symptoms among adolescents in Can Tho City, Vietnam. A cross-sectional study was conducted with 1,054 students aged 15–18 years, recruited from eight high schools using one-off anonymous questionnaires. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale Revised – Vietnamese version. The Self-esteem Scale of Vietnamese Adolescents, the Crandell Cognitions Inventory-Short form scale, the School Connectedness Scale and the Educational Stress Scale for Adolescents were used to assess self-esteem, cognitive distortion, school connectedness and educational stress, respectively. Univariate analyses explored the relationships between sociodemographic variables and depressive symptoms. Pearson correlations were calculated for the associations between variables. Multiple regression was used to adjust for the factors that contributed to depressive symptoms in adolescents. The findings revealed that 37.4% of adolescents in Can Tho City, Vietnam, experienced depressive symptoms. Factors influencing depression in adolescents include cognitive distortions, academic pressure, exposure to interpersonal violence, consumption of alcohol and smoking, family history of depression, family incarceration and experiences of digital sexual violence. These results underscore the urgent need for a multilevel and multidimensional intervention strategy involving parents, educators, mental health professionals and policymakers to promote early identification, provide support and enhance mental health literacy among adolescents.