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All governments ‘do’ industry policy, in the sense that they engage with business activity within their borders in order to create jobs, to further trade, or simply to keep up with technologies considered necessary for future growth. As a subject of scholarly and policy-related inquiry, however, industry policy was, for much of the period from the 1990s onward, overshadowed by what was widely perceived to be the triumphant march of freer trade and globalisation. Now that, for political, economic, and also environmental reasons, globalisation is viewed more critically, interest in industry policy has returned. But the subject remains controversial, not least because national conditions vary so markedly that mainstream economists remain hesitant to endorse more than minimal interventions. Nowhere have these misgivings been more marked than in Australia, which prides itself on its free trade credentials. But the world is changing unpredictably, and for Australia, as for many other trading nations, a new approach is needed to harness, intelligently, the power of the state in these circumstances.
Claystones and related sedimentary lithologies are considered as potential host rocks for the storage of high-level radioactive waste. The properties of claystones, which govern their barrier performance, can vary significantly between sites and formations. This study summarizes relevant barrier properties, with a particular emphasis on those dependent on burial history and maximum rock temperatures. Given the large number of properties influencing barrier quality, ranking them by relative importance is necessary. The predictable, non-linear behaviour of certain characteristics with geological burial depth allows for a substantial reduction in the number of properties requiring determination. Based on a set of representative repository-relevant rock lithologies, a case study comparison of potential claystone host rocks is presented. Hydraulic conductivity was assumed to be the most critical barrier property, with optimal values in rocks that reached peak diagenesis at burial depths exceeding 2000 m. To further distinguish claystone types and related lithologies in terms of barrier suitability, either cation-exchange capacity, reflecting the content of smectitic layers, or maximum temperature of palaeoburial heating (Tmaxgeo) can be used as an example. Pore-size distribution, correlating with the average particle distance, was particularly suited to estimating maximum burial depth, as it is less affected by thermal anomalies, pore fluid composition or cementation effects. Overall, combining key barrier properties with burial depth-dependent behaviour enables efficient assessment and comparison of claystone formations for deep high-level radioactive waste disposal. A quantitative comparison of various claystones, however, requires establishing a reactive solute transport model that simulates radionuclide release fluxes at specific timescales.
Cultural resource management (CRM) in the United States is an industry that thrives (or falters) on tight budgets and short deadlines. To steadily secure a reliable stream of projects from major clients (and to support the limited budgets of smaller clients), CRM firms are often forced to work with bare-bones funding, requiring them to demand a great deal of effort from their field and office personnel to stay within budget and on schedule. When the projects themselves can easily become the main focus, above the needs of the staff, an unhealthy working environment, lack of work–life balance, burnout, and resentment toward management can result. In this article, I reflect on my own leadership experiences and present a model that outlines best practices for CRM leadership professionals to follow to grow and maintain their businesses through the genuine and consistent support of staff members. I recommend three basic components to creating a healthy working environment in CRM: (1) policies and procedures that clearly outline staff safety, approaches to work–life balance, and field and lab protocols; (2) a “practice what you preach” approach to leadership; and (3) access to professional development opportunities for all staff, regardless of their job level or experience.
Rabies is a fatal zoonotic disease causing an estimated 59000 annual human deaths globally and approximately 523 in Kenya, with children disproportionately affected. Despite evidence that school-based educational interventions effectively increase rabies awareness and prevention among children, its implementation in Kenya is limited. This study aimed at utilizing an education programme to increase rabies awareness among primary school learners and evaluate their knowledge uptake. A quasi-experimental study was conducted among 210 learners from four primary schools (two urban, two rural). Pre-tested questionnaires assessed rabies awareness before and after rabies training sessions. Differences between urban and rural schools were assessed using χ2 tests, while Wilcoxon signed-rank test was used for pre- and post-training scores. Post-training, overall knowledge scores improved from 6.14 to 7.61(p < 0.001), with significant increase in learners’ knowledge on rabies transmission, zoonosis, and the importance of annual dog vaccination. Attitudes and perceptions improved from 3.23 to 4.03 (p < 0.001), particularly health-seeking behaviour and reporting post dog bite. In conclusion, school-based rabies education significantly improved learners’ awareness. Being the first report of such intervention in Kenya, it could serve as a model for other zoonoses.
