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Declining labor force participation of older men throughout the 20th century and recent increases in participation have generated substantial interest in understanding the effect of public pensions on retirement. The National Bureau of Economic Research's International Social Security (ISS) Project, a long-term collaboration among researchers in a dozen developed countries, has explored this and related questions. The project employs a harmonized approach to conduct within-country analyses that are combined for meaningful cross-country comparisons. The key lesson is that the choices of policy makers affect the incentive to work at older ages and these incentives have important effects on retirement behavior.
The coarse (0.4–2 µm) clay fraction of an Albian black shale collected in the Atlantic Ocean (Deep Sea Drilling Project leg 11) consists chiefly (90–95%) of smectite and 5–10% illite. Both minerals are locally surrounded by overgrowth structures, such as fine laths about 0.05–0.4 µm long and 0.02–0.1 µm wide. Individual laths or assemblages of laths protrude from the center of smectite flakes at angles of about 60° to each other. Laths occur around illite crystals in a similar manner or coalesce into a rim that consists of 0.05–0.1-µm-size particles. On the basis of scanning transmission electron microscopy: (1) the center of individual illite crystals consists of a dioctahedral mineral, but the overgrowth structures are Al-Fe beidellites; and (2) the smectite flakes have highly variable compositions, but correspond chiefly to Fe-Al-beidellite, whereas the overgrowths are compositionally close to montmorillonite.
The overgrowth structures seem to have formed during early diagenesis. The chemical composition of overgrowths around illite and smectite tend to be similar in response to the new environment, implying an addition of silica to both materials.
Advice from avian influenza experts suggests that there is a high risk that highly pathogenic avian influenza will arrive in the Southern Ocean during the austral summers.
Tobacco use is common in subjects with schizophrenia (SZ) and has sometimes been associated with better functioning in short-term studies. Only few studies embrace an extensive examination of tobacco influence on clinical, cognitive and therapeutic characteristics in stabilized SZ outpatients. The objective of the present study was to assess the association between cognitive performances and smoking status in SZ subjects.
Methods
In total, 1233 SZ participants (73.9% men, mean age 31.5) were included and tested with a comprehensive battery. Tobacco status was self-declared (never-, ex-, or current smokers). Multivariable analyses including principal component analyses (PCA) were used.
Results
In total, 53.7% were smokers with 33.7% of them nicotine-dependent. Multiple factor analysis revealed that current tobacco smoking was associated with impaired general intellectual ability and abstract reasoning (aOR 0.60, 95% IC 0.41–0.88, p = 0.01) and with a lifetime alcohol use disorder (p = 0.026) and a lifetime cannabis use disorder (p < 0.001). Ex- and never-smokers differed for age, mean outcome, cannabis history and medication [ex-smokers being older (p = 0.047), likely to have higher income (p = 0.026), a lifetime cannabis use disorder (p < 0.001) and higher CPZeq doses (p = 0.005)]. Premorbid IQ in the three groups significantly differed with, from higher to lower: ex-smokers, never-smoker, current smokers (all p < 0.001).
Conclusions
This study is the largest to date providing strong evidence that chronic smoking is associated with cognitive impairment in SZ, arguing against the self-medication hypothesis as a contributor to the high prevalence of smoking in SZ. Ex-smokers may also represent a specific subgroup. Longitudinal studies are warranted to determine the developmental impact of tobacco on neurocognition.
Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed.
Methods.
we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment.
Results.
Eighty-seven people with schizophrenia were included and allocated to either the RR group (n = 57) or the TR group (n = 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP], p < 0.001, d = 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative, p < 0.001, d = 0.827; PANSS GP, p < 0.001, d = 0.991; PANSS positive, p = 0.009, d = 0.594), verbal abstraction (p = 0.008, d = 0.554), aggression bias (p = 0.008, d = 0.627), and self-stigma (stereotype endorsement, p = 0.019, d = 0.495; discrimination experiences, p = 0.047; d = 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up.
Conclusions.
Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness.
We assessed the subjective quality of life (QOL) of 30 deficit schizophrenic patients compared to 112 nondeficit schizophrenic patients. The deficit patients did not differ in term of QOL, total score of positive symptoms, general psychopathology from the nondeficit patients. This result suggested an absence of impact of primary negative symptoms on the subjective QOL in schizophrenic patients.
Longitudinal studies of the relationship between cognition and functioning in bipolar disorder are scarce, although cognition is thought to be a key determinant of functioning. The causal structure between cognition and psychosocial functioning in bipolar disorder is unknown.
