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To estimate illness incidence or prevalence from wastewater data, modelling approaches may benefit from incorporating faecal shedding parameters. We systematically searched PubMed and a public repository on shedding data and included 33 studies that met at least one of our objectives. Among 32 studies, the proportion of SARS-CoV-2-infected individuals with detectable virus in stool ranged from 18 to 100%, with a pooled estimate of 54% (95% CI: 52–56%). Stratification by four clinical severity categories, ranging from asymptomatic to critically ill, showed no significant differences among categories (p-value = 0.49). The proportion of individuals with detectable SARS-CoV-2 RNA in stool was higher in children (61%) than in adults (53%; p-value = 0.02). In half of the individuals who initially shed the virus in stool, it remained detectable for an estimated 22 days post-symptom onset. Three studies documented viral load kinetics, indicating a peak between days 3 and 9. Twenty-five studies reported maximum shedding durations ranging from 2 to 12 weeks. Our review summarizes the frequency, dynamics, and duration of SARS-CoV-2 shedding in stool and may serve as a valuable foundation for modelling efforts involving faecal shedding indicators.
The impact of combat injury on the development of chronic pain and mental health concerns in combat-exposed populations is unknown. This study examined associations of combat injury and injury–related pain with pain-related factors and mental health outcomes, and potential mediation of the relation between combat injury and mental health outcomes by pain-related factors.
Methods
Pain interference, pain catastrophizing, pain intensity, post-traumatic stress disorder (PTSD), and major depressive episode (MDE) were assessed in (1) a probability sample of US Army soldiers and veterans cross-sectionally and (2) US Army soldiers before and 1, 3, and 9 months after deployment to Afghanistan. Associations among these variables were modeled using logistic regression and multiple mediation analyses.
Results
Among 5003 service members with cross-sectional data, combat injury–related pain was associated with increased odds of clinically significant pain intensity (OR=2.69), pain interference (OR=3.69), MDE (OR=2.17), and PTSD (OR=3.96) relative to pain from other injuries and conditions. Among 4645 service members assessed pre- and post-deployment, combat injury was associated with increased odds of new-onset pain interference (OR=2.78), pain catastrophizing (OR=2.75), PTSD (OR=4.06), and MDE (OR=2.56) 3 months post-deployment, and PTSD (OR=2.86) and MDE (OR=1.74) 9 months post-deployment. Pain-related factors mediated the relations of combat injury with post-deployment PTSD and MDE.
Conclusions
Combat injury is associated with greater odds of pain interference, pain catastrophizing, PTSD, and MDE compared to other sources of pain in a cohort of US service members. Efforts to address pain-related factors following combat injury may mitigate the risk of subsequent chronic pain and mental health disorders.
Bipolar disorder (BD) is associated with increased cardiometabolic risk, contributing to elevated morbidity and premature mortality. Childhood trauma (CT) is a common environmental risk factor in BD and may exacerbate metabolic dysfunction, but no prior systematic synthesis has focused on their intersection. The objective of this review was to systematically review and synthesize evidence on the association between childhood trauma exposure and metabolic biomarkers in adults with bipolar disorder. This review adhered to PRISMA 2020 guidelines and was registered in PROSPERO (ID CRD420251045565). A comprehensive search of PubMed/MEDLINE, Web of Science, Scopus, and Embase (from inception to September 2025) was conducted. Eligible studies were peer-reviewed observational studies assessing associations between CT and metabolic markers (eg, BMI, lipids, HbA1c, hs-CRP) in adult BD populations. Data extraction and NIH quality assessments were performed independently by multiple reviewers. Sixteen studies were included (total n ≈ 6,200 across study samples). CT was significantly associated with higher body mass index and elevated hs-CRP. Two third of studies reported adverse associations with lipid profiles, and one study showed increased HbA1c among CT-exposed BD patients. Most findings emerged from cross-sectional designs, though one longitudinal study revealed large effect sizes across multiple metabolic markers. CT is consistently associated with adverse metabolic outcomes in individuals with BD, particularly elevated BMI, inflammation, and dyslipidemia. These findings support the need for trauma-informed metabolic screening and personalized interventions in this subgroup BD population. Further prospective studies are warranted to elucidate causal pathways and inform personalized care.
