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Solid atmospheric particles, such as ice crystals, pollen, dust, ash and microplastics, strongly influence Earth’s climate, ecosystems and air quality. Previous studies have typically relied on analytical models valid only for very small particles or experiments in liquids, where the particle-to-fluid density ratio $R$ is much lower than values encountered in the atmosphere. We combine a novel experimental set-up with particle-resolved direct numerical simulations to study the settling of sub-millimetre ellipsoids in still air. Particle shapes span elongation and flatness values $ 0.2 \leqslant {\textit{EL}}, {\textit{FL}} \leqslant 1.0$ at a density ratio $ R = 1000$ and particle Reynolds numbers $ 2.1 \lt {\textit{Re}}_{\!p} \lt 4.5$, a regime well below the onset of wake-induced instabilities. Nonetheless, we observe unexpectedly rich dynamics: all non-spherical particles exhibit damped oscillatory motion, and some triaxial ellipsoids follow fully three-dimensional, non-planar trajectories due to rotation about all three axes. Simulations at lower density ratios ($ R = 10, 100$) confirm that these behaviours are driven by strong lateral forces happening only at $R=1000$. Key settling characteristics exhibit nonlinear and non-trivial dependencies on shape. In the two-dimensional phase space of elongation and flatness, settling velocity is symmetric about the principal diagonal ($ {\textit{EL}} = {\textit{FL}}$), while oscillation frequency and damping rate show symmetry about the anti-diagonal. Flatness strongly influences pressure drag, while elongation governs lateral drift and swept volume, which can reach up to ten times the particle diameter and four times the volume-equivalent sphere, respectively.
There is growing awareness of the role that multinational corporations (MNCs) play in contributing to modern slavery down their supply chains (8.7 Alliance, 2023). According to Global Estimates of Modern Slavery, published by the International Labour Organization (ILO), in 2021 there were 27.6 million people trapped in situations of forced labour around the world, with 17.3 million individuals being exploited in the private sector (ILO, 2022). Sectoral analysis of this finding suggests that a third of exploited workers are employed in export-related sectors and are, presumably, part of global value chains (GVCs) (ILO, 2022). The increasing realization, in the last decade or so, that MNCs’ profits are linked to modern slavery has driven workers, their representatives, global and local activists, consumer organizations, and unions, as well as legislators and policymakers at various levels (local, national, regional, and international), to seek innovative and effective ways to hold MNCs accountable and assign them responsibility (LeBaron, 2020; ITUC, 2020; Trautrims et al., 2021).
This trend suggests a shift in policy responses to modern slavery. Since the adoption of the United Nations Office on Drugs and Crime (UNODC) Trafficking Protocol in 2000,1 there has been a predominant view that human trafficking and modern slavery primarily result from the operation of organized crime (H. Shamir, 2012). The expansion of the anti-trafficking and modern slavery policy response towards addressing the role of mainstream business entities, and particularly MNCs, raises multiple complex questions for scholars, policymakers, and activists. These relate to the exact role of MNCs in modern slavery and the practices they adopt, and MNC and supplier compliance (Han et al., 2022); the causes and drivers of modern slavery; the reality of work on the factory floor (and wherever work takes place); and effective policy solutions to change corporate patterns of purchasing, supply chain management, and engagement with suppliers, as well as with workers and their communities.
The right to roam – balancing inclusion and enclosure. In Norway, the right to roam is an old custom – a right to traverse and gather berries, herbs and firewood on uncultivated lands – dating back to the Viking Age. In 1957, this right was included in Norwegian laws, in the Outdoor Life Act (Friluftslova). The law transformed agrarian lands into areas for outdoor life and recreation, primarily walking and hiking. However, due to modernisation, the activities performed today are very different than those in the 1950s, involving many sorts of technical devices and installations, commercial activities and a different landscape. The law was a manifestation of the Norwegian outfields as a commons, but what is a commons for some can be an enclosure for others. This is the topic of this article: how the right to roam includes many and much but represents encroachment, displacements and enclosures and has created crowding, natural wear and tear and urges for management regimes. The article describes this as a balance between inclusion and enclosure. The article has two major parts: one presenting the academic discussion about inclusion and enclosure, the other discussing the implementation of the principle in Norway in light of this theory.