Aims
We sought to examine the direction of causality between cognitive performance and functional outcome over 2 years in a large cohort of euthymic patients with bipolar disorder.
Method
The sample consisted of 272 adults diagnosed with bipolar disorder who were euthymic at baseline, 12 and 24 months. All participants were recruited via the FondaMental Advanced Centers of Expertise in Bipolar Disorders. We used a battery of tests, assessing six domains of cognition at baseline and 24 months. Residual depressive symptoms and psychosocial functioning were measured at baseline and 12 and 24 months. The possible causal structure between cognition and psychosocial functioning was investigated with cross-lagged panel models with residual depressive symptoms as a covariate.
Results
The analyses support a causal model in which cognition moderately predicts and is causally primary to functional outcome 1 year later, whereas psychosocial functioning does not predict later cognitive performance. Subthreshold depressive symptoms concurrently affected functioning at each time of measure.
Conclusions
Our results are compatible with an upward causal effect of cognition on functional outcome in euthymic patients with bipolar disorder. Neuropsychological assessment may help specify individual prognoses. Further studies are warranted to confirm this causal link and evaluate cognitive remediation, before or simultaneously with functional remediation, as an intervention to improve functional outcome.
Coupled with the social practice of female hypergamy, the male surplus within the never-married population means that today's Chinese marriage market is extremely tight in particular for men from a rural background and the least privileged socio-economic categories. Drawing on quantitative data from a survey conducted in 2014–2015, this article sheds light on the situation of single men who are past prime marriage age in three rural districts of Shaanxi particularly affected by this phenomenon. It compares single men's characteristics to those of their married counterparts and offers insights into the heterogeneity of single men with the aim of challenging some commonly accepted assumptions about bachelorhood in rural China. Results suggest a strong internalization of the various characteristics, centred on being able to offer social mobility to a potential wife, that a man is expected to have to be attractive to women in a context where women have more choice in mate selection. We conclude that mate selection is highly marked by class, social norms, social interactions, health, generation and age, and requires the mobilization of certain amounts of individual, social and economic resources. Unwanted bachelorhood would thus be better understood using an intersectional approach rather than mainly in numeric terms.
Major depressive disorder (MDD) is underdiagnosed and undertreated in schizophrenia, and has been strongly associated with impaired quality of life.
Aims
To determine the prevalence and associated factors of MDD and unremitted MDD in schizophrenia, to compare treated and non-treated MDD.
Method
Participants were included in the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment. MDD was defined by a Calgary score ≥6. Non-remitted MDD was defined by current antidepressant treatment (unchanged for >8 weeks) and current Calgary score ≥6.
Results
613 patients were included and 175 (28.5%) were identified with current MDD. MDD has been significantly associated with respectively paranoid delusion (odds ratio 1.8; P = 0.01), avolition (odds ratio 1.8; P = 0.02), blunted affect (odds ratio 1.7; P = 0.04) and benzodiazepine consumption (odds ratio 1.8; P = 0.02). Antidepressants were associated with lower depressive symptoms score (5.4 v. 9.5; P < 0.0001); however, 44.1% of treated patients remained in non-remittance MDD. Nonremitters were found to have more paranoid delusion (odds ratio 2.3; P = 0.009) and more current alcohol misuse disorder (odds ratio 4.8; P = 0.04). No antidepressant class or specific antipsychotic were associated with higher or lower response to antidepressant treatment. MDD was associated with Metabolic syndrome (31.4 v. 20.2%; P = 0.006) but not with increased C-reactive protein.
Conclusions
Antidepressant administration is associated with lower depressive symptom level in patients with schizophrenia and MDD. Paranoid delusions and alcohol misuse disorder should be specifically explored and treated in cases of non-remission under treatment. MetS may play a role in MDD onset and/or maintenance in patients with schizophrenia.
Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive impairment, based on psychometric properties, to estimate the prevalence of neuropsychological deficits in euthymic BD, and identify risk factors for cognitive deficits using a multivariate approach.
Methods
We investigated neuropsychological performance in 476 euthymic patients with BD recruited via the French network of BD expert centres. We used a battery of tests, assessing five domains of cognition. Five criteria for the identification of neuropsychological impairment were tested based on their convergent and concurrent validity. Uni- and multivariate logistic regressions between cognitive impairment and several clinical and demographic variables were performed to identify risk factors for neuropsychological impairment in BD.
