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Young stellar objects (YSOs) are protostars that exhibit bipolar outflows fed by accretion disks. Theories of the transition between disk and outflow often involve a complex magnetic field structure thought to be created by the disk coiling field lines at the jet base; however, due to limited resolution, these theories cannot be confirmed with observation and thus may benefit from laboratory astrophysics studies. We create a dynamically similar laboratory system by driving a $\sim$1 MA current pulse with a 200 ns rise through a $\approx$2 mm-tall Al cylindrical wire array mounted to a three-dimensional (3-D)-printed, stainless steel scaffolding. This system creates a plasma that converges on the centre axis and ejects cm-scale bipolar outflows. Depending on the chosen 3-D-printed load path, the system may be designed to push the ablated plasma flow radially inwards or off-axis to make rotation. In this paper, we present results from the simplest iteration of the load which generates radially converging streams that launch non-rotating jets. The temperature, velocity and density of the radial inflows and axial outflows are characterized using interferometry, gated optical and ultraviolet imaging, and Thomson scattering diagnostics. We show that experimental measurements of the Reynolds number and sonic Mach number in three different stages of the experiment scale favourably to the observed properties of YSO jets with $Re\sim 10^5\unicode{x2013}10^9$ and $M\sim 1\unicode{x2013}10$, while our magnetic Reynolds number of $Re_M\sim 1\unicode{x2013}15$ indicates that the magnetic field diffuses out of our plasma over multiple hydrodynamical time scales. We compare our results with 3-D numerical simulations in the PERSEUS extended magnetohydrodynamics code.
The clinical high risk for psychosis (CHR-p) syndrome enables early identification of individuals at risk of schizophrenia and related disorders. We differentiate between the stigma associated with the at-risk identification itself (‘labelling-related’ stigma) versus stigma attributed to experiencing mental health symptoms (‘symptom-related’ stigma) and examine their relationships with key psychosocial variables.
Aims
We compare labelling- and symptom-related stigma in rates of endorsement and associations with self-esteem, social support loss and quality of life.
Method
We assessed stigma domains of shame-related emotions, secrecy and experienced discrimination for both types of stigma. Individuals at CHR-p were recruited across three sites (N = 150); primary analyses included those who endorsed awareness of psychosis risk (n = 113). Paired-sample t-tests examined differences in labelling- versus symptom-related stigma; regressions examined associations with psychosocial variables, controlling for covariates, including CHR-p symptoms.
Results
Respondents reported greater symptom-related shame, but more labelling-related secrecy. Of the nine significant associations between stigma and psychosocial variables, eight were attributable to symptom-related stigma, even after adjusting for CHR-p symptoms.
Conclusions
Stigma attributed to symptoms had a stronger negative association with psychosocial variables than did labelling-related stigma among individuals recently identified as CHR-p. That secrecy related to the CHR-p designation was greater than its symptom-related counterpart suggests that labelling-related stigma may still be problematic for some CHR-p participants. To optimise this pivotal early intervention effort, interventions should address the holistic ‘stigmatising experience’ of having symptoms, namely any harmful reactions received as well as participants’ socially influenced concerns about what their experiences mean, in addition to the symptoms themselves.
Leader exemplification involves implicit and explicit claims of high moral values made by a leader. We employed a 2 × 3 experimental design with samples of 265 students in Study 1 and 142 working adults in Study 2 to examine the effects of leader exemplification (exemplification versus no exemplification) and ethical conduct (self-serving, self-sacrificial, and self-other focus) on perceived leader authenticity, trust in leader, and organizational advocacy. In Study 1, we found that exemplification produced elevated levels of perceived authenticity, trust, and advocacy in the form of employment and investment recommendations. We also showed that leader ethical conduct moderated this effect, as ratings were highest following a leader’s self-sacrificial conduct, lowest for self-serving conduct, and moderate for conduct reflecting self-other concerns. In Study 2, we replicated these findings for perceived authenticity and trust, but not organizational advocacy, which yielded mixed results. The leadership implications and future research directions are discussed.
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
Depression is an independent risk factor for cardiovascular disease (CVD), but it is unknown if successful depression treatment reduces CVD risk.
