To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Sociocultural psychology of the lifecourse, which examines the development of the persons in their changing environments, offers here the frame for our exploration of development in older age. Although it has largely addressed the development of children, youth and adults, it has only recently started to approach the specificities of developing with age. This chapter retraces the ontological and epistemological foundation of this approach. It then further explores three sets of concepts of foremost importance when approaching development in the lifecourse into older age: those related to dynamics of distancing and imagining, core when examining semiotic processes in human development; those of interests and engagements, which emphasise sense-making and affects; and what regards the domains of conduct in which people engage. The chapter then sketches the specificities of development in older age within people’s material, social and symbolic environment.
The exploration proposed here is pursued through a complex, regional case study. Regional case studies enable delineating a portion of the world, with a consistent set of institutions and policies as well as geographical and material conditions that set the frame for people’s lives, and to identify the complex dynamics by which sociogenetic, microgenetic and ontogenetic transformation co-occur. This chapter presents how we approached, conceived and analysed this case study. To start with, I define my approach to ageing as a form of personal engagement, which progressively developed into a collaborative project. After showing the relevance of a regional case study for sociocultural psychology of the lifecourse, I present the fieldwork, the data collection, an overview of the participants and the main line of the analysis.
The relationship between frailty, self-efficacy, and advance care planning (ACP) remains unclear in Asia. This study examined how frailty status relates to decisional self-efficacy, ACP engagement, and advance directive completion among older adults receiving home healthcare in Taiwan.
Methods
A cross-sectional analysis was conducted using baseline data from a nationwide cohort in Taiwan. Participants (N = 358) were categorized by Clinical Frailty Scale (CFS): mildly frail (CFS 4–5, n = 60), moderately frail (CFS 6, n = 83), severely frail (CFS 7, n = 147), and very severely frail (CFS 8–9, n = 68). ACP engagement and decision-making self-efficacy were assessed using Likert scales.
Results
Patients with greater frailty had lower odds of high decisional self-efficacy (CFS: 8–9: odds ratio [OR] = 0.38, 95% confidence interval [CI] = 0.14–1.07) but higher odds of ACP engagement (CFS: 6: OR = 3.38, 95% CI = 1.40–8.17; CFS: 7: OR = 2.52, 95% CI = 1.08–5.89) compared with mildly frail individuals. However, this increase did not extend linearly to the very severely frail group. Advance directive completion remained low across all frailty levels (4.8–10.0%) and was not significantly associated with frailty status.
Conclusions
Frailty was associated with lower decisional self-efficacy but higher readiness for ACP, revealing a divergence between perceived confidence and planning motivation. Despite greater engagement, advance directive completion remained low. Stage-sensitive, values-based approaches may help bridge the gap between intention and documentation across the frailty spectrum.
This chapter approaches the concrete, everyday lives of older persons in the Vineyard region. We examine how people living in towns, in villages, alone or in shared housing, organise their lives. Daily trajectories, typical interactions, everyday encounters are described. The chapter first examines informal encounters and networks, daily interactions, occasional meetings, and the importance of social interactions. Both the role of ‘lighthouse watcher’ and tenuous ties are put to the fore. Second, the chapter follows interactions taking place in an institutional setting, a day-care centre. Here also, people can develop meaningful activities and reveal their engagements, while the frame can offer a containing function. Altogether, this chapter shows how evolving material, social and symbolic environments are deeply related to people’s development in older age.
Prolonged grief disorder (PGD), recently classified in ICD-11 and DSM-5-TR, is characterized by persistent and functionally impairing grief lasting beyond 6–12 months. The COVID-19 pandemic was accompanied by widespread mortality, social isolation, disrupted mourning rituals, and social disconnection, raising concerns about a potentially high burden of PGD during the pandemic period. We conducted a systematic review and meta-analysis, following PRISMA guidelines and PROSPERO registration (CRD42023463720), to estimate PGD prevalence under standardized ICD-11 and DSM-5-TR diagnostic frameworks and to examine potential moderators during the COVID-19 pandemic. PubMed, EMBASE, and the Cochrane Library were searched from inception to October 2024. Eligible studies included adults who experienced bereavement during the pandemic and were assessed using validated PGD instruments (PG-13-R, ICG, BGQ). Random-effects models were applied to pool prevalence estimates, with subgroup and meta-regression analyses. Thirteen studies comprising 5,766 participants were included. The pooled prevalence of PGD during the pandemic period was 24% (95% CI: 13%–36%), with the highest estimates observed in China (43%, 95% CI: 33%–54%). In the overall pooled analysis, studies applying DSM-5-TR criteria yielded lower prevalence estimates than those using ICD-11 criteria (18% vs.26%, p = 0.41). Digital interventions showed no statistically significant pooled effects (Hedges’ g = −0.38, 95% CI: −0.90 to 0.14). The high and geographically heterogeneous prevalence of PGD observed during the COVID-19 pandemic underscores the need to strengthen mental health surveillance, standardized assessment, and service accessibility in large-scale public health emergencies, and provides important evidence to inform population-level interventions and resource allocation strategies.