Results
One cut-off had satisfactory psychometric properties and yielded a prevalence of 12.4% for cognitive deficits in euthymic BD. Antipsychotics use were associated with the presence of a cognitive deficit.
Conclusions
This is the first study to validate a criterion for clinically significant cognitive impairment in BD. We report a lower prevalence of cognitive impairment than previous studies, which may have overestimated its prevalence. Patients with euthymic BD and cognitive impairment may benefit from cognitive remediation.
The relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.
Aims
To assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.
Method
We included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.
Results
Only verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.
Conclusions
Cognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.
Small-scale mariculture of high-value species for trade in remote islands can offer valuable alternative livelihoods to local communities. The endangered giant clam species Tridacna maxima is naturally abundant in some atolls in French Polynesia (FP) and has been the focus of commercial mariculture activities since 2012. Shortly after spat collectors became operational in two atoll lagoons, FP rose to become one of the main exporters of giant clams for the aquarium trade. However, this activity has been threatened recently by a mass clam-bleaching event triggered by the 2015–2016 El Niño. This study reviews the roles that international (Convention on International Trade in Endangered Species of Wild Fauna and Flora) and national regulatory frameworks play in the development of this activity in a small island context, and how they can indirectly promote better science and monitoring in order to inform adaptive management strategies. The links between the nine main groups of stakeholders show the necessary adaptation measures required to mitigate climate-driven mortalities. While this case study remains specific to giant clam farming in FP, general lessons are provided that could help in mitigating economic impacts from climate-related events on other islands.
The electrophoretic transport of ions through single walled carbon nanotubes (SWCNTs) of diameters between 1.2 and 1.8 nm was studied for different monovalent chloride salts using microfluidic devices incorporating either a single or few SWCNTs in parallel. The ionic conductance was found to be about one order of magnitude higher than would be expected from simple bulk electrophoresis without any surface effect. Importantly, the ionic conductance measured for different cations did not scale with their bulk electrophoretic mobility thus indicating a selective cation transport through these sub-2 nm SWCNTs. The transport of Na+ was notably found to be favored in comparison to that of Li+, K+ and Cs+. These results highlight the influence of steric and surface effects induced by the nano-confinement on the transport of ions through sub-2 nm SWCNTs.
Previous literature has suggested that laws and regulations may impact the use of palliative sedation. Our present study compares the attitudes of French-speaking physicians practicing in the Quebec and Swiss environments, where different laws are in place regarding physician-assisted suicide.
Method:
Data were drawn from two prior studies, one by Blondeau and colleagues and another by Beauverd and coworkers, employing the same two-by-two experimental design with length of prognosis and type of suffering as independent variables. Both the effect of these variables and the effect of their interaction on Swiss and Quebec physicians' attitudes toward sedation were compared. The written comments of respondents were submitted to a qualitative content analysis and summarized in a comparative perspective.
Results:
The analysis of variance showed that only the type of suffering had an effect on physicians' attitudes toward sedation. The results of the Wilcoxon test indicated that the attitudes of physicians from Quebec and Switzerland tended to be different for two vignettes: long-term prognosis with existential suffering (p = 0.0577) and short-term prognosis with physical suffering (p = 0.0914). In both cases, the Swiss physicians were less prone to palliative sedation.
Significance of results:
The attitudes of physicians from Quebec and Switzerland toward palliative sedation, particularly regarding prognosis and type of suffering, seem similar. However, the results suggest that physicians from Quebec could be slightly more open to palliative sedation, even though most were not in favor of this practice as an answer to end-of-life existential suffering.
This paper addresses the fulfillment of requirements related to case-based reasoning (CBR) processes for system design. Considering that CBR processes are well suited for problem solving, the proposed method concerns the definition of an integrated CBR process in line with system engineering principles. After the definition of the requirements that the approach has to fulfill, an ontology is defined to capitalize knowledge about the design within concepts. Based on the ontology, models are provided for requirements and solutions representation. Next, a recursive CBR process, suitable for system design, is provided. Uncertainty and designer preferences as well as ontological guidelines are considered during the requirements definition, the compatible cases retrieval, and the solution definition steps. This approach is designed to give flexibility within the CBR process as well as to provide guidelines to the designer. Such questions as the following are conjointly treated: how to guide the designer to be sure that the requirements are correctly defined and suitable for the retrieval step, how to retrieve cases when there are no available similarity measures, and how to enlarge the research scope during the retrieval step to obtain a sufficient panel of solutions. Finally, an example of system engineering in the aeronautic domain illustrates the proposed method. A testbed has been developed and carried out to evaluate the performance of the retrieval algorithm and a software prototype has been developed in order to test the approach. The outcome of this work is a recursive CBR process suitable to engineering design and compatible with standards. Requirements are modeled by means of flexible constraints, where the designer preferences are used to express the flexibility. Similar solutions can be retrieved even if similarity measures between features are not available. Simultaneously, ontological guidelines are used to guide the process and to aid the designer to express her/his preferences.
