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The purpose of this ‘Handbook of Compassion in Healthcare: A Practical Approach’ is to help make compassionate care a day-to-day clinical reality for everyone: patients, families, and healthcare professionals. We do not suggest that current health systems are entirely lacking in compassion. All around the world, clinical care is provided by staff who seek to be professional, compassionate, and patient-centered at all times. The very existence of health centres, doctors’ surgeries, outpatient clinics, acute hospitals, daycare centres, dental practices, physiotherapy centres, and many other healthcare facilities is a testament to basic human compassion, to society’s commitment to help the afflicted, and to our fundamental desire to support each other in times of difficulty. We care. At the same time, it is clear that healthcare settings vary widely in relation to compassion, with some already excelling in compassionate care, but others in need of a more conscious or sustained focus on compassion. Many services do well, but most could do better. Improvement is always possible. Health systems are operated by people, for people. Compassion matters deeply. Compassion can be the key value that improves services further and makes our fundamental caring impulses more apparent, more effective, and more human. Always and everywhere, compassion matters.
The term “betel” most accurately refers to the betel pepper (Piper betle). Confusingly, this term is also frequently used to refer to a street drug that often—but not always—includes the betel leaf as a constituent. This linguistic misdirection only intensifies with terms such as “betel nut,” which, in common usage, may refer to this same composite street drug or to a single isolated constituent of that street drug: the nut of the areca palm (Areca catechu), which is otherwise wholly unrelated to the betel pepper. This composite street drug, colloquially referred to as “betel” or “betel nut” or “betel quid,” is one of the most frequently used psychoactive substances in the world. It carries a cultural legacy spanning over 10,000 years and a current user base numbering in the hundreds of millions. Its primary psychoactive constituent is arecoline, a well-established parasympathomimetic agent. Early studies exploring arecoline’s ability to modulate cholinergic signaling pathways and exert therapeutic psychiatric effects on conditions such as Alzheimer’s disease were initially mired by intolerable parasympathetic side effects. Indeed, over the course of its long history, various hints regarding the therapeutic utility of arecoline have been obfuscated by a variety of challenges which have only recently been overcome. Now, developments in psychopharmacology and our growing understanding of neurochemical brain circuitry have unlocked a new mechanism of action by which arecoline-derived medications interact with dopaminergic processes to improve outcomes for schizophrenia patients. One such medication, xanomeline-trospium (Cobenfy), has emerged as the first such agent to receive U.S. Food and Drug Administration (FDA) approval for the treatment of schizophrenia and represents an entirely new class of pro-cholinergic medication within the field of psychiatry. Many in the field believe that this heralds the beginning of a new era of psychopharmacology: the era of muscarinic agonism. This article briefly described the fascinating journey from ancient betel nuts to modern muscarinic therapeutics.
Volcanic fissure eruptions typically start with the opening of a linear fissure that erupts along its entire length, following which, activity localises to one or more isolated vents within a few hours or days. Localisation is important because it influences the spatiotemporal evolution of the hazard posed by the eruption. Previous work has proposed that localisation can arise through a thermoviscous fingering instability driven by the strongly temperature dependent viscosity of the rising magma. Here, we explore how thermoviscous localisation is influenced by the irregular geometry of natural volcanic fissures. We model the pressure-driven flow of a viscous fluid with temperature-dependent viscosity through a narrow fissure with either sinusoidal or randomised deviations from a uniform width. We identify steady states, determine their stability and quantify the degree of flow enhancement associated with localised flow. We find that, even for relatively modest variations of the fissure width (${\lt } 10$ %), the non-planar geometry supports strongly localised steady states, in which the wider parts of the fissure host faster, hotter flow, and the narrower parts of the fissure host slower, cooler flow. This geometrically driven localisation differs from the spontaneous thermoviscous fingering observed in planar geometries and can strongly impact the localisation process. We delineate the regions of parameter space under which geometrically driven localisation is significant, showing that it is a viable mechanism for the observed localisation under conditions typical of basaltic eruptions, and that it has the potential to dominate the effects of spontaneous thermoviscous fingering in these cases.
