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Soil health refers to the ongoing ability of soil as a living ecosystem to maintain environmental quality, support crop productivity, and ensure human health. Evaluating and enhancing soil health is crucial for ensuring more productive and resilient agricultural systems. The aim of this work is to assess soil health using both on-farm and computational methods. The study was carried out on a slope with textural variation at Ponta Grossa–Paraná State, Brazil. The slope was divided into three segments based on altitude and clay content: upper, middle, and lower positions. In each segment, twenty points were sampled, resulting in a total of sixty points along the slope. Soil health was analysed at these points by visual evaluation of soil structure (VESS), and samples were also collected to use the Soil Management Assessment Framework (SMAF) approach in the 0–0.10 m and 0.10–0.20 m soil layers. The indicators used in this approach were soil organic carbon, macroaggregates, bulk density, water-filled pore space, pH, phosphorus, and potassium. The data were analysed using analysis of variance, mean comparison with Tukey’s test (p < 0.05). In addition, principal component analysis was performed on the soil health index (SHI) and its components (chemical, physical, and biological) with clay content and VESS scores. The study discovered that the upper position had the highest clay content, lower visual scores (2.44), and a higher SHI (up to 0.80) compared to the middle (3.7 and 0.78) and lower positions (2.9 and 0.73). This study highlights the significant influence of soil texture, particularly clay content, on soil structural quality and health as assessed by VESS and SMAF. Higher clay content improved soil aggregation and health, while lower clay content in the middle and lower slope positions resulted in poorer structure. VESS proved to be an effective field-based tool for rapid assessment of soil health, complementing the more detailed SMAF framework. The integration of both methods is essential for the development of adaptive and sustainable soil management strategies.
We present the serendipitous radio-continuum discovery of a likely Galactic supernova remnant (SNR) G305.4–2.2. This object displays a remarkable circular symmetry in shape, making it one of the most circular Galactic SNRs known. Nicknamed Teleios due to its symmetry, it was detected in the new Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio–continuum images with an angular size of 1 320$^{\prime\prime}$$\times$1 260$^{\prime\prime}$ and PA = 0$^\circ$. While there is a hint of possible H$\alpha$ and gamma-ray emission, Teleios is exclusively seen at radio–continuum frequencies. Interestingly, Teleios is not only almost perfectly symmetric, but it also has one of the lowest surface brightnesses discovered among Galactic SNRs and a steep spectral index of $\alpha$=–0.6$\pm$0.3. Our best estimates from Hi studies and the $\Sigma$–D relation place Teleios as a type Ia SNR at a distance of either $\sim$2.2 kpc (near-side) or $\sim$7.7 kpc (far-side). This indicates two possible scenarios, either a young (under 1 000 yr) or a somewhat older SNR (over 10 000 yr). With a corresponding diameter of 14/48 pc, our evolutionary studies place Teleios at the either early or late Sedov phase, depending on the distance/diameter estimate. However, our modelling also predicts X-ray emission, which we do not see in the present generation of eROSITA images. We also explored a type Iax explosion scenario that would point to a much closer distance of $\lt$1 kpc and Teleios size of only $\sim$3.3 pc, which would be similar to the only known type Iax remnant SN1181. Unfortunately, all examined scenarios have their challenges, and no definitive Supernova (SN) origin type can be established at this stage. Remarkably, Teleios has retained its symmetrical shape as it aged even to such a diameter, suggesting expansion into a rarefied and isotropic ambient medium. The low radio surface brightness and the lack of pronounced polarisation can be explained by a high level of ambient rotation measure (RM), with the largest RM being observed at Teleios’s centre.
Background: Tenecteplase is a genetically-modified variant of the tissue plasminogen activator alteplase, with increased fibrin-specificity, administered as a more convenient intravenous bolus. Recent data, from the AcT trial, have shown tenecteplase to be non-inferior to alteplase in patients with acute ischemic stroke (AIS) treated within 4.5 hours from symptom onset, the direction of effect favoring tenecteplase. As a result, the Heart and Stroke Foundation of Canada has added tenecteplase to the Stroke Best Practice Recommendations. However, its cost-effectiveness in the Canadian setting remains unknown. Methods: An analysis was performed to estimate the cost-effectiveness of tenecteplase compared to alteplase in the AIS population. The model structure combines a decision tree for the first 90 days post index stroke, where the 7 modified Rankin Scale (mRS) states are informed by the AcT trial, and a Markov model for the remainder of the lifetime horizon. Cost and utility values were derived from the literature and public sources. Canadian health care system and hospital perspectives were used. Results: This economic analysis demonstrates that tenecteplase is dominant compared to alteplase, providing more quality-adjusted life years at lower costs. Conclusions: Adding tenecteplase to hospital formularies for AIS would generate savings for the health care system while providing more benefits.