An inclusive mindset is essential for designing for inclusion. However, without a clear understanding of what an inclusive mindset entails, design educators and practitioners may find it difficult to cultivate. This study clarifies what constitutes an inclusive mindset and how it can be fostered in the design field. Through a scoping review of 47 studies, we systematically analysed research domains, types of inclusivity, definitions, associated attributes and factors influencing an inclusive mindset. The outcome is the development of an inclusive mindset model that outlines the core constructs of an inclusive mindset, its determinants and its translation into inclusive behaviour. The model was further refined and validated through interviews with 23 stakeholders in design and engineering education. Together, these insights provide a nuanced understanding of inclusivity and offer an empirically informed framework for advancing inclusion in design research, education and practice.
AWARE (Approaches for Wellbeing and Mental Health Literacy: Research in Education) is a three-arm, parallel-group, cluster randomised controlled trial. It assessed the effectiveness of two interventions – the Youth Aware of Mental Health (YAM) programme and Mental Health and High School Curriculum Guide – in addressing emotional well-being, compared with usual practice, among year 9 students in England.
Aims
To evaluate the cost-effectiveness of YAM and The Guide to inform policy decisions regarding the implementation of these mental health interventions in schools.
Method
Cost-effectiveness was assessed using self-reported information from participants in the trial at baseline and two follow-ups – at 3–6 months after the start of intervention, and at 9–12 months post-intervention. Quality of life was measured with the Child Health Utility Index. Intervention delivery costs were calculated with data provided by the delivery teams. Service use costs were calculated with a short version of the Client Service Receipt Inventory, with unit costs obtained from publicly available sources.
Results
For both interventions, difference in outcomes (change in quality-adjusted life-years over time) between the intervention group and control group were close to zero, with the largest change being an improvement of 0.0055 quality-adjusted life-years at the second follow-up for students in schools randomised to YAM. Changes in costs were likewise small.
Conclusions
At first follow-up, neither intervention is likely to be considered cost-effective. At second follow-up, YAM has a high probability of being considered cost-effective, with an incremental cost-effectiveness ratio of around £23 000 per unit of improvement in the quality-of-life measure, which falls within the threshold (£20 000 to £30 000) as used by the National Institute for Health and Care Excellence.
In response to President Xi Jinping’s call to accelerate its country’s law-based governance beyond its borders, China has in recent years constructed a growing suite of legal instruments with extraterritorial effect.1 Although these measures serve multiple purposes—including facilitating China’s global expansion and protecting its overseas interests—one of their central functions is to counter U.S. sanctions and trade restrictions.2 China’s weaponization of extraterritorial law, shaped by intensifying U.S.-China rivalry, thus represents a distinct and emerging form of extraterritoriality. It differs from the traditional expansion of extraterritorial jurisdiction, which has often operated as a form of legal imperialism in service of a broader neocolonial project.3
Gaming disorder (GD) is increasingly recognized for its adverse impact on social functioning, yet the underlying neural mechanisms remain unclear, particularly during real-time social interactions. This study examined neural differences in the prefrontal cortex (PFC) and temporoparietal junction (TPJ) during cooperation and competition tasks in adolescents and young adults with GD.
Methods
Using functional near-infrared spectroscopy (fNIRS), we examined 175 male participants, classified into Gaming Disorder (n = 42), Hazardous Gaming (n = 69), and Healthy Control (n = 64) groups. Participants performed cooperation and competition tasks while activation, functional connectivity, and network topology were assessed within the PFC and TPJ.
Results
In the current study, GD participants exhibited significantly greater impairments in social and emotional functioning compared to the HG and HC groups. The GD group showed increased right TPJ activation during cooperation and decreased activation during competition. Both GD and HG groups demonstrated heightened medial PFC activation and functional connectivity, indicating compensatory engagement. Graph theory analysis revealed disrupted network topology in GD, including reduced nodal efficiency and centrality within the PFC and TPJ. Neural alterations were significantly correlated with clinical measures, including gaming duration and social-emotional deficits.
Conclusion
This study identifies critical neural disruptions underlying social dysfunction in GD, particularly within mentalizing and executive control networks. The neural markers observed in the GD group have important implications for clinical diagnosis and targeted intervention, whereas similar patterns in the HG group highlight opportunities for early detection and preventive strategies.
