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The impact of guideline-directed medical therapy (GDMT) has not fully translated to decreases in the disproportionate rates of hospitalization and lengths of stay in African Americans with congestive heart failure (CHF). GDMT is optimized by registered nurses (RNs) and their use of clinical information. Yet, there are no instruments for measuring the influence of clinical information use and nursing care. The study assessed an instrument’s ability to measure the influence of RN performance of social, technical, and socio-technical care tasks on length of stay in the CHF hospitalizations of African Americans.
Methods:
A sample of 200 RNs, who cared for 5060 African Americans with 14,123 heart failure hospitalizations, were surveyed. Descriptive statistics, Cronbach’s alpha, and a generalized linear regression assessed the instrument’s reliability and predictive validity.
Results:
The Cronbach’s alpha was 0.95 (95% CI: 0.94–0.96). The corrected item-total correlations for the 22 items ranged from 0.44 to 0.80. For an increase of one to four points per item in a RN’s performance, the estimated reductions in the patient’s length of stay were 3.34% (6.11,0.5), 6.58% (11.84,1), 9.70% (17.22,1.49), and 12.72% (22.28,1.99), respectively (P = 0.004).
Conclusions:
Increases in a RN’s performance of social, technical, and socio-technical care tasks were significantly associated with clinically meaningful decreases in their patients’ length of stay. The instrument has strong potential for addressing the disproportionate impact of CHF by measuring and tailoring interventions to optimize nursing care and the use of clinical information in the provision and receipt of GDMT.
This parallel randomised controlled trial examined the effect of a 4-week, high dose (Lf-High, 600mg/d) or low dose (Lf-Low, 200mg/d) oral lactoferrin (Lf) intervention versus placebo, on immune cell responses to respiratory virus, circulating immune cell subsets, and systemic inflammation. In healthy older adults (n=103, ≥50 years old), ex vivo cytokine release of interferon (IFN)-α2, IFN-γ, interleukin (IL)-6, and tumour necrosis factor (TNF)-α from isolated peripheral blood mononuclear cells (PBMCs) stimulated with rhinovirus A-16 (RV-16) or influenza A virus (H1N1), circulating immune cell subsets, and plasma IL-6, C-reactive protein (CRP) and TNF-α were assessed at baseline and 4 weeks. Ninety-seven participants completed the intervention (Lf-High n=32, Lf-Low n=31, placebo n=34, withdrawals n=6). There was no difference in RV-16 or H1N1-induced IFN-γ release between groups. At 4-weeks, RV-16-induced IL-6 was lower in Lf-High compared to placebo (P=0.001), and RV-16-induced IFN-α2 was higher in Lf-High compared to Lf-Low (P=0.04). Lf-High increased total T cells (P=0.03) and CD4+ T cells (P=0.03) compared to placebo. Lf-Low reduced neutrophil (P=0.04), natural killer cell (P=0.045), activated CD8+ T cell (P=0.03), and γδ T cell (P=0.03) frequency compared to placebo. Plasma IL-6 (P=0.004) and CRP (P=0.03) were lower following Lf-High compared to Lf-Low, but not placebo. Both high and low dose lactoferrin altered ex vivo immune cell responses after 4 weeks. High dose lactoferrin increased T-cell subsets, promoting adaptive immunity, and reduced systemic inflammation, while low dose lactoferrin reduced proinflammatory and cytotoxic immune cells. High and low dose lactoferrin supplements may have immunoceutical benefits in older adults.