Ricinid lice are exceptionally large-bodied relative to their hosts and tend to form small infrapopulations. They exhibit a more pronounced female bias (predominance of females) than most other lice. Sex ratios (SRs; the proportions of males) of 10 hummingbird-ricinid species pairs collected from South and North America were examined. There was a significant positive relationship between infrapopulation size and SR in 5 cases, and similar non-significant tendencies in 4 cases. Two formerly constructed hypotheses had been considered to explain this relationship. First, Wolbachia infections may account for the female bias, but male aggression during mating could elevate female mortality resulting in higher male proportions in large infrapopulations. Second, the Local Mate Competition (LMC) Hypothesis predicts that highly inbred infrapopulations should exhibit female-biased SRs. Small infrapopulations are likely to be inbred because of stronger genetic drift and are also more likely to originate from single infestations. Conversely, multiple infestations can generate larger and more outbred infrapopulations that are less affected by genetic drift, leading to a shift towards more balanced SRs. This results in a positive correlation between infrapopulation size (infestation intensity) and SR. Both hypotheses provide explanation for the positive association between infestation intensity and the proportion of males, although the LMC aligns more strongly with the actual values of the observed SR bias. Notably, the former hypothesis refers to the physiological mechanism, whereas the latter refers to the adaptive value of the SR bias. These 2 hypotheses are not mutually exclusive.
Endoscopic lens fogging is a frequent problem during diagnostic nasal endoscopy, often necessitating scope withdrawal and increasing patient discomfort. This study compared the defogging efficacy and nasal mucosal tolerance of Savlon and warm sterile saline.
Methods
In this prospective pilot comparative study, 40 adult patients undergoing diagnostic nasal endoscopy with a 0° rigid endoscope were randomly assigned to Savlon or warm sterile saline as the defogging agent. Lens fogging severity, patient-reported discomfort, mucosal irritation and need for repeat defogging were assessed.
Results
Both agents demonstrated comparable effectiveness in preventing lens fogging. However, the Savlon group reported significantly higher nasal discomfort and showed greater mucosal irritation compared with the warm saline group.
Conclusion
Warm sterile saline offers effective lens defogging with improved mucosal tolerance and patient comfort compared with Savlon during routine nasal endoscopy.
Recent advances in disaster countermeasures have reduced the number of direct deaths; however, population aging and medical progress have resulted in an increase in the number of individuals with chronic diseases and disabilities, rendering them vulnerable to secondary health effects caused by disrupted care and environmental changes during disasters. Public support systems for disaster-related health impacts are systematically established only in Japan and the USA. Although compensation schemes for disaster-related deaths have been progressively expanded, comprehensive support for survivors who require long-term medical and social care owing to indirect, post-disaster health effects remains insufficiently developed. After the Great East Japan earthquake, increases in stroke hospitalizations, depression, and cognitive decline were observed, while international cases, such as the post-earthquake cancer incidence in Nepal, highlight global relevance. Thus, the definition of “disaster-related sequelae” and the establishment of comprehensive medical and social support systems, including compensation, continuity of care, and preventive education, are urgently needed.
The use of telehealth in palliative care has expanded rapidly, offering opportunities to enhance symptom management and provide psychosocial support to patients and families. Nurse-led virtual interventions play a critical role in improving access to care, particularly for those facing geographic or logistical barriers.
Objectives
To systematically synthesize global evidence on the effectiveness of tele-palliative nursing interventions in improving symptom management and family support for adults with life-limiting illnesses.
Methods
This study was conducted as a hybrid umbrella review in accordance with PRISMA 2020 guidelines. Six databases and two trial registries were searched through September 2025. Eligible evidence included (a) systematic reviews, scoping reviews, integrative reviews, and mixed-methods reviews, and (b) primary studies such as randomized controlled trials (RCTs), quasi-experiments, observational studies, and pilot/feasibility studies. Systematic reviews were appraised using AMSTAR-2; primary studies using RoB 2, ROBINS-I, or CASP, as appropriate. A narrative synthesis was employed, with review-level evidence prioritized and primary studies used to contextualize effect directions. Potential overlap of primary studies across included reviews was assessed conceptually to avoid double counting. This approach was selected to integrate both review-level and primary evidence within a unified synthesis framework.
