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South Asia's economies, as well as the scholarship on their economic histories, have been transformed in recent decades. This landmark new reference history will guide economists and historians through these transformations in Bangladesh, India and Pakistan. Part I revisits the colonial period with fresh perspectives and updated scholarship, incorporating recent research on topics such as gender, caste, environment, and entrepreneurship. The contributors highlight the complex and diverse experiences of different groups to offer a more nuanced understanding of the past. Part II focuses on economic and social changes in South Asia over the last seventy-five years, offering a comprehensive view of the region's historical trajectory. Together, the contributions to this volume help to reassess the impact of colonialism through a more informed lens, as well as providing analysis of the challenges and progress made since independence.
This book bridges the gap between theoretical machine learning (ML) and its practical application in industry. It serves as a handbook for shipping production-grade ML systems, addressing challenges often overlooked in academic texts. Drawing on their experience at several major corporations and startups, the authors focus on real-world scenarios, guiding practitioners through the ML lifecycle, from planning and data management to model deployment and optimization. They highlight common pitfalls and offer interview-based case studies from companies that illustrate diverse industrial applications and their unique challenges. Multiple pathways through the book allow readers to choose which stage of the ML development process to focus on, as well as the learning strategy ('crawl,' 'walk,' or 'run') that best suits the needs of their project or team.
Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infections, poses a critical threat. Cardiac surgery itself induces a robust inflammatory response, further exacerbated by cardiopulmonary bypass, causing notable clinical and physiological changes. Identifying sepsis early in the post-operative period with elevated septic markers becomes challenging, with delayed antibiotic intervention ultimately posing a fatal risk for the patient.
Methods:
We performed a prospective observational cross-sectional study aimed at identifying sepsis markers that include total leucocyte count, absolute neutrophil count, platelet count, serum albumin, chest X-ray, blood, urine, and tracheal cultures, procalcitonin, c-reactive protein, serum lactate >2.5 mmol/l along with clinical parameters (fever, hypotension, tachycardia) on post-operative days 1, 3, 5, and 10 in paediatric patients undergoing cardiac surgery with prolonged cardiopulmonary bypass time >100 min.
Results:
Total leucocyte count, absolute neutrophil count, and platelet counts were not significant enough to detect early sepsis, especially in patients with prolonged cardiopulmonary bypass time. Chest X-ray was significant from post-operative day 3 onwards. Procalcitonin was significant from day 5, and C-reactive protein was significant only from day 10. Among the clinical parameters, fever, hypotension, tachycardia, and elevated lactate levels were significant from post-operative day 1 in the patients developing sepsis.
Conclusion:
Neonates and infants faced a higher sepsis risk than older children. Longer cardiopulmonary bypass and aortic clamp times correlated with increased sepsis likelihood. Clinical factors outweighed laboratory indicators for early sepsis detection post-cardiac surgery, prompting prompt investigation and intervention.
Recent decades have seen a renewal of interest in panpsychism as a solution to the hard problem of consciousness. This has, in part, also driven an increase in interest in classical Indian philosophical traditions among analytic philosophers of mind. Many of these cross-cultural studies pertaining to panpsychism (and cosmopsychism) have focused on one particularly influential school of Indian philosophy, Advaita (non-dual) Vedānta, the most famous proponent of which is Śaṅkara. In this work, we would like to consider the view of another influential philosopher and the school that developed based on his view – Rāmānuja (eleventh century CE) and Viśiṣṭādvaita (qualified non-dualism) Vedānta. We argue that a cosmopsychist-panentheistic metaphysics that is motivated by Rāmānuja’s views offers a solution to the hard problem that is preferable to other comparable views and could form the basis for a panentheistic conception of God that is compatible with the reality of the freedom of human selves.
Model theory has made substantial contributions to semialgebraic, subanalytic, p-adic, rigid and diophantine geometry. These applications range from a proof of the rationality of certain Poincare series associated to varieties over p-adic fields, to a proof of the Mordell-Lang conjecture for function fields in positive characteristic. In some cases (such as the latter) it is the most abstract aspects of model theory which are relevant. This book, originally published in 2000, arising from a series of introductory lectures for graduate students, provides the necessary background to understanding both the model theory and the mathematics behind these applications. The book is unique in that the whole spectrum of contemporary model theory (stability, simplicity, o-minimality and variations) is covered and diverse areas of geometry (algebraic, diophantine, real analytic, p-adic, and rigid) are introduced and discussed, all by leading experts in their fields.
