As the current Indian Prime Minister Manmohan Singh risks his administration on a bid to override massive public opposition to entering into a nuclear power deal with the United States, hyped as an “historic” accord that will emancipate India's economy and boost its international status, Japan Focus examines a decade of India-Pakistan maneuvering for advantage in the South Asian nuclear sweepstakes. MS

Shifts in U.S. nuclear policies under the Trump Administration may affect Japan in significant ways. The demands of formulating a coherent set of policies and implementing them, and dealing with pushback from other states and domestic opposition make it hard to anticipate exactly what U.S. nuclear policies may look like under Donald Trump. President Trump, however, has been outspoken on nuclear policy issues, and even though the statements are often contradictory, they offer some insight. These statements form the basis of this analysis.

This essay looks at how United States nuclear arms control and disarmament policies may change over the next few years. It begins by looking at Trump's views on nuclear arms control issues, including the New START agreement and U.S. plans for modernization, the possibility of new nuclear weapons and a resumption of nuclear testing. It then looks at Trump's views on U.S. nuclear posture, including the question of the first use of nuclear weapons. The essay also examines how the President has viewed the challenge of nuclear proliferation, especially the case of North Korea and U.S. policy toward Japan. Finally, with talks to begin in March 2017 on a UN mandated treaty to ban nuclear weapons, the essay looks at the abolition of nuclear weapons.

Eotetranychus kankitus is an important pest on several agricultural crops, and its resistance to pesticides has promoted the exploration of biological control strategies. Beauveria bassiana and Neoseiulus barkeri have been identified as potential agents for suppressing spider mites. This study aimed to investigate the pathogenicity of B. bassiana on E. kankitus and its compatibility with N. barkeri. Results showed that among the five tested strains of B. bassiana, Bb025 exhibited the highest level of pathogenicity on E. kankitus. Higher application rates (1 × 108 conidia/mL) of Bb025 led to a higher mortality rate of E. kankitus (90.402%), but also resulted in a 15.036% mortality of N. barkeri. Furthermore, preference response tests indicated that both E. kankitus and N. barkeri actively avoided plants sprayed with Bb025 compared to the control group that was sprayed with Tween-80. In a no-choice test, we observed that N. barkeri actively attacked Bb025-treated E. kankitus with no adverse effect on its predatory capacities. Furthermore, N. barkeri laid more eggs when fed on Bb025-treated E. kankitus compared to Tween-80-treated E. kankitus, but the subsequent generation of surviving individuals fed on Bb025-treated E. kankitus was reduced. These findings demonstrate that the Bb025 strain of B. bassiana is highly virulent against E. kankitus while causing less harm to N. barkeri. Consequently, a promising strategy for controlling E. kankitus could involve the sequential utilisation of Bb025 and N. barkeri at appropriate intervals.

The experiments reported in this research paper aimed to evaluate the physico-chemical and sensory characteristics, microbial quality and antioxidant potential of goat's milk paneer during storage (0–12 d, 4 ± 1°C). The juices from five different citrus fruits were used as coagulant (treatments) to make goat's milk paneer. The pH of all paneer samples decreased during storage whereas titratable acidity increased. Ash (%) fat (%) and protein (%) of paneer increased slightly during storage, whereas sensory perception decreased. The juices from all the citrus fruit varieties showed high contents of total phenolics and total flavonoids which ultimately influenced ferric reducing antioxidant power, total antioxidant capacity and radical scavenging activities. As the contents of different juices were also retained in the paneer matrix, so paneer coagulated with citrus juices also showed encouraging results in terms of total phenolic and flavonoid contents, ferric reducing antioxidant power and radical scavenging activities. Amongst all the paneers, the most promising was that coagulated by kinnow juice. In addition, the whey obtained from paneer coagulated by citrus juices also showed appreciable quantities of total phenolic and flavonoid contents, thereby beneficially influencing ferric reducing antioxidant power andradical scavenging activities. It is concluded that citrus juices improve the sensorial quality and antioxidant potential of goat's milk paneer and its whey.

Indigenous communities in Canada are disproportionately affected by issues related to water security, especially access to clean water to meet human needs. The issues these communities face are diverse and widespread across Canada, with many causes and consequences. This review summarizes the types and magnitudes of risks associated with the water security of these communities, the consequences considering health and social perspectives, and the means of responding to these issues. Risks are broadly divided into quantitative risks (e.g., water quality and availability) and qualitative risks (e.g., lack of funding and jurisdictional conflicts). These risks lead to unique consequences, resulting in challenges in developing generalized risk response frameworks. Management of these risks includes a mix of techniques relying on legislative and technical approaches. Nevertheless, the affected communities should be included in the decision-making process that should be holistic, incorporating indigenous knowledge. Good governance, cooperation between communities, policy improvement and the development of an institutional mechanism for clean water supply will provide a pathway and guidelines to address the water security challenges among indigenous communities.

