According to conventional wisdom, a great power engaging in international retrenchment regularly incurs tremendous costs. Following its withdrawal from a commitment abroad, the argument goes, windows of opportunity emerge that rivals exploit to their benefit, thus imposing significant costs on the retrenching great power. I argue that pundits and policymakers consistently overestimate the dangers associated with strategic withdrawals: great powers can – and in the past frequently have – successfully engaged in international retrenchment without creating opportunities for their rivals to gain significant strategic benefits. To make this case, I develop a new typology of international retrenchment strategies based on the kind and degree of disengagement they entail and demonstrate that most types do not regularly pave the way for rival gains. I support my argument through a series of plausibility probes: the Soviet retrenchment from Romania in the 1950s; the US retrenchment from Korea in the 1970s; and the US retrenchment from Western Europe in the 1990s.

There seems to exist a general consensus on how to conceptualize cooperation in the field of international relations (IR). We argue that this impression is deceptive. In practice, scholars working on the causes of international cooperation have come to implicitly employ various understandings of what cooperation is. Yet, an explicit debate about the discipline's conceptual foundations never materialized, and whatever discussion occurred did so only latently and without much dialog across theoretical traditions. In this paper, we develop an updated conceptual framework by exploring the nature of these differing understandings and situating them within broader theoretical conversations about the role of cooperation in IR. Drawing on an array of studies in IR and philosophy, our framework distinguishes between three distinct types of cooperative state interactions – cooperation through tacit policy coordination (‘minimal’ cooperation), cooperation through explicit policy coordination (‘thin’ cooperation), and cooperation based on joint action (‘thick’ cooperation). The framework contributes to better theorization about cooperation in two main ways: it allows scholars across theoretical traditions to identify important sources of disagreement and previously unnoticed theoretical common ground; and the conceptual disaggregation it provides grants scholars crucial theoretical leverage by enabling type-specific causal theorization.

While fetal alcohol spectrum disorder (FASD) has primarily been thought of as a neurodevelopmental condition, research is beginning to highlight its ‘whole-body’ implications. Accordingly, the current study sought to provide a snapshot of potential health issues. Caregivers of children (median age of 12 years) with an FASD diagnosis were invited to participate in an online survey. Information relating to sample demographics, FASD status of the child and health outcomes were collected. The prevalence of health conditions reported in the FASD sample was compared against national prevalence data. Multiple linear regression utilising a stepwise approach was used to investigate potential predictors of the number of diagnosed health conditions. Survey data were from an international cohort (n = 197), with the majority of respondents based in Australia (40.2%) or the United States (27.7%). The most commonly reported diagnosed health conditions were eye conditions (44.7%), asthma (34.5%), heart conditions (34.0%) and skin conditions (27.4%). Binomial testing indicated the proportion of children diagnosed with these disorders was generally higher in the current FASD population, compared to national prevalence data. Indicators of metabolic dysfunction including diabetes and obesity were not significantly different compared to national prevalence data. Age of FASD diagnosis, existence of comorbid mental health conditions and the primary caregiver being in paid work were identified as being associated with the prevalence of diagnosed health conditions. Overall, the study has provided an up-to-date snapshot of health problems reported in a sample of children with FASD, confirming their increased risk of adverse health outcomes.

Self-interacting dark matter (SIDM) is promising to solve or at least mitigate small-scale problems of cold collisionless dark matter. N-body simulations have proven to be a powerful tool to study SIDM within the astrophysical context. However, it turned out to be difficult to simulate dark matter (DM) models that typically scatter about a small angle, for example, light mediator models. We developed a novel numerical scheme for this regime of frequent self-interactions that allows for N-body simulations of systems like galaxy cluster mergers or even cosmological simulations. We have studied equal and unequal mass mergers of galaxies and galaxy clusters and found significant differences between the phenomenology of frequent self-interactions and the commonly studied large-angle scattering (rare self-interactions). For example, frequent self-interactions tend to produce larger offsets between galaxies and DM than rare self-interactions.

