Spinel lherzolite xenoliths from two localities in the Massif Central are undepleted in Al2O3, CaO, and Na2O. One suite from Tarreyres, is K2O depleted and amphibole-bearing whereas the other, from Monistrol d'Allier some 18 km away, is amphibole-free and has a higher mean K2O content of 0.035 wt.%. We present bulk major and minor element abundances in a harzburgite and a lherzolite from each locality and microprobe analyses of their constituent phases. Amphibole-bearing lherzolite and its pyroxenes are light-rare earth element (LREE) depleted, whereas amphibole-free lherzolite and its pyroxenes are LREE enriched. Both harzburgites and their pyroxenes are LREE enriched and one rock contains LREE enriched glass. The harzburgites are like harzburgite xenoliths from elsewhere but each lherzolite represents a previously unrecognized type of mantle in terms of the mineralogy and REE content. The implication for basalt genesis are briefly discussed.

Characterization of Brazilian agates containing a lower horizontally banded section and an upper chamber with bands parallel to the walls shows that these agates formed much later than the 135 Ma Paraná basalt host rock. Age differentiation between the two types of banding showsthat the horizontal bands formed between 43 to 63 Ma ago with a final infill of wall-lining bands between 7 and 27 Ma later. The horizontal bands have a higher Al3+ concentration and a greater crystallite size than the wall-lining layers; they have a lower mogánite contentand defect-site water content. The formation of these agates appears to be the result of a three-stage process. After the separate formation of horizontally banded and wall-lining agate, a silica infill seals the gap between the agate and the cavity wall. The detection of cristobalite in somespecimens indicates that genesis of both the horizontally banded and wall-lining deposits in the Brazilian samples proceeds along an amorphous silica → opal-CT → opal-C → chalcedony pathway.

The Arizona Department of Health Services identified unusually high levels of influenza activity and severe complications during the 2015–2016 influenza season leading to concerns about potential increased disease severity compared with prior seasons. We estimated state-level burden and severity to compare across three seasons using multiple data sources for community-level illness, hospitalisation and death. Severity ratios were calculated as the number of hospitalisations or deaths per community case. Community influenza-like illness rates, hospitalisation rates and mortality rates in 2015–2016 were higher than the previous two seasons. However, ratios of severe disease to community illness were similar. Arizona experienced overall increased disease burden in 2015–2016, but not increased severity compared with prior seasons. Timely estimates of state-specific burden and severity are potentially feasible and may provide important information during seemingly unusual influenza seasons or pandemic situations.

Phytotoxicity of glyphosate (N-(phosphonomethyl) glycine), applied at 0, 0.56, 1.12, 1.68, 2.24 and 4.49 kg ai/ha to uniform, naturally growing quackgrass, [Agropyron repens (L.) Beauv.] plants, was studied with the electron microscope. Visible damage (yellowing of the leaves) to the plants was observed at the 2.24 and 4.49 kg ai/ha dosage rates within 72 hr. Similar damage became evident 120 hr after treatment at the 0.56 to 1.68 dosages. Leaf discs (1 mm in diameter) were harvested at 24, 48, 96, and 192 hr and prepared for electron microscopy by standard techniques. Cellular damage could be detected at all dosage rates as early as 24 hr after treatment. The type of damage observed was partial to complete disruption of the chloroplast envelope, and swelling of the rough endoplasmic reticulum (RER) with a subsequent formation of vesicles. With loss of integrity of the envelope, the chloroplast became completely disrupted with increased time. Other organelles within the cell were also destroyed.

Introduction/Innovation Concept: In 2014, Eastern Ontario paramedic services, their medical director staff and area community colleges developed an EMS Boot Camp experience to orient Queen’s University and the University of Ottawa emergency medicine residents to the role of paramedics and the challenges they face in the field. Current EMS ride-alongs and didactic classroom sessions were deemed ineffective at adequately preparing residents to provide online medical control. From those early discussions came the creation of a real-world, real-time (RWRT) educational experience. Methods: Specific challenges unique to paramedicine are difficult to communicate to a medical control physician at the other end of a telephone. The goal of this one-day educational experience is for residents to gain insight into the complexity and time sensitive nature of delivering medical care in the field. Residents are immersed as responding paramedics in a day of intense RWRT simulation exercises reflecting the common paramedic logistical challenges to delivering patient care in an uncontrolled and dynamic environment. Curriculum, Tool, or Material: Scenarios, run by paramedic students, are overseen by working paramedics from participating paramedic services. Residents learn proper use of key equipment found on an Ontario ambulance while familiarize themselves with patient care standards and medical directives. Scenarios focus on prehospital-specific clinical care issues; performing dynamic CPR in a moving vehicle, extricating a bariatric patient with limited personnel, large scale multi-casualty triage as well as other time sensitive, high risk procedures requiring online medical control approval (i.e. chest needle thoracostomy). Conclusion: EMS Boot Camp dispels preconceived biases regarding “what it’s really like” to deliver high quality prehospital clinical care. When providing online medical control in the future, the residents will be primed to understand and expect certain challenges that may arise. The educational experience fosters collaboration between prehospital and hospital-based providers. The sessions provide a reproducible, standardized experience for all participants; something that cannot be guaranteed with traditional EMS ride-alongs. Future sessions will evaluate participant satisfaction and self-efficacy with the use of a standard evaluation form including pre/post self-evaluations.

The development of a parametric-based indirect aircraft structural usage monitoring system using artificial neural networks is described. Flight parametric data, captured during Operational Loads Measurement have been used to predict strains or stresses at key structural locations for several military aircraft types, using mapping relationships determined by artificial neural networks. A framework for the development of a neural network-based structural usage monitor is discussed and the basic architecture of the multilayer perceptron artificial neural network is described. Additionally, results from case studies are presented. It is concluded that this technology could provide the basis for accurate, cost-effective structural usage monitoring systems across the range of military aircraft types and roles.

