Tenascin is an extracellular matrix glycoprotein known to be an essential factor for the modulation of reciprocal interactions between the epithelium and mesenchyme during embryogenesis and tumourigenesis. The interactions between the expression of tenascin in the liver of Syrian golden hamster and the development of bile duct cancer in an Opisthorchis viverrini-associated cholangiocarcinoma model were investigated. The tenascin was expressed in connective tissues surrounding the dilated ducts, ductal rims and the stroma of cancers, and strongly in the stroma flame of necrotic cancer nodules. The mRNA signal for tenascin was also recognized in the stroma cells. The potential roles of tenascin as prognostic tumour markers are discussed.

Birthweight has been associated with diabetes in a reverse J-shape (highest risk at low birthweight and moderately high risk at high birthweight) and inversely associated with hypertension in adulthood with inconsistent evidence for cardiovascular disease. There is a lack of population-based studies examining the incidence of cardiometabolic outcomes in young adults born with low and high birthweights. To evaluate the association between birthweight and diabetes, hypertension, and ischemic heart disease (IHD) in young adulthood, we conducted a retrospective cohort study of 874,904 singletons born in Ontario, Canada, from 1994 to 2002, identified from population-based health administrative data. Separate Cox regression models examined birthweight in association with diabetes, hypertension, and IHD adjusting for confounders. Among adults 18–26 years, the diabetes incidence rate was 18.15 per 100,000 person-years, hypertension was 15.80 per 100,000 person-years, and IHD was 1.85 per 100,000 person-years. Adjusted hazard ratios (AHR) for the hazard of diabetes with low (<2500g) and high (>4000g), compared with normal (2500–4000g) birthweight, were 1.46 (95% CI 1.28, 1.68) and 1.09 (0.99, 1.21), respectively. AHR for hypertension with low and high birthweight were 1.34 (1.15, 1.56) and 0.86 (0.77, 0.97), respectively. AHR for IHD with low and high birthweight were 1.28 (0.80, 2.05) and 0.97 (0.71, 1.33), respectively. Overall, birthweight was associated with diabetes in young adults in a reverse J-shape and inversely with hypertension. There was insufficient evidence of an association with IHD. Further evidence is needed to understand the causal mechanisms between birthweight and cardiometabolic diseases in young adults.

Electro- and diffusio-phoresis of particles correspond respectively to the transport of particles under electric field and solute concentration gradients. Such interfacial transport phenomena take their origin in a diffuse layer close to the particle surface, and the motion of the particle is force free. In the case of electrophoresis, it is further expected that the stress acting on the moving particle vanishes locally as a consequence of local electroneutrality. But the argument does not apply to diffusiophoresis, which takes its origin in solute concentration gradients. In this paper we investigate further the local and global force balance on a particle undergoing diffusiophoresis. We calculate the local tension applied on the particle surface and show that, counter-intuitively, the local force on the particle does not vanish for diffusiophoresis, in spite of the global force being zero, as expected. Incidentally, our description allows us to clarify the osmotic balance in diffusiophoresis, which has been a source of debate in recent years. We explore various cases, including hard and soft interactions, as well as porous particles, and provide analytic predictions for the local force balance in these various systems. The existence of local stresses may induce deformation of soft particles undergoing diffusiophoresis, hence suggesting applications in terms of particle separation based on capillary diffusiophoresis.

We present ALMA detection of the [O iii] 88 μm line and 850 μm dust continuum emission in a Y-dropout Lyman break galaxy, MACS0416_Y1. The [O iii] detection confirms the object with a spectroscopic redshift to be z = 8.3118±0.0003. The 850 μm continuum intensity (0.14 mJy) implies a large dust mass on the order of 4×106M⊙. The ultraviolet-to-far infrared spectral energy distribution modeling, where the [O iii] emissivity model is incorporated, suggests the presence of a young (τage ≍ 4 Myr), star-forming (SFR ≍ 60M⊙yr−1), and moderately metal-polluted (Z ≍ 0.2Z⊙) stellar component with a stellar mass of 3 × 108M⊙. An analytic dust mass evolution model with a single episode of star formation does not reproduce the metallicity and dust mass in ≍ 4 Myr, suggesting an underlying evolved stellar component as the origin of the dust mass.