Herbaceous perennials must annually rebuild the aboveground photosynthetic architecture from carbohydrates stored in crowns, rhizomes, and roots. Knowledge of carbohydrate utilization and storage can inform management decisions and improve control outcomes for invasive perennials. We monitored the nonstructural carbohydrates in a population of the hybrid Bohemian knotweed [Polygonum ×bohemicum (J. Chrtek & Chrtková) Zika & Jacobson [cuspidatum × sachalinense]; syn.: Fallopia ×bohemica (Chrtek and Chrtková) J.P. Bailey] and in Japanese knotweed [Polygonum cuspidatum Siebold & Zucc.; syn.: Fallopia japonica (Houtt.) Ronse Decr.]. Carbohydrate storage in crowns followed seasonal patterns typical of perennial herbaceous dicots corresponding to key phenological events. Starch was consistently the highest nonstructural carbohydrate present. Sucrose levels did not show a consistent inverse relationship with starch levels. Lateral distribution of starch in rhizomes and, more broadly, total nonstructural carbohydrates sampled before dormancy break showed higher levels in rhizomes compared with crowns. Total nonstructural carbohydrate levels in crowns reached seasonal lows at an estimated 22.6% of crown dry weight after accumulating 1,453.8 growing degree days (GDD) by the end of June, mainly due to depleted levels of stored starch, with the estimated minimum of 12.3% reached by 1,220.3 GDD accumulated by mid-June. Depletion corresponded to rapid development of vegetative canopy before entering the reproductive phase in August. Maximum starch accumulation in crowns followed complete senescence of aboveground tissues by mid- to late October. Removal of aboveground shoot biomass in late June to early July with removal of vegetation regrowth in early September before senescence would optimize the use of time and labor to deplete carbohydrate reserves. Additionally, foliar-applied systemic herbicide translocation to belowground tissue should be maximized with applications in late August through early fall to optimize downward translocation with assimilate movement to rebuild underground storage reserves. Fall applications should be made before loss of healthy leaf tissue, with the window for control typically ending by late September in Minnesota.
Compulsive cleaning is a characteristic symptom of a particular subtype of obsessive–compulsive disorder (OCD) and is often accompanied by intense disgust. While overgeneralization of threat is a key factor in the development of obsessive–compulsive symptoms, previous studies have primarily focused on fear generalization and have rarely examined disgust generalization. A systematic determination of the behavioral and neural mechanisms underlying disgust generalization in individuals with contamination concern is crucial for enhancing our understanding of OCD.
Method
In this study, we recruited 27 individuals with high contamination concerns and 30 individuals with low contamination concerns. Both groups performed a disgust generalization task while undergoing functional magnetic resonance imaging (fMRI).
Results
The results revealed that individuals with high contamination concern had higher disgust expectancy scores for the generalization stimulus GS4 (the stimulus most similar to CS+) and exhibited higher levels of activation in the left insula and left putamen. Moreover, the activation of the left insula and putamen were positively correlated with a questionnaire core of the ratings of disgust and also positively correlated with the expectancy rating of CS+ during the generalization stage.
Conclusion
Hyperactivation of the insula and putamen during disgust generalization neutrally mediates the higher degree of disgust generalization in subclinical OCD individuals. This study indicates that altered disgust generalization plays an important role in individuals with high contamination concerns and provides evidence of the neural mechanisms involved. These insights may serve as a basis for further exploration of the pathogenesis of OCD in the future.
The Lyman alpha (Ly$\alpha$) forest in the spectra of $z\gt5$ quasars provides a powerful probe of the late stages of the epoch of reionisation (EoR). With the recent advent of exquisite datasets such as XQR-30, many models have struggled to reproduce the observed large-scale fluctuations in the Ly$\alpha$ opacity. Here we introduce a Bayesian analysis framework that forward-models large-scale lightcones of intergalactic medium (IGM) properties and accounts for unresolved sub-structure in the Ly$\alpha$ opacity by calibrating to higher-resolution hydrodynamic simulations. Our models directly connect physically intuitive galaxy properties with the corresponding IGM evolution, without having to tune ‘effective’ parameters or calibrate out the mean transmission. The forest data, in combination with UV luminosity functions and the CMB optical depth, are able to constrain global IGM properties at percent level precision in our fiducial model. Unlike many other works, we recover the forest observations without invoking a rapid drop in the ionising emissivity from $z\sim7$ to 5.5, which we attribute to our sub-grid model for recombinations. In this fiducial model, reionisation ends at $z=5.44\pm0.02$ and the EoR mid-point is at $z=7.7\pm0.1$. The ionising escape fraction increases towards faint galaxies, showing a mild redshift evolution at fixed UV magnitude, $M_\textrm{UV}$. Half of the ionising photons are provided by galaxies fainter than $M_\textrm{UV} \sim -12$, well below direct detection limits of optical/NIR instruments including $\textit{ JWST}$. We also show results from an alternative galaxy model that does not allow for a redshift evolution in the ionising escape fraction. Despite being decisively disfavoured by the Bayesian evidence, the posterior of this model is in qualitative agreement with that from our fiducial model. We caution, however, that our conclusions regarding the early stages of the EoR and which sources reionised the Universe are more model-dependent.
