The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain (${\sim}2.8\,\mbox{K Jy}^{-1}$) low-system temperature (${\sim}18\,\mbox{K at }20\,\mbox{cm}$) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar $\mbox{J}0737{-}3039\mbox{A}$, pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR $\mbox{J}0540{-}6919$, and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR $\mbox{J}2241{-}5236$ exhibits a jitter limit of $<4\,\mbox{ns h}^{-1}$ whilst timing of PSR $\mbox{J}1909{-}3744$ over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities.

An Eclipse is an astronomical event that convenes a large audience. Few days before it, most of the community is aware of the event and the press is activated fully on it. The alignment recovers our most intrinsic human aspects, the curiosity, and enthusiasm for a natural phenomenon. This work is focused to enjoy and perceive it in three different ways: visually, listening, and in an artistic expression.

We focused on the construction of more than one hundred LightSound devices, which the main purpose is to record the light intensity and transform it into different tones. Besides, we created an artistic representation of the Eclipse motivated by the ancestral culture of the people residing in the totality zone. This music adds a sensorial joy to the eclipse event.

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (Prace difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

The Square Kilometre Array will be an amazing instrument for pulsar astronomy. While the full SKA will be sensitive enough to detect all pulsars in the Galaxy visible from Earth, already with SKA1, pulsar searches will discover enough pulsars to increase the currently known population by a factor of four, no doubt including a range of amazing unknown sources. Real time processing is needed to deal with the 60 PB of pulsar search data collected per day, using a signal processing pipeline required to perform more than 10 POps. Here we present the suggested design of the pulsar search engine for the SKA and discuss challenges and solutions to the pulsar search venture.

With the changing distribution of infectious diseases, and an increase in the burden of non-communicable diseases, low- and middle-income countries, including those in Africa, will need to expand their health care capacities to effectively respond to these epidemiological transitions. The interrelated risk factors for chronic infectious and non-communicable diseases and the need for long-term disease management, argue for combined strategies to understand their underlying causes and to design strategies for effective prevention and long-term care. Through multidisciplinary research and implementation partnerships, we advocate an integrated approach for research and healthcare for chronic diseases in Africa.

Second generation antipsychotic (SGA) drugs are effective treatments for psychosis. Common side-effects of SGAs include metabolic dysregulation and risk of cardiometabolic disorders. Metabolic side-effects, including glucose intolerance, can be accurately modelled in rodents. The benefits of interventions used for treating metabolic side-effects of SGAs are mostly unknown. In a 9 wk longitudinal study, female rats were given daily olanzapine (10 mg/kg s.c.) or vehicle. Animals were either sedentary or allowed 1 or 3 h daily access to a running wheel, with total wheel revolutions electronically quantified to reflect exercise intensity. Glucose tolerance tests were performed once weekly to measure glycemic control. Drug levels were measured at week 4. At week 9, abdominal fat and skeletal muscle levels of Glucose Transporter 4 (GLUT4) were measured. Exercise intensity progressively increased over time in all groups given access to running wheels; however, rats treated with olanzapine consistently exercised less than those given the vehicle. Olanzapine caused acute and persistent glucose intolerance throughout the study, which was markedly, though incompletely, ameliorated by exercise. Exercise did not affect glycemic regulation in vehicle-treated rats. Olanzapine-treated rats showed greater central adiposity. Levels of GLUT4 in skeletal muscle were higher in both groups of exercising than in sedentary rats, and GLUT4 values were negatively correlated with glucose intolerance. Routine exercise reduced olanzapine-induced glucose intolerance and increased skeletal muscle levels of GLUT 4, the insulin-responsive transporter that mediates glucose uptake into cells. The current animal model is suitable for evaluating physiological pathways involved with glucose intolerance.

Foetal development may permanently affect muscle function. Indian newborns have a low mean birthweight, predominantly due to low lean tissue and muscle mass. We aimed to examine the relationship of birthweight, and arm muscle area (AMA) at birth and post-natal growth to handgrip strength in Indian children. Grip strength was measured in 574 children aged 9 years, who had detailed anthropometry at birth and every 6–12 months post-natally. Mean (standard deviation (s.d.)) birthweight was 2863 (446) g. At 9 years, the children were short (mean height s.d. −0.6) and light (mean weight s.d. −1.1) compared with the World Health Organization growth reference. Mean (s.d.) grip strength was 12.7 (2.2) kg (boys) and 11.0 (2.0) kg (girls). Weight, length and AMA at birth, but not skinfold measurements at birth, were positively related to 9-year grip strength (β = 0.40 kg/s.d. increase in birthweight, P < 0.001; and β = 0.41 kg/s.d. increase in AMA, P < 0.001). Grip strength was positively related to 9-year height, body mass index and AMA and to gains in these measurements from birth to 2 years, 2–5 years and 5–9 years (P < 0.001 for all). The associations between birth size and grip strength were attenuated but remained statistically significant for AMA after adjusting for 9-year size. We conclude that larger overall size and muscle mass at birth are associated with greater muscle strength in childhood, and that this is mediated mainly through greater post-natal size. Poorer muscle development in utero is associated with reduced childhood muscle strength.