Combining high resolution transmission electron spectroscopy, electron diffraction, and resonant Raman spectroscopy experiments on the same suspended (free-standing) individual carbon nanotubes is the ultimate approach to relate unambiguously the structure and the intrinsic phonon features of these nano-systems.
By using this approach, the effect of coupling between nanotubes on the phonons is investigated in two model nano-systems: (i) a bundle of two non-identical SWNTs (inhomogeneous dimer), (ii) double-walled carbon nanotubes.
Introduction. Mango-based orchards in Senegal occur in a large diversity ofcropping systems, but few typologies of these systems exist and none are associated withtheir comprehensive and quantitative analysis. In this study we defined and characterizedthe typology of these systems based on a quantitative assessment of their planting design,management, vegetative state, hedgerow structure and infestation by a major pest of mango,the Bactrocera invadens fly. Materials and methods.Multivariate analysis and clustering methods were applied to data from 64 mango-basedorchards and their surrounding hedgerows sampled in the Dakar and Thiès regions, inSenegal. Results and discussion. Four types of cropping systems wereidentified according to orchard design and management patterns: (1) ‘No-input mangodiversified orchards’, (2) ‘Low-input mango orchards’, (3) ‘Medium-inputcitrus-predominant orchards’ and (4) ‘Medium-input large mango- or citrus-predominantorchards’. Orchard characteristics varied among these patterns. For instance, vegetationwas dense and homogeneous in system 1, and the mortality rate of trees was high insystem 2 but low in system 3. Orchards of systems 3 and 4 were mostly associated withhedgerows with, respectively, boundary-marking and defensive species. Lastly, the numberof B. invadens flies was high in orchards of system 4, whereas it was lowin those of system 2. Conclusion. The diversity of mango-based croppingsystems in Senegal is now well described and quantified. This characterization is apreliminary step that is essential for further studies aiming to improve these systems.
Pollux is considered as an archetype of a giant star hosting a planet: its radial velocity (RV) presents sinusoidal variations with a period of about 590 d, which have been stable for more than 25 years. Using ESPaDOnS and Narval we have detected a weak (sub-gauss) magnetic field at the surface of Pollux and followed up its variations with Narval during 4.25 years, i.e. more than for two periods of the RV variations. The longitudinal magnetic field is found to vary with a sinusoidal behaviour with a period close to that of the RV variations and with a small shift in phase. We then performed a Zeeman Doppler imaging (ZDI) investigation from the Stokes V and Stokes I least-squares deconvolution (LSD) profiles. A rotational period is determined, which is consistent with the period of variations of the RV. The magnetic topology is found to be mainly poloidal and this component almost purely dipolar. The mean strength of the surface magnetic field is about 0.7 G. As an alternative to the scenario in which Pollux hosts a close-in exoplanet, we suggest that the magnetic dipole of Pollux can be associated with two temperature and macroturbulent velocity spots which could be sufficient to produce the RV variations. We finally investigate the scenarii of the origin of the magnetic field which could explain the observed properties of Pollux.
This article focuses on Jean-Guy Belley's interest in the relationship between law and the economy—an interest illustrated by his major work on the contractual practices of the multinational company Alcan. They lament contemporary economic sociology's lack of interest—until recently—in legal phenomena, which contrasts with the close attention paid by two historic figures in “economic sociology,” Max Weber and John R. Commons, to the relationships between law and economics. The authors argue that to fully grasp the importance of the legal dimension in socio-economic analysis, we must return to the foundational insights of Weber and Commons. However, they particularly stress differences between Weber and Commons as to the unity or heterogeneity of law and the economy, the role of ethics, the search for an all-encompassing approach in the construction of ideal-types, the various forms of constraint that characterize law (whether psychological, economic, or physical), and the distinction between state law and non-state law. The latter element is why the authors, like Belley himself, argue that due consideration for legal plurality should be a central thread in any sociological analysis of the interplay between law and the economy.