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Legal action by communities affected by climate change against high carbon corporate emitters is on the rise. At the same time, with the acceleration of a transition to a net-zero carbon economy, communities impacted by the implementation and operation of renewable energy projects are increasingly challenging shortcomings in the shift to renewable energy through ‘just transition litigation’. This strategy aims to ensure that respect for human rights is at the heart of the new energy paradigm, and that human rights abuses by the fossil fuel and mining sectors are not replicated. Progressive legislative reforms may also contribute to ensuring a fast and fair transition. This article examines how legal action and legislation may provide communities and rights-holders with pathways to climate justice – and sheds light on the need for a rights-centred approach by corporate actors and governments to the new energy transition.
Peripheral perfusion index has been proposed as a possible method for detecting circulatory impairment. We aimed to determine the normal range of peripheral perfusion index in healthy newborns and compare it with that of newborns with CHD.
Methods:
Right-hand saturation and right-hand peripheral perfusion index levels were recorded, and physical examination and echocardiography were performed in newborns who were 0–28 days old and whom were evaluated in our paediatric cardiology outpatient clinic. The saturation and peripheral perfusion index levels of newborns with normal heart anatomy and function were compared with those of newborns with CHD.
Results:
Out of 358 newborns (238 mature and 75 premature) enrolled in the study, 39 had CHD (20 mild CHD, 13 moderate CHD, and 6 severe CHD), of which 29 had CHD with left-to-right shunting, 5 had obstructive CHD, and 5 had cyanotic CHD. No newborn had clinical signs of hypoperfusion or heart failure, such as prolonged capillary refill, weakened pulses, or coldness of extremities. Peripheral perfusion index level was median (interquartile range) 1.7 (0.6) in healthy newborns, 1.8 (0.7) in newborns with mild CHD, and 1.8 (0.4) in newborns with moderate and severe CHD, and there was no significant difference between the groups regarding peripheral perfusion index level.
Conclusion:
Peripheral perfusion index remains unchanged in newborns with CHD without the clinical signs of hypoperfusion or heart failure. Larger studies with repeated peripheral perfusion index measurements can determine how valuable this method will be in the follow-up of newborns with CHD.
We introduce self-divisible ultrafilters, which we prove to be precisely those $w$ such that the weak congruence relation $\equiv _w$ introduced by Šobot is an equivalence relation on $\beta {\mathbb Z}$. We provide several examples and additional characterisations; notably we show that $w$ is self-divisible if and only if $\equiv _w$ coincides with the strong congruence relation $\mathrel {\equiv ^{\mathrm {s}}_{w}}$, if and only if the quotient $(\beta {\mathbb Z},\oplus )/\mathord {\mathrel {\equiv ^{\mathrm {s}}_{w}}}$ is a profinite group. We also construct an ultrafilter $w$ such that $\equiv _w$ fails to be symmetric, and describe the interaction between the aforementioned quotient and the profinite completion $\hat {{\mathbb Z}}$ of the integers.
The discussion of narrative in mashups typically involves how a preexisting message is reinterpreted by the incorporation of new musical material. However, many scholars note how DJ Earworm's technique of creating new lyrics through the combination of samples from up to fifty different tracks conveys an original message that is distinct from its borrowed sources. In his various interviews, DJ Earworm elaborates that his mashups are original compositions that act as musical time capsules that capture the zeitgeist of the age. Nevertheless, DJ Earworm only provides brief commentary on the meaning of his mashups and there is no close examination of these narratives in the literature. This raises the question: To what degree do DJ Earworm's mashups reflect cultural issues in American society? By merging Zbikowski's concept of conceptual integration with Almén's theory of musical narrative, this paper will demonstrate how DJ Earworm's mashups show a consistent pattern of having complex narratives with cultural messages that resonate with contemporary issues in American society, including fossil fuel dependence, income inequality, and political and racial division.
We study the possible structures which can be carried by sets which have no countable subset, but which fail to be ‘surjectively Dedekind finite’, in two possible senses, that there is surjection to $\omega $, or alternatively, that there is a surjection to a proper superset.
Arithmetic quasidensities are a large family of real-valued set functions partially defined on the power set of $\mathbb {N}$, including the asymptotic density, the Banach density and the analytic density. Let $B \subseteq \mathbb {N}$ be a nonempty set covering $o(n!)$ residue classes modulo $n!$ as $n\to \infty $ (for example, the primes or the perfect powers). We show that, for each $\alpha \in [0,1]$, there is a set $A\subseteq \mathbb {N}$ such that, for every arithmetic quasidensity $\mu $, both A and the sumset $A+B$ are in the domain of $\mu $ and, in addition, $\mu (A + B) = \alpha $. The proof relies on the properties of a little known density first considered by Buck [‘The measure theoretic approach to density’, Amer. J. Math.68 (1946), 560–580].
