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Bipolar disorders are a major cause of disability worldwide, with most of the disease burden attributed to those in low- and middle-income countries, including Nigeria. There is limited evidence on culturally appropriate interventions for bipolar disorders in Nigeria.
Aims
The study aims to examine the feasibility, and acceptability of culturally adapted psychoeducation (CaPE) for treating bipolar disorders.
Method
A randomised controlled trial (RCT) compared CaPE plus treatment as usual (TAU) with TAU alone among 34 persons with bipolar disorders in Jos, Nigeria. CaPE comprised 12 group sessions of in-person psychoeducation lasting approximately 90 min each, delivered on a weekly basis by clinical researchers supervised by clinical psychologists and consultant psychiatrists. The primary outcome was feasibility, measured by participants’ recruitment and retention rates. Other outcomes included acceptability as measured by the Service Satisfaction Scale (SSS), Brief Bipolar Disorder Symptom Scale (BBDSS), Patient Health Questionnaire (PHQ-9) and Quality-of-Life scale (EQ5D). Outcomes were assessed at baseline and weeks 12 and 24. Focus group (n = 10) and individual interviews (n = 5) were conducted with the CaPE + TAU group, recorded, transcribed verbatim and analysed using interpretative phenomenological analysis.
Results
The CaPE+TAU group (n = 17) recorded a high participant recruitment and retention rate of 86% across 12 sessions, and also recorded a higher level of satisfaction with SSS compared with the TAU alone group; 87.5% indicated very satisfied compared with 66.7% indicated not sure in the TAU group. In terms of clinical outcomes, for PHQ-9 scores the intervention group showed a reduction from baseline to end of intervention (EOI) and follow-up, with differences of −12.01 and −7.39, respectively (both P < 0.001). The EQ5D index showed a notable improvement in the intervention group at both EOI and follow-up (P < 0.001). Lastly, BBDS scores decreased significantly in the CaPE+TAU group at both EOI and follow-up, with differences of −21.45 and −15.76 (both P < 0.001).
Conclusions
The RCT of CaPE is a feasible, acceptable and culturally appropriate treatment option for bipolar disorders in Nigeria. Further adequately powered RCTs evaluating the intervention’s clinical and cost-effectiveness are warranted.
Studies show that mental health promotion is an effective strategy that can reduce the burden of mental health disorders and improve overall well-being in both children and adults. In addition to promoting high levels of mental well-being and preventing the onset of mental illness, these mental health promotion programmes, including mental illness prevention interventions, help increase levels of mental health literacy in community members. While there is evidence showing the effectiveness of mental health promotion, much of what is known about this field is informed by studies conducted in high-income countries. There is a need to gather evidence about the effectiveness of such interventions in low- and middle-income countries (LMICs) where mental health services are often inadequate. In this systematic review, we synthesised the available published primary evidence from sub-Saharan Africa (SSA) on the types and effectiveness of mental health promotion programmes for young people. We performed a search of selected global databases (PubMed, PsycINFO, ScienceDirect and Google Scholar) and regional databases (Sabinet African Journals). We included observational, mixed methods, trials, pilots and quantitative original papers published from 2013 to 2023. We used the Mixed Methods Appraisal Tool (MMAT) to evaluate the quality of methods in selected studies, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA-2020) for reporting the evidence gathered. We identified 15 types of youth mental health promotion and illness prevention interventions. Among those identified, we found that school-based interventions enhanced mental health literacy, mental health-seeking behaviours and self-assurance and confidence among young people. Family-based interventions also showed a potential to improve relationships between young people and their caregivers. Future studies should explore how to further strengthen school- and family-based interventions that promote mental health among young people.
Research for development (R4D) projects are designed to enhance the research community's contribution to implementation of the 2030 Agenda of the United Nations. We studied seven R4D projects that specifically addressed Sustainable Development Goal (SDG) 15 (life on land) in 14 contexts across Asia, Africa, and South America. We then analyzed how these projects interacted with other SDGs. Our findings reveal that the positive and negative interactions between project objectives and SDG targets vary significantly across contexts, highlighting the importance of considering local conditions when designing and implementing R4D initiatives.