Methods
Using eIMPACT trial data, we examined the effect of modernized collaborative care for depression on indicators of CVD risk. A total of 216 primary care patients with depression and elevated CVD risk were randomized to 12 months of the eIMPACT intervention (internet cognitive-behavioral therapy [CBT], telephonic CBT, and select antidepressant medications) or usual primary care. CVD-relevant health behaviors (self-reported CVD prevention medication adherence, sedentary behavior, and sleep quality) and traditional CVD risk factors (blood pressure and lipid fractions) were assessed over 12 months. Incident CVD events were tracked over four years using a statewide health information exchange.
Results
The intervention group exhibited greater improvement in depressive symptoms (p < 0.01) and sleep quality (p < 0.01) than the usual care group, but there was no intervention effect on systolic blood pressure (p = 0.36), low-density lipoprotein cholesterol (p = 0.38), high-density lipoprotein cholesterol (p = 0.79), triglycerides (p = 0.76), CVD prevention medication adherence (p = 0.64), or sedentary behavior (p = 0.57). There was an intervention effect on diastolic blood pressure that favored the usual care group (p = 0.02). The likelihood of an incident CVD event did not differ between the intervention (13/107, 12.1%) and usual care (9/109, 8.3%) groups (p = 0.39).
Conclusions
Successful depression treatment alone is not sufficient to lower the heightened CVD risk of people with depression. Alternative approaches are needed.
Conductometric titrations of clay suspensions with surfactant solutions offer a rapid method of surface area determination of clay particles suspended in aqueous media. A cationic surfactant, dodecylamine hydrochloride, was used in this investigation. This surfactant was adsorbed by electrostatic bonding at cation exchange sites and by van der Waals forces. A monomolecular or bimolecular layer of the surfactant coats the particle and the completion of the layer is determined from a change in slope of the conductometric titration curve due to the formation of micelles. Good agreement between this method and BET determined values were obtained for kaolinite. The bentonite suspensions had a strong tendency to flocculate after the initial stage of adsorption causing the results to vary considerably. This method of surface area measurement of clay particles offers many advantages over the present techniques: (1) a dry particle is not required; (2) the equipment is inexpensive and available in many laboratories; (3) the method is rapid; (4) vacuum and high temperature are not required, and (5) the method measures the internal as well as external surface area.
This chapter seeks to understand ‘legal science’ from the internal point of view of each tradition and society, in order to avoid a conception too heavily influenced by contemporary views. To do so, reference is made both to the set of activities carried out by ‘legal experts’ in the whole domain of law (legislation, adjudication, legal counseling and education), and to the legal experts themselves, as far as they were regarded as such by their own societies. This approach requires first to establish the extent to which, in each society under consideration, knowledge of law was considered as autonomous knowledge. A sociological perspective is then adopted, identifying who in each society were considered legal experts, i.e. persons deemed to possess the legal knowledge to such a degree that it characterized their social position and/or function. The chapter then proceeds in a progressively more content-oriented manner towards a comparative description of legal science, focusing on how legal training took place in each society under consideration and in what literary forms the legal experts expressed themselves, to finally arrive at the core question, namely the description of the respective forms of legal reasoning.
Albanian cinema truly represents a terra incognita for most of the world. Decidedly Europe's most isolated country during the Cold War era, communist Albania had already been cut off from the West for centuries as a one of the western-most outposts of the Ottoman empire. Nonetheless, and unknown to most of the world, communist Albania had a vibrant cinema tradition. Although bound by official orthodoxy, the films of the state-run Kinostudio enterprise were surprisingly innovative and, at times, daringly subversive. This book opens with examinations of moving images in Albania from the Ottoman period, through those captured under independence and the Fascist occupation. It subsequently foregrounds transformations in Kinostudio, from the early optimism of socialist realism through the brooding social angst of the 1980s, which constitute a bridge to the socioeconomic concerns of Albanian films of the postcommunist period.
