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Landscape pest management has traditionally relied on pesticides, but growing consumer interest in environmentally conscious practices is changing market expectations. A choice-based conjoint survey of 1,000 respondents evaluated willingness to pay for scouting-based integrated pest management (IPM) programs offered by landscape service providers. Attributes included spray reduction, biological controls, non-chemical controls, and price. Consumers were willing to pay $17.86 more per month for programs reducing sprays by at least four applications and up to $24.06 more when non-chemical controls were included. Results suggest scouting-based IPM services may represent a viable market opportunity for landscape service providers.
It is well established that cytochrome P450 monooxygenases (P450s) play a crucial role in herbicide metabolism and resistance evolution in weeds. In most documented cases, P450-mediated resistance is primarily conferred through the overexpression of P450 enzymes. However, the regulatory mechanisms underlying this overexpression remain poorly understood. In insects, amino acid substitutions that enhance P450-mediated metabolic detoxification have been clearly demonstrated as a key mechanism of insecticide resistance. In contrast, their potential role in herbicide resistance in weeds remains unclear. In this study, two CYP96A146 variants from flixweed [Descurainia sophia (L.) Webb ex Prantl], designated CYP96A146-S and CYP96A146-R, were heterologously expressed in Saccharomyces cerevisiae. These variants, which differ by four amino acid residues, were examined for their ability to metabolize model substrates and herbicides. The results indicated that both variants exhibited catalytic activity toward model substrates of p-nitroanisole, methoxyresorufin, ethoxyresorufin, 7-ethoxycoumarin, and benzo[a]pyrene, as well as toward the herbicides tribenuron-methyl, bensulfuron-methyl, and carfentrazone-ethyl. Notably, CYP96A146-R showed significantly higher catalytic activity than CYP96A146-S to both the model substrates (p-nitroanisole, methoxyresorufin, ethoxyresorufin, and 7-ethoxycoumarin) and the herbicides (tribenuron-methyl and carfentrazone-ethyl). These findings suggest that the amino acid substitutions are likely responsible for the enhanced metabolic capability of CYP96A146-R. Such mutations may induce conformational changes of CYP96A146 enzyme, facilitating more frequent molecular collisions between CYP96A146 and the substrates or herbicides, thereby improving catalytic efficiency.
We construct a moduli space that parametrises stable proper holomorphic submersions over a fixed compact Kähler base. Stability is described in terms of the existence of a canonical relatively Kähler metric on the submersion, called an optimal symplectic connection. The construction of the moduli space combines techniques from geometric invariant theory with the study of the geometric PDE defining an optimal symplectic connection. A special case of this moduli space is the moduli space of stable vector bundles over a compact Kähler manifold. We also show that the moduli space is a Hausdorff complex space equipped with a Weil-Petersson type Kähler metric.
I argue that all extant philosophical accounts of gaslighting overgenerate or undergenerate cases, either because they fail to include the internal felt experience of the gaslit or because they include this internal experience in the wrong way. I contend that some act A counts as gaslighting iff: (1) the gaslighter’s act A expresses disagreement with the gaslit without adequately expressing respect for the gaslit, and this makes it the case that (2) the gaslit in fact comes to believe that there is no hope for their fundamental rational competence, either universally or within some specific domain.
Lew-Levy and Amir (L&A)’s hypothesis that peer cultures contribute to cultural adaptation pulls from findings in children’s folklore studies. We consider the implications of two central theoretical concerns in children’s folklore scholarship, the triviality barrier and Newell’s paradox, and argue that the playful, parodical, and taboo-breaking nature of children’s folklore will be important for L&A’s hypothesis. Additionally, we suggest that adults’ tendencies to trivialize children’s folklore support the resilience of peer cultures in an adult-dominated world.
Kay Redfield Jamison’s An Unquiet Mind is a memoir of bipolar disorder written by a clinical psychologist, professor of psychiatry and mood-disorders researcher. In this text, Jamison publicly described her own experience of mania, depression, psychosis, suicidality and lithium. We believe that this book remains a useful training text in psychiatry for three core reasons: what it reveals about treatment refusal, about professional stigma attached to psychiatric illness within medicine, and about the things that syndromic diagnosis can miss. Read critically, An Unquiet Mind remains helpful for thinking about ambivalence, clinician stigma, shared decision-making, and the limits of diagnosis without abandoning clinical precision.