A Neospora sp. was isolated from the brains of two aborted bovine foetuses and grown continuously in vitro in bovine cell cultures. A comparison of the antigenic reactivity of in vitro cultivated tachyzoites with polyclonal antisera to Neospora caninum, Hammondia hammondi or Toxoplasma gondii revealed that the bovine protozoal isolates were similar to N. caninum and antigenically distinct from T. gondii. Tachyzoites of both bovine isolates had similar ultrastructural features, including an apical polar ring, conoid, electron-dense rhoptries and micronemes. The orientation of the micronemes, presence of micropores and a large number of electron-dense granules in the posterior portion of the bovine isolate tachyzoites differed from previous descriptions of N. caninum in vivo. Tachyzoites of the bovine isolates were ultrastructurally more similar to in vitro cultivated N. caninum tachyzoites than to tachyzoites of T. gondii or H. hammondi. The antigenic and ultrastructural similarities between N. caninum and the protozoal parasites isolated from aborted bovine foetuses in this study support the proposition that these parasites belong to the genus Neospora.

The turbulent diffusion of plasma across a magnetic field is studied theoretically using a three-dimensional model which includes the full dynamics of the diffusing particles and which is valid for arbitrary magnetic field strengths. The theory is confined to perpendicular turbulence, i.e. where the build-up of the fluctuations lies primarily in the plane perpendicular to the magnetic field (although it is more generally applicable). A single expression for the diffusion is derived in terms of the fluctuation spectrum, particle energy, the dispersion characteristics of the excited modes and the magnetic field. Earlier results for equilibrium plasmas are confirmed. We demonstrate the continuous transition from anomalous (1/B) diffusion in regimes of low fluctuation levels (or strong magnetic fields) to classical (1/B2) diffusion in regimes where the fluctuation level destroys the coherence sustained by the magnetic field. In this latter regime, the particles behave as if unmagnetized except for a turbulent drift which appears in the presence of anisotropic spectra.

The effects of a d.c. magnetic field on stimulated Raman sidescatter from laser-produced plasmas is studied. For exact sidescatter along the magnetic field, the Raman instability separates into two distinct decays in which the scattered light is either a right (RHCP) or left (LHCP) circularly polarized electromagnetic wave. Growth rates of the instabilities can be enhanced in the former case but are diminished in the latter. The magnetic field induced effects are greatest near the quarter critical density where frequency shifts can be especially significant, being equal to ± ¼Ωc for decay into RHCP and LHCP waves, respectively.

In the interaction of high-intensity lasers with target plasmas the transport of thermal enelgy from the region in which the radiation is absorbed, to the cold dense plasma in the interior of the target, is an issue of central importance. It is also one of great complexity and as such is still largely unresolved. Ion-acoustic turbulence, self-generated magnetic fields and the inadequacy of classical transport theory have all been widely canvassed by way of explaining the observations which show thermal transport much reduced below what would be expected from conventional arguments.

In this paper the role of ion turbulence as a flux limiter is addressed with particular regard to recent experiments in which target plasmas were irradiated by 1·06 µm neodymium laser light at irradiances of 1015W cm−2 and greater. Saturation levels of the ion-acoustic turbulence driven by a combination of a suprathermal electron current and a heat flux have been calculated on the basis of perturbed orbit theory.

The levels of turbulence are found to be markedly lower than those commonly estimated from simple trapping arguments and too low to explain the thermal flux inhibition observed in the experiments used as a basis for the model.

This paper complements an earlier one in which we considered the diffusion and drift across a magnetic field induced by a turbulent spectrum of fluctuations. We examine here the effects of these on the propagation of an unstable spectrum of modes. In the first paper a nonlinear dispersion relation is derived in a general closed form. This is then examined in the limint of short wavelengths (i.e.wavelengths much less than the gyroradii) and results of other authors are retrieved. In particular it is found that modes supported by the magnetic field are quashed whenever a particle may diffuse a wavelength per gyroperiod. For instance, in the context of current-driven instabilities (current across the magnetic field), electron cyclotron instabilities are quashed but not the ion-acoustic. The dispersion characteristics of the latter are unchanged except in that the drift which sustains the instability is altered by the presence of a turbulent (E × B) type drift. Depending on the level of fluctuations and magnetic field strength, this may amount simply to a rotation of the cone of unstable modes or may form a countercurrent which in turn suppresses the original current driving the instability.

In the second half of the paper the problem of calculating the fluctuation spectrum of the electric field is addressed since this is essential for a self-consistent computation of the diffusion tensor and turbulent drift appearing in the nonlinear dispersion relation.

A complex stimulated Raman scattering event against a background of non-thermal ion acoustic waves in an inhomogeneous plasma is described. We obtain analytic forms for the Raman gain due to a five-wave interaction consisting of conventional three-wave Raman scattering followed by the decay of the Raman Langmuir wave into a second Langmuir wave (or a second scattered light wave) and an ion acoustic wave. Very modest levels of ion waves produce a significant effect on Raman convective gain. A combination of plasma inhomogeneity and suprathermal ion fluctuations may offer a means for the control of Raman gain.

The microstructure of narrow metal conductors in the electrical interconnections on IC chips has often been identified as of major importance in the reliability of these devices. The stresses and stress gradients that develop in the conductors as a result of thermal expansion differences in the materials and of electromigration at high current densities are believed to be strongly dependent on the details of the grain structure. The present work discusses new techniques based on microbeam x-ray diffraction (MBXRD) that have enabled measurement not only of the microstructure of totally encapsulated conductors but also of the local stresses in them on a micron and submicron scale. White x-rays from the Advanced Light Source were focused to a micron spot size by Kirkpatrick-Baez mirrors. The sample was stepped under the micro-beam and Laue images obtained at each sample location using a CCD area detector. Microstructure and local strain were deduced from these images. Cu lines with widths ranging from 0.8 [.proportional]m to 5 [.proportional]m and thickness of 1 [.proportional]m were investigated. Comparisons are made between the capabilities of MBXRD and the well established techniques of broad beam XRD, electron back scatter diffraction (EBSD) and focused ion beam imagining (FIB).