Avocado is a delicious fruit crop having great economic importance. Understanding the extent of variability present in the existing germplasm is important to identify genotypes with specific traits and their utilization in crop improvement. The information on genetic variability with respect to morphological and biochemical traits in Indian avocados is limited and as it has hindered genetic improvement of the crop. In the current study, 83 avocado accessions from different regions of India were assessed for important 17 morphological and 8 biochemical traits. The results showed the existence of wide variability for traits such as fruit weight (75.88–934.12 g), pulp weight (48.08–736.19 g), seed weight (6.37–32.62 g), FRAP activity (27.65–119.81 mg AEAC/100 g), total carotenoids (0.96–7.17 mg/100 g), oil content (4.91–25.49%) and crude fibre (6.85–20.75%) in the studied accessions. The first three components of principal component analysis explained 54.79 per cent of total variance. Traits such as fruit weight, pulp weight, seed weight, moisture and oil content contributed more significantly towards total variance compared to other traits. The dendrogram constructed based on Euclidean distance wards minimum variance method divided 83 accessions into two major groups and nine sub clusters suggesting wide variability in the accessions with respect to studied traits. In this study, superior accessions for important traits such as fruit size (PA-102, PA-012), high pulp recovery (PA-036, PA-082,), thick peel (PA-084, PA-043, PA-011, PA-008), high carotenoids (PA-026, PA-096) and high oil content (PA-044, PA-043, PA-046, PA-045) were identified which have potential utility in further crop improvement programmes.

Two designs for comparing a judge's ratings with a known standard are presented and compared. Design A pertains to the situation where the judge is asked to categorize each of N subjects into one of r (known) classes with no knowledge of the actual number in each class. Design B is employed when the judge is given the actual number in each class and is asked to categorize the individuals subject to these constraints. The probability distribution of the total number of correct choices is developed in each case. A power comparison of the two procedures is undertaken.

Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 – 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 – 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 – 7 months after the residual specimen collection. Specimens were tested for IgG antibodies to measles and rubella viruses. Measles and rubella seroprevalence estimates using facility-based specimens were 99% and 92%, respectively, with men having significantly lower rubella seropositivity than women. Age-specific measles and rubella seroprevalence estimates were similar between the two specimen sources. Although measles seropositivity was slightly higher among adults attending the facilities, both facility and community measles seroprevalence estimates were 95% or higher. The similarity in measles and rubella seroprevalence estimates between the community-based and facility serosurveys highlights the potential value of residual specimens to approximate community seroprevalence.

Residual blood specimens provide a sample repository that could be analyzed to estimate and track changes in seroprevalence with fewer resources than household-based surveys. We conducted parallel facility and community-based cross-sectional serological surveys in two districts in India, Kanpur Nagar District, Uttar Pradesh, and Palghar District, Maharashtra, before and after a measles-rubella supplemental immunization activity (MR-SIA) from 2018 to 2019. Anonymized residual specimens from children 9 months to younger than 15 years of age were collected from public and private diagnostic laboratories and public hospitals and tested for IgG antibodies to measles and rubella viruses. Significant increases in seroprevalence were observed following the MR SIA using the facility-based specimens. Younger children whose specimens were tested at a public facility in Kanpur Nagar District had significantly lower rubella seroprevalence prior to the SIA compared to those attending a private hospital, but this difference was not observed following the SIA. Similar increases in rubella seroprevalence were observed in facility-based and community-based serosurveys following the MR SIA, but trends in measles seroprevalence were inconsistent between the two specimen sources. Despite challenges with representativeness and limited metadata, residual specimens can be useful in estimating seroprevalence and assessing trends through facility-based sentinel surveillance.

The system signature is a useful tool for studying coherent systems. For a given coherent system, various methods have been proposed in the literature to compute its signature. However, when any system signature is given, the literature does not address how to construct the corresponding coherent system(s). In this article we propose an algorithm to address this research gap. This algorithm enables the validation of whether a provided probability vector qualifies as a signature. If it does, the algorithm proceeds to generate the corresponding coherent system(s). To illustrate the applicability of this algorithm, we consider all three and four-dimensional probability vectors, verify if they are signatures, and finally obtain 5 and 20 coherent systems, respectively, which coincides with the literature (Shaked and Suarez-Llorens 2003).