Results
Twenty-eight studies (≈2,500 participants from primary studies only) from North America, Europe, Asia, and Australia were included. Interventions included video consultations, structured telephone follow-ups, remote symptom monitoring, and caregiver education programs delivered by nurses. Across studies, nurse-led telehealth interventions were associated with improvements in access to care, symptom monitoring, patient satisfaction, and aspects of family support. Evidence for symptom severity reduction and caregiver burden was mixed, with moderate heterogeneity. Risk of bias was generally low to moderate, with RCTs offering the strongest evidence.
Significance of results
Tele-palliative nursing is a promising model for delivering symptom management and family support remotely. It demonstrates feasibility and acceptability across diverse settings. However, findings should be interpreted cautiously due to heterogeneity in study designs, reliance on secondary evidence, and variable methodological quality. Further large-scale trials with standardized outcome measures are needed to strengthen the evidence base.
Individuals at clinical high risk (CHR) for psychosis exhibit both baseline and progressive brain structural abnormalities. However, the extent to which these changes reflect neurobiological trajectories of illness progression versus iatrogenic effects of antipsychotic (AP) treatment remains unresolved. A total of 148 AP-naïve CHRs and 65 healthy controls (HCs) underwent baseline structural magnetic resonance imaging (MRI) scans. One hundred thirty CHRs received second-generation AP treatment and completed 2-month follow-up scans. HCs also completed the follow-up scans. We compared baseline and longitudinal brain volume changes between CHRs and HCs and explored the relationship between AP treatment and brain structural changes in CHR. At baseline, CHRs showed enlarged third and inferior lateral ventricles compared to HCs. Within CHRs, larger ventricular, as well as smaller hippocampus and amygdala volumes, were associated with more severe symptoms and poorer functioning. No cortical volume differences were observed between groups at baseline, nor were cortical volumes related to clinical symptoms. After 2-month AP treatment, CHRs exhibited continued ventricular enlargement, reduced accumbens volume, and widespread cortical volume loss relative to HCs. Notably, cortical volume reductions were dose-dependent, with higher AP dose correlating with more pronounced cortical reductions. Additionally, cortical volume changes were linked to treatment response, with high-dose responders showing more significant HC-referenced changes compared to high-dose non-responders, low-dose responders, and low-dose non-responders. Our findings underscore the complex, region-specific, and clinically relevant neuroanatomical changes in CHR individuals, emphasizing the critical need to account for AP exposure in CHR neuroimaging studies.
Dr. C. Norman Coleman’s impact is difficult to measure overall, even if one focuses only on his work as NCI’s Radiation Research Program (RRP) leader. His laboratory work spanned immune-oncology and radiation therapy, RNA biology, normal tissue and tumor tissue radiobiology, and the development of tissue chips for use in radiation biology research. His programmatic leadership helped the RRP develop health equity programs addressing Native American access to optimal cancer care, evaluation of hadron therapy biology, radiation biology, reproducibility and rigor, foundational molecular biology of the tumor and normal tissue caused by radiation therapy dynamically, and global health and security issues. While doing all these things, he found time to mentor countless people in the field, many now leaders, and to read and discuss science across disciplines. He was a dedicated, caring, kind scientist who truly wanted to help and improve the world for others.
During the COVID-19 pandemic, educators were impacted across domains of psychological, physical, social, and occupational health. Occupational environments, including classrooms, changed significantly due to COVID-19. This study aimed to characterize the nuanced experience of educators during the COVID-19 pandemic.
Methods
Participants included 918 United States educators (e.g., teachers, paraeducators, support professionals, and administrators). Educators completed the survey via Qualtrics during November and December of 2020. The survey included eight qualitative questions, and responses were randomized to inductive or deductive datasets for analyses.
