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In the summer of 2016, a case of potentially herbicide-resistant redroot pigweed (Amaranthus retroflexus L.) was reported in Saint-Louis-de-Gonzague (QC, Canada) in an identity-preserved soybean [Glycine max (L.) Merr.] field where imazethapyr and chlorimuron-ethyl were applied preemergence, two active ingredients that inhibit acetolactate synthase (ALS). A few years earlier, several A. retroflexus populations resistant to ALS-inhibiting herbicides were reported in Manitoba (MB). Amaranthus retroflexus samples from these fields were collected and analyzed to characterize the presence of a resistance mechanism and the associated level of resistance. Sequencing of the ALS gene revealed a mutation resulting in a serine to asparagine substitution at amino acid position 653. Dose–response experiments indicated resistance factors of 27.7 to 194.0 to imazethapyr (imidazolinones) among these populations, but susceptibility to members of all other ALS inhibitor families that were tested. In one MB population, a serine to isoleucine substitution at position 653 was observed for the first time in A. retroflexus in some of the plants, and this contributed to the detection of resistance to thifensulfuron-methyl when compared with most susceptible control population. The response of the two MB control populations to thifensulfuron-methyl differed, and resistance factors were influenced by the level of susceptibility of the control populations to thifensulfuron-methyl. The same was not observed with imazethapyr. Non–target site resistance (NTSR) was not detected in the MB populations when they were exposed to malathion before exposure to the herbicide. We identified two new mutations on the ALS gene in A. retroflexus that result in ALS inhibitor–specific cross-resistance patterns. Further investigation into NTSR and the mechanism behind the differential response of the control populations to thifensulfuron-methyl are warranted.
Iraq is among the countries most vulnerable to climate change, and it is faced with extreme heat, drought and environmental degradation.
Aims
To examine the prevalence of climate anxiety and its association with depression and generalised anxiety disorder in the Iraqi population.
Method
A cross-sectional survey recruited 1019 adult participants (47.8% males, 52.2% females). Most participants were aged 18–41 years (n = 854, 83.8%); 16.2% (n = 165) were aged 42–72 years. Regionally, 75.6% (n = 770) were from the Kurdistan Region and 24.4% (n = 249) from provinces in central and southern Iraq. The study used the Climate Change Anxiety Scale (CCAS), Patient Health Questionnaire-9 (PHQ-9) and Generalised Anxiety Disorder-7 (GAD-7). Statistical analyses, included descriptive analysis, analysis of variance (ANOVA), t-tests, Pearson’s correlations and regression models, examined variations in climate anxiety by demographics and associations with depression and anxiety.
Results
Overall, 71.4% of participants reported severe climate anxiety, with a higher prevalence in the Kurdistan Region (73.2%) compared with central and southern Iraq (65.9%). Five provinces were found to have significantly higher levels of climate anxiety: Ninawa, Basrah, Najaf, Duhok and Erbil. Age was a significant predictor, and older participants (42–72 years) reported higher levels than younger participants (P = 0.008). A positive correlation was observed between climate anxiety and both depression (r = 0.382, P < 0.001) and generalised anxiety (r = 0.361, P < 0.001). Simple linear regression revealed that climate anxiety was significantly associated with both depression (β = 0.25, P < 0.001) and generalised anxiety (β = 0.214, P < 0.01), accounting for the 14.6 and 13% variance, respectively.
Conclusions
Climate anxiety is prevalent in Iraq and significantly associated with mental health problems. The findings endorse the need for integration of mental health into Iraq’s national climate adaptation and public health policies.
Since the 1990s, the relocation of psychiatric patients from long-stay institutions to community-based supported living has increased globally. However, most evidence on suitable residential services comes from high-income countries, with little from low- and middle-income contexts. This study explored the experiences of residents and carers in three residential care homes for people living with serious mental illness in Sedibeng District, South Africa.
Methods
Three organisations were purposefully selected as in-depth case studies. Ninety-one face-to-face qualitative interviews were conducted with service providers, residents, and family members between October 2022 and June 2023.
Findings
Residents described severe psychosocial disability when living with families, but improved functioning in residential homes. Organisations 1 and 3 operated small 3–4-roomed houses in township areas, accommodating 21 and 40 residents respectively, who had community access and social interaction. In Organisation 3, residents formed romantic relationships, undertook paid work, and lived semi-independently. Organisation 2, a repurposed school-like building with four large dormitories for 86 residents, imposed strict movement controls; medication was used to manage behaviour, and caregivers reported safety concerns.
Conclusions
Smaller residential homes offer more autonomy and integration than large dormitory-style facilities. Policies and funding should support smaller, community-based supported accommodation for people with serious mental illness.
