Biomaterials and Regenerative Medicine

doi:10.1017/CBO9780511997839

Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; and medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine.

Winner, 2015 PROSE Award for Single Volume, Science

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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List of contributors
pp ix-xiv
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Preface
pp xv-xvi
- By Peter X. Ma, University of Michigan
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Part I - Introduction to stem cells and regenerative medicine
pp 1-2
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1 - Embryonic stem cells
pp 3-18
- By Nicole Slawny, University of Michigan, Gary D. Smith, University of Michigan
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2 - Induced pluripotent stem cells
pp 19-33
- By Akitsu Hotta, Kyoto University, Shinya Yamanaka, Kyoto University
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3 - Connective tissue stem and progenitor cells
pp 34-43
- By Pamela Gehron Robey, National Institutes of Health
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4 - Hematopoietic stem cells and their niches
pp 44-63
- By Geeta Mehta, University of Michigan, Yusuke Shiozawa, University of Michigan, Russell Taichman, University of Michigan
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5 - Using biomaterials for fetal stem cell isolation, expansion and directed-differentiation
pp 64-79
- By David Mack, University of Washington, Aleksander Skardal, The Wake Forest Institute for Regenerative Medicine, Shay Soker, The Wake Forest Institute for Regenerative Medicine, Anthony Atala, The Wake Forest Institute for Regenerative Medicine
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6 - The hematopoietic stem cell niche
pp 80-88
- By Aparna Venkatraman, Stowers Institute for Medical Research, Meng Zhao, Stowers Institute for Medical Research, Linheng Li, Stowers Institute for Medical Research
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Part II - Porous scaffolds for regenerative medicine
pp 89-90
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7 - Nanofibrous polymer scaffolds with designed pore structure for regeneration
pp 91-103
- By Zhanpeng Zhang, University of Michigan, Jeremy M. Holzwarth, University of Michigan, Peter X. Ma, University of Michigan
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8 - Electrospun micro/nanofibrous scaffolds
pp 104-132
- By Vince Beachley, Johns Hopkins University, Xuejun Wen, Virginia Commonwealth University
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9 - Biological scaffolds for regenerative medicine
pp 133-150
- By Vineet Agrawal, University of Pittsburgh, Stephen F. Badylak, University of Pittsburgh
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10 - Bioceramic scaffolds
pp 151-182
- By Zhanwen Xiao, Sichuan University, Zhe Wang, Drexel University, Bangcheng Yang, Sichuan University, Xingdong Zhang, Sichuan University
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11 - Collagen-based tissue repair composite
pp 183-202
- By Xiaoming Li, Beihang University, Fu-zhai Cui, Tsinghua University
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12 - Polymer/ceramic composite scaffolds for tissue regeneration
pp 203-214
- By Ian O. Smith, University of Michigan, Melanie J. Gupte, University of Michigan, Peter X. Ma, University of Michigan
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13 - Computer-aided tissue engineering for modeling and fabrication of three-dimensional tissue scaffolds
pp 215-244
- By Qudus Hamid, Drexel University, Chengyang Wang, Drexel University, Jessica Snyder, Drexel University, Wei Sun, Drexel University & Tsinghua University
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Part III - Hydrogel scaffolds for regenerative medicine
pp 245-246
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14 - Polysaccharide hydrogels for regenerative medicine applications
pp 247-262
- By Jacob A. Simson, The Johns Hopkins University, Jennifer H. Elisseeff, The Johns Hopkins University
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15 - Functionalized poly(ethylene glycol) hydrogels for controlling stem cell fate
pp 263-278
- By Chien-Chi Lin, Indiana University-Purdue University Indianapolis
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16 - Fumarate-based hydrogels in regenerative medicine applications
pp 279-294
- By Steven Lu, Rice University, Kyobum Kim, Rice University, Johnny Lam, Rice University, F. Kurtis Kasper, Rice University, Antonios G. Mikos, Rice University
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17 - Hydrogel scaffolds for regenerative medicine
pp 295-316
- By Edward A. Sander, University of Iowa, Erin D. Grassl, Medtronic Inc., Robert T. Tranquillo, University of Minnesota
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18 - Microfabricated gels for tissue engineering
pp 317-331
- By Gulden Camci-Unal, Harvard Medical School, Jesper Hjortnaes, Harvard Medical School, Hojae Bae, Harvard Medical School, Mehmet Remzi Dokmeci, Harvard Medical School, Ali Khademhosseini, Harvard Medical School
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19 - Organ printing
pp 332-374
- By Tao Xu, University of Texas at El Paso, Daniel Reyna-Soriano, University of Texas at El Paso, Jorge I. Rodríguez-Dévora, University of Texas at El Paso, Mohammod Bhuyan, University of Texas at El Paso, Thomas Boland, University of Texas at El Paso
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Part IV - Biological factor delivery
pp 375-376
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20 - Growth factor delivery on scaffolds
pp 377-390
- By Kai Feng, University of Michigan, Jiang Hu, University of Michigan, Zubad Newaz, University of Michigan, Peter X. Ma, University of Michigan
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21 - Gene delivery for periodontal regeneration
pp 391-404
- By Andrei D. Taut, University of Michigan, William V. Giannobile, University of Michigan
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22 - Endogenous stem/progenitor cell recruitment for tissue regeneration
pp 405-418
- By Mildred Embree, Columbia University Medical Center, Chang Hun Lee, Columbia University Medical Center, Ziming Dong, Zhengzhou University, Mo Chen, Columbia University Medical Center, Kimi Kong, Columbia University Medical Center, Hemin Nie, Columbia University Medical Center, Avital Mendelson, Columbia University Medical Center, Bhranti Shah, Columbia University Medical Center, Shoko Cho, Columbia University Medical Center, Takahiro Suzuki, Columbia University Medical Center, Rujing Yang, Columbia University Medical Center, Nan Jiang, Columbia University Medical Center, Jeremy J. Mao, Columbia University Medical Center
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