The turbulent boundary layer (TBL) development over an air cavity is experimentally studied using planar particle image velocimetry. The present flow, representative of those typically encountered in ship air lubrication, resembles the geometrical characteristics of flows over solid bumps studied in the literature. However, unlike solid bumps, the cavity has a variable geometry inherent to its dynamic nature. An identification technique based on thresholding of correlation values from particle image correlations is employed to detect the cavity. The TBL does not separate at the leeward side of the cavity owing to a high boundary layer thickness to maximum cavity thickness ratio ($\delta /t_{max}= 12$). As a consequence of the cavity geometry, the TBL is subjected to alternating streamwise pressure gradients: from an adverse pressure gradient (APG) to a favourable pressure gradient and back to an APG. The mean streamwise velocity and turbulence stresses over the cavity show that the streamwise pressure gradients and air injection are the dominant perturbations to the flow, with streamline curvature concluded to be marginal. Two-point correlations of the wall-normal velocity reveal an increased coherent extent over the cavity and a local anisotropy in regions under an APG, distinct from traditional APG TBLs, suggesting possible history effects.
Many hypersonic flows of interest feature high free-stream stagnation enthalpies, which lead to high flow-field temperatures and thermochemical non-equilibrium (TCNE) effects, such as finite-rate chemistry and vibrational excitation. However, very few studies have considered receptivity for high-enthalpy flows. In this paper, we investigate the receptivity of a high-enthalpy Mach 5 straight-cone boundary layer to slow and fast acoustic free-stream waves using direct numerical simulation alongside linear stability theory and the linear parabolised stability equations. In addition, we investigate the TCNE effect on receptivity by comparing results between the TCNE gas model and a thermochemically frozen gas model. The dominant instability mechanism for this flow configuration is found to be Mack’s second mode, with the unstable mode being the fast mode. Second-mode receptivity coefficients are obtained for a number of frequencies. For free-stream slow acoustic waves, these receptivity coefficients are found to generally increase with frequency. For a small subset of the considered frequency range, the receptivity coefficients corresponding to free-stream fast acoustic waves are found to be several times larger than for free-stream slow acoustic waves. The TCNE effects are found to lead to higher peak $N$-factors while also reducing second-mode receptivity coefficients, indicating that TCNE effects have competing impacts on receptivity versus stability for the considered frequencies.
The motion of several plates in an inviscid and incompressible fluid is studied numerically using a vortex sheet model. Two to four plates are initially placed in line, separated by a specified distance, and actuated in the vertical direction with a prescribed oscillatory heaving motion. The vertical motion induces the plates’ horizontal acceleration due to their self-induced thrust and fluid drag forces. In certain parameter regimes, the plates adopt equilibrium ‘schooling modes’, wherein they translate at a steady horizontal velocity while maintaining a constant separation distance between them. The separation distances are found to be quantised on the flapping wavelength. As either the number of plates increases or the flapping amplitude decreases, the schooling modes destabilise via oscillations that propagate downstream from the leader and cause collisions between the plates, an instability that is similar to that observed in recent experiments on flapping wings in a water tank (Newbolt et al., 2024, Nat. Commun., vol. 15, 3462). A simple control mechanism is implemented, wherein each plate accelerates or decelerates according to its velocity relative to the plate directly ahead by modulating its own flapping amplitude. This mechanism is shown to successfully stabilise the schooling modes, with remarkable impact on the regularity of the vortex pattern in the wake. Several phenomena observed in the simulations are obtained by a reduced model based on linear thin-aerofoil theory.
This paper elaborates the design and analysis of cross-aperture-coupled twin port ceramic radiator. Stimulation of alumina ceramic using a cross slot helps to produce circular waves within 7.35–7.8 GHz. The polarization diversity concept helps to improve the separation level by above 25 dB. Loading of double negative unit cell made metasurface (MS) improves the antenna gain over 11.5 dBi within the working spectrum. Machine learning (ML) techniques, i.e. Decision Tree and Random Forest are utilized to predict the |S11|/Axial ratio parameters. Experimental verification/ML prediction and optimized simulated consequences confirm that the structured radiator works efficiently between 7.21 and 8.2 GHz with over 25 dB isolation between the ports. Directive pattern and decent values of (MIMO) parameters make the radiator applicable for the 6G communication system.
