Children’s externalizing behaviors are associated with impairments across the lifespan. Developmental psychopathology theories propose transactional (bidirectional) associations between child externalizing behaviors and parenting during childhood and adolescence. Yet, these foundational relations in early childhood are not well-studied. Utilizing a large, mixed-sex sample, we examined the reciprocal nature of parenting and child externalizing behaviors across early childhood using robust repeated-measures models. Repeated measures data were drawn from a socioeconomically diverse, longitudinal pregnancy cohort of 1287 (64% Black, 31% White) mother-child dyads at four time points (ages one to six). Three variables were included in cross-lagged panel models: observed parenting quality, child externalizing symptoms, and a maternal risk composite. In covariate-adjusted models, higher parenting quality at Wave 1 predicted lower child externalizing symptoms at Wave 2. Higher externalizing symptoms at Wave 1 and Wave 2 predicted lower parenting quality at Wave 2 and Wave 3, respectively. Maternal risk and parenting quality were not significantly associated. Findings showed both parent-driven and child-driven effects across early childhood that did not vary by child sex. The transactional nature of the parent-child relationship begins in infancy, underscoring the importance of early screening and provision of supports for families to minimize and prevent the development of serious psychopathology.

Background: We evaluated vorasidenib (VOR), a dual inhibitor of mIDH1/2, in patients with mIDH1/2 glioma (Phase 3; NCT04164901). Methods: Patients with residual/recurrent grade 2 mIDH1/2 oligodendroglioma or astrocytoma were enrolled (age ≥12; Karnofsky Performance Score ≥80; measurable non-enhancing disease; surgery as only prior treatment; not in immediate need of chemoradiotherapy). Patients were stratified by 1p19q status and baseline tumor size and randomized 1:1 to VOR 40 mg or placebo (PBO) daily in 28-day cycles. Endpoints included imaging-based progression-free survival (PFS), time to next intervention (TTNI), tumor growth rate (TGR), health-related quality of life (HRQoL), neurocognition and seizure activity. Results: 331 patients were randomized (VOR, 168; PBO, 163). The median age was 40.0 years. 172 and 159 patients had histologically confirmed oligodendroglioma and astrocytoma, respectively. Treatment with VOR significantly improved PFS and TTNI. Median PFS: VOR, 27.7 mos; PBO, 11.1 mos (P=0.000000067). Median TTNI: VOR, not reached; PBO, 17.8 mos (P=0.000000019). Treatment with VOR resulted in shrinkage of tumor volume. Post-treatment TGR: VOR, -2.5% (95% CI: -4.7, -0.2); PBO, 13.9% (95% CI: 11.1, 16.8). HRQoL and neurocognition were preserved and seizure control was maintained. VOR had a manageable safety profile. Conclusions: VOR was effective in mIDH1/2 diffuse glioma not in immediate need of chemoradiotherapy.

Maternal adversity and prenatal stress confer risk for child behavioral health problems. Few studies have examined this intergenerational process across multiple dimensions of stress; fewer have explored potential protective factors. Using a large, diverse sample of mother–child dyads, we examined associations between maternal childhood trauma, prenatal stressors, and offspring socioemotional-behavioral development, while also examining potential resilience-promoting factors. The Conditions Affecting Neurocognitive Development and Learning and Early Childhood (CANDLE) study prospectively followed 1503 mother–child dyads (65% Black, 32% White) from pregnancy. Exposures included maternal childhood trauma, socioeconomic risk, intimate partner violence, and geocode-linked neighborhood violent crime during pregnancy. Child socioemotional-behavioral functioning was measured via the Brief Infant Toddler Social Emotional Assessment (mean age = 1.1 years). Maternal social support and parenting knowledge during pregnancy were tested as potential moderators. Multiple linear regressions (N = 1127) revealed that maternal childhood trauma, socioeconomic risk, and intimate partner violence were independently, positively associated with child socioemotional-behavioral problems at age one in fully adjusted models. Maternal parenting knowledge moderated associations between both maternal childhood trauma and prenatal socioeconomic risk on child problems: greater knowledge was protective against the effects of socioeconomic risk and was promotive in the context of low maternal history of childhood trauma. Findings indicate that multiple dimensions of maternal stress and adversity are independently associated with child socioemotional-behavioral problems. Further, modifiable environmental factors, including knowledge regarding child development, can mitigate these risks. Both findings support the importance of parental screening and early intervention to promote child socioemotional-behavioral health.

