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The classical water-wave theory often neglects water compressibility effects, assuming acoustic and gravity waves propagate independently due to their disparate spatial and temporal scales. However, nonlinear interactions can couple these wave modes, enabling energy transfer between them. This study adopts a dynamical systems approach to investigate acoustic–gravity wave triads in compressible water flow, employing phase-plane analysis to reveal complex bifurcation structures and identify steady-state resonant configurations. Through this framework, we identify specific parameter conditions that enable complete energy exchange between surface and acoustic modes, with the triad phase (also known as the dynamical phase) playing a crucial role in modulating energy transfer. Further, incorporating spatial dependencies into the triad system reveals additional dynamical effects that depend on the wave velocity and resonance conditions: we observe that travelling-wave solutions emerge, and their stability is governed by the Hamiltonian structure of the system. The phase-plane analysis shows that, for certain velocity regimes, the resonance dynamics remains similar to the spatially independent case, while in other regimes, bifurcations modify the structure of resonant interactions, influencing the efficiency of energy exchange. Additionally, modulated periodic solutions appear, exhibiting changes in wave amplitudes over time and space, with implications for wave-packet stability and energy localisation. These findings enhance the theoretical understanding of acoustic–gravity wave interactions, offering potential applications in geophysical phenomena such as oceanic microseisms.
The population of adult CHD patients is continuously increasing. The underlying CHD affects performance and prognosis, but also has a significant impact on quality of life, psychosocial behaviour, anxiety and emotional disturbances. This study analyzes these parameters of patients after one or more heart operations and the possible psychological effects of medical and psychosocial complications at the Department of Cardiology of the Kepler University Hospital Linz.
Methods and Results
A total of 81 subjects participated in the questionnaire survey of the Institute of Cardiology and Clinical Psychology during their annual cardiological check-up. Of these, 80 participants were included in the study and three showed a mild CHD, 49 a moderate one, and 28 a severe one. This study has an exploratory design to assess possible stress factors and limitations in quality of life. For this purpose, a self-administered sociodemographic questionnaire and three standardised questionnaires were used. In summary, the quality of life of adult CHD is considered depending on the severity of the symptoms and compared with the healthy population. Differences in this regard are observed in individuals with lower symptom severity, who report higher psychological well-being. Sex differences are observed in physical role function and physical functioning.
Conclusion:
Based on the results, regular repetitions of the study, as well as continuous psychological and psychosocial support, are necessary, since challenges are predictable with the increasing age of adult CHD patients and since the upholding of good quality of life and dealing with difficult life circumstances must be supported.
Bermudagrass is the most troublesome and difficult-to-control perennial grass weed in Florida sugarcane. Once established, it may be effectively controlled only during the sugarcane fallow period using a combination of nonselective herbicides and tillage. Options for selective management of bermudagrass that escape sugarcane fallow period management programs must be evaluated to mitigate its progressive increase as the crop cycle increases from plant cane to ratoon crops. Greenhouse and field studies were conducted in Belle Glade, Florida, from 2017 to 2018, to determine the response of newly established bermudagrass from sprigs with stolons to two or three sequential applications of topramezone (25 and 50 g ha−1) every 14 d, and combinations of topramezone (25 and 50 g ha−1) with herbicides that inhibit photosystem II (PS II) such as atrazine (2,240 g ha−1), ametryn (440 g ha−1), and metribuzin (2,240 g ha−1). Two or three sequential applications of topramezone with a cumulative total of 75 to 100 g ha−1 provided >93% bermudagrass control 42 d after the first sequential application under greenhouse and field conditions. These treatments exhibited 12% chance of survival 70 d after the first sequential application. There was an additive effect of PS II-inhibitor herbicides on bermudagrass control in mixtures with topramezone. The mixture of topramezone (50 g ha−1) with metribuzin and atrazine provided more than 87% and 92% bermudagrass control under greenhouse and field conditions, respectively, 42 d after treatment. Bermudagrass treated with topramezone (50 g ha−1) in a mixture with metribuzin exhibited 23% chance of survival 70 d after treatment. The results show good efficacy of sequential topramezone applications every 14 d or in a mixture with the PS II-inhibitor herbicides atrazine and metribuzin for control of newly established bermudagrass that typically escape control measures during the sugarcane fallow management period.
