In many areas in linguistic study it is difficult to decide where the study of language ends and the study of other aspects of human cognition begins. In this article, we discuss a particularly striking case of this, the use of the signing space (loci) for marking linguistic relations. The use of loci in the nominal and verbal domains has received a wide range of analyses, from those considering loci to be abstract linguistic mechanisms such as semantic indices and syntactic agreement to those considering them to be making use of nonlinguistic mechanisms such as spatial cognition. We defend the view that the use of loci is both fundamentally linguistic (they are modifiers) and fundamentally spatial (they express an association with space), providing possible descriptive content in both the verbal and the nominal domain. This analysis allows for a uniform account of loci use in the two linguistic domains and accounts for an important, yet less noticed, property of loci, which is that their distribution is pragmatically conditioned for the purpose of disambiguation.