Results
Our deductive results showed that individuals reported changes in several facets of health, with educators reporting increases in stress (38.0%) and feelings of isolation (45.9%). Our results also showed impacted occupational health, citing increased responsibility at work (34.0%) and feeling as though their voice was not heard after voicing concerns to either building- or district-level administration (28.2%).
Conclusions
One of the key findings that emerged at the systemic level was educators reporting a lack of decision-making agency within the workplace. Through including educators in the conversations regarding decisions at all levels, agency may be increased. Educators not only shape the students they teach, but the communities within which they work, making a focus on their health paramount.
Fasciola hepatica infections in cattle often lead to significant production losses. Infection rates are expected to increase due to environmental changes at regional and global level which favour the life cycle of F. hepatica. This study aimed to identify environmental and herd factors associated with F. hepatica antibody positivity in bulk tank milk (BTM) of Dutch dairy cattle herds. In total, 10403 BTM samples were collected yearly in October, from 2018 till 2023. For each farm, monthly averages of weather factors and soil moisture level were obtained for the twelve months preceding October, along with soil type and number and grazing of dairy cows. Logistic regression analyses were performed retrospectively using generalized estimating equations, with continuous variables analysed as quartiles. The odds of F. hepatica antibody positivity in BTM are higher for farms on peat (OR 1.69, 95% CI [1.27, 2.24]) and heavy clay soils (OR 1.75, 95% CI [1.30, 2.35]) compared to those on sand soil. In addition, the odds of antibody positivity increased with higher monthly temperatures (December: ORQ1-Q4 2.94, 95% CI [1.94, 4.46]) and rainfall (November: ORQ1-Q4 2.33, 95% CI [1.62, 3.34]) at the end of the previous grazing season. Stratified analyses by soil type yielded results consistent with those across soil types. Weather patterns that favour the number of overwintering snails infected with F. hepatica seem to increase the infection risk for dairy cattle in the next grazing season, which highlights the potential of prediction tools that facilitate early detection of new F. hepatica infections.
Although mental health is a better understood, more widely discussed topic in our society today, a degree of stigmatization persists, especially in severe cases with links to homelessness, job loss, poverty and human rights. It is also still present in environments such as the workforce, healthcare settings and educational environments, and often internalized by the sufferer themselves. This book provides a philosophical account of what mental illness stigma is, why it persists, what harms it causes to people subject to public stigma or who internalize stigma in themselves, and what can be done about it. It analyzes the process of stigmatization, both public and internalized, in the twenty-first century Western culture, especially in the United States - including the process of stereotyping, the expressive harm of stereotypes, the role of social norms in creating adaptive preferences and shaping behaviour, the moral distancing and status loss involved with social exclusion and dehumanization, and the harm of discrimination.
The southern capital of Kazakhstan, Almaty, located in a seismically active region, experienced two significant earthquakes in January and March 2024. Despite longstanding educational programs, the January event exposed significant gaps in public crisis response, resulting in numerous injuries due to panic-driven behavior. This study aimed to evaluate the shift in public preparedness and crisis communication between these events.
Methods:
A comprehensive content analysis was conducted using over 500 articles from prominent Kazakh- and Russian language news outlets, 300 official publications by the Ministry for Emergency Situations, and approximately 5,000 social media posts. This analysis examined the timing, content, and public response to emergency communications, assessing changes in behavior influenced by the intensified educational efforts after January.
Results:
The January earthquake highlighted critical delays in communication (an average of 20 minutes), leading to widespread panic. Injuries included 12 severe cases from residents jumping from buildings and numerous reports of frostbite, as temperatures reached -15°C. The Ministry for Emergency Situations responded with targeted educational campaigns, distributing over 200,000 printed evacuation guides and conducting over 1,200 focused training sessions. By March, communication response times improved to 5 minutes, and social media analysis revealed a 60% increase in posts mentioning organized and calm public behavior. Posts frequently mentioned that residents knew evacuation points (e.g., nearby schools) and followed pre-established procedures, demonstrating a better understanding of safety protocols.