Several studies have shown the additional benefit of point-of-care ultrasound (POCUS) by prehospital Emergency Medical Services (EMS). Since organization of EMS may vary significantly across countries, the value of POCUS likely depends on the prehospital system in which it is used. In order to be able to optimally implement POCUS and develop a tailored training curriculum, it is important to know how often POCUS is currently used, for which indications it is used, and how it affects decision making. The aims of this study were: (1) to determine the percentage of patients in whom POCUS was used by Dutch Helicopter Emergency Medical Services (HEMS) crews; (2) to determine how often POCUS findings led to changes in on-scene management; and (3) what these changes were.
Methods:
Patients who received prehospital care from December 1, 2020 through March 31, 2021 by a single HEMS crew were included in this prospective cohort study. Clinical data and specific data on POCUS examination, findings, and therapeutic consequences were collected and analyzed.
Results:
During the study period, on-scene HEMS care was provided to 612 patients, of which 211 (34.5%) patients underwent POCUS. Of these, 209 (34.2%) patients with a median age of 45 years were included. There were 131 (62.7%) trauma patients, and 70 (33.7%) of the included patients underwent cardiopulmonary resuscitation (CPR). The median reported time of POCUS examination was three (P25-P75 2-5) minutes. Median prolongation of on-scene time was zero (P25-P75 0-1) minutes. In 85 (40.7%) patients, POCUS examination had therapeutic consequence: POCUS was found to impact treatment decisions in 34 (26.0%) trauma patients and 51 (65.4%) non-trauma patients. In patients with cardiac arrest, POCUS was most often used to aid decision making with regard to terminating or continuing resuscitation (28 patients; 13.4%).
Conclusion:
During the study period, POCUS examination was used in 34.5% of all prehospital HEMS patients and had a therapeutic consequence in 40.7% of patients. In trauma patients, POCUS seems to be most effective for patient triage and evaluation of treatment effectiveness. Moreover, POCUS can be of significant value in patients undergoing CPR. A tailored HEMS POCUS training curriculum should include ultrasound techniques for trauma and cardiac arrest.
The common dandelion (Taraxacum campylodes G.E.Haglund) is known for its medicinal properties and as a non-toxic, highly nutritious edible plant. Even though the herb is mostly collected in the wild, the food and pharmaceutical industries prefer cultivated plant material. Cultivation offers the possibility to achieve predictable yields, ensure the botanical identity of the plants and products can be certified according to organic or biodynamic standards; therefore the interest in domestication is growing. Due to the scarcity of research on dandelion cultivation in agricultural systems, the current study focused on determining the quantitative and qualitative characteristics of 13 wild populations from Latvia in an organic farming system. Populations collected at Gluda, Priekuli, Mundigciems, Marupe as well as variety TA008 had the highest dry root weight (>100 g per plant) and exceeded the root weight of variety Nouvelle more than two-fold. The highest concentration of chlorogenic acid (CHA) (0.12%) and chicoric acid (CCA) (0.15%) was found in the wild population collected in Turaida. The wild populations from Marupe and Mundigciems had a high average root weight as well as a relatively high CHA and CCA content, making them suitable for commercial growing. The present study examined the feasibility of cultivating wild dandelion populations in an organic farming system. The results revealed a high degree of variation within and between populations; therefore, dandelion wild populations can be used for domestication, breeding and selection of accessions most suitable for the pharmaceutical or food industries.
Drawing upon Parker, Bindl, and Strauss' [(2010). Making things happen: A model of proactive motivation. Journal of Management, 36(4), 827–856] model of proactive motivation, we provide an explanation for how employees who exhibit a high need for achievement can take a proactive initiative through the expression of voice. Importantly, the extent to which employee voice can bring about desired changes depends largely on how positively received the behavior is by those in higher positions, such as supervisors. In this regard, we further highlight the facilitating role of supervisor developmental feedback in shaping the effectiveness of voice behavior. Data from 392 independently matched subordinate–supervisor dyads from Japan provide empirical support for proposed relationships as follows: (a) there is a positive mediating relationship between the need for achievement, employee voice, and supervisors' evaluations of employee task performance and discretionary work effort, and (b) the mediating relationship becomes stronger when supervisor developmental feedback is high. Theoretical and practical implications are further discussed.
We show that products of sufficiently thick Cantor sets generate trees in the plane with constant distance between adjacent vertices. Moreover, we prove that the set of choices for this distance has non-empty interior. We allow our trees to be countably infinite, which further distinguishes this work from previous results on patterns in fractal sets. This builds on the authors’ previous work on graphs and distance sets over products of Cantor sets of sufficient Newhouse thickness.
Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed.
Aims
To assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au.
