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Culinary education interventions may effectively improve cooking skills and dietary outcomes; however, interventions lack theoretical underpinning and rigorous evaluation. ‘Let’s Get Cooking’ (LGC) is a culinary education intervention operating a ‘school and community-based’ programme targeting children, and ‘food waste reduction’ programme targeting adults. LGC is delivered through cookery clubs, operating a ‘train the trainer’ model, whereby club leaders are centrally trained and resourced. This study aims to understand initial assessments of LGC’s effectiveness, the content of resources provided for programme delivery, and club leaders’ perceptions of the programme.
Design:
Three previous evaluations of the ‘school and community-based’ programme were synthesised and critically appraised. LGC resources were coded to identify behaviour change techniques (BCTs), map the age-appropriateness of included cooking skills and to identify food waste reduction strategies. Qualitative one-on-one interviews with club leaders (N = 7) were conducted online and thematically analysed.
Setting:
UK
Participants:
N/A
Results:
Previous evaluations suggest LGC’s ‘school and community-based’ programme may effectively disseminate cooking skills. However, reports lacked assessment of ‘fidelity’ or ‘dose delivered’. LGC resources primarily target behaviour change through describing how and when to perform cooking behaviour and contain age-appropriate cooking skills for participating children. ‘Food waste reduction’ resources primarily include appropriate food storage and preparation strategies to reduce waste. Club leaders perceive the intervention and training positively, however, adapt resources and sessions due to delivery challenges.
Conclusions:
LGC may be an effective intervention, however, content improvement may support programme delivery. Rigorous process evaluation is needed to improve understanding of LGC’s effectiveness.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
This chapter rejuvenates the promising but lost field of environmental gerontology. Environmental gerontology threatened to disappear after the death of its initiator, Powell Lawton. The chapter reviews recent developments and problems in these approaches, and shows how the sociocultural perspective presented here may offer a satisfying way to pursue these efforts. The first section comes back to the core concepts of spaces, places and affordances. The next one proposes a dialogue with two propositions made by Lawton: first, the importance of an ideographic approach to environments of ageing, to which we have proposed a regional case study. Second, Lawton made a typology of modes of housing for older persons, calling for intermediary ones; I propose a revised typology. Finally, I integrate our findings in terms of human development together with an ecological understanding of ageing, thus sketching a more complete psychology of ageing in a changing environment.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Successful surgery for Cushing’s disease (CD) leads to an abrupt change in cortisol levels, and patients often experience symptoms that can adversely affect their quality of life (QOL). The goal of this study was to provide a detailed characterization of the changes in QOL before and after successful surgery.
Methods:
The QOL-CD, a CD-specific questionnaire, was administered at routine clinical visits during active disease prior to surgery and during the early postoperative phase following successful surgery. Descriptive statistics and nonparametric tests characterized clinical, endocrinological, and ophthalmological attributes at both phases. Euclidean hierarchical clustering of the 34 patients who completed both pre- and postoperative questionnaires identified latent subgroups of QOL change.
Results:
In the cohort as a whole, hypertension (OR = 0.31, p = .003), emotional health (p = .026) and physical health (p < .001) improved following treatment. Changes in emotional health were correlated with changes in mental status (r = 0.66, p < .001) and social well-being (r = 0.53, p = .001). The cluster analysis revealed five distinct patterns of pre- to postoperative changes in QOL domains, grouped into three categories based on severity. Group 1 (n = 5) patients showed worsening in most domains of QOL, Group 2 (n = 20) showed marginal changes in QOL and Group 3 (n = 9) demonstrated improvements across all QOL domains.