Forced displacement heightens mental health risks for children, including psychological, environmental and economic stressors, yet few interventions address whole-family needs within humanitarian contexts. Family-systemic approaches show promise, but evidence on interventions addressing social determinants of mental health remains limited. We will conduct a single-masked, two-arm randomised controlled trial with 550 families in East Amman, Jordan, to evaluate StrongerTogether, a modular whole-family intervention with a financial literacy component. Families experiencing multiple psychosocial challenges will be randomised 1:1 to receive the intervention or enhanced treatment as usual. The trial employs sequential dual outcomes testing, evaluating effectiveness through: (1) upstream improvements in at least one of three primary outcomes (family functioning, parenting practices and caregiver mental health) and (2) direct improvements in adolescent mental health among those with elevated baseline distress. We will also evaluate two implementation tools: ReachNow for family case detection and FamilyACT for facilitator competency assessment. A mixed-methods process evaluation will examine implementation, effectiveness and potential sustainability of core and optional modules. This will be the first rigorous evaluation of an integrated whole-family intervention addressing social and environmental determinants of mental health in humanitarian settings. Findings will inform evidence-based approaches to family mental health support and contribute validated tools for implementation at scale.
The current study was designed to examine the association between a composite Healthy Lifestyle Score (HLS) and thyroid function biomarkers among American adults. This cross-sectional study utilized data from 5,693 adults aged ≥18 years in the NHANES 2007–2012 cycles. A HLS (range 0–6) was constructed based on six modifiable factors: non-smoking, no heavy alcohol intake, normal BMI (18.5–24.9 kg/m²), high physical activity (upper tertile of MET-min/week), adequate sleep (7–9 h/night), and appropriate energy intake. Serum concentrations of thyroid-stimulating hormone (TSH), free and total thyroxine (FT4, TT4), free and total triiodothyronine (FT3, TT3), thyroglobulin (Tg), and thyroid antibodies (TPOAb, TgAb) were measured. Multivariable linear regression adjusted for sociodemographic factors was used to assess associations. In fully adjusted models, each one-point increase in HLS was associated with lower serum FT4 (β = −0.07 ng/dL; 95% CI: −0.10, −0.03; p < 0.001) and TT4 (β = −0.11 µg/dL; 95% CI: −0.15, −0.06; p < 0.001). Compared with participants with an HLS of 0–1, those with HLS 4–6 had lower FT4 (β = −0.20; 95% CI: −0.30, −0.09; p < 0.001) and TT4 (β = −0.36; 95% CI: −0.49, −0.22; p < 0.001). Associations for other thyroid markers were not statistically significant after correction for multiple comparisons (p > 0.05). A healthier lifestyle is inversely associated with serum FT4 and TT4 levels, highlighting potential links between modifiable behaviors and thyroid physiology.
The urban First Nations population in Australia is rapidly increasing. The health policy and research focus on urban First Nations Australians, however, is limited. To contribute to addressing this situation, The University of Queensland Poche Centre for Indigenous Health (UQ Poche Centre), a First Nations-led health research centre, is working closely with urban Aboriginal Community-Controlled Health Services (ACCHS) across Australia.
Aim:
Our study examined urban ACCHSs stakeholders’ perspectives of the health and wellbeing of urban First Nations Australians and identified their priorities for a national Indigenous urban health research agenda.
Methods:
Ten stakeholders were recruited for in-depth interviews from ACCHS that were members of the Research Alliance for Urban Community-Controlled Health Services (RAUCCHS), a partnership between the UQ Poche Centre and urban ACCHS focused on achieving equitable health outcomes for urban First Nations Australians. Six stakeholders identified as First Nations Australians. Interviews were audio-recorded and transcribed verbatim. Interview data were analysed using inductive thematic analysis.
Results:
Stakeholders highlighted a lack of research focused on the health of urban First Nations Australians. Specific priority areas they identified for an urban First Nations health research agenda were: evaluating the effectiveness and adaptability of Indigenous models of care, strengthening care pathways between ACCHS and specialist services, examining the intersection of cultural identity, racism and determinants of health, and greater investment in Indigenous research governance structures and processes.
Conclusions:
There is a clear opportunity for researchers to engage with RAUCCHS members to establish a body of urban First Nations health research in Australia that responds to their research priorities.