The fossil record offers a unique window into patterns of extinction and biodiversity recovery over deep time, and recent advances in analytical methods have significantly enhanced this research field. Our analysis of an updated dataset that includes 50 terminal taxa and 175 fossil occurrences of Ophiacodontidae, Edaphosauridae, and Sphenacodontidae (OES grade hereafter) using a recent implementation of the skyline fossilized birth–death model (FBD hereafter) confirms our previous conclusion that the OES grade diversified during the latter half of the Pennsylvanian but waned thereafter. However, our new results differ in several important points compared with our previous study (published in 2024). Notably, the transition between these two diversification regimes seems to have occurred earlier (at 298.9 Ma, at the Carboniferous/Permian transition), and it appears to have been marked by a moderate (0.527 survival probability), previously unreported extinction event. Also, the OES grade seems to have experienced a much more severe mass extinction event in the mid-Kungurian, with an estimated survival rate of only 0.113, which left very few surviving OES grade lineages. Climatic instability that started around the Carboniferous/Permian boundary and lasted throughout the Cisuralian, plausibly caused by intense volcanism of the Tarim Large Igneous Province and the Panjal Traps, may explain this pattern, which consists of a stagnating biodiversity followed by a brief, severe extinction event. This is reminiscent of the press–pulse model proposed by Arens and West in 2008, but if there was indeed an end-Carboniferous crisis, it could also be viewed as a new, more complex, pulse–press–pulse pattern.
To examine the psychometric properties of the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) in Mexican cancer patients, and to evaluate their utility as brief screening measures for depressive and anxiety symptoms in oncology care.
Methods
In this cross-sectional study, 357 adult patients receiving oncological treatment at a cancer hospital in Mexico completed the culturally adapted Spanish versions of the PHQ-9 and GAD-7. Exploratory and confirmatory factor analyses were conducted to assess the factorial structure of both instruments, and internal consistency was evaluated using Cronbach’s alpha. Concurrent validity was examined through correlations with related measures.
Results
The PHQ-9 yielded a 2-factor structure with acceptable internal consistency (Cronbach’s α = 0.837), while the GAD-7 showed a 1-factor structure with good internal consistency (Cronbach’s α = 0.881). The PHQ-9 explained 55.3% of the variance and the GAD-7 explained 58.5%. Confirmatory factor analyses indicated adequate model fit for both instruments.
Significance of results
Findings suggest that the PHQ-9 and GAD-7 are brief, valid, and reliable tools for detecting depressive and anxiety symptoms in Mexican cancer patients. Their use may facilitate the early identification of symptoms of anxiety and depression in oncology settings and support both clinical care and psycho-oncology research.
The development of cognitive impairment (CI) is a frequent and debilitating consequence of COVID-19 and can persist for more than 1 year after the acute infection stage. Previous neuroimaging studies in COVID-19 survivors with CI have revealed widespread alterations in functional connectivity (FC), particularly within fronto-parietal circuits and subcortical nuclei such as the hippocampus, basal ganglia, and thalamus. This study focuses on neural correlates of CI in subjects who recovered from COVID-19 and the relationship between FC patterns and discrete cognitive domains.
Methods
Resting-state functional MRI data from 136 subjects were analyzed using a ROI-to-ROI approach across 246 brain regions derived from the Human Brainnetome Atlas. Group comparisons were performed based on the presence or absence of CI, and correlation analyses were conducted between FC and scores obtained from a comprehensive neuropsychological test battery.
Results
Whole-brain FC showed no difference between patients with and without CI. In the whole study sample, hypoconnectivity between two basal ganglia regions and two frontal motor regions was associated with impaired performance in the cognitive domain “Reasoning and Problem-Solving,” while hyperconnectivity between the prefrontal thalamus and the postcentral gyrus was associated with impaired performance in the same cognitive domain.
Conclusions
Our findings indicate that FC alterations within the cortico-striatal and thalamo-cortical circuits may subtend deficits in higher-order executive functions in post-COVID-19 patients and highlight the importance of examining discrete cognitive domains in relation to brain connectivity.