Conclusions:
Our results highlight the need to educate and support patients before and after surgery for CD. Long-term follow-up studies are needed to better understand the trajectory of QOL recovery and to identify predictors of treatment response.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 1.3 considers voluntary health insurance (VHI). VHI is paid for privately by or on behalf of individuals and normally covers care in addition to the publicly financed benefits package. Premiums are not typically based on the policyholder’s income but may well vary depending on their risk of ill health. Key learning includes that
Despite prepayment and risk pooling, VHI has limitations and does not align well with progress towards universal health coverage because:
– Risk pools in VHI schemes are typically much smaller than pools established through statutory schemes which means there are fewer people to share risk
– Inequities are created because of the cost of premiums, which may not be affordable or accessible to everyone including those most in need.
VHI has wider equity implications because it offers those who can afford to pay faster access or greater choice of services (supplementary insurance) or coverage of excluded services or user charges for statutory care (complementary insurance)
Governments seeking to use VHI to expand coverage typically have to make significant interventions, including through tax subsidies to make premiums more affordable, but this creates market distortions and is inefficient.
Policy-makers can secure better value for money by improving access to publicly financed health care than by promoting VHI.
This theoretical chapter first proposes, within an open dynamic approach, a vocabulary to address the embodied person and their experience, and the material, social and symbolic environments in which they live, which are experienced physically, relationally and interpreted via semiotic processes. Then, it highlights the implications of a regional case study for the theorising of human development, notably, thanks to its attention to the interdependency between socio and microgenetic dynamics and ontogenesis. Further, it proposes a new series of concepts and dynamics to account for development in older age, where people are likely to find new ways to develop in a world whose forces may feel progressively more adverse. Hence, the model of reconfiguration of domains of conduct needs to be completed by an understanding of envelopes that supports centripetal dynamics, borrowed from psychoanalysis. Finally, the chapter examines the implication of this proposition for the theorising development in the lifecourse.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
The Twins Early Development Study (TEDS) is a longitudinal population study of over 10,000 twin pairs born in England and Wales between 1994 and 1996. As the twins enter their thirties, a primary focus of TEDS is to better understand the development of common physical and mental health problems and the relationship with the different social milestones of adulthood (e.g., employment, partnerships, and/or parenthood). With over 30 years of prospectively collected questionnaire and genetic data, the study is uniquely placed to answer questions about the health challenges facing young adults today. Incorporating linked medical records with the existing research data will provide a different data perspective on our twin’s health status and outcomes and support more equitable research by helping to address both response and attrition bias. This article provides an overview of the protocol to link TEDS participants to electronic health records collected by the UK National Health Service (NHS). It will outline the linkage process, characterize the available linked study sample and NHS datasets, and describe the legal basis for this work.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 3.2 covers the way hospitals are paid. Methods for paying hospitals vary across countries and include fee-for-service, block contracts, line-item budgeting (where purchasers specify exactly what funds are used for), and activity-based funding (with a fixed rate for each episode of care independent of the hospital’s costs of care). Increasingly, pay-for-performance elements are also used. Key learning includes that
Third-party purchasers: government agencies, social health insurance funds, or insurance companies provide the bulk of hospital revenue giving them levers to shape provision.
Purchasers and hospitals have distinct objectives that are not always aligned — purchasers will pursue the best quality of care at the lowest price for their covered population while hospitals seek stable revenue streams to cover their costs.
Information asymmetries give hospitals advantages over purchasers.
Purchasers use payment methods and financial rewards to incentivize the volume and quality of care, patient-mix and management effort they want. There are complex challenges around
– Specifying the details
– Negotiating effective contracts, and
– Managing payment systems.
Monitoring outputs and safeguarding quality requires structures and systems which are costly.
Reforming funding or transitioning from one payment model to another is often a long process that demands sophisticated design and careful implementation.
Evaluate the utility of comprehensive neuromonitoring to allow for early identification of arterial ischaemic strokes in high-risk critically ill infants with CHD.
Methods:
Design: Single-center, retrospective review of Pediatric Cardiac Critical Care Consortium registry data, internal cardiac ICU database, and electronic health records. Setting: Tertiary care children’s hospital cardiac ICU. Patients: Patients <6 months old who underwent surgical and/or catheter intervention from 01/01/2016 to 12/31/2022.
