Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.

Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (hazard ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate the onset of dementia in prospectively identified MCI.

Wildlife is an essential component of all ecosystems. Most places in the globe do not have local, timely information on which species are present or how their populations are changing. With the arrival of new technologies, camera traps have become a popular way to collect wildlife data. However, data collection has increased at a much faster rate than the development of tools to manage, process and analyse these data. Without these tools, wildlife managers and other stakeholders have little information to effectively manage, understand and monitor wildlife populations. We identify four barriers that are hindering the widespread use of camera trap data for conservation. We propose specific solutions to remove these barriers integrated in a modern technology platform called Wildlife Insights. We present an architecture for this platform and describe its main components. We recognize and discuss the potential risks of publishing shared biodiversity data and a framework to mitigate those risks. Finally, we discuss a strategy to ensure platforms like Wildlife Insights are sustainable and have an enduring impact on the conservation of wildlife.

This study addressed the role of deficits in the organization of the self, or narcissistic pathology, among widows who evidenced depressive outcomes following the loss of their husbands. The significance of object representations and self-regulatory capacities (introjects) within the self-representation in predicting psychiatric status in a sample of 77 widows 1 year after spousal loss was examined. In addition, the link between functional deficits within the self and observable state markers of such deficits as they related to depression was investigated. A combination of projective and self-report measures were used to assess self and object representation. The General Health Questionnaire (Goldberg & Hillier, 1979) and the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) (Spitzer & Williams, 1985) were employed as measures of psychiatric disorder. Analyses revealed that functional aspects of self representations, or introjects, differentiated clinically depressed widows from those experiencing “normal” mourning. However, object representations were relatively weak predictors of depression following bereavement and evidenced little association with self representation. Observable markers of self-pathology were strongly related to functional impairments in the self but did not operate causally to predict depressive outcome. Theoretical and clinical implications of the linkage between functional deficits in the self and depression are discussed.

Trials were carried out in the Shannon estuary, Ireland, to test the effects of continuous (CPs) and responsive pingers (RPs) on bottlenose dolphin behaviour. In controlled trials, active and control pingers were deployed on fixed moorings, with T-PODs—acoustic monitoring devices to detect cetacean activity. In a separate trial, pingers were deployed from a moving boat which actively located dolphin groups in the estuary, and dolphin behaviour was recorded. In the static trials, overall detection rates of dolphin vocalizations on the T-POD were significantly lower in the presence of active CPs, but this was not the case for RPs. Mean inter-click interval values were longer for click trains produced in the presence of inactive RPs than for active RPs, active or inactive CPs. In boat-based trials, both active CPs and RPs appeared to affect bottlenose dolphin behaviour, whereby dolphins immediately left the area at speed and in a highly directional manner, involving frequent leaps.

Clyde Barrow's More Than a Historian provides a fascinating intellectual history of Charles Beard, a political scientist whom he places in the “pantheon of thinkers that most scholars no longer read” (p. xvi). With 42 books, scores of coauthored books, and hundreds of articles and book reviews, Beard can be only characterized as amazingly prolific. Yet the only book that still resonates in political science and American history is An Economic Interpretation of the Constitution (1913). Barrow's history of Beard gives us ample reason finally to read it or read it again.

The history of the American welfare state is often recounted as a long line of missed opportunities. As the story goes, the absence of a labor party, or American exceptionalism, helped create a weak welfare state. Initially, some political scientists, labor economists, and historians attributed American exceptionalism to the pure and simple unionism of the American Federation of Labor (AFL). In the 1990s, however, a number of political scientists and legal historians revised their understanding of American exceptionalism. Given the legal bias within the common law that benefited individuals rather than groups, conservative state and federal court judges pursued peremptory legal strategies, like the labor injunction, that shaped the course of the American labor movement. It was repressive state action, the revisionists argue, that explains why organized labor, and the unions that came to dominate the movement, pursued a less expansive vision of trade unionism and the American state.

Cholesterol oxidation products (COP) have been reported to influence vital cellular processes such as cell growth, cell proliferation, membrane function and de novo sterol biosynthesis. The objectives of the present study were: (1) to develop an in vitro model using newborn rat kidney (NRK) cells to investigate the actions of COP; (2) to investigate the effect of COP on cell viability, endogenous antioxidant enzymes activities, i.e. superoxide dismutase (EC 1.15.1.1; SOD) and catalase (EC 1.11.1.6; CAT), and the extent of lipid peroxidation in this model; (3) to determine whether the addition of 100–1000 nm-α-tocopherol, β-carotene or butylated hydroxytoluene (BHT) could protect against COP-induced cytotoxicity. NRK cells were cultured in the presence of various concentrations (5–50 μM) of cholesterol or cholestan-3β,5α,6β-triol (cholestantriol) for a period of 24 h. Cholesterol over the range 5–50 μM did not induce cytotoxicity as indicated by the neutral-red-uptake assay or the lactate dehydrogenase (EC 1.1.1.27)-release assay. However, cell viability was compromised by the addition of > 10 μM-cholestantriol (P < 0.05). The addition of β-carotene (100–1000 nM) did not increase cell viability significantly in cholestantriol-supplemented cells. However, the addition of α-tocopherol (1000 nM) and BHT (1000 nM) significantly increased percentage cell viability above that of the cholestantriol-supplemented cells but not back to control levels. SOD and CAT activities in NRK cells significantly decreased (P < 0.05) following incubation with cholestantriol. The addition of > 750 nM-α-tocopherol, β-carotene or BHT returned SOD and CAT activities to that of the control. Lipid peroxidation was significantly induced (P < 0.05) in the presence of cholestantriol. Supplementation of the cells with α-tocopherol (250, 500 or 1000 nM) or BHT (750 or 1000 nM) resulted in a reduction in the extent of lipid peroxidation (P < 0.05). The addition of β-carotene over the concentration range of 250–1000 nM did not reduce lipid peroxidation significantly compared with cells exposed to cholestantriol alone. These findings suggest that addition of exogenous antioxidants may be beneficial in the prevention of COP-induced toxicity in vitro.

The emergence of the American Federation of Labor in the 1880s and its ideology of voluntarism or “business unionism” transformed the mainstream American labor movement. Voluntarism, however, had little impact on the formation of the pre-New Deal labor policy. I suggest that members of the progressive movement developed “responsible unionism” as an alternative to “business unionism” and that it was the progressives' alternative that shaped later developments in labor policy. (1) Progressive state and federal court judges relied on the principles of agency, a fiduciary term, to make unions competent contracting parties and enforce collective trade agreements. (2) Although the AFL had long lobbied for anti-injunction legislation sup ported by an underlying ideology of voluntarism, the progressive Republican-Democratic coalition that engineered passage of the Norris-LaGuardia Anti-Injunction Act of 1932 based the legislation on their notion of “responsible unionism.” These progressives interwove the principles of agency into the act. As a result, rather than withdrawing the American state from labor-management relations, the act caused unions to begin to lose their status as private, voluntary associations, thus creating the foundation for the construction of the statist regulatory apparatus, the National Labor Relations Board, during the New Deal.