The present study focused on parents’ social cue use in relation to young children's attention. Participants were ten parent–child dyads; all children were 36 to 60 months old and were either typically developing (TD) or were diagnosed with autism spectrum disorder (ASD). Children wore a head-mounted camera that recorded the proximate child view while their parent played with them. The study compared the following between the TD and ASD groups: (a) frequency of parent's gesture use; (b) parents’ monitoring of their child's face; and (c) how children looked at parents’ gestures. Results from Bayesian estimation indicated that, compared to the TD group, parents of children with ASD produced more gestures, more closely monitored their children's faces, and provided more scaffolding for their children's visual experiences. Our findings suggest the importance of further investigating parents’ visual and gestural scaffolding as a potential developmental mechanism for children's early learning, including for children with ASD.

In recent years, the discovery of massive quasars at $z\sim7$ has provided a striking challenge to our understanding of the origin and growth of supermassive black holes in the early Universe. Mounting observational and theoretical evidence indicates the viability of massive seeds, formed by the collapse of supermassive stars, as a progenitor model for such early, massive accreting black holes. Although considerable progress has been made in our theoretical understanding, many questions remain regarding how (and how often) such objects may form, how they live and die, and how next generation observatories may yield new insight into the origin of these primordial titans. This review focusses on our present understanding of this remarkable formation scenario, based on the discussions held at the Monash Prato Centre from November 20 to 24, 2017, during the workshop ‘Titans of the Early Universe: The Origin of the First Supermassive Black Holes’.

We study runaway stellar collisions in primordial star clusters and formation of intermediate mass black holes (IMBHs). Using cosmological simulations, we identify eight atomic-cooling halos in which the star clusters form. We follow stellar and dark matter (DM) dynamics for 3Myr using hybrid N-body simulations. We find that the runaway stellar collisions occur in all star clusters and IMBHs with masses ∼400–1900M⊙ form. Performing additional N-body simulations, we explore evolutions of the IMBHs in the star clusters for 15 Myr. The IMBH masses grow via stellar tidal disruption events (TDEs) to ∼700–2500 M⊙. The TDE rates are ∼0.3–1.3 Myr−1. DM motions affect the star cluster evolutions and reduce the TDE rates. The IMBHs may subsequently grow to SMBHs by gas supply through galaxy mergers or large-scale gas inflows, or they may remain within or around the clusters.

Between May 1983 and July 1984 glaciological parties of the 24th and 25th Japanese Antarctic Research Expeditions (JARE–24 and 25) carried out ice-core drilling using a thermal drill, down to 700.5 m depth at Mizuho Station (70°41'53"S, 44°19'54"E), as a part of the Glaciological Research Program in east Dronning Maud Land, Antarctica.

The thermal drill, 3.9 m long and capable of taking a core 1.5 m long and 130 mm in diameter, is an improved version of a drill used by JARE–15 in 1975. The most important improvement was the monitoring system during drilling, for which a micro-computer was fitted in the drill. By using this system, such accidents as heater burn-out, tank overflow and failure of water suction would immediately be brought to our attention. The drilling speed was about 1.6 m/h, when the optimum output was 3.6 kW. The core recovery rate was above 99%.

The core quality was good down to a depth of 80 m. Between 80 and 120 m, cracks were found at intervals of 0.15–0.5 m, and horizontal cracks were found continuously at intervals of 0.01 m or less.

Immediately after the core was pulled, the stratigraphy was observed and bulk density was measured. A dust band, presumably volcanic particles, was seen at only 500.2 m depth during stratigraphic observation. The following analyses were carried out at Mizuho Station within a month of recovery:

• (1) Density determination by the hydrostatic method.

• (2) Measurement of total gas content.

• (3) Thin-section analyses, including observation of cracking around air bubbles and the crystalline texture, and ice-fabric studies.

The 700.5 m core has been brought to Japan, and the following analyses are now under way:

• (1) Oxygen-isotope ratio.

• (2) Concentration of microparticles.

• (3) Electric conductivity.

• (4) Chemistry of soluble impurities.

Airborne radio echo-sounding was carried out in order to measure the thickness of the ice sheet in the Shirase Glacier drainage basin and map the bedrock topography. It was found that the elevation of bedrock was approximately at sea-level from Shirase Glacier to 100 km up-stream of the glacier and thereafter it was 500–100 m higher. Investigation of the echo intensity reflected from the bedrock indicates that at ice thicknesses less than 1000 m absorption was about 5.2 dB/100 m, but at greater ice thicknesses echo intensity did not depend upon the ice thickness but became approximately constant. Where ice thicknesses were greater than 1000 m in the main flow area of the Shirase Glacier drainage basin, the reflection strengths of about 9 dB were greater than outside the basin. Since the increase in echo intensity was considered to be due to the existence of water, the strong echo observed in the main part of the basin supported an hypothesis that the base of the basin was wet and the ice sheet was sliding on the bedrock.