Polycystic Ovary Syndrome (PCOS) is a common hormonal condition affecting women of reproductive age(1). Women with PCOS experience a broad range of clinical symptoms, collectively grouped into reproductive, metabolic, psychological and anthropometric features(2). Complementary therapies, such as nutrient supplementation, have been identified as potential adjunct therapeutic approaches to support currently recommended lifestyle and pharmacological interventions(3). However, evidence for their overall efficacy and safety is inconsistent and unclear. This review aimed to systematically map the available literature on the use of nutrient supplementation for the management of PCOS features, including metabolic, reproductive, psychological and anthropometric. This review followed a systematic approach with literature searches using CINHAL, Cochrane reviews, Medline, PsycINFO, Scopus and LILACS conducted up to April 2022. All types of study designs were included if they reported on the efficacy or association between micronutrient supplementation and/or nutraceuticals on features of PCOS in women (≥ 18 years) with a confirmed diagnosis of PCOS. A total of 317 articles were included involving n = 23,926 women. Forty-three different supplements examined various clinical features of PCOS grouped into metabolic, reproductive, psychological and anthropometric. The most studied supplements included Inositols (n = 83), Vitamin D (n = 51), N-acetylcysteine (n = 25), Omega-3 fatty acids (n = 18) and Biotics (n = 14). Most studies (n = 262; 83%) reported on reproductive features followed by metabolic (n = 212; 66%), anthropometric (n = 181; 57%) and psychological (n = 5; 2%). Less than half (n = 148; 47%) of the included studies reported on the potential for adverse events. Our results highlight that the potential therapeutic benefit of micronutrient and nutraceutical supplementation on psychological features of PCOS warrants future exploration. Additional primary studies that are adequately powered are needed to investigate therapeutic doses needed for clinical benefits. Lastly, a more rigorous approach to monitoring and recording adverse event data is recommended.

Polycystic Ovary Syndrome PCOS is an endocrine disorder affecting 8 to 13% of reproductive aged women(1). Dietary and physical activity changes are the first-line therapy to assist with symptom and weight management and to reduce the risk of reproductive, metabolic and psychological comorbidities(2). However, women with PCOS have a higher weight, experience weight gain, and a higher prevalence of living in a larger body. Health care professionals (HCPs) play a crucial role in delivering diet and physical activity advice for people with PCOS. Thus, the aim of this systematic review is to understand the barriers, facilitators, experiences, and perceptions of engagement and compliance with diet and physical activity modifications in people with PCOS and in HCPs providing or referring people with PCOS to diet and physical activity modifications. A mixed-method systematic review was conducted with quantitative studies narratively synthesised and all studies thematically analysed. There were 68 eligible papers, including n = 59 (n = 5198) people with PCOS and n = 17 (n = 2,622) HCPs. Several themes were identified as impacting people with PCOS’ ability to make diet and physical activity changes. HCP education on PCOS management through diet and physical activity was viewed by HCPs and people with PCOS to be inadequate, further impacting the quality of care and health outcomes. Dietary and physical activity advice delivered by a multidisciplinary team, including dietitians, was identified as a key component for change. Both people with PCOS and HCPs agreed that there was a need for individualised and PCOS-specific diet and physical activity advice. However, HCPs viewed that there was limited evidence supporting these recommendations and a lack of time to deliver this care. Weight stigma was identified as impacting both those in larger and smaller bodies with PCOS, reducing the quality of care and affecting self-perception and mental health. People with PCOS perceived that diet and physical activity are overly focused on weight loss and fertility, independent of their own personal motivations and goals. Systemic changes, including receiving diet and physical activity advice that meet the individual’s needs, are necessary for leading to long-term sustainable changes and improvements in health outcomes. A multidisciplinary team approach and an overhaul of HCPs’ perceptions and mentality of weight and weight-centric care for those with PCOS are essential in delivering effective diet and physical activity advice.

The gravity flow of a granular material between two vertical walls separated by a width $2W$ is simulated using the discrete element method (DEM). Periodic boundary conditions are applied in the flow (vertical) and the other horizontal directions. The mass flow rate is controlled by specifying the average solids fraction $\bar {\phi }$, the ratio of the volume of the particles to the volume of the channel. A steady fully developed state can be achieved for a narrow range of $\bar {\phi }$, $\bar {\phi }_{max} \geq \bar {\phi } \geq \bar {\phi }_{cr}$, and the material is in free fall for $\bar {\phi } < \bar {\phi }_{min}$. For an intermediate range of $\bar {\phi }$ ($\bar {\phi }_{cr} > \bar {\phi } \geq \bar {\phi }_{min}$), there are oscillations in the horizontal coordinate of the centre of mass, velocity components and stress. As $\bar {\phi }$ decreases in the range $\bar {\phi }_{cr} > \bar {\phi } \geq \bar {\phi }_{min}$, the amplitude of the oscillations increases proportional to $\sqrt {\bar {\phi }_{cr} - \bar {\phi }}$ and the frequency appears to tend to a non-zero value as $\bar {\phi } \rightarrow \bar {\phi }_{cr}$, indicating a supercritical Hopf bifurcation. The relation between the dominant frequency and the higher harmonics of the position, velocity and stress fluctuations are explained using the momentum balance. It is found that dissipation in the inter-particle and particle–wall contacts is critical for the presence of an oscillatory state.