Despite many reports of similar effectiveness between oral and intravenous antibiotics for bone and joint infections, prescribing practice has been slow to change in the United States. We sought to determine if implementing an intravenous-to-oral treatment guideline could increase prescribing of oral antibiotic regimens at our center.
Design:
Retrospective, quasi-experimental study.
Setting:
Single US academic medical center.
Patients:
Patients with bone or joint infections managed by Infectious Disease providers from September 2020 to December 2022.
Intervention:
An intravenous-to-oral treatment guideline for patients with bone and joint infections.
Methods:
The prescribing rates of fully oral antibiotic regimens before and after implementation of the guideline were compared. Additionally, variables independently associated with oral antibiotic prescribing were identified by logistic regression.
Results:
There were 450 patients included: 213 before and 237 after implementation of the guideline. Oral antibiotic prescribing significantly increased following implementation of the treatment guideline to 59% from 33% of patients (difference 25.8%, 95% CI [16.7%, 34.4%]. In multivariable analysis, the post-intervention phase was associated with a significantly greater likelihood of oral antibiotic prescribing (aOR 2.89 [1.90, 4.45]). Other variables independently associated with oral antibiotic prescribing included male sex (aOR 1.88 [1.20, 2.98]), prosthetic joint infection (aOR 0.29 [0.17, 0.47]), and infection with Enterobacterales (aOR 2.86 [1.45, 5.92]), methicillin-sensitive Staphylococcus aureus [aOR 0.41 [0.26, 0.65]), or coagulase-negative staphylococci (aOR 0.34 [0.18, 0.62]).
Conclusions:
Implementation of a treatment guideline resulted in a significant increase in oral antibiotic prescribing. Antimicrobial stewardship programs should implement similar interventions to improve outpatient antibiotic utilization.
Economic agents often have to make decisions in environments affected by regime switches but expectation formation has hardly been explored in this context. We report about a laboratory experiment whose participants judgmentally forecast three time series subject to regime switches. The participants make forecasts without context knowledge and without support from statistical software. Their forecasts are only based on the previous realizations of the time series. Our interest is the explanation of the average forecasts with a simple model, the bounds & likelihood heuristic. In previous studies it was shown that this model can explain average forecasting behavior very well given stable and stationary time series. We find that the forecasts after a structural break are characterized by a higher variance and less accuracy over several periods. Considering this transition phase in the model, the heuristic performs even slightly better than the Rational Expectations Hypothesis.
Which inequalities among individuals are considered unjust? This paper reports the results of an experiment designed to study distributive choices dealing with arbitrarily unequal initial endowments. In a three-person distribution problem where subjects either know or do not know their endowments, we find impartial behavior to be a stable pattern. Subjects either compensate for initial inequalities fully or not at all in both conditions, and they do so more often when they do not know their endowment than when they know it. Moreover, the type and the size of the good to be distributed also affect the frequency of impartial behavior.
This paper focuses on the developmental tendencies and mechanisms underlying the unfolding of mood systems in Romance complement clauses. In view of the fact that the subsequent dynamics of change can be better understood and motivated against the backdrop of the Latin system, we take the basic structure of the Latin mood system as the reference and necessary starting point of our analysis. After briefly discussing the basic approaches to the mechanisms of mood change in the relevant research literature that puts forward notions like ‘modal harmony’, ‘regrammation’, ‘lexicalization’, and ‘conventionalization’, the article develops a modal–semantic perspective that casts a different light on the convergent and divergent developments of mood in the complement clause domain of Romance languages. The modal–semantic approach allows, apart from a coherent description and analysis of the developments, recasting the question of whether mood, especially the subjunctive, also comes with its own semantic value(s) in complement clauses. This modal–semantic approach not only provides a coherent description and analysis of the developments but also allows for a re-examination of the abstract semantics of the subjunctive mood (in complement clauses), spelling out its basic semantic features.
