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We present the serendipitous radio-continuum discovery of a likely Galactic supernova remnant (SNR) G305.4–2.2. This object displays a remarkable circular symmetry in shape, making it one of the most circular Galactic SNRs known. Nicknamed Teleios due to its symmetry, it was detected in the new Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio–continuum images with an angular size of 1 320$^{\prime\prime}$$\times$1 260$^{\prime\prime}$ and PA = 0$^\circ$. While there is a hint of possible H$\alpha$ and gamma-ray emission, Teleios is exclusively seen at radio–continuum frequencies. Interestingly, Teleios is not only almost perfectly symmetric, but it also has one of the lowest surface brightnesses discovered among Galactic SNRs and a steep spectral index of $\alpha$=–0.6$\pm$0.3. Our best estimates from Hi studies and the $\Sigma$–D relation place Teleios as a type Ia SNR at a distance of either $\sim$2.2 kpc (near-side) or $\sim$7.7 kpc (far-side). This indicates two possible scenarios, either a young (under 1 000 yr) or a somewhat older SNR (over 10 000 yr). With a corresponding diameter of 14/48 pc, our evolutionary studies place Teleios at the either early or late Sedov phase, depending on the distance/diameter estimate. However, our modelling also predicts X-ray emission, which we do not see in the present generation of eROSITA images. We also explored a type Iax explosion scenario that would point to a much closer distance of $\lt$1 kpc and Teleios size of only $\sim$3.3 pc, which would be similar to the only known type Iax remnant SN1181. Unfortunately, all examined scenarios have their challenges, and no definitive Supernova (SN) origin type can be established at this stage. Remarkably, Teleios has retained its symmetrical shape as it aged even to such a diameter, suggesting expansion into a rarefied and isotropic ambient medium. The low radio surface brightness and the lack of pronounced polarisation can be explained by a high level of ambient rotation measure (RM), with the largest RM being observed at Teleios’s centre.
Study coding is an essential component of the research synthesis process. Data extracted during study coding serve as a direct link between the included studies and the synthesis results, allowing reviewers to justify claims about the findings from a set of related studies. The purpose of this tutorial is to provide authors, particularly those new to research synthesis, with recommendations to develop study coding manuals and forms that result in efficient, high-quality data extraction. Each of the 10 easy-to-follow practices is supported with additional resources, examples, or non-examples to help authors develop high-quality study coding materials. With the increase in publication of meta-analyses in recent years across many disciplines, a primary goal of this article is to enhance the quality of study coding materials that authors develop.
We present a re-discovery of G278.94+1.35a as possibly one of the largest known Galactic supernova remnants (SNRs) – that we name Diprotodon. While previously established as a Galactic SNR, Diprotodon is visible in our new Evolutionary Map of the Universe (EMU) and GaLactic and Extragalactic All-sky MWA (GLEAM) radio continuum images at an angular size of $3{{{{.\!^\circ}}}}33\times3{{{{.\!^\circ}}}}23$, much larger than previously measured. At the previously suggested distance of 2.7 kpc, this implies a diameter of 157$\times$152 pc. This size would qualify Diprotodon as the largest known SNR and pushes our estimates of SNR sizes to the upper limits. We investigate the environment in which the SNR is located and examine various scenarios that might explain such a large and relatively bright SNR appearance. We find that Diprotodon is most likely at a much closer distance of $\sim$1 kpc, implying its diameter is 58$\times$56 pc and it is in the radiative evolutionary phase. We also present a new Fermi-LAT data analysis that confirms the angular extent of the SNR in gamma rays. The origin of the high-energy emission remains somewhat puzzling, and the scenarios we explore reveal new puzzles, given this unexpected and unique observation of a seemingly evolved SNR having a hard GeV spectrum with no breaks. We explore both leptonic and hadronic scenarios, as well as the possibility that the high-energy emission arises from the leftover particle population of a historic pulsar wind nebula.
As TeV gamma-ray astronomy progresses into the era of the Cherenkov Telescope Array (CTA), instantaneously following up on gamma-ray transients is becoming more important than ever. To this end, a worldwide network of Imaging Atmospheric Cherenkov Telescopes has been proposed. Australia is ideally suited to provide coverage of part of the Southern Hemisphere sky inaccessible to H.E.S.S. in Namibia and the upcoming CTA-South in Chile. This study assesses the sources detectable by a small, transient-focused array in Australia based on CTA telescope designs. The TeV emission of extragalactic sources (including the majority of gamma-ray transients) can suffer significant absorption by the extragalactic background light. As such, we explored the improvements possible by implementing stereoscopic and topological triggers, as well as lowered image cleaning thresholds, to access lower energies. We modelled flaring gamma-ray sources based on past measurements from the satellite-based gamma-ray telescope Fermi-LAT. We estimate that an array of four Medium-Sized Telescopes (MSTs) would detect $\sim$24 active galactic nucleus flares >5$\sigma$ per year, up to a redshift of $z\approx1.5$. Two MSTs achieved $\sim$80–90% of the detections of four MSTs. The modelled Galactic transients were detectable within the observation time of one night, 11 of the 21 modelled gamma-ray bursts were detectable, as were $\sim$10% of unidentified transients. An array of MST-class telescopes would thus be a valuable complementary telescope array for transient TeV gamma-ray astronomy.