Technical summary
We analyze how the objectives of research for development (R4D) projects that focus on a particular Sustainable Development Goal (SDG) – SDG 15 (life on land) – interact with the targets of other SDGs. We studied seven R4D projects in 14 contexts across Asia, Africa, and Latin America, comparing expert judgement of interactions between project objectives and SDG targets. Our findings indicate that the success of these projects depends largely on whether they are also working toward SDG targets other than those contained in SDG 15. In particular, working toward targets contained within SDGs on poverty, hunger, water, energy, production and consumption, and global partnerships – was often considered indivisible from the project objectives. Further, while all of the projects focused on SDG 15, our findings suggest that addressing only this goal is not sufficient. A range of other targets that were a priori not the immediate focus of the projects were revealed as ‘crucial’ to the project objectives across contexts. Finally, we list several implications, such as the need for policies to integrate local realities and the need for environmental R4D projects to adopt a holistic scope, particularly in terms of (a) securing social foundations, (b) building enabling institutions, and (c) negotiating competing claims on land.
Social media summary
What can we learn from land-related research for development projects and their links to the SDGs in concrete contexts?
Comprehensive coherent structures around a surface-mounted low aspect ratio square cylinder in uniform flow with an oblique angle of $45^{\circ }$ were investigated for cylinder-width-based Reynolds numbers of 3000 and 10 000 by direct numerical simulation based on a topology-confined mesh refinement framework. High-resolution simulations and the critical-point concept were scrutinized to reveal for the first time the reasonable and compatible topologies of flow separation and complete near-wall structures, due to their extensive impact on various engineering applications. Large-scale horseshoe vortices are observed at two notable foci in the viscous sublayer. Within this layer, a wall-parallel jet is formed by downflow intruding into the bottom surface at the half-saddle point, then deflecting in the upstream direction and finally penetrating the bottom surface until the half-saddle point. A pair of conical vortices on the cylinder's top surface switch themselves on two sides of the square cylinder, where the switching frequency is identical with that of the sway of the side shear layer. The undulation of the Kelvin–Helmholtz instability is identified in the instantaneous development of a conical vortex and side shear layer, where the scaling of the ratio of the Kelvin–Helmholtz and von Kármán frequencies follows the power-law relation obtained by Lander et al. (J. Fluid Mech., vol. 849, 2018, pp. 1096–1119). Large-scale arch-shaped vortex is often detected in the intermediate wake region of a square cylinder, involving two interconnected portions, such as the leg portion separated from leeward surfaces and head portion rolled up from the top surface. The leg portion of the arch-shaped vortex was rooted by two foci near the bottom-surface plane.
This research studies the robustness of permanence and the continuous dependence of the stationary distribution on the parameters for a stochastic predator–prey model with Beddington–DeAngelis functional response. We show that if the model is extinct (resp. permanent) for a parameter, it is still extinct (resp. permanent) in a neighbourhood of this parameter. In the case of extinction, the Lyapunov exponent of predator quantity is negative and the prey quantity converges almost to the saturated situation, where the predator is absent at an exponential rate. Under the condition of permanence, the unique stationary distribution converges weakly to the degenerate measure concentrated at the unique limit cycle or at the globally asymptotic equilibrium when the diffusion term tends to 0.
The introduction of the 2012 Labour Code is considered ‘groundbreaking’ in industrial relations in Vietnam. However, knowledge about the effects of this law is still minimal. This study provides the first evidence of the impacts of the law on worker outcomes, disaggregated by location and migration status. The Vietnam Labour Force Survey is used as the primary dataset. Both difference-in-differences and fixed-effect models are applied in the investigation. The estimated results show a relationship between the introduction of the law and the labour supply of contracted workers in urban areas, especially long-term migrant workers. Furthermore, income for these long-term migrant contract workers was affected significantly by the introduction of the law. A link between the law and health insurance participation was also found among non-migrant contracted workers in urban areas. We also perform estimations using a short panel sample and find notable results. The study likewise reveals disadvantages of rural workers compared to urban workers in terms of earnings, and of short-term migrants compared to other workers, in terms of labour supply.
While the South China Sea dispute remains Vietnam's top security concern, the country also confronts a variety of growing non-traditional threats, such as illegal fishing, maritime violence, smuggling, ecological degradation and climate change. These issues adversely affect Vietnam's external relations, socio-economic development, marine ecosystems and political stability, while engendering and exacerbating regional tensions. In response, at the national level, Vietnam has focused on building a blue economy and strengthening its law enforcement capacity. At the international level, Vietnam has participated in a variety of bilateral and multilateral cooperative mechanisms. However, these efforts have been impeded by internal and external factors, such as corruption, inadequate capacity and lack of budget, as well as ASEAN's institutional limitations and sovereignty sensitivities.