Paediatric cardiac catheterization in children with CHD requires anaesthetic techniques that balance procedural conditions with physiological risk. We evaluated anaesthesia management at a tertiary centre and examined associations between anaesthesia strategy and peri-procedural outcomes.
Methods:
This single-centre retrospective cohort included 307 catheterization procedures after exclusions. Anaesthesia was categorized as general anaesthesia or sedation. The primary outcome was any recorded complication.
Results:
Median age was 7.0 years (interquartile range 2.0–13.0), and 155/307 (50.5%) procedures were performed under general anaesthesia and 152/307 (49.5%) under sedation. Overall, 49/307 (16.0%) procedures were associated with at least one recorded complication; complications were more frequent with general anaesthesia than with sedation (20.6% versus 11.2%, p = 0.024). In diagnostic catheterization/angiography (n = 175), general anaesthesia was independently associated with higher odds of any complication compared with sedation (adjusted odds ratio 2.78, 95% confidence interval 1.12–6.91; p = 0.028).
Conclusions:
In this cohort, general anaesthesia was associated with higher recorded complication rates than sedation, and this association persisted after adjustment within diagnostic catheterizations. Comparisons within interventional procedures were limited by sparse sedation data. These findings support procedure-specific, risk-adjusted evaluation when selecting anaesthesia strategy in the paediatric catheterization laboratory.
The COVID-19 pandemic disrupted education and training which led academia to revise well-established instructional content and strategies. This report described and evaluated the curricular response of public health preparedness at Penn State to the COVID-19 pandemic.
Methods
We describe an online, hybrid course focused on the development, approval, and dissemination of the SARS-CoV-2 vaccines. The course was offered in the spring of 2021 and covered real-time laboratory, public health, emergency management, homeland security, medical, and policy aspects of the vaccines. Additionally, we report the student evaluation results of those who completed the course.
Results
The median and mode scores for student evaluations were 7, on a scale of 1 (lowest) to 7 (highest). Students enjoyed the instructors because they were employed in strategic positions and explained real-world challenges. Students reported the course as “timely” and “breaking down complex concepts into simple understanding.”
Conclusions
Penn State responded to the COVID-19 pandemic with an innovative course that developed students’ real-time understanding of pandemic response. Students gained knowledge and skills relevant to the practice of public health. Based on the positive student feedback, the course will serve as a model for future classes on public health and emergency management.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 2.2 investigates the design and implementation of health benefits packages in different contexts. A benefits package is the range of health care goods and services that people covered by a system or scheme are entitled to or should be able to access. Key learning includes that
All health systems have budgetary constraints and set some limits to entitlement, and therefore have some kind of benefits package.
Benefits packages may be explicitly defined or implicit only, with the latter more common in high income countries and the former more common in low and middle income countries.
What is included or excluded, and the ways these decisions are made, vary widely but well-designed benefit packages should address population health needs and ensure the efficient use of health system resources
Defining a package of care is complex and often highly sensitive – using evidence and economic evaluation to determine what to include (or exclude) supports efficiency and equity and allows policy-makers to explain and defend their choices.
There are a range of evidence-led instruments that can support policy choices such as health technology assessment (HTA), which incorporates economic evaluation.
Any decision-making process should
– Gain agreement and buy-in from key stakeholders on the ultimate goals of the benefits package and the level of explicitness.
– Take into account the specific characteristics of the setting where the benefits package will be implemented including its cultural values, market configuration, political system and wealth.