The thickness of supraglacial debris on the Khumbu Glacier, Nepal Himalaya, has been mapped by a combination of direct measurements and morphological and lithological studies. All three processes, englacial, supraglacial, and subglacial, must be considered in establishing the distribution of debris. Taking advantage of the lithological characteristics of the debris and their bedrock source, the denudation rate of the schistose bedrock was estimated to be about 0.02 mm a−1. A rough estimate of the production rate of supraglacial debris indicated that most of the present debris has formed since the last advance of the glacier, which took place a few hundred years B.P.

In order to investigate the distinguishability about the progenitors of FeCCSNe and ECSNe, we calculate the luminosities and spectra of their pre-SN neutrinos and estimate the number of events at neutrino detectors.

In this paper we present the results of spectroscopic observations for 34 emission-line stars (ELSs) in the Orion belt region, which were detected in an extensive survery. Spectral classification and the intensities of Hα and Hβ emission have revealed that the observed ELSs are probably T-Tauri type stars.

Ideal magnetohydrodynamics (IMHD) is strongly constrained by an infinite number of microscopic constraints expressing mass, entropy and magnetic flux conservation in each infinitesimal fluid element, the latter preventing magnetic reconnection. By contrast, in the Taylor relaxation model for formation of macroscopically self-organized plasma equilibrium states, all these constraints are relaxed save for the global magnetic fluxes and helicity. A Lagrangian variational principle is presented that leads to a new, fully dynamical, relaxed magnetohydrodynamics (RxMHD), such that all static solutions are Taylor states but also allows state with flow. By postulating that some long-lived macroscopic current sheets can act as barriers to relaxation, separating the plasma into multiple relaxation regions, a further generalization, multi-region relaxed magnetohydrodynamics (MRxMHD) is developed.

A cross-sectional serological survey was conducted during January to August 2001 to determine the seroprevalence of Leptospira serovars in five species of livestock in Thailand and to identify associations between seropositivity and sex, age, species and geographical locations. Sera from 14188 livestock (9288 cattle, 1376 buffaloes, 1898 pigs, 1110 sheep, 516 goats) from 36 provinces were tested for antibodies against 24 Leptospira serovars with the microscopic agglutination test (MAT) for which the criterion for a positive result was set at a titre of ⩾1:50. A total of 1635 [11·5%, 95% confidence interval (CI) 11·0–12·0] animals were seropositive and the highest prevalence (30·4%, 95% CI 28·2–32·5) of evidence of infection was recorded in the northeast region followed by the central region (22·2%, 95% CI 20–24·6). Seroprevalences recorded for cattle, buffaloes, pigs, sheep and goats were 9·9% (95% CI 9·3–10·5), 30·5% (95% CI 28·1–32·9), 10·8% (95% CI 9·5–12·3), 4·7% (95% CI 3·6–6·1) and 7·9% (95% CI 5·8–10·5), respectively. Buffaloes were 3·1 (95% CI 2·8–3·4) times more likely than cattle to be seropositive. The most commonly detected antibodies were against L. interrogans serovars Ranarum, Sejroe, and Mini in cattle, Mini, Sejroe, and Bratislava in buffaloes, Ranarum, Pomona, and Bratislava in pigs and Mini, Shermani, and Ranarum in sheep and goats. Seroprevalences in cattle and buffaloes trended upwards with increasing age and there was no difference in the risk of seropositivity between males and females.

Monitor of All-sky X-ray Image (MAXI) on board International Space Station is capable ofobserving gamma-ray bursts (GRBs) and sending notices of GRBs or other transient events,using real time connection to the ground. MAXI observed 32 GRBs or short X-ray transientsas of the end of September 2012. Among them, eleven events were simultaneously detected byother satellites. The observed rate of the MAXI GRBs is about one event per month. Thisrate is comparable to a past observation with larger effective area and larger field ofview. The fact indicates that MAXI has better sensitivity to observe GRBs because of lowbackground. The distribution of the spectral hardness of MAXI GRBs is similar to theresults of a past instrument, which is sensitive to similar energy range.

It is difficult to get a real scale image of the solar system through lecture. A scale model is a classical and one of good solutions (e.g. Handa et al.2003, Handa et al.2008). Through this model, people living in or visiting to the city can physically understand the scale of the solar system. This scale gives 1 cm for Earth's diameter and 115 m for 1 AU. However, some gadget is required to make it attractive for public citizens.