Lasing spectroscopy (LS) is emerging as a powerful extension of conventional fluorescence methods for highly sensitive bioanalytical detection. By exploiting stimulated emission and optical feedback mechanisms, LS generates narrow spectral linewidths, threshold-dependent emission, and highly directional radiation, enabling enhanced signal-to-noise ratios and improved sensitivity compared with traditional fluorescence spectroscopy. In bioanalytical systems, subtle molecular events such as biomolecular binding, conformational transitions, or local refractive-index changes can significantly modify lasing thresholds, emission intensity, or spectral position, providing sensitive optical readouts of biochemical processes. This review presents a comprehensive overview of LS methodologies and their emerging applications in biomedical research. The discussion is structured according to a graded framework of increasing optical and methodological complexity, beginning with mirrorless amplified spontaneous emission (ASE) and random lasing (RL) in solid-state biomolecular matrices, followed by engineered photonic architectures, including distributed-feedback gratings and nanoporous anodic alumina (NAA) structures. More advanced resonator-based configurations in liquids, such as Fabry–Pérot (FP) cavities, whispering-gallery-mode microresonators, and optofluidic droplet lasers, are also examined. Across these platforms, LS is shown to enable ultrasensitive bioanalytical detection and novel diagnostic strategies, including early detection of protein aggregation, monitoring nucleic-acid conformational states, tissue- and single-cell laser diagnostics, and label-free refractometric biosensing. Finally, the review highlights current technical challenges, including dye photostability, cavity engineering, and measurement standardization, and discusses future perspectives for translating lasing-based bioanalytics toward clinically relevant diagnostics in neurodegenerative diseases, oncology, metabolic disorders, and infectious diseases.
Anxiety is the most prevalent mental health condition, causing significant distress, disability and cost.
Aims
This pilot study assessed the feasibility and acceptability of an eight-week self-directed online exercise intervention, supported by wearable activity monitors (WAMs), for mid-life and later-life adults with clinically significant anxiety, and provided preliminary estimates of effectiveness.
Method
The Exercise Therapy to Reduce Anxiety (ExTRA) project recruited 21 participants aged 40–77 years with Depression, Anxiety and Stress Scales (DASS-21) anxiety scores >7. The ExTRA online platform integrated with the WAMs, and provided information about anxiety, exercise programmes and strategies to help meet national physical activity guidelines, overcome barriers and set goals.
Results
ExTRA was feasible, with a 63% recruitment rate and 100% retention rate. Overall, evaluation questionnaire responses demonstrated high acceptability. At week 8, WAM average steps/day increased by 1358 (p = 0.036, Hedge’s g = −0.47), and fairly/very active minutes (3/6 metabolic equivalents) increased by 81.2 min/week (p = 0.024, g = −0.51), with moderate effect sizes. There was no statistically significant change on the self-report Global Physical Activity Questionnaire. The DASS-21 anxiety score reduction of 2.3 (p = 0.060, g = 0.42) from baseline to week 8 approached statistical significance. DASS-21 stress and depression scores were significantly reduced by 3.9 (p = 0.013, g = 0.57) and 3.7 (p = 0.02, g = 0.53), respectively, from baseline to week 8. There was no significant change in self-efficacy or dementia risk.
Conclusions
The ExTRA intervention is feasible and acceptable, with positive signals for increasing objectively measured physical activity and improving mental health. Findings support and inform the design of randomised controlled trials to assess efficacy of this potentially automated and scalable intervention.
The basal thermal state of the Antarctic ice sheet strongly influences ice dynamics and mass balance. Although basal thermal states can be simulated using ice-sheet models, significant uncertainties persist, with poorly constrained geothermal heat flux being one important source of uncertainty. The substantial computational cost of ice-sheet models restricts large ensemble simulations essential for uncertainty quantification and sensitivity analyses. To address this limitation, we develop machine-learning emulators for rapidly simulating the basal temperature and melt rate of Totten Glacier. Three distinct machine-learning emulators were trained using outputs of full-Stokes model simulations with different geothermal heat flux fields, achieving accurate replication (R2 up to 0.92). At least five simulations are needed to train a reliable emulator for basal ice temperature. Model interpretability reveals complementary physics learning: Random forest and XGBoost prioritize local dynamic drivers (basal topography, ice velocity), while neural network captures lower-complexity statistical mapping that is more strongly influenced by globally predictive variables (surface temperature, ice thickness). For basal melt rate, surface velocity emerges as the primary driver. These findings highlight substantial potential for integrating machine learning with ice-sheet modeling to efficiently and better predict basal thermal states.
