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The COVID-19 pandemic caused massive disruptions in the job market. It also put the gig economy in the spotlight since many workers began seeing it as a viable career option to their 9-to-5 jobs. Even before the pandemic, the gig economy was forming a significant portion of the workforce in different countries. In light of these changes, this paper has sought to understand the journey and experiences of both location-dependent and purely online gig economy workers in the Philippines. We conducted focus group discussions (FGDs) to explore the experience of those working in the gig economy in the Philippines, with two out of the four groups working as location-dependent gig workers while the remaining two groups working as purely-online gig workers. The study revealed that while gig workers appreciated the flexibility of managing their own time, they also expressed the need for greater government support and regulation to ensure that their welfare is protected. Moreover, while gig work has created additional opportunities for many, certain drawbacks have also emerged over time. It is essential for the government to intervene to safeguard the well-being of these workers, and ensure that labour laws and regulations are adapted to these new circumstances.
By synthesising findings from both clinical and preclinical research, this review aims to provide an understanding of the interplay between 5-HT2A receptor psychedelics and the immune system and considers how their immunomodulatory effects associate with neuronal and behavioural changes.
Methods:
A PubMed literature search covering the past 30 years was conducted using keywords such as “5-HT2A receptor,” “psychedelics,” “immune system,” and “HPA axis.” Studies were included if they addressed the effects of 5-HT2AR psychedelics on immune function, neuroimmune interactions, or HPA axis involvement. This narrative review synthesises evidence highlighting the bi-directional effects of 5-HT2AR psychedelics between the immune and nervous systems, identified through this search process.
Results:
Preclinical and clinical studies report that 5-HT2AR psychedelics have some direct immunomodulatory properties with downregulation of gene regulators like NF-κB, and reduced cytokine expression such as TNF-α, IL-6, and IL-1β at a central and peripheral level, accompanied by modulation of corticotrophin releasing hormone (CRH), adrenocorticotrophic hormone (ACTH), and cortisol. Direct immunomodulatory effects are mediated by pathways involving serotonin receptors, the Sigma-1 receptor, and the TrkB receptor. Immunomodulation is further mediated indirectly via the HPA axis.
Conclusion:
Further studies will determine the molecular and cellular mechanisms underlying these immunomodulatory effects. There is growing interest in the potential of 5-HT2AR psychedelics for treating a range of mental health and brain disorders. In keeping with their immunomodulatory actions, the likely modulation of brain glia and glial-neuronal interaction remains to be determined, representing a promising direction of further research on the therapeutic potential of 5-HT2AR psychedelics.
Astrobiology is a scientific field that is very interdisciplinary and developing very fast, with many new discoveries generating a high level of attention in both the scientific community and the public. A central goal of astrobiology is to discover life beyond Earth which is, with our current instrumentation and knowledge, arguably within our reach. However, knowledge exchange crossing disciplinary boundaries is becoming increasingly challenging due to different usage of nomenclature and scientific controversies often limited to subdisciplines. There have been some efforts to compile organized databases of terms, concepts and other relevant material within some of the subfields contributing to astrobiology, for example through manually curated online portals designed to benefit students, teachers and practitioners of astrobiology-related research. However, the developments within the subfields and the potentially premature communication of research findings are too fast for objective research portals to remain reliable and up-to-date enough to enable well-informed scientific discussions. We suggest here a novel strategy for developing an online tracers portal as a self-maintaining and self-updating information platform, that would allow not only for a relatively unbiased selection of research results, but also provide fast access to latest scientific discoveries together with potential controversies, such that users of the tracers portal can form their own opinion on all available data rather than obtaining an already filtered and potentially biased selection of information.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Threat sensitivity, an individual difference construct reflecting variation in responsiveness to threats of various types, predicts physiological reactivity to aversive stimuli and shares heritable variance with anxiety disorders in adults. However, no research has been conducted yet with youth to examine the heritability of threat sensitivity or evaluate the role of genetic versus environmental influences in its relations with mental health problems. The current study addressed this gap by evaluating the psychometric properties of a measure of this construct, the 20-item Trait Fear scale (TF-20), and examining its phenotypic and genotypic correlations with different forms of psychopathology in a sample of 346 twin pairs (121 monozygotic), aged 9–14 years. Analyses revealed high internal consistency and test-retest reliability for the TF-20. Evidence was also found for its convergent and discriminant validity in terms of phenotypic and genotypic correlations with measures of fear-related psychopathology. By contrast, the TF-20’s associations with depressive conditions were largely attributable to environmental influences. Extending prior work with adults, current study findings provide support for threat sensitivity as a genetically-influenced liability for phobic fear disorders in youth.