Edited by
Jonathan Cylus, European Observatory on Health Systems and Policies,Rebecca Forman, European Observatory on Health Systems and Policies,Nathan Shuftan, Technische Universität Berlin,Elias Mossialos, London School of Economics and Political Science,Peter C. Smith, Imperial College of Science, Technology and Medicine, London
Chapter 2.5 sets out how long term care is provided and how it is paid for. Long-term care (LTC) refers to a broad package of personal, social and medical services provided over extended periods of time which may be delivered by care professionals or by informal care givers. Key learning includes that
Population ageing, particularly in advanced economies, creates growing demands for LTC.
There are inequities in the need for and access to LTC. Older people, women, those with lower incomes and lower levels of education are all more likely to need care, but less likely to have access to it.
Funding arrangements for LTC are problematic in many countries
– Voluntary insurance and out of pocket payments commonly fill public coverage gaps but create inequities.
– Asset-tests for eligibility for publicly funded care are essentially regressive wealth taxes due to the unequal distribution of LTC needs.
– Encouraging for-profit provision theoretically fosters competition, availability and responsiveness but the pressures to generate profits can jeopardize quality and safety.
Countries face urgent pressures on LTC and could usefully consider
– Increasing public expenditure and broadening the funding mix for LTC
– Better, fairer pooling of resources across generations
– Revenue sources independent of payroll contributions since labour markets as a revenue base will shrink at the same time that demand for ageing-related LTC increases
– Better data and indicators to assess access, quality, and value for money
– Patient-centred and coordinated approaches to LTC.
Flow cytometry plays a critical role in the diagnosis of hematopoietic neoplasms. Understanding the key immunophenotypic features of each entity is essential for accurate diagnosis. Filling a crucial gap in current literature, this is a comprehensive reference text that systematically details these immunophenotypic profiles. Grounded in real-world experience, this practice-driven resource offers expert guidance on the use of flow cytometry in the diagnosis and classification of hematolymphoid neoplasms. Covering major disease categories, technical insights, and emerging therapies like CAR T-cells, readers will gain a solid foundation for identifying deviations seen in hematologic malignancies, thereby enhancing diagnostic accuracy. Each chapter concludes with key points and diagnostic pitfalls for efficient comprehension and retention. This is an essential tool for pathologists, hematologists, trainees, and laboratory professionals seeking clarity and confidence in diagnosis.
The Emergency Paramedic Act (EPA; Notfallsanitätergesetz), implemented in 2014, expanded the legal authority of German paramedics to independently perform defined invasive and pharmacological interventions under specific conditions. However, real-world implementation of these competencies within the physician-based German Emergency Medical Services (EMS) system remains insufficiently described.
Objective:
The aim of this study was to evaluate the frequency, type, temporal development, and regional variation of invasive and pharmacological/therapeutic interventions performed independently by paramedics over a six-year period.
Methods:
A retrospective, descriptive multicenter analysis of digital EMS documentation was conducted across three districts in Saxony, Germany, from January 1, 2019 through December 31, 2024. All missions were screened (n = 197,842). Paramedic-led missions without physician presence were included; physician-attended missions and non-emergency interfacility transports were excluded. Interventions were classified according to the 2024 Federal Association of Medical Directors of EMS competency catalogue. Frequencies were analyzed by year and district. Temporal trends were assessed using the Mann–Kendall test, and regional differences were explored using one-way ANOVA with Tukey HSD post hoc testing. All inferential analyses were exploratory.
Results:
Of 197,842 missions, 156,417 (79.1%) were paramedic-led without physician presence. Invasive procedures occurred in 7.6% of missions and were predominantly peripheral intravenous (IV) access (5.7%). Advanced airway management and intraosseous (IO) access were rare (<0.1%). Pharmacological/therapeutic administrations occurred in 11.3% of missions and increased from 9.4% in 2019 to 12.1% in 2024 (Mann–Kendall test), whereas overall invasive procedure rates remained stable.
Conclusion:
Ten years after implementation of the EPA, invasive and pharmacological interventions performed independently by German paramedics remain relatively infrequent and largely confined to basic measures. Advanced procedures are rarely applied, reflecting continued structural characteristics of the physician-based EMS model.
