We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In recent times, Health Professionals (HPs) people may feel a sense of discomfort and nervousness when disconnected from their smartphones, causing the emergence of the new phenomenon of “No Mobile Phone Phobia,” or Nomophobia.
Objectives
We aim to study lifestyle-related factors that influence HPs’ Nomophobia.
Methods
From April- June 2023, a global cross-sectional study was conducted using the modified Nomophobia questionnaire (NMP-Q). The original 20 NMP-Q questions (Qs) were reduced to 14 to avoid repetitive Qs with similar meanings. The Qs were categorized into 4 sections, A- Not Being Able to Access Information; B- Losing Connectedness; C- Not Being Able to Communicate; and D- Giving Up Convenience. A new section, “E- Daily Habits”, and “F- Smartphone Type”, and “Hours Spent Daily” were added. Before the launch, it was internally and externally validated by trained psychiatrists as well as experienced researchers. We utilized social media, WhatsApp, text and emails to share it with HPs of different specialties worldwide. The survey was anonymous and IRB-exempt.
Results
Total 105 countries’ HPs participation led to 12,253 responses. Total 47.3% of HPs agreed/strongly agreed (A/SA) that they prefer to use their smartphone before bedtime. Over half (57.8%) of HPs A/SA checked their notifications immediately after waking up in the morning. Only 19.4 % of HPs A/SA that woke up in the middle of the night to check notifications. Total 40.5% of HPs A/SA, 22% were neutral, and 37.3% of HPs disagreed /strongly disagreed (D/SD) with using smartphones while eating their meals. A total of 52.7% of HPs preferred smartphone usage over exercising as a break, while 454.9% of HPs A/SA that they chose smartphones over exploring other hobbies for relaxation. A total of 44.2% of respondents A/SA with smartphone usage in the restroom, 39.8% D/SD. 37.4% of participants D/SD with getting distracted by notifications and resisted the urge to answer any calls or texts while performing a focused task, whereas 39.6% A/SA and 23% were neutral. A total of 80% of respondents met the modified criteria for moderate-severe nomophobia.
Conclusions
In a large-scale survey-based study on Nomophobia, additional Qs in NMP-Q may help recognize that nomophobia can be a result of daily lifestyle decisions rather than an isolated issue.
Cognitive therapy and behavioural activation are both widely applied and effective psychotherapies for depression, but it is unclear which works best for whom. Individual participant data (IPD) meta-analysis allows for examining moderators at the participant level and can provide more precise effect estimates than conventional meta-analysis, which is based on study-level data.
Aims
This article describes the protocol for a systematic review and IPD meta-analysis that aims to compare the efficacy of cognitive therapy and behavioural activation for adults with depression, and to explore moderators of treatment effect. (PROSPERO: CRD42022341602)
Method
Systematic literature searches will be conducted in PubMed, PsycINFO, EMBASE and the Cochrane Library, to identify randomised clinical trials comparing cognitive therapy and behavioural activation for adult acute-phase depression. Investigators of these trials will be invited to share their participant-level data. One-stage IPD meta-analyses will be conducted with mixed-effects models to assess treatment effects and to examine various available demographic, clinical and psychological participant characteristics as potential moderators. The primary outcome measure will be depressive symptom level at treatment completion. Secondary outcomes will include post-treatment anxiety, interpersonal functioning and quality of life, as well as follow-up outcomes.
Conclusions
To the best of our knowledge, this will be the first IPD meta-analysis concerning cognitive therapy versus behavioural activation for adult depression. This study has the potential to enhance our knowledge of depression treatment by using state-of-the-art statistical techniques to compare the efficacy of two widely used psychotherapies, and by shedding more light on which of these treatments might work best for whom.
This study aimed to describe the microscopic over-under cartilage tympanoplasty technique, provide hearing results and detail clinically significant complications.
Method
This was a retrospective case series chart review study of over-under cartilage tympanoplasty procedures performed by the senior author between January 2015 and January 2019 at three tertiary care centres. Cases were excluded for previous or intra-operative cholesteatoma, if a mastoidectomy was performed during the procedure or if ossiculoplasty was performed. Hearing results and complications were obtained.
Results
Sixty-eight tympanoplasty procedures met the inclusion criteria. The median age was 13 years (range, 3–71 years). The mean improvement in pure tone average was 6 dB (95 per cent confidence interval 4–9 dB; p < 0.0001). The overall perforation closure rate was 97 per cent (n = 66). Revision surgery was recommended for a total of 6 cases (9 per cent) including 2 post-operative perforations, 1 case of middle-ear cholesteatoma and 3 cases of external auditory canal scarring.