Let f be an $L^2$-normalized holomorphic newform of weight k on $\Gamma _0(N) \backslash \mathbb {H}$ with N squarefree or, more generally, on any hyperbolic surface $\Gamma \backslash \mathbb {H}$ attached to an Eichler order of squarefree level in an indefinite quaternion algebra over $\mathbb {Q}$. Denote by V the hyperbolic volume of said surface. We prove the sup-norm estimate
$$\begin{align*}\| \Im(\cdot)^{\frac{k}{2}} f \|_{\infty} \ll_{\varepsilon} (k V)^{\frac{1}{4}+\varepsilon} \end{align*}$$
with absolute implied constant. For a cuspidal Maaß newform $\varphi $ of eigenvalue $\lambda $ on such a surface, we prove that
In this study, we developed and optimized a growth media by evaluating various nitrogen sources for the cultivation of Lactobacillus bulgaricus, a probiotic and an important dairy starter culture. We modified the composition of deMan, Rogosa and Sharpe (MRS) culture media and substituted the nitrogen content with alternative nitrogen sources X-Seed KAT, X-Seed Carbo Max and X-Seed Nucleo Max in various blends of 5 g/l and 10 g/l respectively. Results showed that bacterial growth was significantly higher when the nitrogen source blend KCMax (10/10) was used. The optical density (OD610 nm) of the Lactobacillus bulgaricus strains were higher (1.34 and 1.79) in the KCMax (10/10) medium than in the MRS medium (0.89 and 1.42) (P < 0.05). There was no significant difference in the bacterial counts for both the MRS medium and the KCMax (10/10) medium, and all bacterial counts were estimated at 8 log CFU/ml. The buffering capacity of KCMax (10/10) was also tested and supplemented with l-histidine and was significantly different (P < 0.05) than that of the MRS control medium. Calcium supplemented in the KCMax (10/10) also served as a cryoprotectant for the cells during freezing and freeze-drying. Bacterial counts of the recovered calcium-treated freeze-dried cells were statistically significant (P < 0.05). We hypothesized that alternative nitrogen sources such as selected yeast extracts from the X-Seed brand of complex nitrogen sources could efficiently support the viability of Lb. bulgaricus. Our results thus suggested the growth of Lb. bulgaricus was efficiently supported by the X-Seed KAT, X-Seed Nucleo Max and X-Seed Carbo Max nitrogen sources. Consequently, these alternative nitrogen sources could potentially be recommended for dairy starter culture fermentations.
Posttraumatic stress symptoms (PTSS) are common following traumatic stress exposure (TSE). Identification of individuals with PTSS risk in the early aftermath of TSE is important to enable targeted administration of preventive interventions. In this study, we used baseline survey data from two prospective cohort studies to identify the most influential predictors of substantial PTSS.
Methods
Self-identifying black and white American women and men (n = 1546) presenting to one of 16 emergency departments (EDs) within 24 h of motor vehicle collision (MVC) TSE were enrolled. Individuals with substantial PTSS (⩾33, Impact of Events Scale – Revised) 6 months after MVC were identified via follow-up questionnaire. Sociodemographic, pain, general health, event, and psychological/cognitive characteristics were collected in the ED and used in prediction modeling. Ensemble learning methods and Monte Carlo cross-validation were used for feature selection and to determine prediction accuracy. External validation was performed on a hold-out sample (30% of total sample).
Results
Twenty-five percent (n = 394) of individuals reported PTSS 6 months following MVC. Regularized linear regression was the top performing learning method. The top 30 factors together showed good reliability in predicting PTSS in the external sample (Area under the curve = 0.79 ± 0.002). Top predictors included acute pain severity, recovery expectations, socioeconomic status, self-reported race, and psychological symptoms.
Conclusions
These analyses add to a growing literature indicating that influential predictors of PTSS can be identified and risk for future PTSS estimated from characteristics easily available/assessable at the time of ED presentation following TSE.
Anticholinergic medications block cholinergic transmission. The central effects of anticholinergic drugs can be particularly marked in patients with dementia. Furthermore, anticholinergics antagonise the effects of cholinesterase inhibitors, the main dementia treatment.
Objectives
This study aimed to assess anticholinergic drug prescribing among dementia patients before and after admission to UK acute hospitals.
Methods
352 patients with dementia were included from 17 hospitals in the UK. All were admitted to surgical, medical or Care of the Elderly wards in 2019. Information about patients’ prescriptions were recorded on a standardised form. An evidence-based online calculator was used to calculate the anticholinergic drug burden of each patient. The correlation between two subgroups upon admission and discharge was tested with Spearman’s Rank Correlation.