This article looks at the final years of French colonial rule in Dahomey through the lens of development policies concerning the territory’s main resource: the oil palm tree. It examines how the Dahomean leaders dealt with the issue of development once the Loi Cadre allowed them to have a say in the matter. I argue that the Dahomeans were crucial in finding new development strategies even before formal independence. It also tries to assess the extent to which these solutions followed or departed from previous colonial attempts. The article therefore first describes the main features of colonial oil palm development in Dahomey since the end of the Second World War. Second, it depicts how Dahomean leaders rethought the development approach and why they found in the “syndicate association” the institutional tool to implement it. Finally, it argues that this solution, which combined features of Soviet and Israeli cooperatives with approaches specific to African socialism, was different from any other option previously considered by the colonial administration. By analysing late colonialism from a non-French perspective, this article argues that the Africans were no less crucial actors than the Europeans in the making of the late colonial state.
Climate-induced floods disproportionately affect vulnerable rural communities within Pakistan due their immediate and long-term impacts on mental health. Over time, the community narrative around rain, mostly considered as God’s blessing, has shifted to fear and uncertainty, exacerbating flood-related trauma and anxiety. With excessive damage to infrastructure, disrupted health facilities, socioeconomic inequities and limited access to relief and emergency services, these remote communities are often neglected and remain deprived of basic psychological aid. This paper presents the integration of community-based mobile health services to deliver mental health and psychosocial support in six high-risk districts of Sindh and Balochistan, and provides policy and practice recommendations. Lived experiences of flood affectees have been highlighted to amplify community voices in transforming mental healthcare systems for underserved populations.
As a highly aggressive tumour of the digestive tract, pancreatic cancer has a high mortality rate and poor treatment outcomes. The five-year survival rate for patients with pancreatic cancer is distressingly low, and the recurrence chance remains unacceptably high even with successful treatment. Surgical procedures and chemotherapy are the main treatments of pancreatic cancer, and surgical procedures are the only effective treatment at present. However, these cancer cells can easily develop resistance to chemotherapy agents, which leads to low treatment efficacy and high mortality in pancreatic cancer. Additionally, early diagnosis of pancreatic cancer is challenging due to the absence of obvious symptoms, making surgical intervention unattainable in early stages. However, pancreatic cancer cells show unique changes at genetic and cellular levels, which makes them sensitive to metalrelated cell death or exhibit some characteristics related to metalrelated cell death. These changes and characteristics could be utilized for treatment and diagnosis in pancreatic cancer.
Method
Therefore, our motivation is to explain the potential of metalrelated cell death in treating this aggressive cancer. This review begins by analysing the types of metal-related cell death: ferroptosis, cuproptosis and lysozincrosis. Each form is evaluated based on its unique features and related metabolic pathways.
Results
By examining the key characteristics of metal-related cell death modalities, their primary metabolic patterns and their interactions with pancreatic cancer, our aim is to point the direction to identify potential therapies and treatments.
Conclusions
Our review expands the possibilities for utilizing metal-related cell death and instils hope for its future potential in pancreatic cancer treatment.
This comparative article examines the iterative interactions between the French conception of guerre contre-révolutionnaire and the (re-)legitimation of modern torture techniques from the late nineteenth to the early twenty-first centuries. Based on a threefold argument, and drawing on multilingual historical sources and museal artifacts, it argues that the ideological campaign against the “revolutionary war” was a specifically military-intellectual approach to dealing with real or imagined subversive enemies. This dispositif promoted torture as a method of obtaining information and intimidating victims. First, this article shows how torture and the corresponding knowledge production can be traced back to colonial Indochina. There, archaic techniques were peculiarly blended, often with other experiences and indigenous practices. Later, leading military officers believed that the resulting doctrine of counterrevolutionary warfare was successful largely because of the use of methods of torture that left no trace. This key feature facilitated the export of its techniques to other regions. Therefore, in a second step, this article shows how this intertwined knowledge system was applied to the Algerian War, where it was widely employed and exploited. Subsequently, the fear of the spread of global communism facilitated the emergence of torture as a covert science of the Cold War. Third, this essay demonstrates how leading French theorists globalized their teachings by influencing their South American counterparts through their cross-continental interactions from the 1960s onward. Since the end of the Cold War, traces of this savoir-faire have remained potent, culminating in their influence on U.S. American counterinsurgency doctrine.
While there is consensus about the combined relevance of liberal regime policies and gendered employment and family trajectories in adulthood, for shaping employment in later life, so far there is no single cross-national study simultaneously addressing these dimensions. Drawing on exceptionally rich, harmonised life history data, we explore the association between employment and family patterns in adulthood, and the prevalence, duration and diversity of extended working lives beyond full pension age, among men and women in four predominantly liberal countries: two from Europe (England and Switzerland) and two from the Americas (the United States and Chile). Our findings indicate that employment trajectories – unlike partnership and fertility trajectories – play a significant role in shaping the prevalence, duration and diversity of later-life employment across the four countries examined. Furthermore, gender differences in later-life employment patterns are particularly notable in England and Chile. Our comparative perspective reveals that while liberal regimes share certain characteristics, they also exhibit significant diversity in how extended working lives manifest and are influenced by lifecourse trajectories.
