Land development through pasture improvement has made great strides in recent years in many parts of the world. This has been made possible by a better understanding of the principles of pasture production following the pioneering work of the late Sir George Stapledon and his school of grassland enthusiasts. Improved strains of pasture plants, the use of lime and fertilisers, the development of mechanical aids and a better understanding of the animal in grazing management have all been involved in the development.

Infection surveillance definitions for long-term care facilities (ie, the McGeer Criteria) have not been updated since 1991. An expert consensus panel modified these definitions on the basis of a structured review of the literature. Significant changes were made to the criteria defining urinary tract and respiratory tract infections. New definitions were added for norovirus gastroenteritis and Clostridum difficile infections.

Infect Control Hosp Epidemiol 2012;33(10):965-977

Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infected or damaged sites. Acute inflammatory reactions are usually self-limiting and resolve rapidly, due to the involvement of negative feedback mechanisms. Thus, regulated inflammatory responses are essential to remain healthy and maintain homeostasis. However, inflammatory responses that fail to regulate themselves can become chronic and contribute to the perpetuation and progression of disease. Characteristics typical of chronic inflammatory responses underlying the pathophysiology of several disorders include loss of barrier function, responsiveness to a normally benign stimulus, infiltration of inflammatory cells into compartments where they are not normally found in such high numbers, and overproduction of oxidants, cytokines, chemokines, eicosanoids and matrix metalloproteinases. The levels of these mediators amplify the inflammatory response, are destructive and contribute to the clinical symptoms. Various dietary components including long chain ω-3 fatty acids, antioxidant vitamins, plant flavonoids, prebiotics and probiotics have the potential to modulate predisposition to chronic inflammatory conditions and may have a role in their therapy. These components act through a variety of mechanisms including decreasing inflammatory mediator production through effects on cell signaling and gene expression (ω-3 fatty acids, vitamin E, plant flavonoids), reducing the production of damaging oxidants (vitamin E and other antioxidants), and promoting gut barrier function and anti-inflammatory responses (prebiotics and probiotics). However, in general really strong evidence of benefit to human health through anti-inflammatory actions is lacking for most of these dietary components. Thus, further studies addressing efficacy in humans linked to studies providing greater understanding of the mechanisms of action involved are required.

The growth of ewe lambs of the Shropshire breed declined and in some cases ceased at the end of July, when they grazed permanent pastures at the Experimental Farm, Nappan, Nova Scotia. This decline in growth coincided with a decrease of about three orders of magnitude in the numbers of viable rumen bacteria. At the end of July an increase of one to two orders of magnitude was observed in the numbers of viable fungi collected from the pastures. Lambs grazing pastures developed from tidal marsh of the Bay of Fundy had a better growth performance than lambs grazing adjacent pastures developed from mixed conifer-deciduous forest. The forest soils supported a greater fungal population than the marshland soil, and several species were found predominantly on the forest soil.

To determine the effects of EPA, stearidonic acid (STA) or γ-linolenic acid (GLA) on immune outcomes, healthy male subjects consumed one of seven oil blends for 12 weeks. EPA consumption increased the EPA content of peripheral blood mononuclear cells (PBMC). Consumption of GLA (2·0 g/d) in the absence of STA or EPA increased di-homo-GLA content in PBMC. Neither STA nor its derivative 20:4n-3 appeared in PBMC when STA (<1·0 g/d) was consumed. However, STA (1·0 g/d), in combination with GLA (0·9 g/d), increased the proportion of EPA in PBMC. None of the treatments altered neutrophil or monocyte phagocytosis or respiratory burst, production of inflammatory cytokines by monocytes, T lymphocyte proliferation or the delayed-type hypersensitivity response. Production of cytokines by T lymphocytes increased in all groups, with no differences among them. The proportion of lymphocytes that were natural killer cells decreased significantly in subjects receiving 2·0 g EPA or GLA/d. There were no other effects on lymphocyte sub-populations. Plasma IgE concentration decreased in most groups, but not in the control group. Plasma IgG2 concentration increased in the EPA group. Thus, EPA or GLA at a dose of 2·0 g/d have little effect on key functions of neutrophils, monocytes and T lymphocytes, although at this dose these fatty acids decrease the number of natural killer cells. At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1·0 g/d does not affect human immune function.

Two good friends have supplied me with the material for a note which I dedicate, with kind wishes, to a third.

Michael Ballance inaugurated the epigraphical harvest of our journey in 1954 with the discovery of two remarkable inscriptions at Emircik near Beyce Sultan (territory of Eumeneia). One of these served to clinch an argument in Anatolian Studies, V, 1955, p. 38. The second is no. 1 below.

A few days later Habip Zebir Ağa, itinerant tinker of Sandıklı, called at the excavation headquarters to remind me of an earlier encounter which I had forgotten. He had visited Synnada in the exercise of his craft in 1930 while the American Society's expedition was working there, and I had taught him how to copy Greek inscriptions and urged him to make copies of any monuments he might find in the course of his work in central Phrygia. He brought with him a bundle of copies he had made during the intervening years, mainly from Synnada, the Pentapolis and the Eumeneticus Campus. A number of these copies are of known monuments and show that, for one ignorant of Latin and Greek, he is a careful and reliable copyist. One of his copies is no. 2 below.

The earliest Christians of Phrygia were the nameless converts made by Paul the Apostle when he preached to a congregation of Jews and “Godfearing” gentiles (the latter being Greek or Greco-Phrygian incolae or cives of the colonia and Greek-speaking members of Roman colonial families in the synagogue at Colonia Caesareia Antiocheia in A.D. 49; and before Paul's death the Christian mission to Phrygia had been launched from bases both in the east (Iconium and Antioch) and in the west (Laodicea, Hierapolis and Colossae). Between the middle of the first and the end of the second century, five generations of Phrygian Christians (as Paul expressed it on the same occasion) “fell on sleep and were laid unto their fathers”—in surface family sepulchres along the roads outside the cities and in country graveyards throughout all the hellenised districts of Phrygia. During this period the strong conservatism of Phrygian sepulchral custom, reinforced by the prudence in the face of persecution or proscription held to be enjoined by Scripture (had not Jesus himself withdrawn into Gethsemane?), precluded the open display on tombstones—in all ages the consecrated tokens of sorrow and of hope—of any trace of the Christian profession.