Political Islamism and Islamic reform in East Africa have many strands, but their most salient forms can legitimately be described as populist since they position Muslims in East Africa as ‘little people’ marginalized by a Christian establishment and rhetorically use this opposition for political mobilization (Becker 2006; Loimeier 2011; Mudde 2017). It is also evident that history matters to these populists since they have much to say about historical events. It is harder to decide whether this form of populism should be seen as right-wing or left-wing since it combines calls for economic justice with pronounced gendered inequality and extols political emancipation while remaining vague on its desired political dispensation (Becker 2016; Kresse 2007; Willis and Gona 2013). Moreover, the collective of marginalized Muslim ‘little people’ is internally highly diverse in its religious practices, cultural affiliations, and political views.
This chapter uses a mixture of interviews, sermon recordings, informal conversations, and participant observation to explore how Islamists define a place for Muslims in East Africa's difficult present using claims about the past, historical change, and the future. It examines claims about past greatness and present decline, the dangers and promises of the afterlife, and the difficulty of making futures in this world. While a sense of present hardship and loss of direction is practically omnipresent in this discourse, it contains diverse and sometimes contradictory tropes that different adherents combine flexibly. A distinctive feature is the attention to the domestic realm and gender relations as a site of struggle to live a good life.
This case study, then, seeks to complicate the notion that the appeal of populism lies in its ability to simplify societal problems, which sometimes comes close to suggesting that populism appeals to the simple-minded. It chimes with studies that emphasize tensions and slippages in religious populists’ claims and strategies (Hadiz 2014, 2016, 2018; Baykan 2019; Peker 2019). Populists do strive to use simple oppositions, but since they operate in a messy world, their attempts to simplify tend to create their own complexities. More fundamentally, the tropes of populism work because they can mean different things to different people; because they are polysemous, an effect that has been observed long before the current wave of populist mobilization (Dubow 1995).
The economic burden of migraine is substantial; determining the cost that migraine imposes on the Canadian healthcare system is needed.
Methods:
Administrative data were used to identify adults living with migraine, including chronic migraine (CM) and episodic migraine (EM), and matched controls in Alberta, Canada. One- and two-part generalized linear models with gamma distribution were used to estimate direct healthcare costs (hospitalization, emergency department, ambulatory care, physician visit, prescription medication; reported in 2022 Canadian dollars) of migraine during a 1-year observation period (2017/2018).
Results:
The fully adjusted total mean healthcare cost of migraine (n = 100,502) was 1.5 times (cost ratio: 1.53 [95% CI: 1.50, 1.55]) higher versus matched controls (n = 301,506), with a predicted annual incremental cost of $2,806 (95% CI: $2,664, $2,948) per person. The predicted annual incremental cost of CM and EM was $5,059 (95% CI: $4,836, $5,283) and $669 (95% CI: $512, $827) per person, respectively, compared with matched controls. All healthcare cost categories were greater for migraine (overall, CM and EM) compared with matched controls, with prescription medication the primary cost driver (incremental cost – overall: $1,381 [95% CI: $1,234, $1,529]; CM: $2,057 [95% CI: %1,891, $2,223]; EM: $414 [95% CI: $245, $583] per person per year).
Conclusion:
Persons living with migraine had greater direct healthcare costs than those without. With an estimated migraine prevalence of 8.3%–10.2%, this condition may account for an additional $1.05–1.29 billion in healthcare costs per year in Alberta. Strategies to prevent and effectively manage migraine and associated healthcare costs are needed.
On July 19, 2024, the International Court of Justice (ICJ) rendered an advisory opinion on Legal Consequences Arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, Including East Jerusalem. By votes of 11–4, the Court found that Israel's continued presence in the Occupied Palestinian Territory (OPT) was unlawful and needed to be ended as rapidly as possible. By a 14–1 majority, the Court also found that Israel was obligated to cease all new settlement activities, evacuate existing settlers from the OPT, and make reparation. The ICJ further opined by votes of 12–3 that all states and international organizations were obliged not to recognize as legal the situation arising from Israel's unlawful presence in the OPT, that all states must refrain from giving aid or assistance to the maintenance of that situation, and that the United Nations “should consider the precise modalities” required to bring Israel's unlawful presence in the OPT to an end.