Patients receiving maintenance hemodialysis are frequently exposed to antibiotics, a proportion of which may not be necessary thereby increasing the risk of antibiotic-associated adverse events. Antimicrobial stewardship programs remain underdeveloped in outpatient dialysis facilities. This study aimed to quantify antibiotic prescribing trends across in-center dialysis units and identify patient- and facility-level factors associated with decreased antibiotic use to inform the future stewardship strategies.
Design:
Retrospective observational cohort study among 16 in-center hemodialysis units
Methods:
Antibiotic prescribing patterns and patient- and unit-level characteristics were analyzed among patients receiving maintenance hemodialysis from April 1, 2021, to March 31, 2024. Antibiotic prescribing trends were analyzed using general linear models. Generalized estimating equations were used to identify factors associated with decreased prescribing.
Results:
A total of 937 (26.4%) among 3,549 patients received ≥1 antibiotic dose, with an average of 15.36 doses per 100 patient-months, ranging from 4.82 to 30.87 doses/100 patient months. Types and frequency of antibiotics prescribed among units varied considerably. Trends in antibiotic prescribing did not decrease among 10 (62.5%) of the in-center hemodialysis units. Patient-level characteristics in units associated with a decrease in prescribing included Black race, Hispanic ethnicity, age 56–65, and diabetes as the cause of kidney failure.
Conclusions:
There is substantial variability in antibiotic prescribing across dialysis units. Decreasing trends in prescribing were observed in a subset of units and were associated with patient-level factors. These findings support the need for developing and implementing antimicrobial stewardship programs targeting the outpatient dialysis setting.
Healthcare-associated infections (HAIs) are often preventable and cause significant morbidity and mortality. There is a paucity of data on HAIs in low- and middle-income countries. This study surveyed Dominican Republic hospitals, revealing that 60% had Infection Prevention, and Control (IPC) programs, but gaps remain in IPC committees, training, data tracking, and reporting.
This article focuses on the Punjab-Baluch borderland region during the last decade of the nineteenth century. It shows how this region was a conflict zone, not only between local communities across borders but also between the two colonial frontier governments of Punjab and Baluchistan. The article explores the nature of these conflicts by examining a cross-border dispute involving women. It analyses how different competing legal systems—Shariat, customs, and colonial law—operated on the ground and were used by the disputants to resolve the conflict. Additionally, it discusses how, during this process, the colonial state documented women’s presence and used their voices and actions to serve the objectives of state-making. Through this case study, the article demonstrates that in local feuds involving women, colonial authorities emerged chiefly as disputants rather than just arbitrators. By claiming to be the legitimate custodians of the ‘abducted’ women, the two frontier governments competed against each other to fulfil the aspirations of the tribal communities they represented. This intra-tribal and intra-colonial dispute reveals deep fissures in colonial understanding of questions of state intervention, sovereignty, and colonial subjecthood—rendering the imperial project inconsistent, fragile, and contradictory in the Punjab-Baluch borderlands.
This study uses latent class analysis to map the structure of tax-burden perceptions across income strata and to test whether combined income–asset status gives rise to coalition patterns. Based on Korean panel data, respondents are classified into upper, middle and lower groups by joint income–asset deciles. Five latent classes emerge, and multinomial logistic models show that membership probabilities differ systematically between those above and below the middle-income/middle-asset reference group, reflecting distinct coalition alignments. Notably, support for welfare-financing tax increases is driven more strongly by membership in progressive perception classes than by income or assets alone; moreover, this multilevel coalition structure – spanning different income-asset combinations – reveals that asset holdings, particularly illiquid assets, play a crucial role in shaping tax fairness judgements beyond income considerations. These findings underscore the necessity of tax policies tailored to both income and asset dimensions.
On May 20, 2025, the Swedish parliament passed a new law that criminalizes the purchase of sexual acts taking place “at a distance,” that is, via digital platforms and without physical contact. It prohibits the act of promoting or financially exploiting an individual to perform a sexual act remotely for compensation and specifically bans clients from impacting the content of online sexual acts (Government Bill 2025; SVT Nyheter 2025). By targeting platforms such as OnlyFans, it aims to capture the sex industry’s digitalization and thereby decrease the vulnerability of specific groups and prevent new entries into prostitution.