Results:
Of 362 patients, 25 were diagnosed with arterial ischaemic strokes. The latter had more complex CHD and underwent higher risk operations: 60% (n = 15) had single ventricle CHD versus 15% (n = 50) of controls (P < 0.001); 88% (n = 22) underwent STAT* 4 or 5 operations versus 32% (n = 108) of controls (P < 0.001). Strokes were identified in 13 patients (52%) because of acute post-procedure neuromonitoring, including head ultrasound (n = 5) and continuous video electroencephalography (n = 8). Strokes manifested clinically in less than half of the episodes (11 of 25), and focal neurologic signs were noted in 20% (5 of 25). A head ultrasound first diagnosed 60% of arterial ischaemic strokes (15/25); 36% (9/25) were diagnosed by head CT, and 4% (1/25) were diagnosed by MRI.
Conclusions:
Comprehensive neuromonitoring in high-risk critically ill CHD patients leads to identification of arterial ischaemic strokes even in the context of significant haemodynamic lability and limited neurological examination secondary to sedation and neuromuscular blockade. Head ultrasound is useful as an initial screening modality, with advanced imaging used to confirm an injury or in cases of high clinical suspicion.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 3.5 reflects on how to use payment mechanisms to support the integration of care. Integrated care is about better management of the care patients receive in different settings (primary, secondary) and from different specialists and teams. It is particularly important for patients with multi-morbidity and chronic long-term needs, and as populations age. Key learning includes that
Health systems’ payment models can play an important role in incentivizing integrated care.
Purchasers are now testing innovative payment models (e.g. pay-for-coordination or P4C) which explore how to foster better coordination. These models include
– Appointing a ‘budget holder’ for a patient so a case manager and /or multidisciplinary team has oversight of all care
– Bundling payments to single providers so that the multiple services a patient uses are better linked and
– Bundling payments for patients being treated by multiple providers, creating joint budget responsibility and a need to work together and avoid duplication.
Policy-makers would do well to focus on careful design of information systems to underpin payment schemes because
– Information sharing supports clinical effectiveness
– Quality indicators allow purchasers to tie bonuses or penalties to integration
– Monitoring activity and health outcomes helps assess value for money
– Tracking the distributional consequences of incentive schemes is crucial in protecting equity
– Robust evaluation tools allow immediate lessons to be shared and will capture changes over time and across the healthcare system.
Health systems need to embed financial incentives as part of a broader system approach. Critical elements include
– Committed leadership
– Effective communication among providers
– Structural integration, either through coordinating mechanisms that link provider roles or by the formation of new entities with single management teams.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 3.8 highlights the importance of funding as a tool for preparing for and responding to pandemics. A pandemic can wreak health, societal and economic havoc. Prioritizing common and global public goods for health and specifically for pandemic planning is complex and requires financing mechanisms at national, regional and supranational levels. Key learning, including from COVID-19, is that
– Pandemic preparedness is subject to inherent market and collective action failures and is often underfunded.
– Governments need clear strategies for funding preparedness.
– Preparedness depends on strong health system foundations and contingency funding mechanisms that go beyond simply setting funds aside. It is crucial that funds can be mobilized quickly and in a coordinated fashion.
– Key steps for planning responses include
Assessing existing activities and mapping value for money
Agreeing the need for public financing for population-based functions (i.e. common goods)
Identifying appropriate types of financing that reflect the complexity of determining resource needs and allow for nuanced cost estimation
Developing context-specific financing tools that include flexible funds and address accountability
Holding transparent discussions about trade-offs
Improving budget transfer mechanisms
Integrating domestic finance into multiyear budgets, and
Managing and strengthening international collaboration
International guidance and learning from COVID-19 can help inform preparations. Organizations including the WHO and World Bank offer tools to help decision-makers. It is crucial that these are assessed for suitability to context and customized to the national and local setting.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 3.4 explores how pharmaceutical care is financed. Paying for medicines includes how the end-purchase of existing medicines is managed but also the way investment in research and development (R&D) is handled. Key learning includes that
Pharmaceutical innovation draws on substantial public and private resources.