We investigated an international outbreak of Salmonella Agona with a distinct PFGE pattern associated with an Irish Food company (company X) producing pre-cooked meat products sold in various food outlet chains in Europe. The outbreak was first detected in Ireland. We undertook national and international case-finding, food traceback and microbiological investigation of human, food and environmental samples. We undertook a matched case-control study on Irish cases. In total, 163 cases in seven European countries were laboratory-confirmed. Consumption of food from food outlet chains supplied by company X was significantly associated with being a confirmed case (mOR 18·3, 95% CI 2·2–149·2) in the case-control study. The outbreak strain was isolated from the company's pre-cooked meat products and production premises. Sufficient evidence was gathered to infer the vehicles of infection and sources of the outbreak and to justify the control measures taken, which were plant closure and food recall.

1. A comparison has been made between progeny tests in special stations and those available from field records. The variation between sires in milk yield is much greater at the stations even when they are compared with herds at the same production level.

2. In respect of yield the repeatability of station tests in the field is not good. The regression of field results on station test is only about 0·2 in herds at all production levels. For fat percentage, the regression is 0·5.

3. The tests in special stations (averaging seventeen daughters per bull) were compared with those in high herds (average twenty-seven daughters) in their accuracy of prediction of the performance of bulls in the poorer herds. The field test was slightly (but not significantly) better for both milk yield and fat content.

4. In milk yield, there is undoubtedly some extra variation between progeny groups at the stations which is not repeated in the field. Perhaps the tying of the heifers in distinct daughter groups in the byre may be a cause of this. However, even without this, it is doubted whether the test stations can give as much useful information on the numerical aspects of performance as the field records usually available. It is suggested that the splitting of daughter groups within the byre might increase the accuracy of the special station in the assessment of yield.

1. An analysis has been made of milk records from 13,000 cows bred by artificial insemination in Denmark.

2. The herds were divided into three equal groups on the basis of their average production. The variance of yield within herds increased as the average yield increased, but the coefficient of variation declined slightly. The genetic variance was more than five times as large in the high-yielding herds than in the low, and correspondingly the heritabilities in low, medium and high herds were 0·05, 0·15 and 0·22 respectively. These were estimated from the variation observed between progeny groups of the same 152 bulls at each production level.

3. No evidence was obtained of any sire-herd interaction for yield, either within or between management levels. The true ranking of bulls for breeding value was apparently the same at all levels.

4. The heritability of fat content in the three groups was 0·27, 0·47 and 0·49 respectively, and no evidence of sire-herd interaction was found.

5. The contemporary comparison method of assessing A.I. bulls for yield was found to have the accuracy expected in theory.

6. These results are discussed in relation to those of other workers with which there are some discrepancies. On our results, a policy of choosing bulls on the basis of their daughters' performance in high-yielding herds should be the most satisfactory way of progeny-testing bulls used in artificial insemination.

A continuation of this WG was voted for at the IAU GA 2006 in Prague. The International Celestial Reference Frame (ICRF) is defined by the positions of 212 distant quasars at radio wavelengths. The primary, optical reference frame is the Hipparcos Celestial Reference Frame (HCRF), which is the Hipparcos Catalog without astrometric ‘problem’ stars (in: H. Rickman (ed.) 2001, Proceedings IAU XXIV General Assembly, Transactions IAU XXIVB (San Francisco: ASP), Resolution B1.2). The Tycho-2 catalog with its 2.5 million brightest stars forms the first step in the densification of the optical reference frame. However, the limiting magnitude of about V = 12 of the Tycho-2 catalog is not sufficient for most applications in astronomy and the goal of this IAU Working Group is to further extend the grid of highly accurate positions and motions toward more and fainter stars. The web site of this WG is at <ad.usno.navy.mil/dens_wg/>.

Research into electro-optic effects in nanophase polymer dispersed liquid crystal (PDLC) materials has highlighted their potential as materials for a new class of tuneable filters. The structures, based on UV cured phase separated composites, contain liquid crystal both as discrete nano-scale droplets, and as material dissolved in the polymeric host. The essential difference between these materials and more conventional PDLC's is the scale of the refractive index inhomogeneity which is considerably smaller than the wavelength of visible light. Based upon effective medium approximations, the composite thus acts as a single isotropic medium, whose average refractive index is dependant on the level of applied electric field. Tuneable filters have been fabricated using the composite material for use in the visible spectral band.

We report photometric results from 44 runs at 11 observatories during the international campaign ‘TT Ari–94’. No coherent oscillations in the frequency range 10… 900 cycle d−1 are found. The highest peaks in the power spectrum cover the wide range of 28… 139 cycle d−1. Variations occur at a few preferred time-scales rather than at one cycle length, with a possible secular decrease. In the frequency range 90… 900 cycle d−1 the power spectrum obeys a power law with slope γ ranging from 0.8 to 2.6 for different runs.