To better confront these multifaceted maritime issues, Vietnam will need to (1) formulate a comprehensive national strategy for maritime security; (2) streamline the overlapping responsibilities of maritime security agencies; (3) enhance its maritime domain awareness; (4) ensure proper policy and investment to improve climate resilience and coastal development; and (5) optimize its approach to multilateralism.
Vietnam’s initial response to Covid-19 was conspicuous for various reasons, including how its attempt at securitisation drew deeply from historical narratives, symbols, and traditions specific to the Vietnamese experience, as well as how the securitisation project was not simply top-down and state-driven but also featured ground-up participation where the public was mobilised to participate in and actively reiterate securitisation practices. This richly textured empirical case study of the workings of Vietnamese society and politics represents an invitation to explore key debates surrounding securitisation theory. Reflecting on the empirical material of the case, this paper builds on scholarship seeking to highlight the shortcomings of the Copenhagen School’s model of securitisation and from there further explore securitisation theory and its limits. It takes aim at how the audience and its agency is conceptualised in the theory and develops the notions of ‘historical resources’ and ‘activation architecture’ to more adequately explain the processes of securitisation.
Leonetti and Luca [‘On the iterates of the shifted Euler’s function’, Bull. Aust. Math. Soc., to appear] have shown that the integer sequence $(x_n)_{n\geq 1}$ defined by $x_{n+2}=\phi (x_{n+1})+\phi (x_{n})+k$, where $x_1,x_2\geq 1$, $k\geq 0$ and $2 \mid k$, is bounded by $4^{X^{3^{k+1}}}$, where $X=(3x_1+5x_2+7k)/2$. We improve this result by showing that the sequence $(x_n)$ is bounded by $2^{2X^2+X-3}$, where $X=x_1+x_2+2k$.
Objectives: Healthcare-associated infections (HAIs) are one of the greatest challenges and concerns in Vietnam and around the world. Many studies have shown that HAIs may result in an increase in hospital length of stay, antibiotic use, multidrug-resistant organism (MDROs) infections, treatment costs, and mortality. Therefore, in the past 5 years, the Department of Infection Control of Cho Ray Hospital has carried out many infection and prevention control (IPC) activities to reduce the rates of HAI and MDRO infection. We evaluated IPC activities and results achieved in these efforts at Cho Ray Hospital during 2017–2021. Methods: We described the implemented IPC activities and retrospectively collected data from HAIs surveillance reports during 2017–2021 for 3 intensive care units (ICUs): ICU-B, ICU-D, and the NICU. Results: In the past 5 years, we implemented synchronous IPC activities, including promoting hand hygiene training and surveillance, environmental cleaning surveillance, carrying out improvement projects such as a ventilator-associated pneumonia (VAP) prevention bundle, an MDRO prevention bundle, and an environmental cleaning quality improvement project. Many positive results were achieved, although a slight increase in the HAI incidence occurred in 2021 due to the COVID-19 pandemic. Overall, the hand hygiene compliance rate increased from 49.7% to 83.8%. The rate of HAIs per 1,000 patient days decreased steadily from 5.4 to 2.4. The VAP rate fell from 30.5 to 17.2 per 1,000 patient days, and the central-line–associated bloodstream infection (CLABSI) rate decreased gradually from 5.4 to 2.4 per 1,000 patient days. The catheter-associated urinary tract infection (CAUTI) rate decreased from 2.9 to 0.9 per 1,000 patient days, and the MDRO infection rate decreased significantly from 32.7 to 11.3 per 1,000 patient days. Conclusions: The synchronous implementation of HAI prevention bundles promoting hand hygiene and environmental cleaning achieved significant effects in the efforts to decrease HAIs and MDROs in the ICUs of Cho Ray Hospital.