Bipolar disorders are a major cause of disability worldwide, with most of the disease burden attributed to those in low- and middle-income countries, including Nigeria. There is limited evidence on culturally appropriate interventions for bipolar disorders in Nigeria.
Aims
The study aims to examine the feasibility, and acceptability of culturally adapted psychoeducation (CaPE) for treating bipolar disorders.
Method
A randomised controlled trial (RCT) compared CaPE plus treatment as usual (TAU) with TAU alone among 34 persons with bipolar disorders in Jos, Nigeria. CaPE comprised 12 group sessions of in-person psychoeducation lasting approximately 90 min each, delivered on a weekly basis by clinical researchers supervised by clinical psychologists and consultant psychiatrists. The primary outcome was feasibility, measured by participants’ recruitment and retention rates. Other outcomes included acceptability as measured by the Service Satisfaction Scale (SSS), Brief Bipolar Disorder Symptom Scale (BBDSS), Patient Health Questionnaire (PHQ-9) and Quality-of-Life scale (EQ5D). Outcomes were assessed at baseline and weeks 12 and 24. Focus group (n = 10) and individual interviews (n = 5) were conducted with the CaPE + TAU group, recorded, transcribed verbatim and analysed using interpretative phenomenological analysis.
Results
The CaPE+TAU group (n = 17) recorded a high participant recruitment and retention rate of 86% across 12 sessions, and also recorded a higher level of satisfaction with SSS compared with the TAU alone group; 87.5% indicated very satisfied compared with 66.7% indicated not sure in the TAU group. In terms of clinical outcomes, for PHQ-9 scores the intervention group showed a reduction from baseline to end of intervention (EOI) and follow-up, with differences of −12.01 and −7.39, respectively (both P < 0.001). The EQ5D index showed a notable improvement in the intervention group at both EOI and follow-up (P < 0.001). Lastly, BBDS scores decreased significantly in the CaPE+TAU group at both EOI and follow-up, with differences of −21.45 and −15.76 (both P < 0.001).
Conclusions
The RCT of CaPE is a feasible, acceptable and culturally appropriate treatment option for bipolar disorders in Nigeria. Further adequately powered RCTs evaluating the intervention’s clinical and cost-effectiveness are warranted.
In an aside to his audience after narrating the revolt of the Theruingi and the slaughter of the Roman army under Lupicinus in AD 376, the ’lonely’ historian Ammianus Marcellinus asks the indulgence of his readers on a particularly difficult matter ... The rather poignant parenthesis is consistent with the view that Ammianus presents elsewhere in his history of a public at Rome concerned only with the trivial biographies of emperors and caring more for the details of the private lives of the imperial household than with the grand sweep of res gestae. The last antique historian is indeed a great one, and he may even have been as isolated as is sometimes suggested.
Up to this point our concern has been how the ancient historian justifies himself before his audience and attempts to portray himself as the proper person for the writing of history, that is, with his role as narrator rerum. The present chapter examines how he approaches his task when a participant in the deeds he records, and how he reconciles the dual role of actor and auctor rerum. For many historians of the ancient world had the opportunity to be both participant and rememberer. The historian’s formal method of presenting himself has received comparatively little attention, yet it is of interest not only because it tells us something of the way that men who wrote history in the ancient world approached the writing of their own deeds, but also what their concerns were in doing so. It is usually assumed that in order to give authority to his account, an historian who narrated his own deeds used the third person and maintained a show of formal impartiality. But a study of the surviving (and partially surviving) historians reveals a variety of approaches and methods, changing with time, the specific type of history written, and the individual intention of the historian himself.