This paper examines the relationship between provider market consolidation, setting-of-care (SOC) dynamics, and healthcare costs in the United States. The authors argue that consolidation is not solely a driver of rising unit prices, but also a response to structural pressures, including rising practice costs, stagnant physician reimbursement, and increasing administrative complexity. Drawing on recent empirical analyses, the authors demonstrate that prices vary substantially by SOC, with hospital outpatient departments representing the highest-cost settings. They further show that physician affiliation models are associated with distinct patterns of SOC utilisation. These findings suggest that the relationship between consolidation and cost is not uniform and depends on underlying organisational incentives. The authors contend that current policy discourse around private capital lacks sufficient nuance and risks obscuring more fundamental drivers of cost growth, particularly reimbursement design. They call for a more balanced dialogue and additional research to better understand how consolidation, payment policy, and SOC decision-making interact, concluding that policymakers should prioritise incentives that support clinically appropriate care in lower-cost settings.
Lew-Levy and Amir clearly articulate the importance of children’s peer cultures in broader human culture and evolution. However, peer cultures are juxtaposed against a relatively narrow definition of adult culture, which risks overlooking potential similarities. We argue that a more comprehensive analysis of the underlying psychological mechanisms will be required to elucidate whether children’s peer cultures are truly distinct.
Benchmarking hospitals on their antibiotic use may be facilitated by metrics that adjust for inter-hospital differences in patient case-mix, such as types of infections, procedures, and comorbidities. Metrics that capture antibiotic spectrum [e.g., days of antibiotic spectrum coverage (DASC)] can be more sensitive to stewardship activities than metrics based on days of therapy (DOT). In this study, we developed risk-standardized metrics for both DOT and DASC.
Methods:
We performed a mixed-methods study to build risk-standardized metrics for inpatient antibiotic use, using a modified Delphi process integrating expert- and data-driven strategies to identify nonmodifiable risk factors associated with appropriate inpatient antibiotics. These factors were used to create risk-standardized ratios (RSR) for DOT and DASC. A standardized antimicrobial administration ratio (SAAR)-like metric was also constructed.
Results:
In 2021, there were 497,061 patient-admissions across 121 Veterans Health Administration (VHA) hospitals. The median hospital RSR was 1.00 (interquartile range (IQR) 0.95–1.05) for DOT and 1.00 (IQR 0.96–1.04) for DASC; the median ratio for the SAAR-like metric was 0.85 (IQR 0.68–1.03). The Kendall’s tau for RSR-DOT and the SAAR-like metric was 0.48; RSR-DASC and the SAAR-like metric was 0.33; and RSR-DOT and RSR-DASC were 0.48. Compared to the SAAR-like metric, 60 (49.6%) and 80 (66.1%) hospitals ranked in a different quartile for RSR-DOT and RSR-DASC, respectively.
Conclusions:
Hospital performance on the SAAR-like metric was weakly correlated with the RSR-DASC and moderately correlated with the RSR-DOT. Hospitals’ performance on the SAAR-like metric differed from that of the RSR metrics, suggesting the RSR metrics may have added value over the SAAR.
Lew-Levy and Amir propose that children develop meaningful cultures with the potential to undergird lasting and meaningful societal change. Identifying the domains in which this claim has traction is necessary if we are to accept that there is something special about childhood cultures that transcends considering them as fleeting expressions of an immature life stage.
Fast radio bursts (FRBs) emit broadband radio emission that may, in rare cases, encode atomic hydrogen (Hi) absorption signals as they traverse the interstellar medium of their host galaxies. Though considered in the early FRB literature, the demanding observational prerequisites and the rarity of suitable events have meant that no thorough search for Hi absorption in FRB spectra has yet been undertaken. Here, we present an updated systematic analysis assessing the likelihood of modern facilities to detect such absorption features. As a proof of concept, we search for absorption in the spectrum of the bright ASKAP-localised FRB 20211127I, finding a 3σ opacity upper limit of 0.51. While this test case offers little constraining power, we find that narrow FRBs with fluences exceeding 20/70/150 Jy ms observed with MeerKAT/ASKAP/DSA can probe opacities below 0.1 — a regime in which absorption detections become physically meaningful. We further highlight that stacking thousands of bursts from hyperactive repeaters with FAST offers a very powerful avenue toward detection. Finally, we discuss the broad scientific potential of such detections, including constraints on extragalactic Hi spin temperatures, a means to physically probe the environment surrounding the progenitor, and a path towards disentangling host galaxy contributions to dispersion and scattering.