Much of classical mechanics treats particles as infinitesimally small. But most of our world is not like this. Planets and cats and tennis balls are not infinitesimally small, but have an extended size and this can be important for many applications. The purpose of this chapter is to understand how to describe the complicated motion of extended objects as they tumble and turn.

Jane Dewey (1900−1976) was the only woman in a group that John Slater described as the lucky generation of US physicists: those born near the beginning of the twentieth century and who spent time in Europe, learning with the leading quantum physicists of the era. After completing a PhD at the Massachusetts Institute of Technology in 1925, Dewey went to Niels Bohr’s Institute for Theoretical Physics in Copenhagen. She worked on the Stark effect in helium, a key test of the recently formulated quantum mechanics. Bohr praised her skills in a fellowship application, and Karl Compton later supported her (unsuccessful) efforts to land a permanent job. Although Dewey did pioneering work in the field of quantum optics, the conditions she encountered made it difficult for her to continue on this research path. Her promising abilities did not translate into a successful academic career as they did for many of the men of the lucky generation. Perhaps she was not lucky enough. Or was luck conditional on being a man? This chapter argues that subtle – yet, structural – gender discriminatory practices contributed to her gradual exclusion from physics research, and ultimately from academia.

The purpose of this chapter is to understand how quantum particles react to magnetic fields. There are a number of reasons to do be interested in this. First, quantum particles do extraordinary things when subjected to magnetic fields, including forming exotic states of matter known as quantum Hall fluids. But, in addition, magnetic fields bring a number of new conceptual ideas to the table. Among other things, this is where we first start to see the richness that comes from combining quantum mechanics with the gauge fields of electromagnetism.

For many systems, the full information of an underlying Markovian decription is not accessible due to limited spatial or temporal resolution. We first show that such an often inevitable coarse-graining implies that, rather than the full entropy production, only a lower bound can be retrieved from coarse-grained data. As a technical tool, it is derived that the Kullback–Leibler divergence decreases under coarse-graining. For a discrete time-series obtained from an underlying time-continuous Markov dynamics, it is shown how the analysis of n-tuples leads to a better estimate with increasing length of the tuples. Finally, state-lumping as one strategy for coarse-graining an underlying Markov model is shown explicitly to yield a lower bound for the entropy production. However, in general, it does not yield a consistent interpretation of the first law along coarse-grained trajectories as exemplified with a simple model.

The difference between quantum and classical mechanics does not involve just a small tweak. Instead it is a root and branch overhaul of the entire framework. In this chapter we introduce the key concept that underlies this new framework: the quantum state, as manifested in the wavefunction.

Space and time are not what they seem. Their true nature only becomes clear as particles reach the speeds close to the speed of light where some of the common sense ideas start to break down. Indeed, one of major themes of twentieth century physics is that common sense is not a good guide when we look closely at the universe. In this chapter, we start to understand the true nature of space and time, as encapsulated in Einsteins theory of special relativity. We will see many wonderful things, from time slowing down to the lengths shrinking. There will be stories of twins and trains and elementary particles failing to die.

Diffusion plays crucial roles in cells and tissues, and the purpose of this chapter is to theoretically examine it. First, we describe the diffusion equation and confirm that its solution becomes a Gaussian distribution. Then, we discuss concentration gradients under fixed boundary conditions and the three-color flag problem to address positional information in multicellular organism morphogenesis. We introduce the possibility of pattern formation by feed-forward loops, which can transform one gradient into another or convert a chemical gradient into a stripe pattern. Next, we introduce Turing patterns as self-organizing pattern formation, outlining the conditions for Turing instability through linear stability analysis and demonstrating the existence of characteristic length scales for Turing patterns. We provide specific examples in one-dimensional and two-dimensional systems. Additionally, we present instances of traveling waves, such as the cable equation, Fisher equation, FitzHugh–Nagumo equation, and examples of their generation from limit cycles. Finally, we introduce the transformation of temporal oscillations into spatial patterns, exemplified by models like the clock-and-wavefront model.

Physicists have a dirty secret: we’re not very good at solving equations. More precisely, humans aren’t very good at solving equations. We know this because we have computers and they’re much better at solving things than we are. This means that we must develop a toolbox of methods so that, when confronted by a problem, we have some options on how to go about understanding whats going on. The purpose of this chapter is to develop this toolbox in the guise of various approximation schemes.

The Maxwell demon and the Szilard engine demonstrate that work can be extracted from a heat bath through measurement and feedback in apparent violation of the second law. A systematic analysis shows that, by including the measurement process and the subsequent erasure of a memory according to Landauer’s principle, the second law is indeed restored. For such feedback-driven processes, the Sagawa–Ueda relation provides a generalization of the Jarzynski relation. For the general class of bipartite systems, the concepts from stochastic thermodynamics are developed. This framework applies to systems where one component “learns” about the changing state of the other one, as in simple models for bacterial sensing. The chapter closes with a simple information machine that shows how the ordered sequence of bits in a tape can be used to transform heat into mechanical work. Likewise, mechanical work can be used to erase information, i.e., randomize such a tape. These processes are shown to obey a second law of information processing.

The overdamped Langevin equation for a particle in a potential and, possibly, subject to a nonconservative force is introduced. The corresponding Fokker–Planck equation, the Smoluchowski equation, is derived. In a time-independent potential, any initial distribution finally approaches the equilibrium one. For a constant external force and periodic boundary condition like the motion along a ring, a nonequilibrium steady state is established. As an application, the Kramers escape from a meta-stable well can be discussed. The mean local velocity and the path integral representation are introduced. Thermodynamic quantities like work, heat, and entropy production are identified along individual trajectories and their ensemble averages are determined. Their distributions are shown to obey detailed fluctuation relations. A master integral fluctuation relation can be specialized to yield inter alia the Jarzynski relation, the integral fluctuation relation for entropy production, and the Hatano–Sasa relation.

Hertha Sponer’s (1894-1968) early years in physics were spent at the center of the quantum revolution. Training as an experimentalist under Debye, then heading the spectroscopy labs in Göttingen uniquely situated her to contribute to the development of quantum theory and the emergence of quantum chemistry, by novel interpretations of hitherto unexplained spectrographic data using quantum mechanics, and suggesting new applications of the theory to atoms and diatomic molecules. Sponer’s name has nevertheless been largely written out of scientific accounts of these years. When mentioned in the context of quantum theory, it is usually as Franck’s “assistant” (incorrect) and second wife – descriptions that obscure her status as a world-renowned scientist who’d contributed importantly to physics and chemistry over a long and illustrious career. Extant accounts of Sponer’s life and work almost exclusively concern her postwar years as a professor at Duke. But by then quantum theory was well established, and her research had pivoted in other directions. This chapter aims to introduce Sponer into the history of early quantum theory, with appropriate attention to her achievements.

The full beauty of Maxwell equations only becomes apparent when we realise that they are consistent with Einstein’s theory of special relativity. The purpose of this chapter is to make this relationship manifest. We rewrite the Maxwell equations in relativistic notation, where the four vector calculus equations are condensed into one, simple tensor equation. Viewed through the lens of relativity and gauge theory, the Maxwell equations are forced upon us: the world can’t be any other way.