During the era of colonial expansion, the European colonizers, backed by the military power of their imperial forces, carried their law to the colonized world. They even set up extraterritorial courts in the non-European colonial territories or in formally independent (but de facto not so) countries to exercise jurisdiction over European subjects.1 This was a form of “legal imperialism” as defined by Turan Kayaoğlu: “the extension of a state’s legal authority into another state and limitation of legal authority of the target state over issues that may affect people, commercial interest, and security of the imperial state.”2 In the contemporary era, powerful countries need not carry guns or set up extraterritorial courts in overseas territories; their laws often have reach well beyond their territories. Thus, smaller states have tended to perceive broad assertions of extraterritorial jurisdiction by the Global North as a form of regulation not only of the activities of individual or corporate actors but of the states of the Global South themselves.3
The taxonomy of wide distributed parasites across continents has rarely been evaluated using molecular data, and it remains unclear whether their apparent broad distributions reflect true cosmopolitan and monophyletic lineages. There is also the expectation that long-term parasite–host associations shape the evolution of parasitic lineages and should therefore be reflected in parasite taxonomy. Laelaps Koch, 1836 (Mesostigmata: Laelapidae) is an example of a widespread genus, reported from multiple continents, parasitizing Cricetidae and Muridae rodents. The aim of this study is to evaluate whether Laelaps is monophyletic and truly broadly distributed across continents. To this end, we generated new nuclear (18S-ITS1-5.8S-ITS2-28S) and mitochondrial (cytochrome oxidase I) sequences from 8 species of Laelaps, and 4 related laelapid mite species of the genera Androlaelaps Berlese, 1903, Gigantolaelaps Fonseca, 1939 and Mysolaelaps Fonseca, 1936 associated with cricetid rodents from Argentina. Those sequences were analysed together with sequences from laelapids parasitizing native South American cricetids and from South Africa available in GenBank. Phylogenetic analyses revealed that Laelaps is polyphyletic. Within Cricetidae, tribal host association appears to drive phylogenetic structure, with cricetid-associated Laelaps lineages recovered as more closely related to Gigantolaelaps and Mysolaelaps than to each other. Murid-associated Laelaps from South Africa were recovered as lineages separated from cricetid-associated Laelaps, suggesting that the deep divergence between Cricetidae and Muridae may also shape laelapid phylogeny, a pattern that requires broader sampling to be conclusively evaluated. These results challenge the monophyly and broad distributional status of Laelaps and highlight the need for integrative taxonomic revision of this genus.
We demonstrate that tailoring the laser–target interaction at the PW-class VEGA-3 facility (by controlling the focusing conditions, pulse duration, chirp sign and solid-target properties) enables the enhancement of ion flux, divergence and cutoff energy for high-energy-density physics experiments. The existence of optimal pulse duration, focusing conditions, target thickness and target material is experimentally demonstrated. We further show that a reduction in ion acceleration efficiency under best-compression conditions leads to delayed relative depletion of the hydrogen population compared to carbon ions, accompanied by a decrease in both ion flux and cutoff energy. For metallic targets, scintillator detectors reveal a more divergent and deflected proton beam than that produced from thick plastic targets. The product of the magnetic field strength and the interaction length acting on the ions is estimated to reach up to 400 MG μm, resulting in a ring-like spatial distribution of protons generated from aluminum and copper targets.
Receipt of violence (victimisation) is associated with a higher risk of severe mental illness and with worse illness severity; however, associations with routine clinical outcomes are less clear.
Aims
To investigate associations between victimisation and subsequent clinical outcomes in people presenting with severe mental illness, using a south London health records data resource.
Method
Data were extracted for 16 372 patients presenting between January 2007 and October 2022, aged 18+ years and receiving diagnoses of schizophrenia-related disorders, mania or bipolar disorder. Recorded victimisation and subtype (any, physical, domestic or sexual) were ascertained via natural language processing from the first 3 months of the record following presentation. Cox regression models were deployed to investigate subsequent risk of mental health emergency care assessment, crisis intervention, in-patient care, Mental Health Act (MHA) detention and mortality. Poisson regression models investigated the numbers of attended healthcare events and antipsychotic agents received. Covariates included sociodemographic characteristics and clinical status (service receipt, medication, symptom profile).
Results
All victimisation exposures were associated with a higher risk of all outcomes, apart from mortality and number of antipsychotics, following adjustment for sociodemographic factors, and with emergency assessment (hazard ratio for any victimisation 1.17, 95% CI 1.09–1.27), in-patient/MHA detention (hazard ratio 1.32, 95% CI 1.06–1.65/1.82, 95% CI 1.31–2.55) and higher numbers of attended events (incidence rate ratio 1.17, 95% CI 1.16–1.19) following full adjustment. Associations were similar for subtypes of victimisation and exposures, and between men and women following sociodemographic adjustment, but the associations were slightly weaker for women following full adjustment.
Conclusion
Experiences of violence, to the extent to which patients report their experiences and these are recorded, are risk factors for worse outcomes in severe mental illness, only partly accounted for by clinical status around the time of presentation. More systematic ascertainment and recording of victimisation needs to be considered if interventions are to be appropriately targeted.