This essay examines the overlooked 1979 strike by Palestinian workers at the Jerusalem District Electricity Company (JEDC) as a pivotal moment of anti-colonial resistance. It argues that the strike, which fused demands for better wages with a political struggle against Israel’s erosion of the company’s concession and autonomy, demonstrates the inextricable link between class and national liberation. By mobilizing broad popular solidarity to defend a critical national infrastructure, the JEDC workers’ union articulated a mode of resistance in which labor solidarity became a primary vehicle for asserting sovereignty and contesting the political economy of settler colonial occupation. Their actions foreground the central role of an organized urban working class in the broader Palestinian struggle for development and liberation.
This chapter traces the history of the UK Human Rights Act 1998, from its inspiration in the Universal Declaration of Human Rights in 1948, through the adoption of the European Convention on Human Rights in 1950, the cases lost by the United Kingdom after the acceptance of the individual right to petition the European Court of Human Rights in 1966, the movement to ‘bring rights home’ which culminated in the 1998 Act, the attacks on the Act by media and politicians, and the ill-fated Bill of Rights Bill to replace it, culminating in 2023 with the insidious disapplication of the Act in the particular context of migration and asylum and a new willingness of the government to promote legislation which is incompatible with the Convention rights, coupled with renewed calls in some quarters for the United Kingdom to withdraw from the Convention.
Postdischarge antibiotics are often sub-optimal or unnecessary. This study sought to measure the risk of diarrhea in recently hospitalized patients treated with postdischarge antibiotics
Design:
Retrospective cohort study.
Setting:
125 acute-care hospitals in the Veterans Health Administration (VHA).
Patients:
Patients hospitalized within VHA during 2018–2021.
Methods:
The primary exposure was postdischarge antibiotics. The primary outcome was time to C. difficile testing, which served as a surrogate marker for clinically significant diarrhea. Only tests that were performed during the 30 days after discharge and before all-cause hospital readmission were captured. We constructed a final Cox proportional hazards model with 27 fixed-effect predictors as well as a random intercept for each hospital.
Results:
There were 1,686,819 qualifying admissions, and 333,310 (19.8%) received postdischarge antibiotics. There were 13,387 patients (0.8%) who had a test for C. difficile done. Among those tested, the median time to testing was 6.7 days for those tested while on postdischarge antibiotics and 14.1 days for those tested while not on postdischarge antibiotics. Compared to patients not on postdischarge antibiotics, the hazard ratio for testing was 1.40 (95% CI, 1.29–1.51) among patients on low-risk postdischarge antibiotics and 1.56 (95% CI, 1.42–1.71) among those on high-risk postdischarge antibiotics.
Conclusions:
In this national VHA hospital cohort, patients prescribed postdischarge antibiotics had a 40–56% increased risk of C. difficile testing compared to those not prescribed postdischarge antibiotics. Efforts to optimize antibiotic-prescribing at hospital discharge, particularly by reducing excessive duration and avoiding high-risk agents, may help mitigate these risks.
Music was important in John Stuart Mill’s life. He was an accomplished pianist and a talented improviser. His works include treatments of various philosophical aspects of music, including its metaphysics, its epistemology, the sources and nature of its value, and its aesthetics. Some of his ideas on musical aesthetics are still of interest. This applies to his distinction between those reactions to music that are based on associations with non-musical experiences and those that are based on properties of the music itself. It also applies to his concepts of poetic and oratorical modes of musical expression. In addition to his other achievements, he should be recognized as a philosopher of music.
We examine whether intellectual property protection facilitates the greater incorporation of firm-specific information into the stock price. Employing the staggered, country-level adoption of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), we find that after adoption, stock prices become less synchronous, consistent with more firm-specific information being impounded into the stock price. We further show that this effect is more pronounced for more innovative firms, firms in countries with stronger law enforcement, and firms with more financial analyst coverage. Finally, we document that TRIPS induces a richer information environment characterized by more management forecasts and media coverage.
The Statute of Uses enacted radical reform which can still be felt across the common law world. It was from exceptions to the statute’s execution of uses to perform last wills that the modern trust emerged. Our understanding of the passage of the statute has been shaped by the survival of several draft bills and ancillary documents. It has been argued that a draft bill introduced in 1529 was rejected by the Commons in March 1532. This in turn inspired the landmark litigation in Dacre’s Case (1533–35), which paved the way for the subsequent enactment of the Statute of Uses. This chapter challenges that orthodox position by demonstrating that there were in fact three early drafts which were considered. It then considers what this tells us about the role of the crown, parliament and the courts during this pivotal period in our legal history.
We study the impact of opioid abuse on real estate prices. We document that opioid death rates and excess prescription rates are negatively associated with house prices. Exploiting the staggered passage of opioid-limiting legislation, we find that a decrease in opioid abuse results in higher county-level house prices. This effect is due to fewer mortgage delinquencies, lower vacancy rates, more home improvement loans, and increased population inflow. Our findings are consistent with improved real estate conditions and a rise in local demand. These results highlight the importance of public health policy in mitigating the economic costs of the opioid epidemic.