Conclusion:
The comparison of the January and March 2024 earthquakes demonstrates the essential role of adaptive public education and rapid crisis communication in enhancing community preparedness. Targeted interventions improved public knowledge, reduced injuries, and restored confidence in emergency management systems. These findings emphasize the need for continuous, practical, and localized educational efforts to effectively bridge gaps in public readiness for disasters.
The mobile Smart Cyber Operating Theater (SCOT), an advanced medical vehicle developed collaboratively by Tokyo Women’s Medical University and NTT Docomo, has been designed to deliver crucial medical treatment and support under normal as well as disaster situations. This cutting-edge system leverages 5G technology and a cloud-based framework to facilitate real-time sharing of critical medical information, including surgical images and data on patients’ vitals, with surgeons in remote locations. The application of this innovation has greatly improved the decision-making speed and efficacy during medical interventions. In disaster scenarios, demonstration experiments of telemedicine in surgical care were conducted using simulated patients with femur fractures, mandibular fractures, and colonic injuries. Using a robust 5G network alongside a multi-access cloud system, the experiment enabled the seamless sharing of surgical footage and physiological data with remote medical teams, enabling quick clinical decisions. The experiments highlighted the system’s capacity to enable uninterrupted collaboration among medical personnel and provide specialized telemedicine in surgical care. The system addresses three critical challenges in disaster medical care: preventing communication disruptions, ensuring real-time responsiveness, and avoiding loss of medical information. Collectively, the system’s features markedly bolster rapid medical responses and enhance its potential to deliver swift and efficient medical interventions during normal as well as disaster situations. By integrating advanced software and hardware technologies, the system supports the provision of comprehensive medical care in disaster-stricken areas. This is particularly vital in locations where traditional medical infrastructure is compromised. The deployment of the mobile SCOT in disaster situations is expected to improve the outcomes and prognosis of disaster victims, marking a substantial advancement in emergency medical services and highlighting the importance of technological integration in health care.
The Mountain Plains Regional Disaster Health Response System (MPRDHRS) is a US federally funded program to “leverage, build, or augment the highly specialized clinical capabilities critical to unusual hazards or catastrophic events”. MPRDHRS‘ mission is to “provide leadership, knowledge, expertise, and support in disaster response for patients and citizens in our region.” Developing accurate, accessible, and opportune educational materials is
encompassed within MPRDHRS’s mission and objectives.
Methods:
After performing a gap analysis and curating accessible disaster educational materials, we identified asynchronous, just-in-time (JIT) educational modules (EM) to be high yield for responders in our region. To ensure equal opportunity and appropriate representation, JIT subject matter experts (SME) ought to be recruited by a nomination and strict selection process. A standardized system for module development and recording was implemented.
Results:
Thirty-six initial topics were identified as a priority for JIT EM. A diverse and representative group of SMEs was selected, and EMs were recorded. Over two-thirds of modules with their accompanying “one-pager,” where key points are summarized, are currently available on our website. Remaining topics outlined for production are continuously recruited for and produced as the project enters its 2nd year. As of 10/17/24, EMs average 54 views, the most popular module garnering 362 views. Modules can be found at: https://mountainplainsrdhrs.org/just-in-time/
Conclusion:
Despite the availability of relevant materials created and distributed by SME networks, professional societies, and federal partners, discovery by non-disaster response experts, particularly in the wake of a disaster, is unlikely. The JIT EMs fill gaps to enable a safe and coordinated response to disasters and can be updated for emerging threats.
The EviMaPS study aimed to identify the state of knowledge and practice on disaster mental health and psychosocial support (MHPSS) initiatives globally. This study was conducted through a collaboration between a multinational team of investigators and the World Health Organization (WHO).
Methods:
Phase 1 consisted of a key informant survey to identify current and emerging MHPSS policies and programs to reduce mental health risks and enhance protective factors before and after disasters. Phase 2 consisted of a rapid literature review to identify empirical research on the impacts of disaster-related MHPSS initiatives. Programs identified in each stage were mapped against the MHPSS Minimum Services Package (MSP) Checklist, the Inter Agency Standing Committee (IASC) Intervention Pyramid, and the WHO Health Emergency and Disaster Risk Management Framework.