Conclusion
Over-under cartilage tympanoplasty is effective at improving clinically meaningful hearing with a low rate of post-operative complications.
To assess the feasibility of non-contrast T2-weighted magnetic resonance imaging as compared to T1-weighted post-contrast magnetic resonance imaging for detecting acoustic neuroma growth.
Methods
Adult patients with acoustic neuroma who underwent at least three magnetic resonance imaging scans of the internal auditory canals with and without contrast in the past nine years were identified. T1- and T2-weighted images were reviewed by three neuroradiologists, and tumour size was measured. Accuracy of the measurements on T2-weighted images was defined as a difference of less than or equal to 2 mm from the measurement on T1-weighted images.
Results
A total of 107 magnetic resonance imaging scans of 26 patients were reviewed. Measurements on T2-weighted magnetic resonance imaging scans were 88 per cent accurate. Measurements on T2-weighted images differed from measurements on T1-weighted images by an average of 1.27 mm, or 10.4 per cent of the total size. The specificity of T2-weighted images was 88.2 per cent and the sensitivity was 77.8 per cent.
Conclusion
The T2-weighted sequences are fairly accurate in measuring acoustic neuroma size and identifying growth if one keeps in mind the caveats associated with the tumour characteristics or location.
Community-led total sanitation (CLTS) is an intervention that strives to end the practice of open defaecation. This study measured the effectiveness of CLTS in Nyando District by examining the association between community open defaecation-free (ODF) status and childhood diarrhoeal illness. A cross-sectional study design was used among households with children ⩽5 years old to ascertain information on acute diarrhoea in the past year (outcome), sanitation and health behaviours. Water testing was conducted to determine Escherichia coli and turbidity levels for 55 water sources. Data were obtained from 210 parents or caregivers from an ODF community and 216 parents or caregivers in a non-ODF community. The non-ODF participants reported a non-significant 16% increased risk of diarrhoea compared with the participants from the ODF community. Children's HIV positivity (adjusted prevalence ratio (aPR) = 2.29; 95% CI 2.07–2.53), unsafe child stool disposal (aPR = 1.92; 95% CI 1.74–2.12) and low household income (aPR = 1.93; 95% CI 1.46–2.56) were associated with diarrhoea, in the non-ODF community. The ODF location had a higher percentage of E. coli in the drinking water compared with the non-ODF location (76.7% vs. 60%). Diarrhoeal disease rates in children ⩽5 years old did not differ by whether a latrine intervention was implemented. Water sampling findings suggest water safety may have decreased the effectiveness of the CLTS’ improvement of childhood diarrhoea. Improved water treatment practices, safe stool disposal and education may improve the CLTS intervention in ODF communities and therefore reduced the risk of childhood diarrhoea.
Predicting recurrent Clostridium difficile infection (rCDI) remains difficult. METHODS. We employed a retrospective cohort design. Granular electronic medical record (EMR) data had been collected from patients hospitalized at 21 Kaiser Permanente Northern California hospitals. The derivation dataset (2007–2013) included data from 9,386 patients who experienced incident CDI (iCDI) and 1,311 who experienced their first CDI recurrences (rCDI). The validation dataset (2014) included data from 1,865 patients who experienced incident CDI and 144 who experienced rCDI. Using multiple techniques, including machine learning, we evaluated more than 150 potential predictors. Our final analyses evaluated 3 models with varying degrees of complexity and 1 previously published model.
RESULTS
Despite having a large multicenter cohort and access to granular EMR data (eg, vital signs, and laboratory test results), none of the models discriminated well (c statistics, 0.591–0.605), had good calibration, or had good explanatory power.
CONCLUSIONS
Our ability to predict rCDI remains limited. Given currently available EMR technology, improvements in prediction will require incorporating new variables because currently available data elements lack adequate explanatory power.
A powerful mechanism for the generation of secondary flow, which does not rely on viscous or turbulent stress, is lateral skewing of a shear layer such as that encountered by the body boundary layer in a wing/body junction. For a given entry shear, the characteristics of the secondary flow (a horse-shoe vortex) will depend on the wing nose shape. The effects of three wing nose shapes on the size, position and strength of the horse-shoe vortex have been studied in low-speed flow. As expected, the vortex size and strength increased with nose bluntness; quantitative data describing this effect are presented in this paper. The results include contours of streamwise velocity and secondary velocity plots from which vorticity contours and a non-dimensional circulation were derived. The results should be of use in wing design where this secondary flow needs to be controlled.