In the wake of the 2015 attacks claimed by the Islamic State on the satiric magazine Charlie Hebdo, the Bataclan theater, cafés in Paris, and the Stade de France in Saint-Denis, survivors were granted reparation based on an already existing legal framework. This article traces the history of compensation for terrorism in France back to a previous campaign of bombings carried out by Lebanese Hezbollah on iconic Parisian sites in 1985–1986 and, beyond the conjuncture of the late 1980s, to the Algerian War of Independence (1954–1962). While genealogies of human rights have so far focused on the aftermath of World War II and the history of the Holocaust, the paper uncovers the wars of decolonization as a key historical conjuncture for the emergence of contemporary humanitarianism and for the structuring of its fundamentally ambivalent discourse. A review of the successive arguments over how to draft, amend, and rewrite the reparation statutes in the late 1950s reveals how compensation was weaponized as an integral part of the “war on terror.” The paper then brings the analysis into the 1980s and the creation of a compensation fund as part of the 1986 Prevention of Terrorism Act. Reparations for terrorism emerge not only as a form of humanitarian intervention but also as a tool of counterinsurgency warfare in its own right. On a historiographical level, I draw on David Scott’s concept of “problem-space” to analyze the late 1950s and 1980s as imbricated conjunctures bearing an exceptional testimony to the history of the present.
Product configuration is a successful application of answer set programming (ASP). However, challenges are still open for interactive systems to effectively guide users through the configuration process. The aim of our work is to provide an ASP-based solver for interactive configuration that can deal with large-scale industrial configuration problems and that supports intuitive user interfaces (UIs) via an application programming interface (API). In this paper, we focus on improving the performance of automatically completing a partial configuration. Our main contribution enhances the classical incremental approach for multi-shot solving by four different smart expansion functions. The core idea is to determine and add specific objects or associations to the partial configuration by exploiting cautious and brave consequences before checking for the existence of a complete configuration with the current objects in each iteration. This approach limits the number of costly unsatisfiability checks and reduces the search space, thereby improving solving performance. In addition, we present a UI that uses our API and is implemented in ASP.
Answer Set Programming (ASP) is a successful method for solving a range of real-world applications. Despite the availability of fast ASP solvers, computing answer sets demands significant computational resources, since the problem tackled is on the second level of the polynomial hierarchy. Answer set computation can be accelerated if the program is split into two disjoint parts, bottom and top. Thus, the bottom part is evaluated independently of the top part, and the results of the bottom part evaluation are used to simplify the top part. Lifschitz and Turner have introduced the concept of a splitting set, that is, a set of atoms that defines the splitting.
In a previous paper, the notion of g-splitting set, which generalize the concept of splitting sets for disjunctive logic programs, was introduced. In this paper, we further investigate the topic of splitting sets and g-splitting sets. We show that the set inclusion problem for splitting sets can be reduced to a classic Search Problem and solved in polynomial time. We also show that the task of computing g-splitting sets with desirable properties is relatively easy and straightforward. Finally, we show that stable models can be decomposed to models of rules inspired by g-splitting sets and models of the rest of the program. This interesting property can assist in incremental computation of stable models.
There is a marked tendency to view Latin America’s twentieth-century international history through the lens of US hegemony, and Europe has been particularly impacted by this historiographical trend. On the basis of a review of 41 articles published in The Americas over the past 81 years, this essay explores The Americas’ important role in promoting scholarship on the variety of connections between Latin America and Europe. By bringing together two temporal currents—the chronology of history and the chronology of historiography—it traces how scholarship on Latin America’s twentieth-century relationship with the wider world has evolved. During the Cold War years, the majority of articles focused on Latin America as an arena for great power/superpower rivalry, but from the end of the previous century, scholars publishing in the journal made increasing use of different scales of analysis to uncover the multidimensional flows across the Atlantic. Ultimately, work published in The Americas on twentieth-century transnational relations has shown that Latin America and Latin Americans are important actors on the global stage with significant agency in drawing upon separate international influences and alliances to best suit their own domestic purposes, sometimes with significant consequences for the wider world.
Voters are frustrated by the influence of money in politics. They cannot be certain whether politicians follow the money or the will of the people. Disclosing side income may therefore serve as a means to increase trust in politicians. To investigate whether this mechanism works, we analyze data from a vignette survey experiment on parliamentarians’ side jobs with respondents from seven European countries (N$ \approx $ 14,100). Our results show that compared to parliamentarians who are unwilling to disclose their side income, transparent parliamentarians, even those with especially high extra-parliamentary earnings, are seen as more trustworthy and electable. We also find that voters rely on the combined information of the number and type of side jobs (companies versus public interest groups) when evaluating non-transparent parliamentarians. Furthermore, voters’ income, education level, and ideological leaning moderate their perceptions of (non-)transparent parliamentarians. Overall, our findings suggest that politicians’ disclosure of side income benefits representative democracy.