The historian’s task is to narrate, but he must also win credibility for that narrative: his task is therefore also to persuade his audience that he is the proper person to tell the story and, moreover, that his account is one that should be believed. In his capacity as persuader, the historian will often try to shape the audience’s perception of his character and to use this as an additional claim to authority; indeed, among the Roman historians, where explicit professions of research are rarer than with the Greeks, the shaping of the narrator’s character takes on a correspondingly larger role. But most of the historians, Greek and Roman, try to shape their audience’s perception of their character. Nor is this surprising when we consider the teachings of rhetoric.
At the court of the Phaeacians, Demodocus sings of the quarrel between Odysseus and Achilles and delights his listeners, all except the still unrevealed Odysseus who covers his head and weeps. During the feast that follows, Odysseus, despite his grief, sends the singer a rich portion of meat and salutes him, praising how well he sang ’all that the Achaeans did and suffered and toiled, as if you were present yourself, or heard it from one who was’. In this simile, Odysseus anticipates the twin methods of validation for contemporary historians: eyewitness (autopsy) and inquiry of the participants in events. In ancient historiography, professions of autopsy and inquiry are found from Herodotus to Ammianus, and they serve as one of the most prominent means of claiming the authority to narrate contemporary and non-contemporary history. In this chapter, we shall survey some of the issues revolving around inquiry for ancient historians, treating the theoretical observations of the historians on the difficulties and problems raised by inquiry, as well as the explicit claims made by historians in the course of their narratives.
Although I have regularly cited Authority and Tradition in Ancient Historiography in the twenty-five years or so since it appeared, it is only with the current reissue of the work that I have gone back and read it through from beginning to end. About ten years after it was published, I gave serious thought to writing a revised version, both to incorporate much material that I had left out of the original and also (naturally) to update it in the light of more recent scholarship. In the end, I decided not to do so, mostly from the belief that scholarship is an ongoing conversation, and that a work, once published, becomes part of that conversation, dependent on its time and context. Authority and Tradition appeared at a particular point in the discussion of the nature of Greco-Roman historiography, when the linguistic and literary turn was becoming more and more prominent, and the book reflects that moment.
Our study has concentrated on the explicit attempts by the ancient historians to convince the reader of their authority to narrate deeds, and to portray themselves as believable narrators of those deeds. We have seen how the dictates of ancient literary criticism enjoined authors to work within a tradition, and to show their innovation within that tradition. As certain historians became accepted models for imitation, their concerns and approach dictated for those who followed the proper way to write history. As the earlier historians were ’authoritative’, so their followers sought to imitate the manner by which those predecessors had constructed their own authority. It was in this way that authority and tradition were closely related, and so long as the belief in imitation held sway, there could be no authority outside of tradition.
This book is a study of the explicit attempts by the ancient Greek and Roman historians to claim the authority to narrate the deeds encompassed in their works. The term ’authority’ has many meanings over a range of disciplines, but in this book it is used to refer to literary authority, the rhetorical means by which the ancient historian claims the competence to narrate and explain the past, and simultaneously constructs a persona that the audience will find persuasive and believable. The work is thus a study of certain forms and conventions of persuasion employed by the historians. No attempt is made to evaluate the truth or falsity of historians’ claims; rather, I try to set out the various claims which are part of the construction of the author’s historiographical persona; to see how and why these claims are made; to explain how the tradition of such claims developed; and to show how the tradition moulded the way in which writers claimed historiographical authority.
Most of the ancient historians give some indication to their audience why they embarked upon writing their history. These remarks sometimes concern themselves with the unique nature of the historian’s subject matter; in addition to the greatness of the deeds, historians will frequently explain other circumstances that led them to the composition of their histories. There is, in general, a tendency as time goes on for authors, while not abandoning the magnification of their theme, to present a more ’personal’ call to history, that is, to say something of themselves and the personal experiences that underlay their writing of history.