There has been a drop in clinical research in India following stringent conditions put in place by the Indian Supreme Court in 2013. The Court's orders came in the wake of irregularities highlighted in the conduct of clinical trials in the country. This paper highlights the steps taken by the Indian regulator, the Central Drugs Standard Control Organisation to comply with these directions. These are of three kinds: strengthening regulatory institutions, protecting participant safety and creating regulatory certainty for sponsors and investigators. Examples include the large-scale training of Ethics Committees, framing detailed guidelines on compensation and audiovisual recording of the informed consent process, as well as reducing the time taken to process applications. It is expected that these measures will inspire confidence for the much-needed resumption of clinical research.
Most research on interventions to counter stigma and discrimination has focused on short-term outcomes and has been conducted in high-income settings.
Aims
To synthesise what is known globally about effective interventions to reduce mental illness-based stigma and discrimination, in relation first to effectiveness in the medium and long term (minimum 4 weeks), and second to interventions in low- and middle-income countries (LMICs).
Method
We searched six databases from 1980 to 2013 and conducted a multi-language Google search for quantitative studies addressing the research questions. Effect sizes were calculated from eligible studies where possible, and narrative syntheses conducted. Subgroup analysis compared interventions with and without social contact.
Results
Eighty studies (n = 422 653) were included in the review. For studies with medium or long-term follow-up (72, of which 21 had calculable effect sizes) median standardised mean differences were 0.54 for knowledge and −0.26 for stigmatising attitudes. Those containing social contact (direct or indirect) were not more effective than those without. The 11 LMIC studies were all from middle-income countries. Effect sizes were rarely calculable for behavioural outcomes or in LMIC studies.
Conclusions
There is modest evidence for the effectiveness of anti-stigma interventions beyond 4 weeks follow-up in terms of increasing knowledge and reducing stigmatising attitudes. Evidence does not support the view that social contact is the more effective type of intervention for improving attitudes in the medium to long term. Methodologically strong research is needed on which to base decisions on investment in stigma-reducing interventions.
The contribution of subsidized food commodities to total food consumption is unknown. We estimated the proportion of individual energy intake from food commodities receiving the largest subsidies from 1995 to 2010 (corn, soyabeans, wheat, rice, sorghum, dairy and livestock).
Design
Integrating information from three federal databases (MyPyramid Equivalents, Food Intakes Converted to Retail Commodities, and What We Eat in America) with data from the 2001–2006 National Health and Nutrition Examination Surveys, we computed a Subsidy Score representing the percentage of total energy intake from subsidized commodities. We examined the score’s distribution and the probability of having a ‘high’ (≥70th percentile) v. ‘low’ (≤30th percentile) score, across the population and subgroups, using multivariate logistic regression.
Setting
Community-dwelling adults in the USA.
Subjects
Participants (n 11 811) aged 18–64 years.
Results
Median Subsidy Score was 56·7 % (interquartile range 47·2–65·4 %). Younger, less educated, poorer, and Mexican Americans had higher scores. After controlling for covariates, age, education and income remained independently associated with the score: compared with individuals aged 55–64 years, individuals aged 18–24 years had a 50 % higher probability of having a high score (P<0·0001). Individuals reporting less than high-school education had 21 % higher probability of having a high score than individuals reporting college completion or higher (P=0·003); individuals in the lowest tertile of income had an 11 % higher probability of having a high score compared with individuals in the highest tertile (P=0·02).
Conclusions
Over 50 % of energy in US diets is derived from federally subsidized commodities.
It has been reported recently (Stott, 1974) that in cattle, reproductive efficiency is increased by keeping the animals under cool climatic conditions. However, in buffaloes very limited information is available. Roy, Sengupta & Misra (1962) have reported that all buffaloes exhibited oestrus and were inseminated in a group protected from direct sun radiation whereas in a non-protected group only one showed oestrus. There is no systematic information available on the effect of wallowing and showers on the oestrual behaviour of buffaloes. Therefore, the present investigation was undertaken to study the effect of cooling on oestrual behaviour in buffaloes.
Detailed mean flow and turbulence measurements have been made in a low-speed turbulent boundary layer in zero pressure gradient with an isolated, artificially generated vortex pair imbedded in it. The vortices, generated by two half-delta wings on the floor of the wind-tunnel settling chamber, rotate in opposite directions such that the ‘common flow’ between the vortices is away from the surface, and the vortex pair draws boundary-layer fluid upwards. The distance of the vortex cores above the surface grows downstream, and is roughly twice the local boundary-layer thickness. The cancellation of circulation by mixing of fluid from the two vortices is slow, and the vortices are identifiable down the full length of the test section. As in the case of the single vortex investigated in Part 1 of this series, large changes in structural parameters of the turbulence occur.
