Our objective was to measure the efficacy of ivermectin (IVM) and benzimidazoles (BZ, i.e. fenbendazole and albendazole) in 15 cattle farms in western France and southern Italy. A total of 11 groups were treated with IVM and 11 with BZ. Efficacy was assessed by calculating the percentage of faecal egg count reduction (%FECR) using the pre- and post-treatment arithmetic means. Anthelmintic resistance was considered to be present when the %FECR was <95% and the lower limit of the 95% confidence interval <90%. For IVM, the percentages of FECR ranged from 73% to 100%. Lack of efficacy to IVM was detected in two farms out of four in France, but was not detected in any of the seven farms in Italy. For BZ, the percentages of FECR ranged from 95% to 100%. No case of BZ resistance was detected in the five farms in France and the six farms in Italy.

The history of socialism has, without a doubt, been met with renewed interest in France in recent years. Several publishers have republished nineteenth-century texts (by Proudhon, Saint-Simon, Marx, Jaurès, etc.) and, particularly in the fields of history, philosophy, and political science there have been a series of scholarly research projects following various approaches (including the history of the diversity of Europe's socialist movements). All this is testament to a renewal of scholarly approaches, moving away from the more ideological approaches that had previously been predominant. The fact that this renewed interest comes twenty years after the disappearance of “actually-existing socialism” shows how far approaches have changed from the studies that were being published thirty years ago.

The suitability of a single mid-season targeted selective treatment (TST) for gastrointestinal nematodes control, based on flexible average daily weight gain (ADWG) thresholds, was investigated in 23 groups of first grazing season calves. In each group, animals were weighed three times: before turnout, at mid-season and at housing. Just after the first weighing, each group was divided in two homogenous sub-groups in terms of age, breed and weight, and randomly allocated to one of two sub-groups intented for two different mid-season anthelmintic treatment strategies: (1) a treatment of all calves composing the sub-group (whole-group treatment (WT)) or (2) a targeted selective weight gain-based treatment (TST) of the animals showing an individual pre-treatment ADWG inferior to the mean pre-treatment ADWG of the corresponding WT sub-group. Anthelmintic treatment (levamisole 7.5 mg/kg BW) was performed 3 to 4 months after turnout. At housing, two parasitological parameters (the anti-Ostertagia ostertagi antibody level-Ostertagia optical density ratio (ODR) and the pepsinogen level) and a clinical parameter (the breech soiling score) were assessed at individual level in each group. Then, the high exposed groups to gastrointestinal nematode (GIN) were defined as groups for which untreated animals exhibited a mean Ostertagia ODR ⩾0.7 and among these groups, the ones characterized by high abomasal damage due to Ostertagia for which untreated animals exhibited a mean pepsinogen level ⩾2.5 U Tyr were also identified. Among TST sub-groups, the treatment ADWG thresholds varied from 338 to 941 g/day and the percentage of treated animals from 28% to 75%. Pre- and post-treatment ADWG as well as parasitological and clinical parameters measured at housing were similar between TST and WT sub-groups including the 17 high exposed groups to GIN. Within these 17 groups, the treatment allowed to significantly improve post-treatment ADWG compared with untreated animals. In the six high exposed groups showing mean pepsinogen level ⩾2.5 U Tyr, the average effect of treatment on post-treatment ADWG was the highest and estimated up to 14 kg after a grazing duration of 4 months. In contrast, in six other groups showing mean Ostertagia ODR<0.7 in untreated animals, no effect of treatment was seen suggesting an absence of production losses related to a low level of GIN infection. This study highlighted the suitability of a convenient mid-season TST strategy for first grazing season calves, based on the use of flexible thresholds of ADWG, allowing similar growth compared with a whole-group treatment while keeping a GIN population in refugia.