There is widespread evidence that schizophrenic symptomatology is best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samples predominantly treated with typical neuroleptics, which frequently induce parkinsonian symptoms that are hard to disentangle from primary negative symptoms and may have inflated correlations with neurocognition. A newly developed psychopathological instrument called the Positive and Negative and Disorganized Symptoms Scale (PANADSS) was evaluated in 60 schizophrenic patients. Forty-seven participants treated with atypical neuroleptics performed several neurocognitive tasks.

A three-factor solution of schizophrenic symptomatology emerged. Negative symptomatology was associated with diminished creative verbal fluency and digit span backward, whereas disorganization was significantly correlated with impaired Stroop, WCST and Trail-Making Test B performance.

Data suggest that disorganization is associated with tasks that demand executive functioning. Previous findings reporting correlations between negative symptomatology and neurocognition may have been confounded by the adverse consequences of typical neuroleptics.

Until recently, psychological therapy for schizophrenia was considered inefficient or even harmful by many clinicians. The reservation against psychotherapy is partly rooted in the assumption that delusions are not amenable to psychological understanding. However, meta-analyses suggest that cognitive intervention is effective in ameliorating schizophrenia symptoms. In addition, evidence has accumulated that cognitive biases, such as jumping to conclusions (JTC), are involved in the pathogenesis of schizophrenia positive symptoms, particularly delusions. A recently developed group program, called metacognitive training (MCT), is presented targeting cognitive biases. The MCT is a hybrid of psychoeducation, cognitive remediation and cognitive-behavioural therapy. Patients are taught strategies how to identify and defuse “cognitive traps”. The program can be downloaded at no cost at www.uke.de/mkt and is currently available in more than 20 languages. New evidence on the feasibility and efficacy of the MCT is presented. At the end, a novel individualized variant entitled MCT+ is demonstrated targeting individual delusional ideas. A random-controlled study asserts the efficacy of the MCT+ to reduce JTC as well as delusion severity and conviction.

Although antipsychotic medication still represents the treatment of choice for schizophrenia, its objective impact on symptoms is only in the medium effect size range. Hence, clinical researchers are intensively looking for complementary therapeutic options. Cognitive research has elucidated a number of cognitive biases in schizophrenia that seem to play a crucial role in the formation and maintenance of the disorder: jumping to conclusions, attributional biases, a bias against disconfirmatory evidence, overconfidence in errors, and distorted theory of mind. Metacognitive training for schizophrenia patients (MCT) is a group intervention that seeks to sharpen the awareness of schizophrenia patients on these biases. The training is available in 25 languages at no cost via www.uke.de/mkt/. The talk will also present a new treatment program called MCT+ which is a hybrid of MCT and individualized cognitive-behavioral therapy. Results assert that MCT and MCT+ are feasible interventions. According to randomized controlled trials, metacognitive intervention leads to an accelerated symptom improvement and alleviates some cognitive biases (particularly jumping to conclusions) in patients relative to active control interventions.

Persistent psychotic symptoms represent a major challenge for psychiatric care. Basic research has shown that psychotic symptoms are associated with cognitive biases. Metacognitive training (MCT) aims at helping patients to become aware of these biases and to improve problem-solving. Fifty-two participants fulfilling diagnostic criteria of schizophrenia or schizoaffective disorders and persistent delusions and stabilized antipsychotic medication were enrolled in this study. Following baseline assessment patients were randomized either to treatment as usual (TAU) conditions or TAU + MCT. The intervention consisted of eight weekly 1-hour sessions (maximum: 8 hours). Participants were assessed at 8 weeks and 6-months later by blind assessors. Participants were assessed with the Psychotic Symptoms Rating Scales (PSYRATS) and the positive subscale of the PANSS. Between-group differences in post- and pre-test values were significant at a medium effect size in favor of the MCT for the PSYRATS delusion scale and the positive scale of the PANSS both at post and follow-up. The results of this study indicate that MCT training has a surplus antipsychotic effect for patients suffering from schizophrenia-related disorders who demonstrate only a partial response to antipsychotic treatment and that the effect of the intervention persists for at least 6 months after the intervention.