TT Ari is one of the brightest cataclysmic variables and remains one of the most interesting objects of this class. It exhibits a variety of phenomena observed at time-scales from seconds to months. A recent detailed photometric study of this object and a bibliographical overview may be found in Tremko et al. (1996). Tremko et al. (1992, 1993, 1994) discuss aspects of the TT Ari–88 campaign. Our campaign TT Ari–94 was unprecedented, as the observations were longitude-dispersed, from Japan through Turkmenia, to Europe and the American continent. Moreover, our optical data on October 7 partially overlap with the HST observations obtained by Home & Welsh (1995, private communication). The numerical results of observations obtained during these nights are shown in Table 1.

With the financial services industries in the member countries of the European Union coming under increasing attention resulting in relaxation of cross border controls, this paper addresses some pensions matters in this European context and how they may relate to the U.K. The main theme of the paper is the book reserve approach to pensions provision. Details of the German book reserve method are provided before developing possible ways in which this philosophy could be introduced into the U.K. These possibilities are assessed and consideration given to the effect they may have on the economy, commerce, the pension fund industry and, not least, the actuarial profession in the U.K.

A beef progeny test was organized for 66 British Friesian bulls standing at AI centres in England. Eighty-one progeny groups averaging 8-5 steers each were reared on the farms of various co-operating organizations and their growth and carcass characters were recorded. Heritability of various measurements of gain varied from 0 to 0·34, of carcass conformation measures from 0·24 to 0·50, of muscle and fat percentage in the rib joint was 0·58 and 0·46 respectively, of other measures of fatness varied from 0·04 to 0·18, of weight of feet was 0·4 and of weight of hide 0·5.

Phenotypic correlations among beef characters gave no indication that carcass composition could be predicted from the external carcass measurements or subjective scores used in this study. Genetic correlations suggested that selection for weight for age would produce a fatter and more compact carcass. Genetic correlations were high and negative between milk yield (contemporary comparison) and weight for age, carcass weight/length, and blockiness of leg, and high and positive between milk yield, and carcass depth/length and percentage bone in the rib joint. Their standard errors were also high.

It has been estimated (Mason, 1963) that about 70% of beef stores bred in Britain are out of dairy cows. Some 30–40% of them are by beef bulls, so that about 40–50% of animals slaughtered for beef are of pure dairy breeding.

1. Some characteristics are described of 10 steer progeny of a Friesian bull which is known to have carried the factor for muscular hypertrophy.

2. On average these steers had a higher birth weight, lighter hide and liver, smaller feet and cannon bones, a lower percentage of fat and higher percentage of lean in the 10th rib joint, than the progeny of three other Friesian bulls reared at the same time and under the same conditions.

3. No one character was an adequate criterion for separating affected from normal progeny. It appears possible that the bull concerned was homozygous for the double muscling gene, and that all his progeny showed one or more symptoms of the condition.

1. An analysis has been made of production records and body measurements of dairy cattle from farms and special progeny testing stations in Denmark.

2. Heritability estimates of various measurements of body size and also of gross efficiency of food conversion were all in the neighbourhood of 0·50. Body weight was more closely correlated with girth than with height.

3. Milk yield had a very high correlation, both phenotypic and genetic, with gross efficiency. This was shown on theoretical grounds to be a necessary result of any standard system of feeding.

4. Correlations between production characteristics and body measurements were slight. There was some suggestion that selection for yield would increase skeletal size but decrease fleshing.

5. The best index on which to select for efficiency of food conversion under these conditions would be the yield divided by the height.

There are two schools of thought concerning the most appropriate environment in which to select breeding animals. One says ‘ Always select animals under environmental conditions similar to those where they are to be used ‘. The other says ‘ Select breeding animals in the optimum environment so that they have the best chance of revealing their genetic capabilities ‘. Experiments on growth of laboratory mice and experience with European cattle in the tropics have shown the advisability of the first course in these cases. In regard to hill sheep and dairy cattle in Britain, on the other hand, practice favours the second course, but there is little experimental evidence to support it.

During the last decade or more we have heard a great deal about progeny testing. Discussion has centred round three chief points. Under what conditions can selection by progeny testing lead to an increase in the rate of genetic improvement ? What method of testing and interpretation of results is most efficient and most practical ? How should the results be applied—that is in what way should the tested animals be used ?

In their paper reprinted herein (page 79) Johansson and Robertson have shown to what extent modern genetical theory can answer the second of these questions. It now remains for the executive agencies of livestock improvement to demonstrate the practical utility of the schemes they outline. We must wait some time, especially for slow-breeding animals like cattle, before the results of such a demonstration are available.