This chapter outlines the methodological approach for reconstructing the top of the wealth distribution of early-imperial Italy. Traditional social-table models are deemed inadequate for this purpose. Instead, I advocate for an economic model that assumes the top of the Italian wealth distribution can be represented by a simple mathematical function– a power law.
The present work experimentally investigates the interaction of a buoyant (rigid) spherical particle with a single translating (water) vortex ring, focusing on the effects of particle-to-vortex core size ratio ($D_p/D_{c,o}$) on both the particle dynamics and ring dynamics ($D_p$ = particle diameter, $D_{c,o}$ = vortex core diameter). These interactions are studied for $D_p/D_{c,o}$ = 0.6–1.7, over ring Reynolds numbers ($Re={\varGamma }/{\nu }$; $\varGamma$ = ring circulation) of 6000–67 300. As the buoyant particle comes close to the ring, it gets captured into the low-pressure vortex core, and the interaction begins. The particle within the core undergoes radial oscillation, spins and translates along the ring’s azimuthal axis. As $D_p/D_{c,o}$ increases, the particle undergoes higher-amplitude radial oscillation and a relatively shorter azimuthal translation. The differences in the particle size and its motion within the ring lead to large differences in the ring’s dynamics. A larger particle is seen to lead to a higher ring disruption, substantially reducing the ring’s convection speed and azimuthal enstrophy, which are seen to scale as $(D_p/D_{c,o})^{2.3}Re^{-0.37}$ and $(D_p/D_{c,o})^{1.3}Re^{-0.25}$, respectively. The ring disruption is significant above $D_p/D_{c,o}\approx$ 1.0, beyond which the ring fragments, with up to 60 % drop in convection speed and 90 % drop in enstrophy, at low $Re$, as compared with the base ring. These results for the rigid particle size effects on the vortex ring dynamics are more dramatic than for a deforming bubble. Our results could help to better understand and model buoyant particle (and bubble) interactions with coherent structures in turbulence.
This chapter assesses wealth inequality among the elites of the Italian civitates, using four sets of wealth proxy data. The analysis reveals significant variation in the implied inequalities, which nonetheless fall within the same range as those implied by other premodern datasets. Interestingly, these levels of inequality do not appear to correlate with the size of the civitas.
Postpartum depression is prevalent among Black women and associated with intersecting systemic factors and interpersonal discrimination. However, gaps remain in understanding pregnancy-related changes in discrimination experiences that influence postpartum mental health and could inform preventive interventions. We hypothesized that young Black women would experience increasing levels of discrimination across the transition to parenthood, heightening depression risk relative to non-pregnant peers.
Methods
Participants comprised 335 Black primiparous women (ages 17-30 at delivery) and 335 age- and discriminationmatched non-pregnant controls from the Pittsburgh Girls Study. Self-reported discrimination experiences were collected at four timepoints: two years pre-pregnancy, one year pre-pregnancy, pregnancy, and one year postpartum for the childbearing sample, with corresponding data from the non-pregnant sample across the same interval (matched pairwise).
Results
Linear increases in discrimination were observed for the nonpregnant participants (BS = .480, SE = .090, p <.001), while childbearing participants showed no overall changes, though younger age predicted greater increases over time. For childbearing participants, both baseline discrimination (BI = .626, SE = .077, p < .001) and increasing discrimination (BS = 2.55, SE = .939, p < .01) predicted postpartum depressive symptoms, controlling for pre-pregnancy depression. Among non-pregnant participants, only baseline discrimination predicted later depression (BI = .912, SE = .081, p < .001).
Conclusions
Experiencing increasing levels of interpersonal discrimination across the transition to parenthood may heighten postpartum depression risk among young Black women, indicating a need for interventions supporting well-being and promoting resilience before, during and after pregnancy.
The Introduction sets out the theme of the book. It discusses the census qualifications (wealth minimum requirements) that prevailed in the Roman timocratic political system.