While mentors can learn general strategies for effective mentoring, existing mentorship curricula do not comprehensively address how to support marginalized mentees, including LGBTQIA+ mentees. After identifying best mentoring practices and existing evidence-based curricula, we adapted these to create the Harvard Sexual and Gender Minority Health Mentoring Program. The primary goal was to address the needs of underrepresented health professionals in two overlapping groups: (1) LGBTQIA+ mentees and (2) any mentees focused on LGBTQIA+ health. An inaugural cohort (N = 12) of early-, mid-, and late-career faculty piloted this curriculum in spring 2022 during six 90-minute sessions. We evaluated the program using confidential surveys after each session and at the program’s conclusion as well as with focus groups. Faculty were highly satisfied with the program and reported skill gains and behavioral changes. Our findings suggest this novel curriculum can effectively prepare mentors to support mentees with identities different from their own; the whole curriculum, or parts, could be integrated into other trainings to enhance inclusive mentoring. Our adaptations are also a model for how mentorship curricula can be tailored to a particular focus (i.e., LGBTQIA+ health). Ideally, such mentor trainings can help create more inclusive environments throughout academic medicine.
The coarse, non-clay fraction of many flint-like kaolinitic claystones often contains mineral grains diagnostic of the claystone's origin and, in the case of tonsteins (altered volcanic ashes), may also provide minerals suitable for radiometric dating. Separation of the non-clay mineral fraction is often difficult because flint clays and flint-like clays resist slaking in water and thus are difficult to disaggregate. Chemical disaggregation of resistant kaolinitic claystones may be achieved by immersion in either hydrazine monohydrate or DMSO for periods ranging from one day to several weeks. Generally, hydrazine monohydrate works more quickly and efficiently than DMSO to disaggregate most kaolinitic claystones and flint clays.
Boron has been shown to be a useful trace element in clay-mineralization reactions, raising the possibility that B studies may provide a means to investigate environmental controls on palagonitization. The objective of the present study was to address calibration, matrix effects, and B exchangeability issues such that meaningful secondary ion mass spectrometry (SIMS) microanalysis of B in thin sections of palagonite will be feasible. Silver Hill illite (IMt-1) was found to be a suitable calibration reference material, based on compositional similarity, relatively high B content, and ease of mounting on thin-section samples for SIMS microanalysis. Matrix effects of borated sideromelane and illite were compared and found to be similar, confirming previous studies which showed no matrix effects for B among minerals. Boron substitutes for Si in tetrahedral sites and also can be adsorbed in exchangeable sites of 2:1 clay minerals. Similarly, B can be found in tetrahedral and exchangeable sites within palagonite, which consists of both layered and amorphous volumes. In order to measure tetrahedral B content and isotopic ratio in the palagonite, exchangeable B was removed by soaking sample thin sections in a 1 M NH4Cl solution until exchangeable cation concentrations were constant. Treated samples showed decreases in B content and isotopic ratio with exchange. Extraction of exchangeable B permits the direct measurement of tetrahedral B content and isotopic ratio. The exchange technique devised and tested here should have broad applicability to thin-section microanalysis of B in clay and clay-like materials where cation exchange can be used for surface-analytical techniques. The present study represents an initial attempt to address samplepreparation, calibration, and potential matrix-effects problems for analyses by SIMS. Further refinements may improve the accuracy of the measurements, but the results presented here indicate that meaningful measurements are possible.
Traumatic brain injury (TBI) and concussion are associated with increased dementia risk. Accurate TBI/concussion exposure estimates are relatively unknown for less common neurodegenerative conditions like frontotemporal dementia (FTD). We evaluated lifetime TBI and concussion frequency in patients diagnosed with a range of FTD spectrum conditions and related prior head trauma to cavum septum pellucidum (CSP) characteristics observable on MRI.
Participants and Methods:
We administered the Ohio State University TBI Identification and Boston University Head Impact Exposure Assessment to 108 patients (age 69.5 ± 8.0, 35% female, 93% white or unknown race) diagnosed at the UCSF Memory and Aging Center with one of the following FTD or related conditions: behavioral variant frontotemporal dementia (N=39), semantic variant primary progressive aphasia (N=16), nonfluent variant PPA (N=23), corticobasal syndrome (N=14), or progressive supranuclear palsy (N=16). Data were also obtained from 217 controls (“HC”; age 76.8 ± 8.0, 53% female, 91% white or unknown race). CSP characteristics were defined based on width or “grade” (0-1 vs. 2+) and length of anterior-posterior separation (millimeters). We first describe frequency of any and multiple (2+) prior TBI based on different but commonly used definitions: TBI with loss of consciousness (LOC), TBI with LOC or posttraumatic amnesia (LOC/PTA), TBI with LOC/PTA or other symptoms like dizziness, nausea, “seeing stars,” etc. (“concussion”). TBI/concussion frequency was then compared between FTD and HC using chi-square. Associations between TBI/concussion and CSP characteristics were analyzed with chi-square (CSP grade) and Mann-Whitney U tests (CSP length). We explored sex differences due to typically higher rates of TBI among males.
