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The risk of creating cerebral organoids/assembloids conscious enough to suffer is a recurrent concern in organoid research ethics. On one hand, we should, apparently, avoid discovering how to distinguish between organoids that it would be permissible (non-conscious) and impermissible (conscious) to use in research, since if successful we would create organoids that suffer. On the other, if we do not, the risk persists that research might inadvertently continue to cause organoids to suffer. Moreover, since modeling some brain disorders may require inducing stress in organoids, it is unclear how to eliminate the risk, if we want to develop effective therapies. We are committed to harm avoidance but hamstrung by a presumption that we should avoid research that might tell us clearly when suffering occurs. How can we negotiate this challenge and maximize the therapeutic benefits of cerebral organoid research? The author interrogates the challenge, suggesting a tentative way forward.
Drawing primarily from qualitative interviews conducted between 2017 and 2018, this empirical study tells a granular story of how legal actors mobilised during the Lawyers’ Movement in Pakistan (2007–2009) from the perspective of lawyer-leaders who organised, steered and sustained support for the Movement through rapidly shifting political conditions. By underscoring the contribution of lawyer-leaders in empowering judges, the article seeks both to displace uncritical assumptions and arguments about courts as the nucleus of legal mobilisation in Pakistan, and to highlight the crucial role of political parties in the restoration of the judiciary against the backdrop of disintegrating lawyer-judge coalitions. Given Pakistan’s political context of a ‘hybrid regime’, the article reflects on the unsuitability of the ‘legal complex’ theory of ‘political liberalism’ for analysing and understanding the Movement, and locates it instead in the literature on legal mobilisation in authoritarian regimes.
The Ming court launched its famous expeditions overseas in the early fifteenth century and suddenly terminated these voyages after 1436. This article attempts to reassess the driving force of this event and its termination in the context of the Ming's domestic financial system, revealing that both the initiation and the cessation of Zheng He's voyages could be explained by the political and fiscal tension between emperors and bureaucrats. This article will also discuss how the cessation of Zheng He's voyages contributed to the onset of private sailings after the mid-fifteenth century.
The Buddhist doctrine of transmigration (saṃsāra) offers a coherent model of a cycle of existence wherein a sentient being continues throughout life, survives death, traverses the afterlife, and is, sooner or later, reborn, thus inaugurating another lifecycle as a new life-form. The Buddhist tenets of no-self (anātman) and impermanence, however, deny the possibility of a self, soul, or any form of spiritual substance that persists throughout the cycle of transmigration. This article examines the argumentation developed by the Indic Buddhist philosopher, Saṅghabhadra (fl. fifth- century ce), as part of his effort to reconcile the doctrines of no-self and karmic continuity. In his *Nyāyānusāraśāstra and the *Samayapradīpikāśāstra, two seminal, yet vastly understudied, doctrinal treatises of Sarvāstivāda Abhidharma Buddhism that survive only within the translation corpus of the Sinitic scholar-monk Xuanzang (602?–664 ce), Saṅghabhadra defines the antarābhava, the ‘intermediate state of existence’, as the interstitial space and interim time-period existing between the locus wherein the sequentially reproducing psychic constituents of an individual sentient being, including consciousness, desert the no-longer viable body at the moment of biological death, and the locus wherein these psychic constituents become associated with a new gross physical body in the form of a new viable embryo at the moment of rebirth. By instantiating the antarābhava as an actual interval with real extension in space and time, necessarily traversed by the vast majority of sentient beings after dying in order to reach the next gross physical body, Saṅghabhadra provides, for Sarvāstivāda Abhidharma Buddhism, a rigorous account for how karma is transmitted, via the psychic constituents of a sentient being, beyond biological death into future lives, as well as future afterlives.
The article uses archival sources to critique the currently dominant etymological approach to the history of the word ’ndrangheta as used to refer to the Calabrian mafia. Scholars such as Paolo Martino and John Trumper have latched onto the word's ancient Greek origins to argue that the mafia organisation that we today call ’Ndrangheta has origins dating back many centuries. Moreover, according to Martino in particular, the flattering connotations of the word ’ndrangheta (courage, martial prowess, manliness) indicate that the ’Ndrangheta as a social phenomenon was rooted in the same positive values, and that it only later degenerated into criminality. This article proposes that the work of Martino and Trumper represents a largely evidence-free extension of etymology into the field of history. Analysing the latest archival evidence about the word from criminal trials conducted in the 1920s and early 1930s, and setting it in the context of current historiography and criminology on the ’Ndrangheta, the article argues that two conclusions about the history of the word are likely: that the use of ’ndrangheta as a name for the Calabrian mafia began at around the time it first appeared in the documentary sources; that the first to adopt it were mafiosi themselves.