This chapter explores the concepts of self-compassion and moral injury, and ways of navigating complex healthcare roles with self-awareness, kindness, and greater compassion. Self-compassion involves recognising our suffering, being moved by it, and offering kindness and understanding towards ourselves. Human beings can be our own worst enemies and toughest critics. Cultivating self-compassion helps to address this tendency, increase resilience, and empower us to show greater compassion towards others. Moral injury stems from situations in which a person must make choices that go against their core values and can corrode compassion. There are many kinds of moral injury, ranging from a single large, conflictual decision to a sustained pattern of smaller but still conflictual decisions that arise on a day-to-day basis. The latter is common in large healthcare systems owing to rapid decision-making, inadequate resources, outsized expectations of healthcare providers, and working conditions that are often not conducive to clear thought: long hours, sleep deprivation, inadequate personal support, and lack of compassion for staff. This chapter examines how to manage the risk of moral injury in these situations, how to boost self-care for staff, and the importance of self-compassion when managing or living with difficult experiences or situations, especially on a recurring basis.
At its heart, compassion is the feeling of being motivated to act in the presence of suffering. From a psychological perspective, the construct is conceived as having two dimensions: state and trait. The compassionate state reflects the feeling of compassion or having a compassionate response in the moment, while a compassionate trait is more stable, reflecting a general tendency towards compassion or towards feeling and responding compassionately most of the time. For people who are expected or required to be compassionate in their everyday life or work, compassion requires sustained courage and a continued willingness to engage with suffering, rather than avoid it. This chapter explores compassion from psychological, evolutionary, and physiological viewpoints. Despite a useful and growing literature in this area, a precise definition of compassion in practice can remain elusive. The meaning of compassion is not written in stone; it flows. As a result, what the concept means in healthcare, and how it works in practice, are, perhaps, made most tangible through providing compassionate care to patients, interacting with families, discussing compassion with colleagues, and teaching students about compassionate healthcare. If compassion is defined flexibly and understood wisely, it can shape care in positive ways, improve outcomes, and change lives.
Our special issue examines the regulation and practice of constitutional risk management in the V(isegrád)-4 countries (Czech Republic, Hungary, Poland and Slovakia). Unfortunately, the treatment of the COVID-19 pandemic made this enterprise relevant, as all four countries had to face a similar health emergency. This article presents the most important experiences and trends in the constitutional crisis management of the four countries, identifying the challenges that the constitutional emergency regulatory regimes have encountered so far. Our paper argues that despite the basically similar constitutional frameworks, these countries typically handled the crisis in a different way, and in the process many constitutional problems arose for which there was no clear or uniform solution. Since the purpose of the international comparative research that is the basis of our special issue was to examine the emergency constitution of these four countries in general (since it will have to be applied to possible later, other types of emergencies), in the last chapter of the article we examine the possibilities of a proposition that represents a novelty in the constitutional discourse on emergency situations: this is an option for the convergence of emergency constitutions.
The announcements by President Trump in April 2025, of unilateral hikes of 10–50 percentage points on U.S. import tariffs on all countries’ goods, are under threat of coming into force on July 9, 2025. This article estimates their likely effects on trade in alcoholic beverages, using a global model of national beverage markets. Various scenarios are compared. They suggest that if the tariff hike was restricted to just 20% on goods from the European Union, the value of global trade in each of the three beverages would shrink by one-tenth. But the U.S. tariff hikes are to apply to all countries’ goods, which are estimated to shrink global exports by 13% for wine, 22% for spirits and 33% for beer. In that broader scenario, most countries’ wine exports would shrink, but exports of beer and spirits would expand for some countries thanks to the trade divergence generated by the varying tariff hikes. If the increasing uncertainty associated with these developments led to a cumulated 2% drop in consumer spending, virtually all wine-exporting countries would sell less wine to both the U.S. and the rest of the world. That is, wine trade destruction would outweigh trade diversion.
This chapter introduces a new model to represent the heterogeneity of the Italian civitates. The model is based on the abundant archaeological evidence of the inhabited areas of their administrative centres, using it as a proxy for various economic and socio-political aspects of the civitas. This new variation model surpasses previous ones by being continuous (rather than categorical) and by formally incorporating the uncertainties associated with missing data.