Recent improvements in archaeomagnetism applied to archaeological baked clay, in France and Bulgaria, are presented in this paper. After reviewing the historical development of the method in France and Bulgaria, and the principles of the method, we present sampling techniques for in situ structures (kilns and hearths) and sets of displaced materials (bricks or tiles). In the analysis protocol, we stress the importance of correcting the magnetic anisotropic effects especially for bricks. We also show how the problem of brittle specimens can be solved by induration. After a review of the published archaeomagnetic data currently available for France and Bulgaria, we present different smoothing techniques applied to data obtained in these countries. Finally, we present the usage of the variation curves of the geomagnetic elements in the past to calculate the archaeomagnetic dates. One of these techniques is based on a Bayesian approach, similar to the case of the dendro-chronological calibration of radiocarbon ages. The main goal of the paper is to highlight for the archaeologists the possibilities of archaeomagnetism for dating purposes and for other problems in archaeology, on the basis of the experience of the laboratories in France and Bulgaria. The developments of selected archaeomagnetic studies in other European countries are quoted and referenced.

With the development of high contrast imaging techniques and instruments, vast efforts have been devoted during the past decades to detect and characterize lighter, cooler and closer companions to nearby stars, and ultimately image new planetary systems. Complementary to other planet-hunting techniques, this approach has opened a new astrophysical window to study the physical properties and the formation mechanisms of brown dwarfs and planets. In this review, I will briefly describe the different observing techniques and strategies used, the main samples of targeted nearby stars, finally the main results obtained so far about exoplanet discoveries characterization of their physical properties, and study of their occurrence and possible formation and evolution mechanisms.

Heat shock protein 90 (HSP90) is a key component of the molecular chaperone complex essential for activating many signalling proteins involved in the development and progression of pathogenic cellular transformation. A Hsp90 gene (BQHsp90) was cloned and characterized from Babesia sp. BQ1 (Lintan), an ovine Babesia isolate belonging to Babesia motasi-like group, by screening a cDNA expression library and performing rapid amplification of cDNA ends. The full-length cDNA of BQHsp90 is 2399 bp with an open reading frame of 2154 bp encoding a predicted 83 kDa polypeptide with 717 amino acid residues. It shows significant homology and similar structural characteristics to Hsp90 of other apicomplex organisms. Phylogenetic analysis, based on the HSP90 amino acid sequences, showed that the Babesia genus is clearly separated from other apicomplexa genera. Five Chinese ovine Babesia isolates were divided into 2 phylogenetic clusters, namely Babesia sp. Xinjiang (previously designated a new species) cluster and B. motasi-like cluster which could be further divided into 2 subclusters (Babesia sp. BQ1 (Lintan)/Babesia sp. Tianzhu and Babesia sp. BQ1 (Ningxian)/Babesia sp. Hebei). Finally, the antigenicity of rBQHSP90 protein from prokaryotic expression was also evaluated using western blot and enzyme-linked immunosorbent assay (ELISA).

Cerebrotendinous xanthomatosis (CTX) is a rare inborn disorder of sterol storage with autosomal recessive inheritance and a variable clinical presentation. We describe two siblings with an early psychiatric presentation of CTX-associated attention-deficit/hyperactivity disorder and oppositional defiant disorder, also associated with a mild intellectual disability and major behavioral impairments. In both cases, treatment with chenodeoxycholic acid improved externalized symptoms and a partial recovery of cognitive impairments was observed. This suggests that CTX is potentially reversible, demonstrating the need for early diagnosis and treatment of this disorder before irreversible neurological lesions can occur.

For very high intensity accelerators, not only beam power but also space charge is a concern. Both aspects should be taken into consideration for any analysis of accelerators aiming at comparing their performances and pointing out the challenging sections. As high beam power is an issue from the lowest energy, careful and exhaustive beam loss predictions have to be done. High space charge implies lattice compactness making the implementation of beam diagnostics very problematic, so a clear strategy for beam diagnostic has to be defined. Beam halo is no longer negligible. Its dynamics is different from that of the core and plays a significant role in the particle loss process. Therefore, beam optimization must take the halo into account and beam characterization must be able to describe the halo part in addition to the core one. This paper presents the advanced concepts and methods for beam analysis, beam loss prediction, beam optimization, beam diagnostic, and beam characterization especially dedicated to very high intensity accelerators. Examples of application of these concepts are given in the case of the IFMIF accelerators.