Results:
History of any TBI with LOC (FTD=20.0%, HC=19.2%), TBI with LOC/PTA (FTD:32.2%, HC=31.5%), and concussion (FTD: 50.0%, HC=44.3%) was common but not different between study groups (p’s>.4). In both FTD and HC, prior TBI/concussion was nominally more frequent in males but not significantly greater than females. Frequency of repeat TBI/concussion (2+) also did not differ significantly between FTD and HC (repeat TBI with LOC: 6.7% vs. 3.3%, TBI with LOC/PTA: 12.2% vs. 10.3%, concussion: 30.2% vs. 28.7%; p’s>.2). Prior TBI/concussion was not significantly related to CSP grade or length in the total sample or within the FTD or HC groups.
Conclusions:
TBI/concussion rates depend heavily on the symptom definition used for classifying prior injury. Lifetime symptomatic TBI/concussion is common but has an unclear impact on risk for FTD-related diagnoses. Larger samples are needed to appropriately evaluate sex differences, to evaluate whether TBI/concussion rates differ between specific FTD phenotypes, and to understand the rates and effects of more extensive repetitive head trauma (symptomatic and asymptomatic) in patients with FTD.
American politics has become sharply polarized. Partisan deadlock has prevented the addressing of critical public policy issues. A prime example is Congress’s inability to pass campaign finance legislation. Corporations spend unlimited amounts of company funds to promote management’s preferred candidates without disclosure. The distortive effects of large unaccountable corporate political expenditures are evident, and the opportunity for corrupting our politics is clear. In addition, large undisclosed corporate contributions pose a threat to a well-functioning marketplace and democracy. This chapter addresses the challenge of addressing corporate political spending through the informal, non-state suasion and advocacy of the nonprofit Center for Political Accountability. CPA is a case study in successful private ordering, prompting S&P 500 companies to disclose corporate political spending; develop policies that will ensure good compliance and governance; adopt codes of conduct to reflect and inspire pro-accountability behavior; and successfully compete with other firms for best disclosure and accountability practices.
The Albanian earthquake of 26 November 2019, which was especially devastating in the port city of Durres and environs, led to an international outpouring of humanitarian aid. Although considerably less affected, the capital city of Tirana, located only some 37 kilometres away, was also catapulted into chaos and panic. Yet this was short-lived. The invincible children of Skanderbeg rallied, and the country was soon vibrating with energy. There were only a few short months separating the earthquake from the arrival of COVID-19, and in this context, Albania once again proved itself to be rebellious in spirit, in many ways living on the edge. While most of the European Union closed its borders, the neighbouring land of the eagle remained defiantly open. The quake and the virus notwithstanding, Albania has welcomed foreign visitors even from countries whose citizens, at the time of the pandemic, were barred from most places.
Slightly over a decade ago, the Australian-based Lonely Planet guides picked Albania as the number-one tourist destination in the world for 2010. It announced that this country, which had once been considered ‘only for the brave’, is indeed one of ‘azure beaches, confrontingly good cuisine, heritage sites, nightlife, affordable adventures and the possibility of old-style unplanned journeys complete with [a welcoming populace] for whom travellers are still a novelty’. Lonely Planet asserts, ‘Sick to death of being dismissed with blinged-up crime-boss clichés, […] Albania won't be off the beaten path for much longer’ (Lonely Planet, 2010). Indeed, during the few years prior to the Lonely Planet homage, the Balkan outpost had exchanged armed for open-armed locals! In April 2020, Prime Minister Edi Rama announced his goal to make Albania the tourism champion of the Western Balkans (Semini, 2021). An emphasis on this transformation is not an exaggeration. Over the course of its history, Albania has arguably been the most remote and mysterious of all European nations in the eyes of both East and West. Depending on the period, it has been alternatingly exoticized or vilified, or both at once. Albania has conjured up the romance of Lord Byron and Ali Pasha's court, not to mention the remote forests of Harry Potter. It has further been a paradise for anthropologists with its ancient blood feuds and sworn virgins.