Most of the currently available three-degree-of-freedom manipulators are light load and cannot achieve full continuous rotation; given this, we designed a heavy-load manipulator that achieves unrestricted and continuous rotation. Due to manufacturing and assembly errors, parameter deviations between the real manipulator and its underlying theoretical model were unavoidable. Because of the lack of high-precision, high-frequency, and real-time closed-loop detection methods, we proposed a type of kinematics calibration of parameterized ant colony optimization and feedforward control methods. This was done to achieve high-precision motion control. First, an error model combining structural parameters and joint output angles was established, and the global sensitivity of each error source was analyzed to distinguish both primary and secondary sources. Based on the measured data of a laser tracker, the ant colony optimization was then used to identify six error sources. This resulted in both link length and joint driving errors of the designed manipulator. As it is a type of systematic error, the rounding error of the theoretical trajectory was carefully analyzed, and feedforward control methods with different coefficients were designed to further improve positioning accuracy based on the kinematic calibration. Experimental results showed that the proposed kinematic calibration and feedforward control methods achieved relatively precise motion control for the designed manipulator.

Cumulative oxidation of cellular macromolecules during storage reduces seed longevity. This study was undertaken to unravel the physiological and biochemical changes in rice seeds that contribute to deterioration during storage. Rice seeds maintained at three different seed moisture contents (SMC; 10, 12 and 14%) were stored in airtight glass jars. Half of the jars were flushed with nitrogen gas to provide modified oxygen conditions, while the other half were sealed with natural air (21% O2). Seed quality in terms of germination and antioxidant defence mechanisms was monitored after 3 and 6 months of storage at 25°C. The results showed that seeds performed better when stored at low SMC (10 and 12%), whereas the deterioration process accelerated in seeds stored at higher SMC (14%). Coupling high SMC with the availability of oxygen in the storage environment produced a negative effect on seed quality and longevity. Results from the antioxidant analysis showed more activity in seeds stored with oxygen at high SMC (14%) compared to lower SMC stored in modified oxygen conditions. Therefore, it is recommended that storage with low moisture levels (12%) or below (10%) is the best to preserve rice seed quality. However, at higher moisture levels (14%), the availability of oxygen in storage is more harmful to seed lifespan and quality.

Wild badgers (Meles meles) in Wytham woods, Oxfordshire, are routinely trapped, transported to a central field laboratory, studied and released as part of an on-going population study. These procedures have been carefully developed to minimise impact on the badgers' welfare; however they are potentially stressful, and, as part of our on-going welfare refinements, and our exploration to develop methods for quantifying stress in wild mammals, we studied the effects of transport stress on neutrophil activation in wild trapped badgers. Blood samples were obtained from 28 badgers. We compared three transport regimes: transported (n = 9), transported and rested for at least 30 mins (n = 11), and not transported (n = 8). Total and differential white cell counts were carried out and neutrophil activation was measured by the nitroblue tetrazolium test. Our goal was primarily to validate neutrophil activity as an indicator of stress, on the basis that the transport treatment was expected to be more stressful than the non-transport treatment. There were significant increases in % activated circulating neutrophils in response to transport. This study supports the proposition that stress affects circulating neutrophil numbers and the state of their activation, as determined by the nitroblue tetrazolium reduction assay, and therefore adds weight to the idea that neutrophil activation is a potential measure of stress in wild animals.

Small mammals are routinely live-trapped and subsequently handled for a range of ecological and behavioural studies. Despite the techniques commonly employed being potentially stressful for the individual animals involved, it has hitherto been difficult to quantify the physiological impact. Here, we report on the first instance of using the Leukocyte Coping Capacity technique (LCC) in bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus) to investigate the physiological impact of routine trapping and handling techniques. Twenty microlitres of blood were obtained from 40 animals, of which 25 were handled following standard protocols and 15 were not. We found that even a short period of acute stress is sufficient to trigger an immune response which was measurable using the LCC technique. These results further validate the use of the LCC technique for measuring the physiological impact of standard trapping and handling treatments on wild mammals.