No existing dietary metric simultaneously captures key dimensions of sustainable healthy diets (SHD): dietary variety, intake of animal products and extent of food processing. This methods and construct development study aimed to identify indicators of an SHD that can be used to inform a multidimensional diet quality score. A modified Delphi was used to gain expert consensus regarding the development of an SHD score. Three iterative surveys were conducted between November 2022 and May 2023. Surveys asked participants’ opinions regarding the measurement of the three dimensions of SHD (Dimension 1: variety of unprocessed and minimally processed foods; Dimension 2: intake of animal products; and Dimension 3: intake of ultra-processed foods (UPF)) and weighting and aggregation of a score that assesses these three dimensions. Thirteen international experts completed all three surveys. Consensus from experts led to the identification of food-based indicators of SHD. Experts agreed that Dimension 1 should be comprised of twelve food groups, with food groups and scoring ranges informed by the Global Diet Quality Score; Dimension 2 comprised of five food groups with scoring ranges informed by the EAT-Lancet planetary health diet; and Dimension 3 as one food group measured as a cut-off value of ≤10 % energy from UPF. There was consensus that each dimension should be equally weighted. Outcomes from this work have been used to inform the development and validation of a multidimensional diet quality score to assess the healthfulness and environmental sustainability of diets among healthy adult populations.
Dignity is a crucial value in caring for nursing home residents. These residents are extremely vulnerable due to, among others, their physical, social, and mental health risks. These risk factors can undermine their sense of dignity and induce feelings of inferiority and even depression.
Dignity Therapy is a short, individualized psychotherapy aimed at decreasing the existential distress of patients with a terminal illness. It appeared to be successful in patients with incurable cancer and could be a valuable addition to the treatment of loss of dignity in nursing homes. We evaluated the feasibility of implementing Dignity Therapy in Dutch nursing homes and explored its potential effects on residents’ dignity, depression, and self-esteem.
Methods
A pre–post feasibility study was conducted in 2 nursing homes. Psychologists were trained to recruit residents and deliver Dignity Therapy. Standardized questionnaires were administered at baseline and follow-up to assess dignity, depressive symptoms, and self-esteem.
Results
Psychologists were able to recruit and deliver the intervention to 36 residents. Participants generally evaluated the experience as pleasant and meaningful. No significant differences were found between pre- and post-measurements for dignity, depressive symptoms, and self-esteem. Regarding depressive symptoms, men and non-religious residents showed higher levels of depressive symptoms after the 8-week follow-up.
Significance of results
Dignity Therapy is feasible and acceptable for residents in Dutch nursing homes. Although no significant effects on dignity, depression, or self-esteem were detected, further research with larger samples and optimized implementation strategies is needed to understand the potential impact of Dignity Therapy in this setting.
This study aimed to evaluate patients with beta thalassaemia major using the cardiac electrophysiological index of balance, a new electrocardiography parameter, and to predict ventricular arrhythmias.
Methods:
In this study, 60 beta thalassaemia major and 60 healthy children were included. All patients were evaluated with echocardiography. P-wave dispersion, repolarisation times, repolarisation dispersion times, and cardiac electrophysiological balance index were measured using 12-lead electrocardiography. Heart rate variability parameters were evaluated with a 24-hour Holter electrocardiography.
Results:
Left ventricular functions were similar between the groups. Although repolarisation times (QT, JT, and JTp) were significantly lower in the beta thalassaemia major group, heart rate-corrected repolarisation times were similar. Except for Tpe/QT, which is one of the repolarisation dispersion parameters, the other parameters were similar. The heart rate-corrected cardiac electrophysiological index of balance ratio was significantly higher in the beta thalassaemia major group. QRS duration and QRS-dispersion duration (QRS-d) were similar between the groups. There was a correlation between blood ferritin levels and LVmass-i, Tpe/QT, Tpe/QTc, QTc/QRS ratio, and QT, JT, and JTp values.
