To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Systematic reviews and meta-analysis, particularly of randomized trials, are considered the highest quality of evidence supporting causal associations. But they are not immune to bias, bias in the included studies themselves and in the process of synthesizing studies and pooling data. This chapter considers methods for systematically reviewing a complete body of literature, deciding if the data are amenable to meta-analysis, and appropriately conducting such an analysis.
Edited by
Katherine Warburton, California Department of State Hospitals, University of California, Davis, USA,Stephen M. Stahl, University of California, Riverside, USA
This chapter explores the ethical, legal, and clinical dimensions of treatment without consent in psychiatry, particularly in the context of neuroethics. Drawing on principles from the European Convention on Human Rights (ECHR), the authors argue for a goal-oriented, process-based approach to ethical decision-making that prioritizes restoring mental capacity, dignity, and autonomy. The chapter critiques the limitations of functional mental capacity assessments and advocates for a layered understanding of consciousness grounded in neuroscience. It emphasizes the ethical duty to intervene when necessary, especially in cases involving neurodegenerative psychotic disorders (NDPPD), and highlights the importance of early, potentially disease-modifying interventions. The authors call for inclusive research practices, structured clinical decision-making, and a compassionate, scientifically grounded framework that transcends simplistic dichotomies of paternalism and liberty.
Double aortic arch with bilateral interruptions is a rare abnormality. Indeed, to the best of our knowledge, it has not previously been reported before. Rare variants, such as a double arch with ligamentous atresia of the left component and double arch with bilateral coarctation, have received previous attention. These rare examples can pose significant diagnostic challenges for those relying on transthoracic echocardiography. Use of cardiac CT or MRI is now critical for prompt surgical planning and correction.
This chapter discusses biases that are of particular importance in the field of pharmacology, the most important of which is confounding by indication. How can researchers delineate those side effects owed to a drug from effects of the disease the drug is treating? A related bias occurs when early symptoms of disease are being treated by a drug that is later falsely implicated as causing the disease (protopathic bias). The adverse event reporting system (AERS) is often used to detect drug effects and one bias, the Weber effect, is reviewed.
Edited by
Katherine Warburton, California Department of State Hospitals, University of California, Davis, USA,Stephen M. Stahl, University of California, Riverside, USA
Edited by
Katherine Warburton, California Department of State Hospitals, University of California, Davis, USA,Stephen M. Stahl, University of California, Riverside, USA
Balancing autonomy and beneficence remains an ongoing challenge in the ethical treatment of patients with schizophrenia and other psychiatric disorders of thought. Psychiatric advance directives (PADs) offer one mechanism through which individuals can guide their own care, but unlike medical advance directives, they are not widely utilized in the United States. They are also highly limited by state law in the scope of their legal authority. This article explores the evidentiary basis for PADs as well as the legal and ethical issues that arise in the use of PADsin individuals with schizophrenia, arguing that providers’ fears of complete opt-out from care by patients are likely unfounded and that PADs offer a powerful tool through which individuals with schizophrenia can ensure meaningful consideration of their own values and goals.
Are people already at increased risk for disease more likely to be exposed to the risk factor of interest? Does closer observation of people with a disease lead to a false association? In retrospective studies, do people with a disease recall prior exposures more (or less) that healthier people? Are research interviewers a source of biased data collection? Confounding is an existential threat in biomedical research; here a second factor, which is associated with both the disease and the risk factor being studied, is an actual cause of the disease. If studies cannot fully control for the effect of the second risk factor, residual confounding will bias the risk estimate. Who participates and doesn’t participate in research is another source of bias. How diseases and risk factors are classified and categorized may introduce bias, and changing defined categories is yet another source of bias.
Genetic studies carry some unique sources of bias but are also subject to many of the biases found throughout biomedical research. The importance of specific phenotype definition, avoiding population stratification and unacknowledged family relatedness are described. Bias in DNA collection, including through using different techniques, sequencing platforms, amplification methods, and reference genomes is referenced.