In this paper, we study the shape and dynamics of helical coherent structures found in the flow field of an annular swirling jet undergoing vortex breakdown. The flow field is studied by means of time-resolved tomographic particle image velocimetry measurements. The obtained flow fields are analysed using both classic and spectral proper orthogonal decomposition. Despite the simple geometrical set-up of the annular jet, the flow field is very complex. Two distinct large-scale helical flow structures are identified: a single and a double helix, both co-rotating with the swirl direction, and it is revealed that these structures are not higher harmonics of each other. The structures have a relatively low energy content which makes it hard to separate them from other dynamics of the flow field, notably turbulent motions. Because of this, classic proper orthogonal decomposition fails to identify both structures properly. Spectral proper orthogonal decomposition, on the other hand, allows them to be identified accurately when the filter size is set at around eight times the precession period. The precession frequencies of the single and double helices correspond to Strouhal numbers of 0.273 and $0.536\pm 0.005$, respectively. A global stability analysis of the mean flow field shows that these structures correspond to two separate global modes. The precessing frequencies obtained by the stability analysis and the related spatial structures match very well with the experimental observations. The current work extends our knowledge on turbulent vortex breakdown and on mean field global stability theory in general. It leads to the following conclusions. Firstly, single- and double-helix vortex breakdown are both manifestations of global modes. Previous studies have shown that both $m=1$ and $m=2$ modes can coexist in swirling jets. However, the $m=2$ mode has been identified as a second harmonic of the first mode, while this study identifies both as two independent global modes. Secondly, this work shows that the simultaneous occurrence of multiple helical global modes is possible within a turbulent flow and their shapes and frequencies are very well predicted by mean field stability analysis. The latter finding is of general interest as it applies to a wide class of fluid problems dominated by multiple oscillatory structures.

Maternal insufficiency during fetal development can have long-lasting effects on the offspring, most notably on nephron endowment. In polycystic kidney disease (PKD), variability in severity of disease is observed and maternal environment may be a modifying factor. In this study, we first established that in a rodent model of PKD, the Lewis polycystic kidney (LPK) rat’s nephron numbers are 25% lower compared with wildtype animals. We then investigated the effects of prenatal and postnatal maternal environment on phenotype and nephron number. LPK pups born from and raised by homozygous LPK dams (control) were compared with LPK pups cross-fostered onto heterozygous LPK dams to improve postnatal environment; with LPK pups born from and raised by heterozygous LPK dams to improve both prenatal and postnatal environment and with LPK pups born from and raised by Wistar Kyoto-LPK heterozygous dams to improve both prenatal and postnatal environment on a different genetic background. Improvement in both prenatal and postnatal environment improved postnatal growth, renal function and reduced blood pressure, most notably in animals with different genetic background. Animals with improved postnatal environment only showed improved growth and blood pressure, but to a lesser extent. All intervention groups showed increased nephron number compared with control LPK. In summary, prenatal and postnatal environment had significant effect in delaying progression and reducing severity of PKD, including nephron endowment.

Alcohol consumption around the time of conception is highly prevalent in Western countries. Exposure to ethanol levels during gestation has been associated with altered development of the mesolimbic reward pathway in rats and increased propensity to addiction, however the effect of exposure only around the time of conception is unknown. The current study investigated the effects of periconceptional alcohol exposure (PC:EtOH) on alcohol and palatable food preferences and gene expression in the ventral tegmental area (VTA) and the nucleus accumbens of the adult offspring. Rats were exposed to a liquid diet containing ethanol (EtOH) (12.5% vol/vol) or a control diet from 4 days before mating until 4 days after mating. PC:EtOH had no effect on alcohol preference in either sex. At 15 months of age, however, male PC:EtOH offspring consumed more high-fat food when compared with male control offspring, but this preference was not observed in females. Expression of the dopamine receptor type 1 (Drd1a) was lower in the VTA of male PC:EtOH offspring compared with their control counterparts. There was no effect of PC:EtOH on mRNA expression of the µ-opioid receptor, tyrosine hydroxylase (Th), dopamine receptor type 2 (Drd2) or dopamine active transporter (Slc6a3). These data support the hypothesis that periconceptional alcohol exposure can alter expression of key components of the mesolimbic reward pathway and heighten the preference of offspring for palatable foods and may therefore increase their propensity towards diet-induced obesity. These results highlight the importance of alcohol avoidance when planning a pregnancy.