Preservation of stochastic orders through the system signature has captured the attention of researchers in recent years. Signature-based comparisons have been made for the usual stochastic order, hazard rate order, and likelihood ratio orders. However, for the mean residual life (MRL) order, it has recently been proved that the preservation result does not hold true in general, but rather holds for a particular class of distributions. In this paper, we study whether or not a similar preservation result holds for the mean inactivity time (MIT) order. We prove that the MIT order is not preserved from signatures to system lifetimes with independent and identically distributed (i.i.d.) components, but holds for special classes of distributions. The relationship between these classes and the order statistics is also highlighted. Furthermore, the distribution-free comparison of the performance of coherent systems with dependent and identically distributed (d.i.d.) components is studied under the MIT ordering, using diagonal-dependent copulas and distorted distributions.

Rice crop is affected by different types of floods at different stages of the crop cycle. Constant efforts of researchers resulted in the development of rice varieties for anaerobic germination, flash floods and stagnant flooding by both conventional and molecular breeding approaches. Detection of QTLs for different types of floods in new genetic source (AC39416A) is needed to combat adverse effects of climate change. Present investigation was carried out to identify QTLs for flood tolerance using recombinant inbred lines derived from Indra and AC39416A. QTL mapping resulted in identification of QTLs, qAG3.1 on chromosome 3 for anaerobic germination and qSF10.1 on chromosome 10 for plant survival % under stagnant flooding. These QTLs explain 59.08 and 13.21% of phenotypic variance respectively. Two candidate genes were identified in qAG3.1 region, LOC_Os03g42130 gibberellin 20 oxidase2 and LOC_Os03g44170 glutathione S-transferase. The underlying mechanism might be the inhibition of gibberellic acid synthesis and thereby protecting seedlings from oxidative stress under anoxia condition. Genomic region of qSF10.1 revealed LOC_Os10g35020 glycosyltransferase and LOC_Os10g35050 aquaporin protein loci, which might be responsible for adaptive mechanism for plant survival % under stagnant flooding. This indicates that the new genetic resource AC39416A has an ability to adopt to different types of flood tolerance in response to environmental stress. Unveiling physiological and molecular mechanisms for flood tolerance in AC39416A using advanced omics studies would help in precise genomic selections for sustained production in flood-prone areas.

Subduction-related kimberlite-borne eclogite xenoliths of the Precambrian age may provide significant information about the evolution and recycling of a subducting crust as exhumed/orogenic eclogites of the pre-Mesoproterozoic time-frame are globally rare. In this paper, we report a kimberlite-borne eclogite xenolith from the diamondiferous Kalyandurg kimberlite cluster of the Eastern Dharwar Craton, India, which contains a plethora of ultra-high-pressure minerals such as coesite, majoritic garnet, and supersilicic K-rich omphacite. The presence of these ultra-high-pressure minerals is confirmed by in situ X-ray diffractometry, laser Raman spectra and electron probe microanalysis. The presence of coesite undisputedly pinpoints a subduction origin for the eclogite at ∼2.8 GPa pressure, which corresponds to ∼100 km depth. The geothermobarometric estimations involving garnet–omphacite–kyanite–coesite reveal that such an eclogitic assemblage equilibrated at ∼5–8 GPa (∼175–280 km) pressure during ultra-deep subduction. The textural relationship between omphacite, coarse-grained garnet and majoritic garnet coupled with the laser Raman spectra and geobarometric estimations obtained from the majoritic garnet demonstrate that the majoritic garnet formed at ∼8–19 GPa (∼280–660 km) owing to disassociation of omphacite and coarse-grained garnet to majoritic garnet during increment of pressure up to the mantle transition zone. Thus, the mineralogical and geothermobarometric data suggest that the studied eclogite possibly travelled down to the mantle transition zone before it was rapidly carried up by a pre-Mesoproterozoic mantle plume, and subsequently entrained as a xenolith by the Mesoproterozoic (∼1.1 Ga) kimberlite.