To assess the impact of ethnicity on survival following paediatric cardiac surgery.
Methods:
Observational study of a regional tertiary paediatric cardiac surgical centre in Yorkshire, UK. All children (age 0–15 years) undergoing their first cardiac surgical procedure from January 2005 to December 2021 inclusive. The primary outcome was 5-year survival. Secondary outcomes included 30-day, 1-year, and pre-discharge survival.
Results:
3,508 children (46% female) underwent their first cardiac surgical procedure during the study period. Within the study cohort 2,578 (73%) children were White, 634 (18%) were South Asian, 95 (3%) were Black and 201 (6%) were from other ethnic groups. South Asian children were more likely to have a functionally single-ventricle (10% vs. 7% White; relative risk 1.41, 95% confidence interval 1.15–1.69).
Mortality after surgery, adjusted for deprivation, was higher for South Asian (hazard ratio 1.50, 1.12–2.01) and Black children (hazard ratio 1.69, 0.93–3.06), compared to White children. Survival differences were not present at discharge or 30 days post-procedure, but widened progressively at 90 days, 1 year and 5 years. This was not influenced by diagnosis or pre-operative risk factors. One-year survival improved for South Asian children across the study period and was similar to that of White children from 2017–2021 (94.7% (89.8–97.3%) vs. 96.8% (94.9–97.9%) White).
Conclusions:
Black and South Asian children have a greater risk of death following cardiac surgery compared to White children, independent of pre-operative risk. The majority of excess deaths occurred after hospital discharge. Although inequities have steadily reduced over the past two decades, the explanation for this effect remains unclear.
Protein intake is essential for maintaining physiological functions, with standard recommendations suggesting ∼0.7 g/kg/day for healthy adults. In recent years, high-protein diets have gained popularity due to their potential metabolic benefits, including reduced visceral adiposity, improved hormonal regulation, and preservation of muscle mass. However, the effects of high-protein intake on gut microbiota and overall health remain controversial. Emerging evidence indicates that excessive protein consumption, particularly from animal sources, may negatively impact gut health by increasing intestinal permeability, promoting chronic low-grade inflammation, and impairing mucosal immunity. These effects appear to depend on protein source, intake level, duration, and host-specific factors such as age, metabolic status, and immune function. While moderate protein intake seems to have minimal effects on microbial diversity, chronic high intake may disrupt gut microbiota composition and favor pro-inflammatory profiles, potentially contributing to metabolic dysfunction. Additionally, co-ingested dietary factors, including fat content, processed meat compounds, and fiber intake, may confound these outcomes. Certain populations, such as athletes, older adults, and individuals with type 2 diabetes, may benefit from higher protein intake, although these effects are context-dependent. In contrast, high-protein diets may be detrimental for individuals at risk of chronic kidney disease. Overall, the gut microbiota plays a central role in mediating the health effects of dietary protein, highlighting the importance of balanced and personalized nutritional strategies.
Metabolic dysfunction-associated steatotic liver disease is the most prevalent liver condition worldwide, affecting approximately 30% of the population globally. MASLD often coexists with hypertension, central obesity, type 2 diabetes, and dyslipidaemia, yet globally, national treatment strategies are still being established. Pharmacological options are limited and lifestyle modification to achieve weight loss through combining diet, physical activity (PA) and structured exercise remains the cornerstone of MASLD management. The Mediterranean diet (MedDiet) is an evidence-based dietary approach for MASLD prevention and treatment; however, its application in culturally and linguistically diverse, non-Mediterranean populations requires adaptation. In fact, the need for cultural adaptation for all lifestyle interventions (diet, physical activity, sleep) needs better acknowledgement and implementation. There are limited interventions which combine all lifestyle behaviours and even fewer that consider cultural safety and appropriateness Furthermore, limited healthcare staffing resources, geographical location and health system pressures highlight the need for more accessible and cost-effective delivery methods. This review summarises evidence on MedDiet for MASLD in multicultural populations, explores the synergistic benefits of combining with PA and sleep interventions, and provides practical recommendations for culturally tailored approaches. Finally, we outline future directions for research and healthcare delivery, emphasising the urgent need for holistic, culturally safe, culturally responsive, efficient, and digitally-enabled strategies to address the growing global burden of MASLD.