Discussion:
Patients with beta thalassaemia major are at high risk for ventricular arrhythmia due to a high QTc/QRS ratio, despite normal left ventricular systolic, diastolic, and autonomic function in the early period. We believe that there is a moderate correlation between blood ferritin levels and the QTc/QRS ratio and that the QTc/QRS ratio can provide important information for the follow-up and evaluation of patients with beta thalassaemia major.
Conclusions:
Despite normal early ventricular function in the beta thalassaemia major group, they were at high risk of ventricular arrhythmias.
The prenatal period, childhood, and adolescence are critical periods of development characterized by high plasticity. As an extension of the Developmental Origins of Health and Disease (DOHaD) paradigm, known as Origins of Paternal Health and Disease (POHaD), recent studies in rodents provide evidence that paternal obesity is associated not only with infertility but also with an increased risk of metabolic disorders in the offspring. In rodents, litter size reduction is used to induce lactational overfeeding by increasing the amount of breast milk to pups, which causes metabolic and reproductive disorders in adulthood. This work evaluated the metabolic and reproductive alterations in the offspring of males raised in normal or small litter (SL) in the prepubertal period and in adult life. The results show that paternal obesity due to early overfeeding affects the offspring in a sex-specific manner. During the prepubertal period, male offspring of SL fathers showed decreased Lee index, tibia length, and HDL plasma levels, and increased weight of gastrocnemius muscle, while female offspring of SL fathers only showed reduced HDL plasma levels. In adulthood, male offspring of overfed males showed glucose intolerance and reduced food intake and triglycerides plasma levels, signs of metabolic dysfunction. Female offspring of overfed males showed delayed puberty onset and higher prevalence of infertile periods in the estrous cycles, indicating a potential susceptibility to reproductive dysfunction. The results of the current study show that paternal obesity due to early overfeeding affects energy balance and reproduction of their offspring in a sex-specific manner.
This study examined the relationship between food safety, food access, and nutritional status among earthquake victims in Kahramanmaraş and Hatay, Türkiye.
Methods
This descriptive, cross-sectional study was conducted face-to-face with 209 earthquake victims in 2023.
Results
The median age was 42 years, and 52.6% were female. Among women, the perception of unhealthy food, inadequate mass feeding services, and dissatisfaction with meals increased the risk of food safety concerns. In men, those with an associate degree or higher were 20.7 times more likely to perceive food safety as inadequate, while the perception of unhealthy food raised this risk by 12.4 times. Lack of access to sufficient drinking water increased the risk of food inaccessibility by 2.6 times among women. In men, employment and dissatisfaction with meals increased this risk by 2.7 and 2.8 times, respectively. Both genders exhibited inadequate intake of water, energy, protein, polyunsaturated fats, fiber, folate, potassium, calcium, magnesium, iron, zinc, and several vitamins (P <0.05), while phosphorus and sodium levels were elevated (P <0.01).
Conclusions
Food safety and access issues were critical among earthquake victims, significantly impacting nutritional status. Findings emphasize the need for improved emergency food aid and distribution systems to mitigate post-disaster nutritional risks.
Mental health is a global issue, and mobile applications, such as chatbots, offer a partial solution by providing improved services through various communication forms. This study aimed to identify chatbots and their technical features in mental health services. This study conducted a systematic review of mental health chatbots and their technical features from 2000 to 2025. A search was performed across databases such as PubMed, Scopus, ProQuest and the Cochrane database. The CASP (Critical Appraisal Skills Programme) appraisal checklist was used to assess the quality of the studies. In the next step, the Braun and Clarke’s approach was utilized for conducting thematic analysis on the data. The search yielded 2,921 records, of which 10 were duplicates and removed. After screening for relevance and eligibility, 33 papers met all the requirements. The mean quality score of the included studies was 13.36 (standard deviation = 1.36). The studies had a moderate risk of bias, as they mostly had a clear question, searched for the right type of papers, included all relevant papers and reported the results precisely. The research conducted an analysis of 138 mental health chatbots, categorizing them based on five distinct attributes: the disorder they target, their input and output modalities, the platform they operate on and their method of generating responses. The research emphasized the need for designing chatbots that suit patients’ preferences and needs, and also indicated that the digital divide within societies should be taken into account when designing and producing chatbots for mental health services. Although mental health chatbots can assist underserved communities, ethical concerns must be addressed before their deployment.