We present a new radio detection from the Australian Square Kilometre Array Pathfinder Evolutionary Map of the Universe (EMU) survey associated with the Reflection Nebula (RN) VdB-80. The radio detection is determined to be a previously unidentified Hii region, now named Lagotis. The RN is located towards Monoceros, centred in the molecular cloud feature known as the ‘Crossbones’. The 944 MHz EMU image shows a roughly semicircular Hii region with an integrated flux density of 30.2$\pm$0.3 mJy. The Hii region is also seen at 1.4 GHz by NRAO VLA Sky Survey (NVSS), yielding an estimated spectral index of 0.65$\pm$0.51, consistent with thermal radio emission. Gaia Data Release 3 (DR3) and Two Micron All Sky Survey (2MASS) data give a distance to the stars associated with the Hii region of $\sim$960 pc. This implies a size of 0.76$\times$0.68($\pm$0.09) pc for the Hii region. We derive an Hii region electron density of the bright radio feature to be 26 cm$^{-3}$, requiring a Lyman-alpha photon flux of $10^{45.6}$ s$^{-1}$, which is consistent with the expected Lyman flux of HD 46060, the B2 ii type star which is the likely ionising star of the region. The derived distance to this region implies that the Crossbones feature is a superposition of two filamentary clouds, with Lagotis embedded in the far cloud.
Rates of psychiatric illness among the child and adolescent population have increased over the past several decades. As social and government agencies work to expand access to mental health treatment, more and more children and adolescents are receiving medications for their symptoms. However, many drugs used in this population are not approved for people under the age of 18, and have not been studied in terms of long-term impact on the developing brain. A significant proportion of these patients receive psychiatric polypharmacy, or the prescription of 2 or more psychotropic agents. This rate has increased from about 8% in 1996 to over 40% in 2005. Factors correlated with polypharmacy include older age, male gender, White race, and low socioeconomic status. Polypharmacy can increase the risk of drug-drug interactions, increase morbidity/mortality through cumulative toxicity, and cause decreased medication adherence.
Study Aims: This study aimed to examine psychiatric polypharmacy specifically among psychiatrically hospitalized patients in a New York City hospital, and to determine the impact of the COVID-19 pandemic.
Methods
This IRB-approved study reviewed the medical records of 1101 child and adolescent patients that were psychiatrically hospitalized between June 1 2018 and November 30 2021 at Mount Sinai Morningside. Sociodemographic and clinical information was collected and analyzed using SPSS.
Results
In this sample, 29.4% of patients received psychotropic polypharmacy. The polypharmacy group contained a higher percentage of males, White patients, and fewer Asian/South Asian patients. They had on average more hospitalizations, a longer hospitalization period, and were more likely to be diagnosed with an impulsive/behavioral disorder, developmental disorder, or bipolar spectrum disorder. The polypharmacy group were twice as likely to receive medication for agitation while hospitalized. A regression model identified positive predictors of polypharmacy as having a history of violence and a higher number of psychiatric hospitalizations. Negative predictors included non-White race. White patients had the highest average number of medications and Asian/South Asian patients had the lowest. No impact of the COVID-19 pandemic was found.
Conclusion
Psychiatric polypharmacy is extremely common in the child and adolescent population that requires psychiatric hospitalization. Increased behavioral needs, such as episodes of violence, as well as greater illness severity, as indicated by greater number of hospitalizations, may be the driving factors behind polypharmacy. Further investigation is indicated to determine other contributing causal factors and to track long-term consequences of psychiatric polypharmacy.
This case discusses a 33-year-old transgender Army Veteran, diagnosed with co-occurring Bipolar Disorder Type 1 (Bipolar I) and Post-Traumatic Stress Disorder (PTSD), both with psychotic features. The patient exhibited recurrent mood swings, delusions, auditory hallucinations, and passive suicidal thoughts. Concurrent symptoms, such as disrupted sleep, irritability, and intrusive thoughts, complicated diagnosis and treatment. The patient’s medical history included migraines, chronic pain, medication-induced seizures, traumatic brain injury (TBI), and Borderline Personality Disorder.
During the assessment, the patient displayed mood fluctuations, cognitive issues, and intermittent tearfulness. They were averse to sedative medications and preferred non-pharmacological approaches. The Alpha-Stim (Cranial Electrical Stimulator – CES) was recommended for anxiety, depression, insomnia, and chronic pain.
Medication options (Aripiprazole, Lurasidone, and Risperidone) were discussed, and the patient chose Aripiprazole. The treatment plan included Dialectical Behavior Therapy for Borderline Personality Disorder and potential polysomnography to evaluate sleep disorders.
This case underscores the management challenges of co-occurring Bipolar I and PTSD with psychotic features, emphasizing the need for further research on their interplay, impact on functioning, and optimal treatments. It also explores CES as a potential intervention for psychosis during mood episodes.