Results
Table 1 shows patient demographics. On admission, 37.8% of patients had an anticholinergic burden score ≥1 and 5.68% ≥3. At discharge, 43.2% of patients had an anticholinergic burden score ≥1 and 9.1% ≥3. The increase was statistically significant (rho 0.688; p=2.2x10-16). The most common group of anticholinergic medications prescribed at discharge were psychotropics (see Figure 1). Among patients prescribed cholinesterase inhibitors, 44.9% were also taking anticholinergic medications.
Conclusions
This multicentre cross-sectional study found that people with dementia are frequently prescribed anticholinergic drugs, even if also taking cholinesterase inhibitors, and are significantly more likely to be discharged with a higher anticholinergic drug burden than on admission to hospital.
Conflict of interest
This project was planned and executed by the authors on behalf of SPARC (Student Psychiatry Audit and Research Collaborative). We thank the National Student Association of Medical Research for allowing us use of the Enketo platform. Judith Harrison was su
The aim of this review was to present various topics related to lactose intolerance with special attention given to the role of fermented foods and probiotics in alleviating gastrointestinal symptoms. Lactose intolerance is a common digestive problem in which the human body is unable to digest lactose, known as milk sugar. Lactose intolerance can either be hereditary or a consequence of intestinal diseases. Recent work has demonstrated that fermented dairy products and probiotics can modify the metabolic activities of colonic microbiota and may alleviate the symptoms of lactose intolerance. We suggest that, lactose free dairy products could be recommended as alternatives for the alleviation of lactose intolerance and for the promotion of human health and wellness.
Nosocomial transmission of influenza is a major concern for infection control. We aimed to dissect transmission dynamics of influenza, including asymptomatic transmission events, in acute care.
Design:
Prospective surveillance study during 2 influenza seasons.
Setting:
Tertiary-care hospital.
Participants:
Volunteer sample of inpatients on medical wards and healthcare workers (HCWs).
Methods:
Participants provided daily illness diaries and nasal swabs for influenza A and B detection and whole-genome sequencing for phylogenetic analyses. Contacts between study participants were tracked. Secondary influenza attack rates were calculated based on spatial and temporal proximity and phylogenetic evidence for transmission.
Results:
In total, 152 HCWs and 542 inpatients were included; 16 HCWs (10.5%) and 19 inpatients (3.5%) tested positive for influenza on 109 study days. Study participants had symptoms of disease on most of the days they tested positive for influenza (83.1% and 91.9% for HCWs and inpatients, respectively). Also, 11(15.5%) of 71 influenza-positive swabs among HCWs and 3 (7.9%) of 38 influenza-positive swabs among inpatients were collected on days without symptoms; 2 (12.5%) of 16 HCWs and 2 (10.5%) of 19 inpatients remained fully asymptomatic. The secondary attack rate was low: we recorded 1 transmission event over 159 contact days (0.6%) that originated from a symptomatic case. No transmission event occurred in 61 monitored days of contacts with asymptomatic influenza-positive individuals.
Conclusions:
Influenza in acute care is common, and individuals regularly shed influenza virus without harboring symptoms. Nevertheless, both symptomatic and asymptomatic transmission events proved rare. We suggest that healthcare-associated influenza prevention strategies that are based on preseason vaccination and barrier precautions for symptomatic individuals seem to be effective.
We show that there is a Borel graph on a standard Borel space of Borel chromatic number three that admits a Borel homomorphism to every analytic graph on a standard Borel space of Borel chromatic number at least three. Moreover, we characterize the Borel graphs on standard Borel spaces of vertex-degree at most two with this property and show that the analogous result for digraphs fails.
We provide a finite basis for the class of Borel functions that are not in the first Baire class, as well as the class of Borel functions that are not $\sigma $-continuous with closed witnesses.