Perhaps it was the fact that my first United States passport, issued when I was only seventeen, bore the menacing inscription, ‘Not valid for travel to Albania, Cuba and North Korea’ that my attention was first drawn to this Balkan nation. It was, for me, who grew up in the west of the United States, terra incognita. I subsequently learned of its politics and isolationism in a secondary school class called ‘Current World Problems’, and I was at once daunted and charmed. Although my curiosity was aroused, I knew that Albania was not merely out of reach, but also forbidden. And hence it disappeared from my radar for seven years or so. During my unrelated graduate studies in Hispanic Languages and Literatures at the University of California, Los Angeles, in the late 1970s and early 1980s, my obsession with Albania was rekindled. At that time, an extensive bibliography project was required as part of my doctoral coursework. I opted to explore scholarly work on Brazilian literature in Eastern Europe. Although Yugoslavia was rather extensively represented, I was chagrined that I could not find anything at all published on the topic in Albania. During my doctoral studies, I quenched my thirst for all things Albanian by purchasing a typical 1970s audio-lingual method for the language at a small boutique for educational materials on MacArthur Park. This was the only course available at the time with an audio supplement that used the current spoken language. I further invested in a dated language course from the Defense Language Institute. More will be said to this effect in the ‘Introduction’ to this book.
I was determined to ascertain whether Albania was really all that inaccessible. Could Americans somehow get there? Through the kindness of a stranger, I was put into contact with Rose Dosti, a culinary writer for the Los Angeles Times, who dispatched me off to Ajeti's Albanian restaurant in Hermosa Beach, where I was able to meet my first live Albanian, Haki, a young gentleman born in Vlora. Also, through Rose, I entered into contact with the late Mary Romano, an Albanian-American, who had visited Albania multiple times. Although I never met Mary face to face, I was enthralled by her over-the-phone anecdotes on Albanian travel and culture. I learned that I was not alone in my interest.
Abstract: This chapter first explores Albania's cultural and political ties with the Soviet Union. It then proceeds with a study of Albanian-made newsreels and documentaries, the sole existing film genres made in the early years of the country's cinema trajectory. It looks at the training of future Albanian film professionals in Moscow and examines a large-scale coproduction between the two countries. The documentary work of Endri Keko and Viktor Stratobërdha, who were both trained in the Soviet Union and who brought the genre to a higher level of artistic integrity, will be foregrounded. The chapter concludes with a discussion of Kinostudio's first feature film productions, an ode to socialist realism and an exploration of the partisan movement, the latter coproduced with Mosfilm.
This chapter explores the establishment of a socialist film industry in Albania following the birth of the communist state. It examines early works in the newsreel and documentary genres, which, for the country's first decade, constituted its sole film output. These years saw the consolidation of the People's Republic of Albania and the formation of the Warsaw Pact, of which Albania was a founding member. During this period, Albania had strong ties with the Soviet Union, which considered it a very strategic ally given its proximity to the West. The newsreels and documentaries produced by Albania gave strong voice to the triumphs of the young state, and this was framed in the context of Albanian-Soviet friendship. Films for entertain-ment were imported, a good number from the Soviet Union. Given that the new Kinostudio had few trained professionals, and moreover, was not yet in a position to provide its own training, future film artists and technicians were sent abroad to study in the Soviet Union, Hungary, and Czechoslovakia. This chapter will discuss the first cohort of these students. Although brief mention will be made here of Stalinist film practices, references to Enver Hoxha's views on the arts and cinema will be reserved for Chapter III, given that these topics stem from Hoxha's speeches and documents of the 1960s and 1970s, as well from a contemporaneous Kinostudio manifesto.
The foregoing discussion will primarily proceed in chronological order, though not exclusively.