One-third of schizophrenia patients show a lack of response to conventional antipsychotic drugs because of adverse effects and limited efficacy. Emerging treatments target muscarinic and nicotinic receptors, leveraging cholinergic dysfunction implicated in the pathophysiology of schizophrenia.
Aims
To evaluate the efficacy and safety of cholinergic modulators in schizophrenia.
Methods
Reviewers extracted data from clinical trials sourced via MEDLINE/PubMed, Embase, Scopus, Cochrane databases and registries. Quality was assessed with a risk-of-bias tool and a random-effects model estimated effect size. Subgroup analysis, meta-regression and sensitivity analysis were performed as needed, adhering to PRISMA guidelines.
Results
A total of 30 randomised controlled trials (3128 participants) tested cholinergic modulators as monotherapy or adjunct therapy. They did not significantly improve Positive and Negative Syndrome Scale (PANSS) total scores (standardised mean difference (SMD): −0.38; 95% CI: −0.93, 0.18; moderate certainty evidence) but did improve negative symptom scores (SMD: −0.42; 95% CI: −0.59, −0.25; moderate certainty evidence). Muscarinic agonists improved total (SMD: −0.57; 95% CI: −0.72, −0.42), positive (SMD: −0.58; 95% CI: −0.73, −0.43) and negative symptoms of PANSS (SMD: −0.40; 95% CI: −0.59, −0.21), as well as Clinical Global Impression-severity (CGI-S) (SMD: −0.48; 95% CI: −0.65, −0.31). Nicotinic agonists aided negative symptoms (SMD: −0.28; 95% CI: −0.47, −0.09) and CGI-S (SMD: −1.31; 95% CI: −2.38, −0.24). Adverse events were higher (odds ratio: 1.21; 95% CI: 0.94, 1.56) in the experimental group.
Conclusion
Cholinergic modulators significantly improve negative symptoms, with muscarinic agonists showing improvement across symptom domains and severity, without notable differences in adverse effects from placebo. Most studies were at low bias risk; evidence quality ranged from very low to moderate.
We perform direct numerical simulations of sub-Kolmogorov, inertial spheroids settling under gravity in homogeneous, isotropic turbulence, and find that small-scale clustering, measured via the correlation dimension, depends sensitively on the spheroid aspect ratio. In particular, such spheroids are shown to cluster more as their anisotropy increases. Further, the approach rate for pairs of spheroids is calculated and found to deviate significantly from the spherical-particle limit. Our study, spanning a range of Stokes numbers and aspect ratios, provides critical inputs for developing collision models to understand the dynamics of sedimenting, anisotropic particles in general, and ice crystals in clouds in particular.
Bone-conduction hearing devices provide good hearing outcomes for conductive/mixed hearing losses. Complications post-insertion can lead to additional procedures. Identifying factors that may increase likelihood of developing complications can mitigate risk and inform patients.
Method
A retrospective cohort analysis of 166 adults receiving bone-anchored hearing aid connect operations from 2016–2021 was performed assessing complication rate and contributing factors causing revision procedures.
Results
Twenty-nine per cent of patients had post-operative complications. In total, 17.5 per cent needed additional procedures. Skin overgrowth/infection, granulation and traumatic extrusion were most common reasons. No difference was found in complication rate between different surgical techniques, surgeon grade or general versus local anaesthetic. More complications were observed in decreasing age, male gender and severity of skin reaction.
Conclusion
Revision procedure and complication rates are similar to those reported in published literature. Patient characteristics are important in identifying those likely to develop complications. Non-patient factors did not seem to affect complication rate.
Various factors are considered when designing a floorplan layout, including the plan’s outer boundary, room shape and size, adjacency, privacy, and circulation space, among others. While graph-theoretic approaches have proven effective for floorplan generation, existing algorithms generally focus on defining the boundary of the plan or different room shapes, lacking the investigation of designing circulation space within a floorplan. However, the circulation design in architectural planning is a crucial factor that affects the functionality and efficiency of areas within a building. This paper presents a graph-theoretic approach for integrating circulation within a floorplan. In this study, we use plane graphs to represent floorplans and develop graph algorithms to incorporate various types of circulation within a floorplan as follows:
i. The first phase generates a spanning circulation, that is, a corridor leading to each room using a circulation graph.
ii. Subsequently, using an approximation algorithm, the circulation space is minimized, that is, generation of minimum circulation space covering all the rooms, thereby enhancing space utilization in the floorplan.
iii. Furthermore, customized circulations are generated to cater to user preferences, distinguishing between public and private spaces within the floorplan.