India, a country with more than 1.3 billion people living in an area of 1,269,219 square miles has only three teaching positions dedicated to the history of education. This denotes little importance given to the discipline. India produced no historian of education during the first twenty-six years after attaining independence. Bhagaban Prasad Majumdar, the first historian of education in independent India, published his First Fruit of English Education in 1973, through a local publisher that no longer exists. The book analyzed the answers written in annual examinations during the first half of the nineteenth century to evaluate the growth of modern education in India. It is indispensable for anyone seeking to understand curriculum history in India, particularly a teacher education student. However, the book is seldom quoted and difficult to find. In all of Delhi, only one library holds a single copy. This is representative of the fate that has befallen even scholars who have worked in the field at the international level and published books and papers in recognized journals. This year, India is celebrating seventy-five years of independence, and so far, it has produced six sets of major historical works and five micro studies that are limited in scope, again, are seldom quoted and recognized in the public debates on education in India.

The steady dense granular flow in a vertical channel bounded by flat frictional walls in one horizontal direction and with periodic boundary conditions in the other horizontal and vertical directions is studied using the discrete element method. The shape of the scaled velocity profile is characterized quantitatively by a universal exponential function, and the ratio of the maximum and slip velocities is independent of the average volume fraction $\bar {\phi }$ and the channel width $W$. For sufficiently wide channels, the maximum and slip velocities increase proportional to $\sqrt {W}$, and the thickness of the shearing zones increases proportional to $W$. There are four zones in the flow, each with distinct dynamical properties. There is no shear in the plug zone at the centre, but there is particle agitation, and the volume fraction $\phi$ is lower than the random close packing volume fraction $\phi _{rcp}$. In the adjoining dense shearing zone, $\phi$ is greater than the volume fraction for arrested dynamics $\phi _{ad} = 0.587$, and the granular temperature and shear rate depend on the particle stiffness. Adjacent to the dense shearing zone is the loose shearing zone where $\phi < \phi _{ad}$. Here, the properties do not depend on the particle stiffness, and the constitutive relations are well described by hard-particle models. The rheology in the loose shearing zone is similar to the dense flow down an inclined plane. There is high shear and a sharp decrease in $\phi$ in the wall shearing zone of thickness about two particle diameters, where the particle angular velocity is different from the material rotation rate due to the presence of the wall.

Design education increasingly blends technology learning with sociotechnical challenges, but little is understood about how students simultaneously engage with both of these elements. In this preliminary study, we describe the results of two offerings of a design course focusing on disaster response at a major public research institution. We present a preliminary analysis of 52 students’ course reflections suggesting that sociotechnical challenges uniquely contextualize technology during project-based learning, presenting promising opportunities for future design education and research study.

The flow of granular materials through a vertical channel is examined using the discrete element method (DEM) and the recent continuum models of Henann & Kamrin (Proc. Natl Acad. Sci. USA, vol. 110, 2013, pp. 6730–6735), Barker et al. (Proc. R. Soc. Lond. A, vol. 473, 2017, p. 20160846), Schaeffer et al. (J. Fluid Mech., vol. 874, 2019, pp. 926–951) and Dsouza & Nott (J. Fluid Mech., vol. 888, 2020, p. R3). The channel is bounded by walls separated by a distance $2 \, W$ in the $x$-direction. For the DEM, periodic boundary conditions are used in the $z$- and $y$- (vertical) directions with no exit at the bottom of the channel. The governing equations reduce to ordinary differential equations in the $x$-direction. There is a plug layer near the centre and a shear layer near the wall, as observed in experiments. There is a decrease in the solids fraction $\phi$ in the shear layer, except for the models of Barker et al. and Henann & Kamrin. A modification of the latter gives more realistic $\phi$ profiles. The thickness of the shear layer depends on $2\,W$ and the bulk solids fraction $\bar {\phi }$. For all the models, solutions could not be obtained for some parameter values. An example is the negative fluidity in the model of Henann & Kamrin. The model of Dsouza & Nott predicts much higher normal stresses, possibly because of large contributions from the non-local terms. None of the models specify a complete set of boundary conditions (b.c.). The DEM results suggest that the slip velocity and the wall friction b.c. lead to a slip length and an angle of wall friction that are independent of $2\,W$. The models are based on extensions of the equations for slow, rate-independent flow. A model that includes collisional effects, such as kinetic theory, should be combined with the present models. A preliminary analysis of the kinetic theory model of Berzi et al. (J. Fluid Mech., vol. 885, 2020, p. A27), shows that it may have undesirable feature.