Research has shown a strong relationship between hallucinations and suicidal behaviour in general population samples. Whether hallucinations also index suicidal behaviour risk in groups at elevated risk of suicidal behaviour, namely in individuals with a sexual assault history, remains to be seen.
Aims
We assessed whether hallucinations were markers of risk for suicidal behaviour among individuals with a sexual assault history.
Methods
Using the cross-sectional 2007 (N = 7403) and 2014 (N = 7546) Adult Psychiatric Morbidity Surveys, we assessed for an interaction between sexual assault and hallucinations in terms of the odds of suicide attempt, as well as directly comparing the prevalence of suicide attempt in individuals with a sexual assault history with v. without hallucinations.
Results
Individuals with a sexual assault history had increased odds of hallucinations and suicide attempt compared to individuals without a sexual assault history in both samples. There was a significant interaction between sexual assault and hallucinations in terms of the odds of suicide attempt. In total, 14–19% of individuals with a sexual assault history who did not report hallucinations had one or more suicide attempt. This increased to 33–52% of individuals with a sexual assault history who did report hallucinations (2007, aOR = 2.85, 1.71–4.75; 2014, aOR = 4.52, 2.78–7.35).
Conclusions
Hallucinations are a risk marker for suicide attempt even among individuals with an elevated risk of suicidal behaviour, specifically individuals with a sexual assault history. This finding highlights the clinical significance of hallucinations with regard to suicidal behaviour risk, even among high-risk populations.
Experiences of felt presence (FP) are well documented in neurology, neuropsychology and bereavement research, but systematic research in relation to psychopathology is limited. FP is a feature of sensorimotor disruption in psychosis, hypnagogic experiences, solo pursuits and spiritual encounters, but research comparing these phenomena remains rare. A comparative approach to the phenomenology of FP has the potential to identify shared and unique processes underlying the experience across these contexts, with implications for clinical understanding and intervention.
Methods
We present a mixed-methods analysis from three online surveys comparing FP across three diverse contexts: a population sample which included people with experience of psychosis and voice-hearing (study 1, N = 75), people with spiritual and spiritualist beliefs (study 2, N = 47) and practitioners of endurance/solo pursuits (study 3, N = 84). Participants were asked to provide descriptions of their FP experiences and completed questionnaires on FP frequency, hallucinatory experiences, dissociation, paranoia, social inner speech and sleep. Data and code for the study are available via OSF.
Results
Hierarchical linear regression analysis indicated that FP frequency was predicted by a general tendency to experience hallucinations in all three studies, although paranoia and gender (female > male) were also significant predictors in sample 1. Qualitative analysis highlighted shared and diverging phenomenology of FP experiences across the three studies, including a role for immersive states in FP.
Conclusions
These data combine to provide the first picture of the potential shared mechanisms underlying different accounts of FP, supporting a unitary model of the experience.
We describe an ultra-wide-bandwidth, low-frequency receiver recently installed on the Parkes radio telescope. The receiver system provides continuous frequency coverage from 704 to 4032 MHz. For much of the band (${\sim}60\%$), the system temperature is approximately 22 K and the receiver system remains in a linear regime even in the presence of strong mobile phone transmissions. We discuss the scientific and technical aspects of the new receiver, including its astronomical objectives, as well as the feed, receiver, digitiser, and signal processor design. We describe the pipeline routines that form the archive-ready data products and how those data files can be accessed from the archives. The system performance is quantified, including the system noise and linearity, beam shape, antenna efficiency, polarisation calibration, and timing stability.
Virtual Reconstruction is a powerful tool broadly suited to a diverse array of archaeological heritage applications. In practice, however, reconstruction has largely focused on grand and monumental sites. Here we present two case studies–one from southern Oklahoma, the other from western Nebraska–to explore the use of this technology for more common heritage applications. The goal of this article is to advertise the dilemma we faced with communicating information on ephemeral sites and how we, as nonspecialists, solved the issue using affordable and accessible digital tools. Our workflow makes use of common tools (GIS) and open source software and online tutorials provide step by step instruction to support its replication. In presenting our experiences and the results of these efforts, we hope to spur similar applications in the use of Virtual Reconstruction to communicate information on archaeological heritage more broadly.
Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.
Aims
To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how fist-episode patients (FEP) may differ from multiple episode patients (MEP).
Method
These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.
Results
The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.
Conclusions
The negative symptoms are a major source of individual differences, and there are potential implications for treatment.
Combinatorial auctions represent one of the most prominent areas of research in the intersection of Operations Research (OR) and Economics. First proposed for practical governmental applications by Rassenti et al. (1982), a combinatorial auction (CA) is an auction for many items in which bidders submit bids on combinations of items, or packages. CAs also are referred to as “package auctions” or auctions with “package bidding.” In a general CA, a bidder may submit bids on any arbitrary collection of packages. The “winner-determination problem” identifies the value maximizing assignment given the package bids. This problem is as complex as the Weighted Set-Packing problem, and hence NP-hard (see Rothkopf et al. 1998).
Thus, in the many real-world applications of CAs, the computational techniques of OR facilitate more efficient economic outcomes in environments too complex for classical (i.e., non-computational) economic theory. Conversely, the game-theoretic framework surrounding CAs provides a host of new computational challenges and optimization problems for OR.
One critical element of any CA is the pricing rule, which determines what each winner pays for the package won. In this paper, we present a new class of optimization based pricing rules for combinatorial auctions in general, demonstrate some of their unique features, and elaborate upon some properties of the larger class of core-selecting mechanisms. We also describe the use of this algorithm for recent and upcoming spectrum-license auctions in the United Kingdom, for upcoming spectrum auctions in several European countries (e.g., the Netherlands, Denmark, Portugal, and Austria), and for use in the United States for the Federal Aviation Administration's (FAA) proposed allocation of landing rights to control congestion at airports. Further, we provide the relevant economic interpretation and theoretical basis for our algorithm's various features.
The use of auctions for allocating spectrum-license-rights to telecommunications companies gained prominence in 1994 when the Federal Communications Commission (FCC) began to use a Simultaneous Ascending Auction (SAA) to sell spectrum licenses in the United States. The initial design, which is still used today with only slight modifications, avoided the idea of a “combinatorial” or “package” auction, in which bidders bid on packages of licenses because of the inherent computational difficulty.
This paper provides a contextual summary of a diachronic analysis of ceramic vessels and hunter-gatherer societies from the final Pleistocene to the later Holocene in a remote corner of the Vitim Basin in Eastern Siberia. An integrated programme of ceramic analysis, raw materials survey, and archaeological investigation is drawn into new models of group mobility and social behaviour. The results challenge widespread assumptions about the relationship between ceramics, sedentarisation, and social complexity. Evidence of these transformations, though potentially identifiable in the archaeological record, could not be associated with the adoption of pottery.
This chapter provides an account of the formation in the 1960s and development of the Gypsy Council and its successor organisations (Figure 2.1). Most accounts of the origins, trajectories and achievements of Romani organisations concentrate upon the story of how they interacted with state authorities and what result they had upon the overt policy and actions of the local and central state and, more recently, transnational organisations. Over the last 25 years narratives have been set within the banal discourse of the ‘NGO’. Although the phrase ‘non-governmental organisation’ appeared in the UN Charter of 1945 (in a rather different context), the acronym NGO was popularised only in the 1980s, through the abbreviation of the somewhat more euphonious acronym the ‘QUANGO’, or ‘quasi-autonomous non-governmental organisation’. That phrase, first used in 1967, was itself acronymised only in 1969 (Pifer, 1987), but was picked up by right-wing governments, such as the Heath government (1970–74) in the UK as the welfare state staggered under the twin shocks of the oil price rises and the rapid growth in the number of old-age pensioners and sought to outsource welfare provision to independent agencies that it nevertheless had to fund. Acknowledging that they were only quasi-autonomous, however, meant that the government was still held accountable for their performance. Neoliberal discourse swiftly dropped the ‘quasi’ bit, and reinvented government as the righteous, avenging popular regulator of the agencies that perpetually failed to manage the poor on the budgets they are given. The modern use of the term ‘NGO’ invites one to consider them only in relation to governments. How strange it is that at the very moment when the last major version of state utopian authoritarianism lost legitimacy in 1989, the neoliberal ascendancy was able thus to appropriate an inverted vision of the ubiquity of the state. Most of the Romani organisations bravely and ineffectually (according to some) taking grants across Europe to cover for the failings of the welfare state might better be termed ‘wholly non-autonomous fully funded non-governmental organisations’ (WONNAFFUNGOs).