Data from neurological and radiological research show an abnormal neurological development in patients treated for hypoplastic left heart syndrome. Thus, the aim of this study was to survey the quality of life scores in comparison with healthy children and children with other heart diseases (mild, moderate, and severe heart defects, heart defects in total). Children with hypoplastic left heart syndrome (aged 6.3–16.9 years) under compulsory education requirements, who were treated at the Children’s Heart Center Linz between 1997 and 2009 (n = 74), were surveyed. Totally, 41 children and 44 parents were examined prospectively by psychologists according to Pediatric Quality of Life Inventory, a health-related quality of life measurement. The results of the self-assessments of health-related quality of life on a scale of 1–100 showed a wide range, from a minimum of 5.00 (social functioning) to a maximum of 100 (physical health-related summary scores, emotional functioning, school functioning), with a total score of 98.44. The parents’ assessments (proxy) were quite similar, showing a range from 10 (social functioning) up to 100. Adolescent hypoplastic left heart syndrome patients rated themselves on the same level as healthy youths and youths with different heart diseases. The results show that patients with hypoplastic left heart syndrome aged 6–16 years can be successfully supported and assisted in their psychosocial development even if they show low varying physical and psychosocial parameters. The finding that adolescent hypoplastic left heart syndrome patients estimated themselves similar to healthy individuals suggests that they learnt to cope with a severe heart defect.
Field studies were conducted on organic soils in Belle Glade, FL, in 2016 to 2017 to evaluate sugarcane tolerance and fall panicum control with topramezone applied alone or in combination with triazine herbicides (atrazine, metribuzin, ametryn). Treatments included topramezone (25 and 50 g ai ha−1) applied alone or in combination with atrazine (2,240 g ai ha−1), metribuzin (2,240 g ai ha−1), and ametryn (440 g ha−1) on four plant cane varieties to evaluate tolerance, and on second ratoon fields to determine efficacy on fall panicum control. Topramezone applied alone had no effect on sugarcane chlorophyll fluorescence (i.e., the ratio of variable fluorescence to maximum fluorescence), total chlorophyll, and carotenoid 7 to 28 d after treatment (DAT), suggesting sugarcane tolerance. Significant reduction of these parameters occured 7 to 14 DAT when topramezone (50 g ai ha−1) was applied with ametryn or metribuzin; however, reductions were not detected thereafter, indicating recovery. Sugarcane yield was not affected by topramezone applied alone or in combination with the triazine herbicides. Topramezone (50 g ai ha−1) plus metribuzin resulted in acceptable control of fall panicum (84%) with limited to no regrowth of meristematic tissue at sugarcane canopy closure, equivalent to 56 to 70 DAT. These results indicate that when sequential applications of topramezone, applied alone or in combination with these triazine herbicides, are required for efficacious weed control, topramezone applications alone can be made after 7 d, whereas the combinations can be made after 14 or 21 d, depending on sugarcane sensitivity.
New data on the Gongo Soco palladium-oxygenated compounds are presented for the first time since the work of Johnson and Lampadius (1837). A variety of PdO species is documented, always in association with Cu, Fe and Mn, and includes Pd(OH)2 or PdO.H2O, and phases with metal excess in relation to oxygen, interpreted as metastable. Their remarkable occurrence in ‘ouro preto’ (black gold) and jacutinga (auriferous itabirite/iron ore) is the result of mertieite-II alteration. It involves leaching of Sb and As, limited removal of Pd, and incorporation of Cu, Mn and Hg into PdO species. The locus of Hg-bearing PdO species in microfractures parallel to the enclosing gold-mineralized shear band suggests at least one low-temperature hydrothermal generation. The presence of a halite crystal attached to gold testifies to the involvement of Cl-saturated hydrothermal fluids in the oxidizing environment of jacutinga formation.
A massive ground-ice body was found exposed in the headwall of a thaw flow developed within the Chapman Lake terminal moraine complex on the Blackstone Plateau (Ogilvie Mountains, central Yukon Territory), which is contemporaneous to the Reid glaciation. Based on visible cryostructures in the 4-m-high headwall, two units were identified: massive ground ice, overlain sharply by 2 m of icy diamicton. The nature and origin of the Chapman Lake massive ground ice was determined using cryostratigraphy, petrography, stable O–H isotopes and the molar concentration of occluded gases (CO2, O2, N2 and Ar) entrapped in the ice, a new technique in the field of periglacial geomorphology that allows to distinguish between glacial and non-glacial intrasedimental ice. Collectively, the results indicate that the Chapman Lake massive ground ice formed by firn densification with limited melting–refreezing and underwent deformation near its margin. Given that the massive ground-ice body consists of relict glacier ice, it suggests that permafrost persisted, at least locally, on plateau areas in the central Yukon Territory since the middle Pleistocene. In addition, the d value of Chapman Lake relict glacier ice suggests that the ice covering the area during the Reid glaciation originated from a local alpine glaciation in the Ogilvie Mountains.