This scoping review aims to synthesize the literature on pediatric health technology assessments (HTAs) and map out the challenges of assessing new technologies for use in children, with a particular focus on pharmaceutical interventions.
Methods
Conducted in accordance with the Joanna Briggs Institute Methodology, this scoping review addressed HTAs in the pediatric domain through searches of PubMed, Embase, Web of Science Core Collection, and EconLit through 22 January 2024, as well as the gray literature. Sources were excluded if they (i) were a clinical trial investigating a specific technology or an HTA of that technology, (ii) did not address the challenges of HTAs, or (iii) had no relevance to pediatrics. Two authors performed screening and data extraction independently and in duplicate.
Results
One hundred and three reports were included. Of these, sixty were full journal articles, twenty-three were conference abstracts, and twenty were guidelines, reports, and other documents. Two important themes emerged from this work. The first was the unique position of children within society and the resulting difficulty of incorporating them within a population-wide HTA system. The second was the uncertainty that characterized pediatric HTAs due to data constraints and either a lack of guidance by HTA bodies or variations in guidance between bodies.
Conclusions
Many factors inherent to children, including the heterogeneity of pediatric disease populations, long-term outcomes, and children’s distinct social positions, render conducting pediatric HTAs challenging. Innovative approaches are required to address these challenges and respond to the needs of pediatric populations.
This study investigates the influence of multiple jet parameters on the flow field of translating impinging inclined water jets. We conducted full-scale stereoscopic particle image velocimetry and pressure measurements and three-dimensional computational fluid dynamics simulations for Reynolds numbers in the range of $Re = 23{,}000{-}43{,}750$. Considering the complex mechanism of a translating impinging jet, a good concordance is observed between the experimental and numerical results. The translation-to-jet velocity ratio ($R$) is identified as a critical parameter in determining whether the jet flow predominantly exhibits impinging characteristics or behaves as a jet in cross-flow. It is found that, for $R \gt 0.22$, jet impingement is minimal. The stand-off distance to nozzle diameter ratio ($H/D$) determines the relative influence of the cross-flow on the jet flow. The effect of $H/D$ is similar to a stationary impinging jet, with the potential core extending up to $H/D \approx 4$, but entrainment is enhanced by the relative cross-flow. For an inclined jet, i.e. jet angle $\theta \neq 90^{\circ}$, the direction of the jet, either backward or forward, governs the deflection of the flow. Higher pressures are recorded for a backward directed jet compared with a forward directed jet for supplementary angles.
This chapter explores the roles of different generations of lawyers in Estonia’s post-1991 democratic transformation. Focused on young, progressive lawyers familiar with Western legal culture and established leaders educated under the Soviet regime, the study draws on extensive interviews and document analysis to trace how these actors shaped the nation’s transition from Soviet legal structures to a contemporary democratic framework. The findings highlight the critical importance of individual efforts in redefining legal practices, emphasising the dual impact of innovative youth and experienced mentors in driving significant legal and institutional reforms. The study enhances understanding of the dynamics of legal transitions in post-Soviet states, highlighting the essential blend of innovation and experience necessary for successful legal reform.
Dietary phytosterols exert hypocholesterolemic effects by inhibiting cholesterol absorption in the small intestine. However, oxidised phytosterols exert harmful effects. In this study, we compared the effects of dietary stigmasterol or oxidised stigmasterol (OS) on cholesterol absorption and metabolism in mice. Institute of Cancer Research (ICR) male mice were fed one of the following diets: a standard American Institute of Nutrition (AIN) diet; the standard diet plus 0·25 % cholesterol; the standard diet plus 0·25 % cholesterol and 0·25 % stigmasterol or the standard diet plus 0·25 % cholesterol and 0·25 % OS. Stigmasterol, but not OS, decreased plasma total cholesterol levels. Unlike stigmasterol, dietary OS increased the cholesterol levels in micellar solutions. Thus, OS could not exert hypocholesterolemic effects as it could not displace cholesterol in micellar solutions. In contrast, dietary OS downregulates the mRNA expression of genes involved in cholesterol synthesis and upregulates the mRNA expression of genes involved in cholesterol catabolism in mice fed cholesterol. In addition, dietary stigmasterol and OS increased the levels of faecal-neutral steroids by downregulating the mRNA expression of Niemann-Pick C1-like 1 protein (NPC1L1) in the small intestine. Dietary stigmasterol may directly regulate the mRNA expression of NPC1L1, whereas dietary OS may reduce the mRNA expression of sterol regulatory element-binding protein 2 and act as a Liver X receptor α agonist, reducing the mRNA expression of NPC1L1. Therefore, OS may affect cholesterol absorption and metabolism through a mechanism different from that of stigmasterol.