In addition to the theoretical framework, we have implemented our algorithms in Python and developed a user-friendly graphical interface (GUI), enabling seamless integration of our algorithms into architectural design processes.
We extend a comparison theorem of Anandavardhanan–Borisagar between the quotient of the induction of a mod $p$ character by the image of an Iwahori–Hecke operator and compact induction of a weight to the case of the trivial character. This involves studying the corresponding non-commutative Iwahori–Hecke algebra. We use this to give an Iwahori theoretic reformulation of the (semi-simple) mod $p$ local Langlands correspondence discovered by Breuil and reformulated functorially by Colmez. This version of the correspondence is expected to have applications to computing the mod $p$ reductions of semi-stable Galois representations.
Whole genome sequencing (WGS) can help identify transmission of pathogens causing healthcare-associated infections (HAIs). However, the current gold standard of short-read, Illumina-based WGS is labor and time intensive. Given recent improvements in long-read Oxford Nanopore Technologies (ONT) sequencing, we sought to establish a low resource approach providing accurate WGS-pathogen comparison within a time frame allowing for infection prevention and control (IPC) interventions.
Methods:
WGS was prospectively performed on pathogens at increased risk of potential healthcare transmission using the ONT MinION sequencer with R10.4.1 flow cells and Dorado basecaller. Potential transmission was assessed via Ridom SeqSphere+ for core genome multilocus sequence typing and MINTyper for reference-based core genome single nucleotide polymorphisms using previously published cutoff values. The accuracy of our ONT pipeline was determined relative to Illumina.
Results:
Over a six-month period, 242 bacterial isolates from 216 patients were sequenced by a single operator. Compared to the Illumina gold standard, our ONT pipeline achieved a mean identity score of Q60 for assembled genomes, even with a coverage rate as low as 40×. The mean time from initiating DNA extraction to complete analysis was 2 days (IQR 2–3.25 days). We identified five potential transmission clusters comprising 21 isolates (8.7% of sequenced strains). Integrating ONT with epidemiological data, >70% (15/21) of putative transmission cluster isolates originated from patients with potential healthcare transmission links.
Conclusions:
Via a stand-alone ONT pipeline, we detected potentially transmitted HAI pathogens rapidly and accurately, aligning closely with epidemiological data. Our low-resource method has the potential to assist in IPC efforts.
Experiments were conducted to assess the impact of crown architecture on light availability beneath the trees, flowering, fruiting, yield and quality of jamun (Syzygium cumini [L.] Skeels). Trees were maintained as control, palmette and open centre crown. Impact was evaluated for three consecutive years, i.e. 2017–2019. Diffuse light beneath the trees ranged from 69.7 ± 2.22 to 45.9 ± 1.45%, whereas direct light varied from 30.4 ± 0.97 to 54.1 ± 1.78%. At flowering and fruit development stage (June), photosynthesis rate (A) in control trees was 12.5 ± 0.43 μmol CO2/m2/s; however, at fruit maturity and dormancy (August), it was only 9.5 ± 0.35 μmol CO2/m2/s. Similarly, in palmette and open centre trees, photosynthesis rate at flowering and fruit development stage was 13.5 ± 0.46 and 15.7 ± 0.54 μmol CO2/m2/s, respectively; whereas at fruit maturity and dormancy, photosynthesis rate dropped to 10.5 ± 0.39 and 11.7 ± 0.43 μmol CO2/m2/s, respectively. Substantial variation in stomatal conductance (gs), vapour pressure deficit (VPD) and transpiration rate (E) was also found. Days to start flowering ranged from 92 ± 0.33 to 98 ± 0.33. Similarly, days to end flowering varied from 99 ± 0.07 to 107 ± 0.36, days to fruit set 132 ± 0.33 to 139 ± 0.33 and days to fruit maturity 176 ± 0.48 to 184 ± 0.63. Significant variation in fruit length, fruit width and fruit weight was also found. Total soluble solids in fruit pulp varied from 9.0 ± 0.15 to 12.2 ± 0.149°Brix and fruit yield 62.3 ± 1.5 to 86.7 ± 1.33 kg per tree. Noteworthy variation in fruit quality traits was also recorded. This study illustrates that crown architecture has considerable impact on gas exchange parameters, flowering, fruiting, yield and quality of jamun.