This study aimed to assess the impact of hypertensive disorders of pregnancy on infant neurodevelopment by comparing 6-month and 2-year psychomotor development outcomes of infants exposed to gestational hypertension (GH) or preeclampsia (PE) versus normotensive pregnancy (NTP). Participating infants were children of women enrolled in the Postpartum Physiology, Psychology and Paediatric (P4) cohort study who had NTPs, GH or PE. 6-month and 2-year Ages and Stages Questionnaires (ASQ-3) scores were categorised as passes or fails according to domain-specific values. For the 2-year Bayley Scales of Infant and Toddler Development (BSID-III) assessment, scores > 2 standard deviations below the mean in a domain were defined as developmental delay. Infants (n = 369, male = 190) exposed to PE (n = 75) versus GH (n = 20) and NTP (n = 274) were more likely to be born small for gestational age and premature. After adjustment, at 2 years, prematurity status was significantly associated with failing any domain of the ASQ-3 (p = 0.015), and maternal tertiary education with increased cognitive scores on the BSID-III (p = 0.013). However, PE and GH exposure were not associated with clinically significant risks of delayed infant neurodevelopment in this study. Larger, multicentre studies are required to further clarify early childhood neurodevelopmental outcomes following hypertensive pregnancies.

Black and Latinx caregivers face high risk for parenting stress and racism-related stress due to experiences of racial discrimination (RD). This study aimed to explore the associations between RD, parenting stress, and psychological distress in caregiver-child dyads, as well as the impact of a mentalizing-focused group intervention on caregivers’ experiences of RD distress. Ethnoracially minoritized caregivers of children aged 5–17 years old participated in a non-randomized clinical trial (N = 70). They received either a 12-session mentalizing-focused group parenting intervention or treatment-as-usual in outpatient psychiatry. We assessed self-reported frequency and distress related to RD, parenting stress, and psychological distress at baseline (T1) and post-intervention (T2). Caregiver- and self-reported child psychological distress were also measured. The results showed that greater RD frequency and greater RD distress separately predicted higher overall parenting stress and parental role-related distress. Greater RD distress was linked to increased psychological distress in caregivers. Similarly, greater RD frequency and distress among caregivers were associated with higher caregiver-reported, but not self-reported, child psychological distress. No significant changes in RD distress were observed between T1 and T2 for either of the treatment groups. These findings highlight the exacerbating role of RD on parenting stress and psychological distress among ethnoracially minoritized caregivers and their children.

Effective communication with the public is essential during health emergencies. As evident during the coronavirus disease 2019 (COVID-19) pandemic, the lack of effective public health communication with equity-deserving groups has contributed to higher morbidity and mortality than the non-racialized community. This concept paper will describe a grassroots community effort to provide culturally safe public health information to the East African community in Toronto at the beginning of the pandemic. Community members collaborated with The LAM Sisterhood to create a virtual aunt, Auntie Betty, and record voice notes with essential public health guidance in Swahili and Kinyarwanda. This manner of communicating with the East African community was well-received and has shown great potential as a tool to support effective communication efforts during public health emergencies that disproportionately impact Black and equity-deserving communities.

Intrauterine preeclampsia exposure affects the lifelong cardiometabolic health of the child. Our study aimed to compare the growth (from birth to 6 months) of infants exposed to either a normotensive pregnancy or preeclampsia and explore the influence of being born small for gestational age (SGA). Participants were children of women participating in the Post-partum, Physiology, Psychology and Paediatric follow-up cohort study. Birth and 6-month weight and length z-scores were calculated for term and preterm (<37 weeks) babies, and change in weight z-score, rapid weight gain (≥0.67 increase in weight z-score) and conditional weight gain z-score were calculated. Compared with normotensive exposed infants (n = 298), preeclampsia exposed infants (n = 84) were more likely to be born SGA (7% versus 23%; P < 0.001), but weight gain from birth to 6 months, by any measure, did not differ between groups. Infants born SGA, irrespective of pregnancy exposure, were more likely to have rapid weight gain and had greater increases in weight z-score compared with those not born SGA. Preeclampsia exposed infants born SGA may benefit from interventions designed to prevent future cardiometabolic disease.

We carefully consider numerous explanations for the sulfur abundance anomaly in planetary nebulae. No one rationale appears to be satisfactory, and we suggest that the ultimate explanation is likely to be a heretofore unidentified feature of the nebular gas which significantly impacts the sulfur ionization correction factor.

In a survey of 1794 UK NHS hospital consultants 1308 (73%) responded.Psychiatric morbidity (General Health Questionnaire—12 score ⩾4) was presentin 32% of responders, who were twice as likely to report drinking hazardouslevels of alcohol, being irritable with patients and colleagues, reducingtheir standards of care and intending to retire early (all P<0.001). Male and mid-aged consultants were alsoparticularly at risk. Approaches that support consultants to practicemedicine safely throughout their careers are required.

We have used interference lithography to create surfaces with di-periodic topography with periods less than 400 nm and formed gold particle arrays on these substrates through the dewetting of thin solid films. Under appropriate conditions, we have found that dewetting of gold films on di-periodic arrays of {111} bound pits in silicon leads to periodic square arrays of particles with very narrow size distributions. In addition, we find that topography can significantly reduce the diameter of particles formed by the dewetting process. We present a mechanism for this self-organization process based on modulation of the local curvature of a conformal film on topography.