Philosophers have spilled much ink over the discovery of ideas in the classical “context of discovery.” However, there has been little engagement with the question of what constitutes a discovery of “things in the world.” A much-overlooked answer to this question is provided by T. S. Kuhn. In this article, I show that discoveries awarded the Nobel Prize in Physics over the past 53 years accord with a basic premise of Kuhn’s account and his distinction between two types of natural kind discoveries. I also draw normative conclusions for credit attribution in science.
Widowers make occasional appearances in Icelandic sagas of the thirteenth and fourteenth centuries and—even though Old Norse did not even have a word for them—they exhibit some distinctive behavioral patterns. This article uses the framework of bereavement studies to examine the interplay of gender, affect, and small-scale politics in the wake of the loss of a wife. It proposes two archetypes of dysfunctional bereaved husband, observable in the medieval Norse world which the sagas describe (ca. 800–1300): the widower on the warpath and the widower on the bridal path. Both followed cultural scripts for widowers’ conduct, but did so imperfectly, in a manner that exposes their society’s constructions of masculinity, its prescriptive family codes, and the clandestine channels linking private emotional turmoil with public socio-political disruption. My typology of maladjusted Norse widowers offers heuristic tools for further study of bereaved husbands in other periods and places, as well as for comparison with bereaved wives and with men in other life-stages.
In the current study, Hebrew norms were collected for a set of 320 colored realistic pictures. Interestingly, participants were adult speakers of Hebrew as a first-language (L1) or as a second-language (L2, native Arabic speakers). Thus, both L1 and L2 norming were compiled. For each picture, participants typed its name, and then rated its visual complexity, familiarity, and typicality on scales of 1–7. To establish the predictive utility of the norms, we examined timed picture-naming performance on a subset of 135 items of the normed pictures. Two groups of participants with Hebrew as an L1 (native Hebrew speakers) or as an L2 (native Arabic speakers), were asked to name each picture as quickly and accurately as possible and their reaction times (RT) and accuracy were recorded. Results showed that norms collected from L1 speakers significantly predicted L1 participants’ picture naming RT and accuracy while controlling for objective lexical characteristics (frequency and length), validating the usefulness of the norms. Critically, these same norms were inefficient in predicting L2 picture naming performance. However, norms collected from L2 speakers were significant predictors of L2 picture naming performance. The study, therefore, carries important general implications for L2 production research based on picture naming tasks.
From the 1890s to the 1920s across the American Midwest, newspapers reported arrests and altercations in ‘Cocaine Alleys’. Not all of these arrests involved people under the influence of drugs, but the term nevertheless became a non-geographic cultural construct highlighting readers’ fears about racialized drug use. By describing low-income Black women as ‘queens’ central to these spaces, newspapers mingled gender, race, criminality and drug use. The ‘Cocaine Alley Queen’ stereotype applied to Black women obscured the reality of White women’s greater propensity to recreational and medical narcotic addiction. As Black migrants moved from Southern states to Northern Midwestern industrialized cities, this reporting trend appeared in cities with higher Black populations than the state average. Newspapers created an intersectional, geographic identity that collected fears and stereotypes about drug use and Black communities when narcotics were accessible, and reformers sought to discipline Black, urban, female working-class bodies and impose middle-class behaviours on them.
This article examines how the labor and community structures of female skin-divers, the Japanese ama and Korean haenyeo, believed to exemplify the primitive ability to adapt to extreme climates, became staple research subjects for global adaptation-resilience science. In the context of development studies, adaptation-resilience discourse has been seen as reflecting the emergence of neoliberal governmentality. In contrast, this article frames adaptation-resilience as a reactionary technological response that emerges in times of scarcity and crisis. This article demonstrates how the discourse can be traced back to interwar Japanese physiologists, who saw themselves as rescuing Japan from the ills of modernity through a socio-biological development program that drew on the diver’s adaptability as a means to create subjects not only capable of surviving extreme deprivation but willing to do so in the service of the community and the state. These scientists and their research were taken up uncritically in the postwar by international science and development organizations, who found in them a shared vision of a labor-intensive and low ecological impact model of community-rooted development that offered a sustainable and healthier alternative to capitalism, one that could help humanity overcome crises of modern excess such as climate change. However, sustainability meant the valorization of absolute austerity as a development goal, ruling out relief for suffering marginalized populations. This article therefore suggests that resiliency-based development entraps its subjects in a regime of self-exploitation that forces them into a constant state of emergency, paradoxically deepening their vulnerability in the process.