Expressing gratitude and patronage in the form of dedication or acknowledgment can be traced back to the 16th century (Görlach, 2004). In the present time, writing an acknowledgment section has become a common practice in scholarly works, such as books, dissertations, theses, and journal articles. Research on acknowledgments as a text type, however, is relatively new. In his pioneering work, Hyland (2003) dubbed dissertation acknowledgments ‘a Cinderella genre’ because it is often regarded as a taken-for-granted component in a dissertation and has not received due academic attention. Unlike other conventional academic genres that aim to establish claims and reputation, dissertation acknowledgments reflect the reciprocal gift-giving among scholars, constituting ‘the most explicitly interpersonal genre of the academy’ (Hyland, 2004: 323). In addition to expressing gratitude to others, writers also use the acknowledgments section to build interpersonal relationships with their academic colleagues and/or professional communities (Chan, 2015). In this study, we adopt computerized text analysis to further explore how language patterns mark the interpersonal features in English dissertation acknowledgments.

We surveyed healthcare workers at an urban academic hospital in the United States about their confidence in and knowledge of appropriate personal protective equipment use during the coronavirus disease 2019 (COVID-19) pandemic. Among 461 respondents, most were confident and knowledgeable about use. Prescribers or nurses and those extremely confident about use were also the most knowledgeable.

Estimating the spread of SARS-CoV-2 infection in communities is critical. We surveyed 2244 stratified random sample community members of the Gardena valley, a winter touristic area, amidst the first expansion phase of the COVID-19 pandemic in Europe. We measured agreement between Diasorin and Abbott serum bioassay outputs and the Abbott optimal discriminant threshold of serum neutralisation titres with recursive receiver operating characteristic curve. We analytically adjusted serum antibody tests for unbiased seroprevalence estimate and analysed the determinants of infection with non-response weighted multiple logistic regression. SARS-CoV-2 seroprevalence was 26.9% (95% CI 25.2–28.6) by June 2020. The bioassays had a modest agreement with each other. At a lower threshold than the manufacturer's recommended level, the Abbott assay reflected greater discrimination of serum neutralisation capacity. Seropositivity was associated with place and economic activity, not with sex or age. Symptoms like fever and weakness were age-dependent. SARS-CoV-2 mitigation strategies should account for context in high prevalence areas.

The aim of this study was to explore the impact of polymorphism of PD-1 gene and its interaction with tea drinking on susceptibility to tuberculosis (TB). A total of 503 patients with TB and 494 controls were enrolled in this case–control study. Three single-nucleotide polymorphisms of PD-1 (rs7568402, rs2227982 and rs36084323) were genotyped and unconditional logistic regression analysis was used to identify the association between PD-1 polymorphism and TB, while marginal structural linear odds models were used to estimate the interactions. Genotypes GA (OR 1.434), AA (OR 1.891) and GA + AA (OR 1.493) at rs7568402 were more prevalent in the TB patients than in the controls (P < 0.05). The relative excess risk of interaction (RERI) between rs7568402 of PD-1 genes and tea drinking was −0.3856 (95% confidence interval −0.7920 to −0.0209, P < 0.05), which showed a negative interaction. However, the RERIs between tea drinking and both rs2227982 and rs36084323 of PD-1 genes were not statistically significant. Our data demonstrate that rs7568402 of PD-1 genes was associated with susceptibility to TB, and there was a significant negative interaction between rs7568402 and tea drinking. Therefore, preventive measures through promoting the consumption of tea should be emphasised in the high-risk populations.

Internet and Communication Technology/electrical and electronic equipment (ICT/EEE) form the bedrock of today’s knowledge economy. This increasingly interconnected web of products, processes, services, and infrastructure is often invisible to the user, as are the resource costs behind them. This ecosystem of machine-to-machine and cyber-physical-system technologies has a myriad of (in)direct impacts on the lithosphere, biosphere, atmosphere, and hydrosphere. As key determinants of tomorrow’s digital world, academic institutions are critical sites for exploring ways to mitigate and/or eliminate negative impacts. This Report is a self-deliberation provoked by the question How do we create more resilient and healthier computer science departments: living laboratories for teaching and learning about resource-constrained computing, computation, and communication? Our response for University College London (UCL) Computer Science is to reflect on how, when, and where resources—energy, (raw) materials including water, space, and time—are consumed by the building (place), its occupants (people), and their activities (pedagogy). This perspective and attendant first-of-its-kind assessment outlines a roadmap and proposes high-level principles to aid our efforts, describing challenges and difficulties hindering quantification of the Department’s resource footprint. Qualitatively, we find a need to rematerialise the ICT/EEE ecosystem: to reveal the full costs of the seemingly intangible information society by interrogating the entire life history of paraphernalia from smartphones through servers to underground/undersea cables; another approach is demonstrating the corporeality of commonplace phrases and Nature-inspired terms such as artificial intelligence, social media, Big Data, smart cities/farming, the Internet, the Cloud, and the Web. We sketch routes to realising three interlinked aims: cap annual power consumption and greenhouse gas emissions, become a zero waste institution, and rejuvenate and (re)integrate the natural and built environments.