Measuring the masses of rocky planets is quite difficult, as the relevant signal produced by such planets is often dwarfed by stellar activity by an order of magnitude or more. Developing a more robust way to isolate the stellar activity in these measurements is crucial to the search for Earth-like planets. We estimate the mass of Earth-size planet Kepler-78b using a Gaussian process estimator to describe the stellar activity in both photometric and radial velocity (RV) data, confirming previous results with a more robust technique that can be extended toward Earth analogues.
Quantitative measurement of the medical severity following multiple-casualty events (MCEs) is an important goal in disaster medicine. In 1990, de Boer proposed a 13-point, 7-parameter scale called the Disaster Severity Scale (DSS). Parameters include cause, duration, radius, number of casualties, nature of injuries, rescue time, and effect on surrounding community.
Hypothesis
This study aimed to examine the reliability and dimensionality (number of salient themes) of de Boer's DSS scale through its application to 144 discrete earthquake events.
Methods
A search for earthquake events was conducted via National Oceanic and Atmospheric Administration (NOAA) and US Geological Survey (USGS) databases. Two experts in the field of disaster medicine independently reviewed and assigned scores for parameters that had no data readily available (nature of injuries, rescue time, and effect on surrounding community), and differences were reconciled via consensus. Principle Component Analysis was performed using SPSS Statistics for Windows Version 22.0 (IBM Corp; Armonk, New York USA) to evaluate the reliability and dimensionality of the DSS.
Results
A total of 144 individual earthquakes from 2003 through 2013 were identified and scored. Of 13 points possible, the mean score was 6.04, the mode = 5, minimum = 4, maximum = 11, and standard deviation = 2.23. Three parameters in the DSS had zero variance (ie, the parameter received the same score in all 144 earthquakes). Because of the zero contribution to variance, these three parameters (cause, duration, and radius) were removed to run the statistical analysis. Cronbach's alpha score, a coefficient of internal consistency, for the remaining four parameters was found to be robust at 0.89. Principle Component Analysis showed uni-dimensional characteristics with only one component having an eigenvalue greater than one at 3.17. The 4-parameter DSS, however, suffered from restriction of scoring range on both parameter and scale levels.
Conclusion
Jan de Boer's DSS in its 7-parameter format fails to hold statistically in a dataset of 144 earthquakes subjected to analysis. A modified 4-parameter scale was found to quantitatively assess medical severity more directly, but remains flawed due to range restriction on both individual parameter and scale levels. Further research is needed in the field of disaster metrics to develop a scale that is reliable in its complete set of parameters, capable of better fine discrimination, and uni-dimensional in measurement of the medical severity of MCEs.
BayramJD, ZuabiS, McCordCM, SherakRAG, HsuEB, KelenGD. Disaster Metrics: Evaluation of de Boer's Disaster Severity Scale (DSS) Applied to Earthquakes. Prehosp Disaster Med. 2015;30(1):1-6.
At the University of Glasgow in 1961, a committee of senior members of the academic staff in economics and allied social sciences began thinking of a suitable way to celebrate the bicentenary in 1976 of the first publication of Adam Smith's Wealth of Nations. Their plans did not at first include any project for a new edition of Collected Works. The initial impulse for that came from Professor G. J. Stigler of the University of Chicago in October 1961. Sir Laurence Hunter, now Emeritus Professor of Applied Economics at Glasgow, was at that time a newly graduated student of the Department of Political Economy. He went to Chicago for a year's postgraduate study, and soon after his arrival Professor Stigler asked him whether the University of Glasgow was going to produce a new edition of Adam Smith's works. Stigler thought this would be a highly appropriate way to celebrate the bicentenary of the Wealth of Nations. Hunter communicated this information in a letter to Professor A. L. Macfie, Emeritus Adam Smith Professor of Political Economy at Glasgow. He added that there was a Professor of some seniority at Chicago who might be ready to undertake an edition of the Collected Works. ‘But,’ he went on, ‘I fancy Stigler would not want to intrude on other plans provided the work was done, and he asked me if I knew of anything in that direction.’
Macfie sent a brief interim reply to ensure that Chicago should hold its hand meanwhile. He then drafted a reply for consideration by the committee.
Our Committee has authorised me to write to you as follows:
There is no doubt Glasgow will do something big for 1976. The Court [i.e. the University Court, the governing body of the institution] has been approached, and has indicated its support in principle. We feel sure we shall get it. The scheme we have in mind is something like this. First, we will produce a volume of critical essays on Smith's work and its influence. […]