Objectives: In Vietnam, the burden of healthcare-associated infections (HAIs), especially by multidrug-resistant organisms (MDROs), can be greater at national hospitals where a high number of severe patients from lower-tier hospitals are received for treatment. To reduce MDRO and HAI incidences at the tropical diseases intensive care unit (ICU) of Cho Ray Hospital, the final line of treatment for 20 southern provinces of Vietnam, a comprehensive infection prevention bundle was developed and implemented in 2019. In this retrospective study, we evaluated the effectiveness of this intervention in preventing MDRO infections and HAIs among patients at risk. Methods: The infection prevention bundle included elements to improve administration controls, environmental controls, and personal protective equipment usage. The bundle was implemented via training and active monitoring. Medical data, such as microbiology results, length of hospital stay, treatment cost of all patients admitted to the targeted ICU, and data on adherence to the bundle elements, were collected via routine monitoring from July to December 2019. These data were reviewed and analyzed. An independent 2-sample t test was used to calculate the significance of the differences in MDRO and HAI rates before and after the intervention. Results: The mean number of MDRO infections decreased significantly after implementation of the infection prevention bundle (7.0 vs 3.3; P = .011). HAI and ventilator-associated pneumonia (VAP) rates also decreased significantly (5.9 vs 3.7; P= .013 and 20.4 vs 13.7; P=0.047, respectively). The mean total treatment cost per patient was reduced by 1.8 million VND (US $76.76). Bundle-element adherence was high throughout the intervention period, ranging from 72.7% (putting MDRO sign on beds) to 100% (hand hygiene, cohort patients, environment cleaning). Conclusions: Implementation of an appropriate infection prevention bundle with a high adherence rate by healthcare workers helped to effectively reduce MDRO infection and HAI rates in the tropical diseases ICU.
Objectives: Studies have revealed that a relatively high incidence of severe infection and mortality in COVID-19 patients is attributed to healthcare-associated infections (HAIs). We implemented a study in 2 field hospitals dedicated to COVID-19 treatment in Da Nang, Vietnam (July–August 2020), and Ho Chi Minh City, Vietnam (August–October 2021), to identify pathogens, risk factors, and outcomes associated with HAIs. Methods: We applied a prospective study tool to estimate HAI incidence among 1,454 patients. HAIs are diagnosed and ascertained using surveillance criteria established by the US Centers for Disease Control and Prevention. All patients hospitalized for COVID-19 for at least 2 days were enrolled in this assessment of HAI risks, pathogens, and outcomes. Results: Among 1,454 sampled patients, 391 patients had 423 HAIs (27.1%). The highest proportion occurred in ICUs, with 422 HAI patients (34.1%). Pneumonia (n = 331, 78.3%) and bloodstream infections (n = 55, 13.1%) were the most common HAIs. Multidrug-resistant (MDR) bacteria, such as Klebsiella pneumonia (27.9%) and Acinetobacter baumannii (25.3%), were the most commonly isolated organisms. Ventilators and central venous catheters were independently associated with HAIs. Regarding the mortality rates, 55% of deaths occurred in intensive care units. Patients with HAIs (70.3%) were twice as likely to die compared to patients without HAIs (38.8%). HAIs leading to septic shock caused almost triple mortality (n = 58, 90.6%) compared with non-HAI patients (n = 412, 38.8%). HAIs prolonged hospital stay: 24.7 days for patients with HAIs and 19.1 days for patients without HAIs (P < .001). Conclusions: Patients with COVID-19–related critical illnesses are at high risk of HAIs from multidrug-resistant (MDR) bacteria. HAIs prolong hospitalization, whereas HAIs with septic shock almost tripled mortality. Guidelines and procedures to prevent and control HAIs caused by MDR bacteria as well as training and monitoring on aseptic-compliant techniques during invasive clinical procedures are needed.
Ho Chi Minh, Vietnam’s national liberation hero, once said, “Land is the house, sea is the door. How can we protect the house without guarding the door?”. Throughout history, foreign powers cracked open “the door” to Vietnam through sea-borne attacks multiple times. As such, defending Vietnam’s maritime space is of utmost importance, especially since Vietnam’s land borders have been secured through the conclusion of border treaties with Laos (1977), Cambodia (1985) and China (1999).
Vietnam prioritizes the maritime frontier also for reasons beyond historical experience. It is a maritime nation with a coastline of 3,260 km and an exclusive economic zone (EEZ) of more than 1 million km²—three times the size of its land area. Many of Vietnam’s 3,000 islands and archipelagos are of economic, security and strategic significance. Half of the Vietnamese population resides in 28 coastal provinces, and 80 per cent live within 160 km of the coastline. Economically, Vietnam relies on the South China Sea, which encompasses vital arteries of international commerce through which an estimated one-third of global shipping passes. The South China Sea’s abundant marine resources, including oil reserves, gas, minerals, fisheries, and renewable energy, sustain Vietnam’s galloping economy. The marine economy and coastal cities account for nearly half of the country’s GDP.