Method
This phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4.
Results
The final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h.
Conclusions
Adequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible.
The aim of this study was to analyse whether specialised musical training influences auditory discrimination, working memory, learning strategies and academic performance. Sixty students (30 with at least four years of musical training and 30 without) of the same socioeconomic level were compared. Significant differences were found between students with and without musical training in terms of learning strategies, working memory and academic performance (p= <.05). This study shows the benefits of musical training offered at specialised centres, the development of students’ cognitive skills and the contributions of neuroscience to improving professional practice.
Despite the use of case formulation being encouraged for in-patient psychiatric care, there have been no previous examples and evaluations of this type of work on a psychiatric intensive care unit (PICU).
Aims:
To evaluate whether a schema-informed formulation with a patient diagnosed with emotionally unstable personality disorder (EUPD), autism spectrum disorder (ASD) and mild learning difficulties was effective in reducing the use of restrictive interventions.
Method:
A biphasic n = 1 quasi-experimental design with an 8-week baseline versus an 8-week intervention phase. The restrictive outcomes measured were use of physical restraint, seclusion, and intramuscular rapid tranquilisation. The formulation was developed through eight one-to-one sessions during the baseline period, and was implemented via six one-to-one sessions during the intervention phase and discussion at the ward reflective practice group. The intervention encouraged better communication of schema modes from the patient and for staff to then respond with bespoke mode support.
Results:
Incidents involving need for seclusion, restraint and rapid tranquilisation extinguished.
Discussion:
The need for making access to psychological input a routine aspect of the care in PICUs and the necessity for developing a methodologically more robust evidence base for psychological interventions on these wards.
The influence of the method of evaluating developmentally competent oocytes on their viability after cryopreservation still needs to be better understood. The objective of this study was to determine the cleavage and embryo developmental rates after parthenogenetic activation of cumulus–oocyte complexes (COCs) selected by different concentrations of brilliant cresyl blue (BCB) and cryopreservation. In the first experiment, COCs were separated into groups and incubated for 1 h in medium containing BCB (13 μM, 16 μM, or 20 μM). The control group was not exposed to BCB staining. In the second experiment, COCs were divided into four groups: 13 μM BCB(+), 13 μM BCB(−), fresh control (selected by morphologic observation and immediately in vitro matured) and vitrified control (selected by morphologic evaluation, vitrified, and in vitro matured). In the first experiment, the 13 μM BCB group displayed greater development rates at the morula stage (65.45%, 36/55) when compared with the other groups. In the second experiment, cleavage (47.05%, 72/153) and morula development (33.55%, 51/153) of the control group of fresh COCs were increased compared with the other groups. However, when comparing morula rates between vitrified COC control and BCB(+) groups, the BCB(+) group had better results (19.23%, 5/26 and 64.7%, 11/17, respectively). Our best result in rat COC selection by BCB staining was obtained using a concentration of 13 μM. This selection could be a valuable tool to improve vitrification outcomes, as observed by the BCB(+) group that demonstrated better results compared with the vitrified COC control.
Experimental data on the effects of lifestyle interventions on fetal neurodevelopment in humans remain scarce. This study assessed the impact of a pregnancy nutrition+exercise intervention on offspring neurodevelopment at 12 months of age. The Be Healthy in Pregnancy (BHIP) randomized controlled trial (RCT) randomly assigned pregnant persons with stratification by site and body mass index (BMI) to bi-weekly nutrition counselling and high dairy protein diet, walking goal of 10,000 steps/day plus usual prenatal care (UPC; intervention group) or UPC alone (control group). This study examined a subset of these mothers (> 18 years, singleton pregnancy, BMI <40 kg/m2, and enrolled by ≤12 weeks gestation) and their infants (intervention = 42, control = 32), assessing cognition, language, motor, social-emotional, and adaptive functioning at 12 months using the Bayley Scales of Infant and Toddler Development third edition (BSID-III) as the outcome measure. We also examined if maternal factors (prepregnancy BMI, gestational weight gain (GWG)) moderated associations. Expressive language (MD = 9.62, 95% CI = (9.05–10.18), p = 0.03, ƞ2p = 0.07) and general adaptive composite (GAC) scores (MD = 103.97, 95% CI = (100.31–107.63), p = 0.04, ƞ2p = 0.06) were higher in infants of mothers in the intervention group. Effect sizes were medium. However, mean cognitive, receptive language, motor, and social-emotional scale scores did not differ between groups. A structured and monitored nutrition+exercise intervention during pregnancy led to improved expressive language and general adaptive behavior in 12-month-olds, but not cognitive, receptive language, motor, or socioemotional functioning. While these experimental data are promising, further research is needed to determine the clinical utility of nutrition+exercise interventions for optimizing infant neurodevelopment.