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The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID-19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.
Methods
Participants (n = 5486) aged 55–75 years were included in this longitudinal cohort. COVID-19 status (positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.
Results
COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15–40) weeks post-infection [fully adjusted β = 0.65 points, 95% confidence interval (CI) 0.15–1.15; p = 0.011]. This association was particularly prominent in women (β = 1.38 points, 95% CI 0.44–2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II ≥ 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13–2.30, p = 0.008).
Conclusions
COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.
To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms.
Design:
An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used.
Setting:
Spanish older adults with metabolic syndrome (MetS).
Participants:
A total of 6625 adults aged 55–75 years from the PREDIMED-Plus study with overweight or obesity and MetS.
Results:
Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v. Q1 = 0·76 (95 % CI (0·64, 0·90)). This was driven by high diversity compared to low diversity (C3 v. C1) of vegetables (OR = 0·75, 95 % CI (0·57, 0·93)), cereals (OR = 0·72 (95 % CI (0·56, 0·94)) and proteins (OR = 0·27, 95 % CI (0·11, 0·62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v. C1 = (β = 0·70, 95 % CI (0·05, 1·35)).
Conclusions:
According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings.
The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over time. Dietary habits were assessed with validated FFQ at baseline and repeatedly every year during 4 years of follow-up. Using multivariate models to adjust for covariates, long-term weight and waist circumference changes according to quartiles of change in energy-adjusted white and whole-grain bread consumption were calculated. The present results showed that over 4 years, participants in the highest quartile of change in white bread intake gained 0·76 kg more than those in the lowest quartile (P for trend = 0·003) and 1·28 cm more than those in the lowest quartile (P for trend < 0·001). No significant dose–response relationships were observed for change in whole-bread consumption and anthropometric measures. Gaining weight (>2 kg) and gaining waist circumference (>2 cm) during follow-up was not associated with increase in bread consumption, but participants in the highest quartile of changes in white bread intake had a reduction of 33 % in the odds of losing weight (>2 kg) and a reduction of 36 % in the odds of losing waist circumference (>2 cm). The present results suggest that reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat.
We propose a general geometric method of derivation of invariant relations for hydrodynamic dissipationless media. New dynamic invariants are obtained. General relations between the following three types of invariants are established, valid in all models: Lagrangian invariants, frozen-in vector fields and frozen-in co-vector fields. It is shown that frozen-in integrals form a Lie algebra with respect to the commutator of the frozen fields. The relation between frozen-in integrals derived here can be considered as the Backlund transformation for hydrodynamic-type systems of equations. We derive an infinite family of integral invariants which have either dynamic or topological nature. In particular, we obtain a new type of topological invariant which arises in all hydrodynamic dissipationless models when the well-known Moffatt invariant vanishes.
The problem of the interaction of large-scale vortices with small-scale homogeneous isotropic helical turbulence in a compressible medium is considered. Averaged equations are derived using a closure procedure which is based on the functional technique. It is shown that the averaged vorticity equation has solutions that grow exponentially in time and which describe the effect of amplification of large-scale helical vortices by turbulence (hydrodynamical α-effect). The dependence of the growth rate on the compressibility is analysed, the limiting cases of incompressible fluid and turbulence δ-correlated in time being considered. The applications of the hydrodynamical α-effect discussed include the Earth's atmosphere and interstellar gas of spiral galaxies.
We develop a new asymptotic method of resolution of the two-dimensional equilibrium equation of collisionless plasmas described by the Maxwell–Vlasov equations. This method differs from the classical one proposed by K. Schindler [Earth’s Magnetospheric Processes (ed. B. M. McCormac). Norwood, MA: Reidel, 1972, pp. 200–209.] since we consider free-boundary plasmas. Our method is a generalization of the usual multiscale asymptotic developments. The first-approximation asymptotic solutions are found from the elimination of increasing and singular terms in the next approximation. We apply the method to the mathematical description of nonlinear structures that may form in neutral sheets. Particular solutions describing localized plasmoids (O-point configuration) as well as X-point magnetic configurations are obtained. We also find more general solutions describing a finite number of ‘magnetic islands’ (multiplasmoid solutions) separated by X points.
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