Detailed mean-flow and turbulence measurements have been made in a low-speed turbulent boundary layer in zero pressure gradient with an isolated, artificially generated vortex imbedded in it. The vortex was generated by a half-delta wing on the floor of the wind-tunnel settling chamber, so that the vortex entering the working section had the same circulation as that originally generated, while axial-component velocity variations were very much reduced, relative to the local mean velocity, from values just behind the generator. The measurements show that the circulation around the vortex imbedded in the boundary layer is almost conserved, being reduced only by the spanwise-component surface shear stress. Therefore the region of flow affected by the vortex continues to grow downstream, its cross-sectional dimensions being roughly proportional to the local boundary-layer thickness. The behaviour of the various components of eddy viscosity, deduced from measured Reynolds stresses, and of the various triple products, suggests that the simple empirical correlations for these quantities used in present-day turbulence models are not likely to yield flow predictions which are accurate in detail.
Flow-visualization investigations and correlation measurements show that the essentially two-dimensional structures which dominated the turbulent mixing layer of Brown & Roshko (1974) are formed only if the free-stream turbulence is low. If free-stream disturbances are significant, as is likely in most practical cases, including a mixing layer entraining ‘still air’ from the surroundings, three-dimensionality develops at an early stage in transition. Other recent experiments strongly suggest that the Brown-Roshko structure will not form if the initial mixing layer is turbulent or subject to instability modes other than spanwise vortices. Therefore the Brown-Roshko structure will be rare in practice. The alternative large structure in a mixing layer, found by several workers, is intense, but fully three-dimensional and thus less orderly than the Brown-Roshko structure.
The balance of evidence suggests that if the Brown-Roshko structure does appear it will eventually relax into the alternative fully three-dimensional form: the Kármán vortex street behind a bluff body provides a precedent for slow development of three-dimensionality. However the Brown-Roshko structure, if formed, may well relax so slowly as to be identifiable for the full length of a practical flow.
CdSe and CdTe nanoparticles dispersed in silicon dioxide films have been grown by magnetron sputtering technique followed by thermal annealing. Effect of thermal annealing conditions on the structural and optical properties of CdTe and CdSe nanoparticles has been studied. Glancing angle x-ray diffraction (GAXRD), optical absorption (OA), transmission electron microscope (TEM) and spectroscopic ellipsometry (SE) techniques have been used to study the crystal structure, particle size and dielectric function spectra of nanoparticles. ε2 spectra of CdTe nanoparticles show a decrease in dielectric constant values in comparison to bulk CdTe. ε2″ spectrum of CdTe nanoparticles show four critical points in the electronic band structure of CdTe. Optical absorption studies in the case of CdTe and CdSe nanoparticles clearly show the blue shift of fundamental absorption edge due to quantum confinement effect.
CdSexTe1-x nanoparticles (with different stoichiometry ratio x) dispersed in silicon dioxide films have been grown by magnetron sputtering technique followed by thermal annealing. Effect of thermal annealing conditions on the structural, compositional, optical and electronic properties of nanoparticles has been studied using GAXRD, XPS, TEM, and spectroscopic ellipsometry techniques. A structural transformation in the nanoparticle core mediated purely by surface layer effects in the case of CdTe and a spontaneous self-organization of nanoparticles into nanorods in the case of CdSe via fractal growth has been observed. Preliminary observations from the ellipsometry measurements carried out on some of these nanoparticle films shows a blue shift of absorption edge.
High-κ dielectrics based the oxide of Al were prepared by atomic layer deposition (ALD) on 200-mm p-type Si wafers. Films were deposited directly on clean Si or on 0.5-nm underlayers of rapid thermal oxide or oxynitrides grown in O2 and/or NO ambients. The purpose of the underlayer films is to provide a barrier for atomic diffusion from the crystal Si to the high-κ dielectric film. Deposited Al-oxide films varied in thickness from 2 to 6 nm. Post deposition anneals were used to stabilize the ALD oxides. Equivalent SiO2-oxide thickness varied from 1.0 to 3.5 nm. In situ P-doped amorphous-Si 160 nm films were deposited over the oxides to prepare heavily doped n-type gate electrodes in MOS structures. Samples were rapid thermal annealed in N2 ambient at 800°C for 30 s, or spike annealed at 950, 1000, and 1050°C (nominally zero time at peak temperature). Flat band voltages, VFB were determined from C-V measurements on dot patterns. The 800°C anneals were used as a baseline, at which the poly-Si electrodes are crystallized and acquire electrical activation while subjecting the high-κ dielectrics to a low thermal budget. Positive shifts in VFB were observed, relative to a pure SiO2 control, ranging from 0.2 to 0.8 V. Spike annealing reduces the VFB shift for ALD films deposited over underlayer films. The VFB shift and the changes with annealing temperature show systematic dependence on the nitridation of the underlayer.