Results:
Phase 1 elicited information about 92 programs and 9 policies in use between 2007 and 2024 across 19 countries and regions. Phase 2 elicited 33 primary research articles published between 2007 and 2024 across 13 countries and regions.
Conclusion:
The field of disaster mental health is dynamic and evolving. This presentation will underscore the need for an ongoing commitment to recognizing developing practices and building evidence on mental health and psychosocial support initiatives in disaster settings. The implications of the present findings for leading agencies such as the WHO will also be presented, for example, concerning updating guidelines, frameworks, and setting priorities to address research gaps.
The ASEAN Joint Research on Hospital Safety Index (HSI) is one of the implementations of the start-up program under the ASEAN Academic Network on Disaster Health Management (AANDHM). The objective of this joint research is to analyze the implementation of the self-assessment Hospital Safety Index (HSI) for safe hospital evaluation in ASEAN countries. However, conducting multinational research presents unique challenges.
Methods:
This study employs a narrative approach to analyze the challenge of ASEAN joint research implementation.
Results:
The findings indicate three key challenges. First is the challenge of choosing a methodology that is both rigorous and universally applicable in diverse multinational settings. This diversity necessitated several changes and modifications of the research methodology in the proposals, adding substantial delays to project timelines. Secondly, email communication for participant recruitment presents challenges, whereas direct meetings and facilitation by the ARCH Project have proven valuable for initiating further engagement. A third challenge concerns the ethical clearance (EC) process. Understanding and adhering to the various Institutional Review Board (IRB) protocols of each participating country was time-consuming and complex. The Fifth Meeting of the Steering Committee for AANDHM recommended that the research team follow EC and IRB procedures according to their country’s regulations, while participants are only required to undergo EC review if mandated by their country. This guidance helps resolve the EC confusion that stalled the joint research process.
Conclusion:
This study reveals that selecting methodologies applied in different contexts of disaster health management and diverse IRB protocols poses significant challenges to the ASEAN Joint Research on Hospital Safety Index. Addressing these issues is essential for developing regional mechanisms for the promotion of joint research activities. Future recommendations include training on developing research methodology, developing efficient communication platforms, and conducting surveys on EC guidelines across ASEAN to enhance research collaboration.
Children are frequently victims of disasters. However, gaps remain in pediatric disaster preparedness. The New York City Pediatric Disaster Coalition (NYCPDC) is funded by the NYC Department of Health and Mental Hygiene (DOHMH) to prepare NYC for mass casualty events involving children. In the fall of 2022, there was a significant
increase in pediatric emergency department visits and hospitalizations due to Rhinovirus, Enterovirus, COVID-19, Influenza, and RSV throughout many areas of the United States. This, coupled with underlying staffing and other shortages, created a strain on the healthcare system. In many facilities, surge capacity was exceeded, Emergency Departments and Pediatric Intensive Care Units were closed to new patients, and inter-hospital transports were denied.
Methods:
In response, the NYCPDC rapidly (over four days) developed a one-hour webinar focused on: epidemiological data sharing, impacts on patient care, a review of prevention, treatment, and supply issues, and a discussion on current and future strategies to respond to the outbreak. The one-hour webinar included a total of four presenters with representation from the NYCPDC, DOHMH, as well as two major NYC children’s hospitals and a national audience.
Results:
Over 400 healthcare workers registered for the webinar from around the United States. Prior to the conclusion of the webinar, participants had the opportunity to ask questions and contribute to the session by sharing their firsthand surge experiences, including capacity expansion, challenges, and best practices. Following the session, a recording of the webinar as well as a curated listing of resources developed in cooperation with the National Pediatric Disaster Coalition were distributed to every participant.
Conclusion:
This presentation will provide a summary of the webinar and highlight effective strategies to respond to future outbreaks. This includes managing a large influx of pediatric patients in the emergency department and pediatric intensive care unit, as well as effective transfer strategies.