For a Megawatt class accelerator, classical safety measures may not be sufficient. Precise knowledge of beam loss location and power deposition in the most various scenarios is crucial for the definition of appropriate protection systems. In this work, the case of the Linear IFMIF Prototype Accelerator is studied, where, due to its very high continuous wave beam intensity, the high power part concerns almost the whole accelerator. Beam dynamics simulations are performed to allow the ability to estimate beam losses in all the different situations of the accelerator lifetime: starting from scratch, beam commissioning, tuning or exploration, routine operation, sudden failures. All the results of these studies are given, establishing the catalogue of losses. Recommendations for hot point protection, beam stop speed, beam power limitation are given accordingly.

For the purpose of material studies for future nuclear fusion reactors, the IFMIF deuteron beams present a simultaneous combination of unprecedentedly high intensity (2 × 125 mA CW), power (2 × 5 MW) and space charge. Special considerations and new concepts have been developed in order to overcome these challenges. The global strategy for beam dynamics design of the 40 MeV IFMIF accelerators is presented, stressing on the control of micro-losses, and the possibility of online fine tuning. Start-to-end simulations without and with errors are presented for the prototype accelerator. Considerations about conflicts between halo and emittance minimization are then discussed in this very high space charge context.

In order to investigate further the interest of using the Chilean gene pool in potato breeding programmes, the genetic diversity and population structure of a collection of Solanum tuberosum L. genotypes including 350 worldwide varieties or breeders' lines (referred to as the modern group) and 30 Chiloé Island landraces were examined using simple sequence repeat markers. The close genetic proximity of the Chiloé Island landraces to the modern group was confirmed using several structure analysis methods: principal coordinate analysis; hierarchical clustering analysis; analysis of molecular variance; Bayesian model-based clustering analysis. The latter analysis, in particular, revealed no clear genetic structure between the modern group and the Chiloé Island landraces. The Chiloé Island germplasm appears to represent an interesting gene pool that could be exploited in potato breeding programmes using an association mapping approach.

The young (12+8−4 Myr) and nearby (19.44±0.05 pc) star β Pictoris is considered one of the best laboratories for the study of early phases of planetary systems formation since the identification of an extended debris disk surrounding the star in 1984. In 2009, we imaged at 3.8 μm with NaCo at VLT a gas giant planet around β Pictoris, roughly along the disk mid-plane, with a semi-major axis between 8 and 14 AU. We present here the first images of the planet in the J (1.265 μm), H (1.66 μm), and M' (4.78 μm) bands obtained between 2011 and 2012. We used these data to build the 1-5 μm spectral energy distribution (SED) of the companion, and to consolidate previous semi-major axis (8-10 AU) estimates. We compared the SED to seven atmospheric models to derive Teff = 1700 ± 100 K. We used the temperature and the luminosity of β Pictoris b to estimate new masses for the companion. We compared these masses to independent constraints set by the orbital parameters and the radial velocities and use them to discuss the formation history of the object.

Here we present the installation and successful commissioning of an L'-band Annular Groove Phase Mask (AGPM) coronagraph on VLT/NACO. The AGPM is a vector vortex coronagraph made from diamond subwavelength gratings tuned to the L' band. The vector vortex coronagraph enables high contrast imaging at very small inner working angle (here 0″.09, the diffraction limit of the VLT at L'), potentially being the key to a new parameter space. During technical and science verification runs, we discovered a late-type companion at two beamwidths from an F0V star (Mawet et al. 2013), and imaged the inner regions of β Pictoris down to the previously unexplored projected radius of 1.75 AU. The circumstellar disk was also resolved from ≃ 1″ to 5″ (see J. Milli et al., these proceedings). These results showcase the potential of the NACO L-band AGPM over a wide range of spatial scales.