Skinfold callipers are used internationally in research, clinical and field settings to assess body composition and nutritional status. Notably, currently available instruments differ in important specificities that impact measurement. In this sense, this report proposes a methodological approach that organises skinfold callipers into three categories (Original, Generic and Hybrid) and three configurations (Type A, Type B and Type C) based on physical-mechanical properties and characteristics. Therefore, this concept provides technical support for choosing the most appropriate skinfold calliper in different contexts.
Carbon-14 (14C) is an important contributor to the collective effective dose to the public due to releases from nuclear power plants (NPPs). In Sweden, only airborne emissions of 14C from NPPs are currently routinely monitored, and the existing data on waterborne 14C discharges are limited. A recent study of 14C in brown algae (Fucus spp.) in Swedish coastal waters showed higher F14C values collected at Ringhals NPP, on the Swedish west coast, than expected. Therefore, this study aimed at assessing if blue mussels (Mytilus edulis) could be used to retrospectively estimate the 14C concentration of dissolved inorganic carbon (DIC) in seawater at three sites. A method was developed to extract the fibrous layer that forms visible annual structures in the shells. All samples were analyzed with accelerator mass spectrometry and the results compared with 14C data from Fucus spp. For one of the analyzed shells (structures from 1974–1978), from the site Särdal, F14C in Fucus spp. and M. edulis agreed very well. For another shell (1972–1978), shell structures from some of the earlier years displayed up to 6% lower F14C than Fucus spp. F14C in one shell from a remote site, Båteviken, only had small annual variations (2017–2022: F14C = 1.070 ± 0.015 (1 σ)). Two shells from Ringhals NPP had higher average F14C, and a significant temporal variability (2014–2022: F14C = 1.427 ± 0.268 (1 σ)). Difficulties in unambiguous identification of the annual structures in the shells, as well as the future potential of this method, are discussed.
In 1636, a set of nine paintings was installed on the ceiling of the Banqueting Hall in Whitehall Palace. Three central and six side panels. The set had arrived from the studio of Peter Paul Rubens in Antwerp, and had been commissioned by King Charles I in honour of his father James. They were intended to summate three aspirations which defined James’s reign. The three central panels were entitled The Apotheosis of King James, The Peaceful Reign of King James, and The Union of Crowns. Each spoke to a matter of constitutional urgency, then and now; respectively, the nature of monarchy, relations with the rest of Europe, and the possibility of forging a union between England and Scotland. The purpose of this chapter is to revisit the reign of King James I and see if we can spot some resonances.
This chapter deals with child labour in value chains, whether global value chains (GVCs) or domestic value chains (DVCs). This chapter goes beyond the usual question of the regulation of child labour in value chains to consider the conditions necessary for the elimination of child labour. This chapter is the product of many years of research on this topic by the two authors, sometimes jointly and at times along with other researchers. The empirical base of the analysis in this chapter comprises the various studies carried out by the authors, jointly or separately, of child labour in the garment GVCs in Delhi (Bhaskaran et al., 2010); in the global and DVCs of handicrafts in Jaipur, matches in Sivakasi, stone quarries in Rajasthan, brick kilns in Malda, West Bengal, knitwear and fireworks in Tirupur, Tamil Nadu (Nathan and George, 2012); cotton production in Punjab and Haryana (IHD and Save the Children, 2014); and of gems, lac bangles, and embroidered garments in Jaipur (The Freedom Fund, 2018). One of the authors (Varsha Joshi) led the Child Helpline, which is the key agency in the identification and rescue of child labour in Jaipur, so we were able to use the insights gathered in the course of her work in rescuing child labourers. While the data leading to the chapter's analysis are mainly from Indian cases, the analysis itself is applicable to other, developing countries in the Global South where child labour still exists in serious dimensions. The chapter's policy prescription of combining higher adult earnings at the base of the labour force pyramid with compulsory and quality education is relevant to all developing countries of the Global South.
After this introduction, the next section deals with types of child labour and the implications for different types of interventions. This is followed by a summary of the different types of interventions of both public and private regulation that have been undertaken to eliminate child labour in value chains, both global and domestic. The elimination of child labour involves a change in the business strategy of both the lead firm or principal employer and the supplier.