As nationalist and populist rhetorics have gained momentum in Central and Southeastern Europe, there is an urgency to disentangle the historical narratives and political agendas displayed by national museum paradigms. And yet, equally significant is the urgency to illuminate the strategies and mnemonic devices through which the past is rendered worthy of commemoration, both in those memory cultures that come to life in opposition, or those which are complementary to the national museum’s paradigms. In line with these considerations, this special issue addresses the vernacular dimension of public memory, with a special focus on those memory cultures instantiated by mnemonic actors who do not necessarily possess the public epistemic authority to materialize their narratives about violent pasts as official memories.
In Preference, Value, Choice, and Welfare, I argued, among other things, that preferences in economics are and ought to be total subjective comparative evaluations, that the theory of rational choice is a reformulation of everyday folk-psychological explanations and predictions of behaviour, and that revealed preference theory is completely untenable. All three of these theses have been challenged in essays by Erik Angner (2018), Francesco Guala (2019) and Johanna Thoma (2021a, 2021b). This essay responds to these criticisms and defends these three theses.
Multimodal composing, which has sometimes been referred to synonymously as multimodal composition or multimodal writing, is the use of different semiotic resources (e.g., audio, visual, gestural, and/or spatial resources) in addition to linguistic text for making meaning. Notably, multimodal composing is neither a new type of writing nor a new area of research, with studies dating back to the early 2000s. In the domain of second language (L2) research, Tardy's (2005*) study on multimodal composition in academia was one of the earliest to bring attention to the nonlinguistic features of L2 written output. Even after this pioneering study, in the few years that followed, only a handful of studies further explored aspects of L2 learners’ multimodal compositions. However, over the past decade, the fields of applied linguistics and second language acquisition (SLA) have witnessed an explosion of interest in both its study and classroom applications, with teachers’ adoption of multiple modes becoming an indispensable part of their pedagogical toolkits (e.g., Kessler, 2022; Li, 2021; Zhang et al., 2021).
This article reinterprets the tension between sound and music in Pierre Schaeffer's 1966 Treatise on Musical Objects. Schaeffer famously insisted that the Treatise did not address music or composition; scholars have therefore engaged with it primarily as a theoretical text on sound and listening. In this article, however, I argue that the denial and deferral of music throughout the Treatise should be considered a discrete and key part of its theoretical contributions. By the early 1960s, Schaeffer's aesthetic frustration with the practice of musique concrète had blossomed into something of an ethical imperative and paradox. He saw it necessary to suspend all musical activity in the present, so as to salvage music's future. This dynamic is key to understanding Schaeffer's controversial and influential calls for the deferral of cultural responses to sound in the Treatise, as illustrated by the practices of ‘deconditioning’ and ‘reconditioning’.
This article explores how complaint investigations undertaken by health ombudsman contribute to the improvement of the healthcare system. Using a qualitative case-study approach, semi-structured interviews were conducted with participants form the Scottish Public Services Ombudsman (SPSO) and three health boards within its jurisdiction. Health board participants were frustrated by complaints process used by the SPSO, in particular the lack of communication during an SPSO investigation especially when there were differences in clinical judgment. Using Braithwaite’s typologies of motivational postures and Hertogh’s models of administrative control it was found that a sense of capitulation was the primary determinant in ensuring health board compliance with SPSO recommendations and that the relationship between SPSO and health boards was predominantly coercive in nature. For the SPSO to be more effective in contributing to system improvement requires it to review its role and means of conducting complaint investigations.
The environmental assessment literature has neglected the distorting effect of cognitive and unconscious motivational biases (CUMB) in environmental assessment processes. This is problematic because CUMB are present in most, if not all, decision-making situations and can significantly distort decision-making processes. This article assesses how debiasing techniques are, or should be, incorporated in (supra)national environmental assessment legislation. The Dutch case study undertaken for this article shows that EU and Dutch legislation do not sufficiently incorporate debiasing techniques to ensure sound environmental decision making. Furthermore, the extent to which Dutch legislation incorporates debiasing techniques was found to be decreasing. Based on these findings, the article presents ways to incorporate debiasing techniques in environmental assessment legislation more generally, and in EU and Dutch legislation in particular.
The present article reflects on the concept of ‘spatial repertoire’ through a ‘trans’-perspective in order to explain the trans-formation of migrants’ homescapes during the pandemic—a time of restricted mobility. In the context of translocal im~mobility, this ethnographically informed multiple case study explores how three Greek ‘brain drain’ immigrants performed homescapes in the online-offline nexus from October to February 2020. Employing a critical discourse analytic approach, the findings showcase the pandemic biopolitics that have resulted in the de/reterritorialisation of everyday sociospatial activities, thus creating heterotopic places within the home. Specifically, the integration of work and political activity into the homescape has led to the resemiotisation of the linguistic landscape of homes and the dissolution of boundaries between ‘named’ spaces in homes. The concept of ‘transpatial repertoire’ captures the hybridisation of the pandemic-affected homescape, taking into consideration the vulnerabilities and emergent resistances to biopolitical control. In other words, it sheds light on the emergent heterotopias of im~mobility. (Pandemic, heterotopia, transpatial repertoire, linguistic landscape, homescape)*