Edited by
Katherine Warburton, California Department of State Hospitals, University of California, Davis, USA,Stephen M. Stahl, University of California, Riverside, USA
Anosognosia, commonly understood as a lack of insight, renders individuals with schizophreniaand schizoaffective disorder unable to understand that they are living with a disease, often resulting in a refusal to accept treatment. Typically, to impose involuntary commitment in an effort to obtain treatment, an individualmust be a danger to others or themselves. Even if involuntary commitment is imposed, however, an individualmay remain competent to refuse medication—despite symptoms of anosognosia and an inability to understand that they are ill. This article examines the existing legal theories of competency and informed consent and proposes a statutory definition of competency that encompasses the specific needs of people with anosognosia, while considering the significant interests at stake when taking away an individual’s right to choose or refuse treatment.
Identification, a cognitive process by which individuals think of themselves as similar to another person, may be associated with distress during traumatic events. This study examined the association of identification with psychological responses among disaster workers not directly exposed to an airline crash.
Methods
Participants were 421 workers (aged 18-60 [M (SD) = 36.2 (9.9)], 86.4% male, 98.3% White, 71.8% married). Surveys at 2 months (Time 1; T1) and 7 (T2) months post-disaster assessed identification (i.e., extent to which participants identified victims as similar to themselves, a friend, and/or family member), previous disaster exposure, and acute stress and anger/hostility. Linear and logistic regression analyses examined the relationship of identification to psychological responses over time.
Results
Approximately 15% of participants reported that they had high levels of acute stress within a week of the airplane crash when assessed 2 months later. Among those with high identification, 30.2% had high acute stress. In multivariable models, adjusting for covariates, greater identification was associated with acute stress and anger/hostility at T1, but not anger/hostility at T2.
Conclusions
Identification is associated with high levels of acute stress and anger/hostility in non-exposed individuals. Those with greater identification, regardless of exposure, could be at increased risk of distress and may benefit from early interventions.
Cognitive neuropsychological models propose that antidepressants exert their therapeutic effects by modifying negative emotional processing biases early in treatment. However, evidence from large, long-term clinical samples is limited.
Methods
We conducted a mechanistic analysis within the Antidepressants to Prevent Relapse in Depression randomized controlled trial, which compared maintenance antidepressant treatment with placebo substitution in adults with recurrent depression who were currently well (N = 478). Participants completed a computerized facial emotion recognition task at baseline, 12 weeks, and 52 weeks, in which faces morphed from happy to sad. The primary outcome was the number of faces classified as happy (0–45). Linear and longitudinal mixed-effects models were used to compare treatment groups and examine associations with depressive (PHQ-9) and anxiety (GAD-7) symptoms.
Results
Of the 462 participants completing at least one task, there was no evidence that discontinuing antidepressants altered performance compared with maintenance at 12 weeks (adjusted mean difference = 0.23, 95% CI –0.5 to 1.0, p = 0.5) or 52 weeks (0.29, –0.5 to 1.2, p = 0.5). Depressive symptoms were negatively associated with happy face classifications both cross sectionally (β = –0.20 per PHQ-9 point, p = 0.02) and longitudinally (β = –0.09, p = 0.05). Anxiety symptoms were positively associated with happy classifications (β = 0.11, p = 0.047).
Conclusions
Maintenance antidepressant treatment did not sustain positive emotional processing biases as indexed by facial emotion recognition, despite robust associations between such biases and depressive symptoms. These findings challenge the generalizability of laboratory evidence on emotional bias modification to long-term clinical treatment and highlight the need for further mechanistic research on antidepressant action.
Pronounced variations in suicide mortality persist across Europe. Understanding long-term temporal patterns through age, period and cohort (APC) effects, alongside suicide means, is essential for tailored prevention. This study aims to determine how suicide mortality rates in Europe have changed across APC dimensions at national and subregional levels.
Methods
Our analysis was restricted to European countries with complete age- and sex-specific suicide mortality data from 1990 to 2019 within the World Health Organization mortality database. The analysis comprised two components. The first component disentangled long-term suicide mortality trends (1990–2019) into APC dimensions using an age-period-cohort model via the National Cancer Institute’s APC Web Tool. The second component involved an assessment of suicide means, restricted to 2010–2019 and to countries with detailed International Classification of Diseases, 10th Revision (ICD-10) cause-of-death data.