– The public sector primarily supports early-stage research, regulates the industry and incentivizes development.
– The private sector is typically central to development, commercialization, manufacture and marketing. It seeks high profit margins and is not always transparent or responsive to policy priorities.
Novel and specialized therapeutics as well as population ageing are likely to accelerate medicines expenditures. This requires careful management of pricing and reimbursement.
Policy-makers can leverage a mix of push and pull strategies to align industry efforts with societal need including through
– Clear communication of health system priorities
– Transparent incentive and pricing systems and measures to enhance R&D efficiency
– Payment mechanisms that foster equity and sustainability
– Cross-country collaboration including on preparedness, procurement and pricing transparency.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 3.10 evaluates innovative financing for neglected diseases. Neglected diseases (NDs) account for about a fifth of the global burden of disease and affect over a billion people. They are neglected because the pharmaceutical sector does not consider it profitable to develop treatments for them. This reflects that fact that NDs are most prevalent in low- and middle-income countries with relatively low purchasing potential. Key learning includes that
Global pharmaceutical research and development (R&D) invests a disproportionate share of innovation, activity and resources in low burden diseases and fosters significant inequities.
A range of push and pull incentive mechanisms have been developed to delink the cost of research from market profitability and promote innovation in areas of need.
These include measures to
– Reduce the upfront costs by subsidizing R&D pre-discovery (push incentives) and
– Offer a reward post-discovery (pull incentives)
The evidence on the effectiveness and reach of incentive schemes is scant and more needs to be done to understand the relative cost-effectiveness of the different incentive mechanisms and the extent to which they mitigate inequalities in innovation and access to new medicines.
A global, unified governance framework for needs assessment and resource allocation could usefully
– Carry out systematic comparison of the relative needs associated with NDs globally
– Assess the costs and benefits of addressing these
– Set priorities for the coordinated global allocation of funding and targeted incentive mechanisms, and
– Consider payment mechanisms that will translate research into market launches.
Anxiety disorders are associated with disrupted amygdala connectivity; however, resting-state functional MRI studies have reported heterogeneous findings. To clarify these inconsistencies, we conducted a meta-analysis of amygdala-based connectivity studies.
Methods
A systematic search of Embase, PubMed, and Web of Science was performed through December 26, 2025. Studies comparing amygdala-based whole-brain resting-state functional connectivity in patients with anxiety disorders versus healthy controls were included. Meta-analysis was conducted with the latest software – Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), which employs voxel-wise tests and multiple corrections to minimize false positives. Subgroup analyses were performed to examine differences by age and hemisphere.
Results
Fifteen datasets (378 patients, 405 controls) were included. Compared to healthy controls, patients with anxiety disorders had decreased amygdala-anterior cingulate cortex (ACC, g = −0.54, 95% confidence interval [CI]: −0.73 to −0.35) connectivity and increased connectivity with the left superior temporal gyrus (g = 0.46, 95% CI: 0.27–0.65), middle temporal gyrus (g = 0.38, 95% CI: 0.19–0.57), and cuneus (g = 0.35, 95% CI: 0.17–0.53). After threshold-free cluster enhancement correction, only reduced amygdala-ACC connectivity remained significant (g = −0.54, 95% CI: −0.73 to −0.35). Subgroup analyses confirmed this effect was driven mainly by adult patients and the left amygdala.
Conclusions
Reduced connectivity between the left amygdala and the ipsilateral ACC was the most robust neuroimaging marker of anxiety disorders, which suggests a lateralized vulnerability. By applying updated analytic methods, this study refines our understanding of the neuropathology of anxiety disorders and provides a potential primary target for biomarker development and novel interventions.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London