Vietnam is a South China Sea disputant and claims sovereignty over the entirety of the Paracel Islands (Hoang Sa) and the Spratly Islands (Truong Sa). There have been voluminous studies done on Vietnam’s perspective on this topic for two main reasons. First, Vietnamese strategists and leaders consider the South China Sea dispute their country’s most pressing national security threat, not least because of China’s recent militarization of disputed features and maritime coercion. Given Vietnam’s power asymmetry, geographical proximity, and troubled history vis-à-vis China, leaders in Hanoi are wary of Beijing’s intentions. Second, scholars and policymakers alike are interested in how small and medium-sized states like Vietnam cope with the intensifying great power competition in the Indo-Pacific, which manifests prominently in the highly contested South China Sea.
However, non-traditional security concerns have also been high on the Vietnamese leadership’s agenda.
• While the South China Sea dispute remains Vietnam’s top security concern, the country also confronts a variety of growing non-traditional threats, such as illegal fishing, maritime violence, smuggling, ecological degradation and climate change.
• These issues adversely affect Vietnam’s external relations, socio-economic development, marine ecosystems and political stability, while engendering and exacerbating regional tensions.
• In response, at the national level, Vietnam has focused on building a blue economy and strengthening its law enforcement capacity.
• At the international level, Vietnam has participated in a variety of bilateral and multilateral cooperative mechanisms. However, these efforts have been impeded by internal and external factors, such as corruption, inadequate capacity and lack of budget, as well as ASEAN’s institutional limitations and sovereignty sensitivities.
• To better confront these multifaceted maritime issues, Vietnam will need to (1) formulate a comprehensive national strategy for maritime security; (2) streamline the overlapping responsibilities of maritime security agencies; (3) enhance its maritime domain awareness; (4) ensure proper policy and investment to improve climate resilience and coastal development; and (5) optimize its approach to multilateralism.
The economic, political, strategic and cultural dynamism in Southeast Asia has gained added relevance in recent years with the spectacular rise of giant economies in East and South Asia. This has drawn greater attention to the region and to the enhanced role it now plays in international relations and global economics.
The sustained effort made by Southeast Asian nations since 1967 towards a peaceful and gradual integration of their economies has had indubitable success, and perhaps as a consequence of this, most of these countries are undergoing deep political and social changes domestically and are constructing innovative solutions to meet new international challenges. Big Power tensions continue to be played out in the neighbourhood despite the tradition of neutrality exercised by the Association of Southeast Asian Nations (ASEAN).
The Trends in Southeast Asia series acts as a platform for serious analyses by selected authors who are experts in their fields. It is aimed at encouraging policymakers and scholars to contemplate the diversity and dynamism of this exciting region.
We report on the modification of the spectrum of a passive scalar inside a turbulent flow by the injection of large bubbles. Although the spectral modification through bubbles is well known and well analysed for the velocity fluctuations, little is known on how bubbles change the fluctuations of an approximately passive scalar, in our case temperature. Here we uncover the thermal spectral scaling behaviour of a turbulent multiphase thermal mixing layer. The development of a $-3$ spectral scaling is triggered. By injecting large bubbles (${Re}_{{bub}} = {O}(10^2)$) with gas volume fractions $\alpha$ up to 5 %. For these bubbly flows, the $-5/3$ scaling is still observed at intermediate frequencies for low $\alpha$ but becomes less pronounced when $\alpha$ further increases and it is followed by a steeper $-3$ slope for larger frequencies. This $-3$ scaling range extends with increasing gas volume fraction. The $-3$ scaling exponent coincides with the typical energy spectral scaling for the velocity fluctuations in high-Reynolds-number bubbly flows. We identify the frequency scale of the transition from the $-5/3$ scaling to the $-3$ scaling and show how it depends on the gas volume fraction.
Viet Nam has entered into more than 80 investment treaties, including bilateral investment treaties and free trade agreements. In recent years, the country has also faced an increasing number of investor-state disputes, focusing the attention of government action. This paper examines the extent to which Viet Nam has internalised its investment treaty obligations, both before and after its experience with investment treaty claims. The chapter analyses the current investment law and policy landscape of Vietnam, against the backdrop of three decades of government policy addressing foreign investment. The chapter concludes that Vietnam has made significant efforts to internalise the provisions of investment treaties into national governance. It has done so through formal regulation, i.e. mechanisms for legislative screening, and informal coordination and education processes. Still, the paper reveals that the awareness and understanding of investment treaties by local governments remains limited, suggesting the existence of further factors affecting the internalisation process.