Results
In 2019, Europe recorded 47,793 male and 13,111 female suicide deaths. Overall suicide mortality rates declined in most subregions from 1990 to 2019, with the largest reductions among Eastern European men, from 77.81 (95% CI: 77.17–78.45) per 100,000 in the mid-1990s to 22.93 (95% CI: 22.58–23.28) per 100,000 by 2019, although this region retained the highest male suicide burden. Age-specific risk patterns differed markedly: among men, risk peaked in early adulthood and then declined in Eastern Europe, while in Western and Southern Europe, it was lower and more stable but rose after age 60; for women, risk was generally lower, with peaks in early adulthood in Eastern Europe and in midlife elsewhere. Period reflected continued improvement, especially in Eastern Europe where the period risk in 2015–2019 was approximately 60% lower than 2000–2004. Cohort effects similarly showed progressive declines. However, upward trends emerged among younger generations. In Northern Europe, the cohort relative risk for females increased from 0.73 (95% CI: 0.68–0.78) in the 1980 cohort to 0.90 (95% CI: 0.70–1.04) in the 2000 cohort. While the completeness of suicide means analysis varied by subregion, the primary data indicated that hanging was the predominant means for both sexes during 2010–2019.
Conclusions
Despite an overall decline, suicide mortality in Europe exhibits persistent regional and demographic differences. This study reveals emerging risks among younger cohorts, specifically Northern European women and Southern European men, signalling shifting patterns that are not apparent from overall temporal trends alone. This evolving risk profile calls for sustained surveillance and research to investigate the drivers of these population-specific vulnerabilities.
This study aimed to assess knowledge, lifestyle behaviours, and sociodemographic associations regarding hypertension control among adults in urban Ghana.
Background:
Hypertension is a major contributor to cardiovascular morbidity and mortality in Ghana. However, data on population-level knowledge of its risk factors and related lifestyle behaviours in urban settings remain limited.
Methods:
A cross-sectional analytical survey was conducted between August 2023 and September 2024 across four urban regions. Using stratified convenience sampling, 7096 adults aged 18–67+ years were recruited. Data on sociodemographic, lifestyle behaviours, and hypertension knowledge were collected via a structured questionnaire.
Findings:
Participants had a mean age of 37.27 (±8.73) years, with a majority being female (63.85%) and married (97.66%). Educational attainment varied. Females constituted most hypertensive cases, particularly for stage 2 hypertension, while males had a notably higher prevalence of pre-hypertension among those aged 27–53 years. Age and body mass index showed significant positive correlations with systolic and diastolic blood pressure (p < 0.01). Men were significantly more likely to smoke and consume alcohol (p < 0.01). Logistic regression indicated that regular exercise reduced the odds of hypertension diagnosis (OR = 0.72, CI: 0.54–0.96), while older age increased the odds. The study underscores the need for targeted public health strategies. Priorities include promoting physical activity and weight management, alongside smoking/alcohol cessation programs tailored for high-risk men. Early intervention for younger adults with pre-hypertension and enhanced educational outreach for less-educated groups are crucial.
Shift work is associated with an increased risk of metabolic disorders, including type 2 diabetes, largely due to circadian misalignment, irregular meal patterns, and suboptimal diet quality. Chrononutrition, which focuses on aligning nutrient intake with circadian rhythms, has emerged as a promising strategy to improve metabolic health. Protein intake plays a key role in glucose homeostasis, and high-protein hypocaloric diets have shown benefits in people with type 2 diabetes. However, the effects of higher evening protein intake in shift workers remain unclear. This trial aims to analyze the effect of three hypocaloric diets differing in macronutrient composition and distribution throughout the day on glycemic control, body composition, and other secondary outcomes in shift workers with overweight or obesity and prediabetes or type 2 diabetes. This is a 12-week, three-arm, parallel-group, single-blind randomized controlled trial including 126 shift workers. Participants are randomized equally to: (A) a high-protein diet with protein-enriched dinner (50–60% of daily protein); (B) a high-protein diet with protein-restricted dinner (10–20% of daily protein); or (C) a normoproteic control diet with usual protein distribution. Primary outcomes include changes in glycemic control and DXA-derived body composition. Secondary outcomes are lipid profile, sleep quality, and quality of life. Other clinical and lifestyle parameters are evaluated to monitor changes throughout the intervention. Assessments are performed at baseline, week 6, and week 12. All analyses will follow the intention-to-treat principle. This study will provide new evidence on how evening protein intake may influence metabolic health in populations exposed to circadian disruption.