Reducing stigma and discrimination has been a priority in many national mental health policies for decades. Focusing efforts requires us to understand where this has the greatest impact on people with mental health problems. In 2024, we conducted a nationally representative survey that aimed to assess the burden of discrimination (as a product of frequency and impacts of experiences). Secondary aims were to quantify the types of discrimination experienced in different life domains and the sociodemographic and mental health problem characteristics of those experiencing higher burden.
Methods
Online surveys were completed by 6032 members of the general Australian community aged 18 years and over. The survey was carried out by the survey company The Social Research Centre, using their Life in Australia™ probability-based panel. Those who reported a mental health problem or scored high on the Kessler 6 measure of psychological distress (n = 2613) were asked about the past 12-month frequency and impact of their experiences of discrimination in a broad range of settings, including family, friends, workplaces and health services. The data were initially analysed using percent frequencies and 95% confidence intervals. A burden score was calculated for each domain, incorporating frequency and impact among those who reported discrimination experiences.
Results
Overall, discrimination in social life was the most common (43.6% [95% CI 41.2, 45.9]), followed by discrimination from family (41.4% [95% CI 39.1, 43.7]) or in making or keeping friends (41.0% [95% CI 38.7, 43.3]). However, the highest burden was from discrimination in finding or keeping a job, in dating/intimate relationships, in housing (including renting or public housing) and in obtaining welfare benefits or disability pensions. The most common type of discrimination experience in the workplace and among friends, family and partners was of people lacking understanding of the impact of the person’s mental health problem. People aged 35–64 years were more likely than those aged 18–34 years to report higher burden in multiple domains; people with depression or attention-deficit/hyperactivity disorder also reported burden in more domains than people with anxiety or severe mental health conditions. Overall, 67.7% (95% CI 65.5, 69.9) agreed that stigma and discrimination was worse than the mental health problem itself.
Conclusions
Our study suggests that reducing the frequency and impact of discrimination in workplaces, welfare benefits and housing should be key targets for policy and practice. Improving the capacity of people in workplaces and intimate partners, families and friendship groups to better understand the impacts of mental health problems on individuals should also be a priority.
On September 17, 2024, a coordinated detonation of approximately 5,000 pager devices in Lebanon produced a large mass-casualty incident. Devices contained pentaerythritol tetranitrate (PETN). We report 5 pediatric patients transferred to a tertiary referral center for management of complex multisystem injuries.
Methods
We performed a brief report of 5 children (<12 years) referred to Baqiyatallah Hospital, Tehran. Demographics, injury pattern, surgical interventions, and short-term outcomes (up to 3 months) were abstracted from medical records. All patients received multidisciplinary care (ophthalmology, plastic surgery, orthopedics, otolaryngology, pediatrics, infectious disease).
Results
Mean age was 9.2 years (range 5–11). All 5 children sustained ocular, facial, and hand injuries. Three eyes were auto-eviscerated, and 4 children underwent partial hand amputations. Multiple operative procedures were required per patient (ocular surgery, facial reconstruction, orthopedic fixation). Early outcomes were poor for vision and hand function in the majority; reconstructive planning and prosthetic rehabilitation were anticipated for longer-term care.
Conclusion
Close-range exposure to small PETN-containing devices produced a distinctive pediatric injury pattern dominated by severe ocular and upper-extremity trauma. These findings emphasize the need for pediatric-focused acute care algorithms and sustained rehabilitation resources after blast incidents.