From necessity, military aircraft often operate in a highly fatigue damaging environment and history has shown in lost lives and aircraft the consequences of failure to appreciate fully the usage environment. The need for robust and cost effective structural usage monitoring of military aircraft to ensure operations are conducted within acceptable levels of risk is paramount. Furthermore, increased economic pressures require ever-inventive methods to be employed to maximise the lives of military fleets; structural usage monitoring will be a key asset in this drive. A highly cost effective indirect structural health and usage neural network (SHAUNN) monitoring system is proposed. A SHAUNN uses regression relationships determined by artificial neural networks to predict stresses, strains, loads, or fatigue damage from flight parameters. Within this paper the development of a SHAUNN monitoring system is described. Flight parametric data, captured during Operational Loads Measurement of the Royal Air Force Dominie TMk1 aircraft have been used to predict stresses at the key structural location in the wing, using mapping relationships determined by artificial neural networks. A framework for the development of the SHAUNN monitoring system is discussed and the basic architecture of the multilayer perceptron artificial neural network is described. It is concluded that this technology could provide the basis for an accurate, cost-effective structural usage monitoring system and further work to investigate the prediction of ground – based stresses in the wing is recommended.

Background: There are no disease modifying agents for the treatment of Alzheimer’s disease (AD). Pathologically, AD is associated with the misfolding of two peptides: beta-amyloid (plaques) and tau (tangles). Methods: Using large-scale computer simulations, we modelled the misfolding of both beta-amyloid and tau, identifying a common conformational motif (CCM; i.e. an abnormal peptide shape), present in both beta-amyloid and tau, that promotes their misfolding. We screened a library of 11.8 million compounds against this in silico model of protein misfolding, identifying three novel molecular classes of putative therapeutics as anti-protein misfolding agents. We synthesized approximately 400 new chemical entity drug-like molecules in each of these three classes (i.e. 1200 potential drug candidates). These were comprehensively screened in a battery of five in vitro protein oligomerization assays. Selected compounds were next evaluated in the APP/PS1 doubly transgenic mouse model of AD. Results: Two new classes of molecules were identified with the ability to block the oligomerization of both beta-amyloid and tau. These compounds are drug-like with good pharmacokinetic properties and are brain-penetrant. They exhibit excellent efficacy in transgenic mouse models. Conclusion: Computer aided drug design has enabled the discovery of novel drug-like molecules able to inhibit both tau and beta-amyloid misfolding.

We analysed a cross-sectional telephone survey of U.S. adults to assess the impact of selected characteristics on healthcare-seeking behaviours and treatment practices of people with influenza-like illness (ILI) from September 2009 to March 2010. Of 216 431 respondents, 8·1% reported ILI. After adjusting for selected characteristics, respondents aged 18–64 years with the following factors were more likely to report ILI: a diagnosis of asthma [adjusted odds ratio (aOR) 1·88, 95% CI 1·67–2·13] or heart disease (aOR 1·41, 95% CI 1·17–1·70), being disabled (aOR 1·75, 95% CI 1·57–1·96), and reporting financial barriers to healthcare access (aOR 1·63, 95% CI 1·45–1·82). Similar associations were seen in respondents aged ⩾65 years. Forty percent of respondents with ILI sought healthcare, and 14% who sought healthcare reported receiving influenza antiviral treatment. Treatment was not more frequent in patients with high-risk conditions, except those aged 18–64 years with heart disease (aOR 1·90, 95% CI 1·03–3·51). Of patients at high risk for influenza complications, self-reported ILI was greater but receipt of antiviral treatment was not, despite guidelines recommending their use in this population.

There is increasing emphasis on the need for effective ways of sharing knowledge to enhance environmental management and sustainability. Knowledge exchange (KE) are processes that generate, share and/or use knowledge through various methods appropriate to the context, purpose, and participants involved. KE includes concepts such as sharing, generation, coproduction, comanagement, and brokerage of knowledge. This paper elicits the expert knowledge of academics involved in research and practice of KE from different disciplines and backgrounds to review research themes, identify gaps and questions, and develop a research agenda for furthering understanding about KE. Results include 80 research questions prefaced by a review of research themes. Key conclusions are: (1) there is a diverse range of questions relating to KE that require attention; (2) there is a particular need for research on understanding the process of KE and how KE can be evaluated; and (3) given the strong interdependency of research questions, an integrated approach to understanding KE is required. To improve understanding of KE, action research methodologies and embedding evaluation as a normal part of KE research and practice need to be encouraged. This will foster more adaptive approaches to learning about KE and enhance effectiveness of environmental management.

At the summit of the Antarctic plateau, Dome A offers an intriguing location for future large scale optical astronomical observatories. The Gattini Dome A project was created to measure the optical sky brightness and large area cloud cover of the winter-time sky above this high altitude Antarctic site. The wide field camera and multi-filter system was installed on the PLATO instrument module as part of the Chinese-led traverse to Dome A in January 2008. This automated wide field camera consists of an Apogee U4000 interline CCD coupled to a Nikon fisheye lens enclosed in a heated container with glass window. The system contains a filter mechanism providing a suite of standard astronomical photometric filters (Bessell B, V, R) and a long-pass red filter for the detection and monitoring of airglow emission. The system operated continuously throughout the 2009, and 2011 winter seasons and part-way through the 2010 season, recording long exposure images sequentially for each filter. We have in hand one complete winter-time dataset (2009) returned via a manned traverse. We present here the first measurements of sky brightness in the photometric V band, cloud cover statistics measured so far and an estimate of the extinction.