The Gypsy Council, from its foundation in 1966 down to its local offshoots, and the two Gypsy Councils which dispute the title to be its legitimate successor today, have never been one of these WONAFFUNGOs.
To explore changes in urban food environments near schools, as potential contributors to the rising prevalence of overweight and obesity among children.
Design
Addresses of food premises and schools in 1966, 1976, 1986, 1996 and 2006 were geo-coded. For each year, the number and proportion of outlets by category (supermarket/grocery; convenience; fast-food outlet) within 800 m of schools were calculated. The degree of spatial clustering of outlets was assessed using a bivariate K-function analysis. Food outlet categories, school level and school social deprivation quintiles were compared.
Setting
Christchurch, New Zealand.
Subjects
All schools and food outlets at 10-year snapshots from 1966 to 2006.
Results
Between 1966 and 2006, the median number of supermarkets/grocery stores within 800 m of schools decreased from 5 to 1, convenience stores decreased from 2 to 1, and fast-food outlets increased from 1 to 4. The ratio of fast-food outlets to total outlets increased from 0·10 to 0·67. The clustering of fast-food outlets was greatest within 800 m of schools and around the most socially deprived schools. Over the 40-year study period, school food environments in Christchurch can be characterized by increased densities of fast-food outlets within walking distance of schools, especially around the most deprived schools.
Conclusions
Since the 1960s, there have been substantial changes to the food environments around schools which may increasingly facilitate away-from-home food consumption for children and provide easily accessible, cheap energy-dense foods, a recognized contributor to the rise in prevalence of overweight and obesity among young people.
Clinical audit methodology was used to compare the treatment of alcohol misusers at risk of Wernicke's encephalopathy in an acute medical setting, and to assess the impact of providing information about best practice to prescribing doctors. All patients prescribed thiamine during an admission to an acute hospital trust over a 6-month period were identified, and data about their treatment episode were collected retrospectively. Hospital pharmacists then provided all prescribers with a flowchart summarising current prescribing guidelines, and prescribing patterns were re-audited 6 months later.
Results
Over two audit periods, half of the patients prescribed thiamine whose case notes we examined had symptoms suggestive of Wernicke's encephalopathy, and another 30% were at high risk. Prescribing adhered to hospital guidelines only in 14% of cases, with the pharmacy-led intervention associated with a small but significant increase in the number of patients receiving adequate treatment for Wernicke's encephalopathy.
Clinical implications
Wernicke's encephalopathy is relatively common in alcohol-dependent individuals admitted to hospital, and it is easily and cheaply managed. However, even when potential cases are identified, prescribing guidelines are followed in a minority of cases, even with prompting by a hospital pharmacist. This may be related to the limited research base concerning the optimum dosing schedule of thiamine, or fears about possible anaphylaxis when using parenteral preparations.
Benjamin Thompson, better known as Count Rumford, discovered the mechanical equivalent of heat. He was also soldier, administrator, founder of the Royal Institution in London and the English Garden in Munich. Fellow of the Royal Society and Membre de l'Institut, his career embraced rural New England, London society, service to the Elector of Bavaria and an unhappy marriage in Paris to the widow of Antoine Lavoisier.
Preliminary evidence suggests that consumption of Porphyridium cruentum (PC) biomass results in hypocholesterolaemic effects; however, mechanisms responsible have not been elucidated. The aim of the present study was to determine whether PC biomass lowers circulating cholesterol concentrations, dose dependently, in hamsters fed hypercholesterolaemic diets for 28 d and determine whether cholesterol biosynthesis is affected. Biomass added to diets at 2·5, 5 and 10 % resulted in 14, 38 and 53 % reductions (P < 0·001) in total plasma cholesterol, respectively, compared with a control diet. Similarly, non-HDL-cholesterol concentrations in the 5 and 10 % PC groups were reduced (P < 0·001) 28 and 45 %, respectively, v. controls. These effects were unrelated to cholesterol fractional synthesis rate (FSR), as this did not differ between either treatment or control animals. PC consumption had no effect on food intake, plasma glucose concentrations or energy expenditure, but percentage of body fat was lower (P < 0·001) in the 5 and 10 % PC groups compared with controls. These data show that PC reduces total plasma cholesterol and non-HDL-cholesterol when incorporated into the diet at levels as low as 2·5 %. The mechanism of action for this reduction may be related to increased excretion since food intakes and cholesterol FSR were not reduced in the animals receiving the PC. In conclusion, the use of PC biomass reduces circulating cholesterol, dose dependently, in hypercholesterolaemic hamsters but not via reductions in cholesterol FSR. There is potential for the use of this biomass as a functional ingredient to aid in the management of blood cholesterol concentrations.