The Wisconsin high-temperature superconductor axisymmetric mirror experiment (WHAM) will be a high-field platform for prototyping technologies, validating interchange stabilization techniques and benchmarking numerical code performance, enabling the next step up to reactor parameters. A detailed overview of the experimental apparatus and its various subsystems is presented. WHAM will use electron cyclotron heating to ionize and build a dense target plasma for neutral beam injection of fast ions, stabilized by edge-biased sheared flow. At 25 keV injection energies, charge exchange dominates over impact ionization and limits the effectiveness of neutral beam injection fuelling. This paper outlines an iterative technique for self-consistently predicting the neutral beam driven anisotropic ion distribution and its role in the finite beta equilibrium. Beginning with recent work by Egedal et al. (Nucl. Fusion, vol. 62, no. 12, 2022, p. 126053) on the WHAM geometry, we detail how the FIDASIM code is used to model the charge exchange sources and sinks in the distribution function, and both are combined with an anisotropic magnetohydrodynamic equilibrium solver method to self-consistently reach an equilibrium. We compare this with recent results using the CQL3D code adapted for the mirror geometry, which includes the high-harmonic fast wave heating of fast ions.

In A Cosmopolitan Legal Order: Kant, Constitutional Justice and the European Convention on Human Rights, Alec Stone Sweet and Clare Ryan argue that there has been the emergence of, and increasing prospects for, a cosmopolitan legal order based on the Convention. This symposium aims to engage with, and to better explore, the theoretical implications and practical legal ramifications of their argument. In doing so, this first article acts as a general introduction to the symposium, laying out the major arguments of the book as well as arguments presented by the symposium contributors. Moving beyond the summative, this introduction also situates A Cosmopolitan Legal Oder within broader debates in global constitutionalism, while defending its use of Kant’s cosmopolitan theory. Lastly, it explores some of the key implications and challenges that arise from the symposium itself, rooting these insights within the current context of anti-globalism, nationalism, populism and neo-sovereigntism, and the corresponding necessity for a more transitional and pluralistic response as offered in A Cosmopolitan Legal Order.

We identified a pseudo-outbreak of Mycobacterium avium in an outpatient bronchoscopy clinic following an increase in clinic procedure volume. We terminated the pseudo-outbreak by increasing the frequency of automated endoscope reprocessors (AER) filter changes from quarterly to monthly. Filter changing schedules should depend on use rather than fixed time intervals.

OBJECTIVES/SPECIFIC AIMS: The Institute for Transnational Sciences (ITS) has developed novel methods to ethically engage stakeholders across the transnational research spectrum, up to and including public health practice and policy. METHODS/STUDY POPULATION: In 2014, the ITS co-founded The Research, Education, And Community Health (REACH), the mission of which was to facilitate communication, collaborative research, and service activities between faculty and scientists and area community leaders. The intent was to identify and meet the needs of our communities without gaps and/or redundancies, thus better leveraging time, funding, and efforts. RESULTS/ANTICIPATED RESULTS: REACH now boasts 23 Centers, Departments, and Institutes, as well as 39 community organizations, including public and mental health agencies, clinicians, policy makers, family service centers, cultural and faith-based organizations, business, and local schools/colleges. We offer 3 methods for consideration as best practices: (1) a comprehensive community health needs assessment, (2) an “Offer and Ask” community/campus partnership mechanism, and (3) Community Science Workshops, based on the European Union’s Science Shops. DISCUSSION/SIGNIFICANCE OF IMPACT: Results of REACH’s work have been used to provide guidance for enhanced, data-driven programs and allocation of resources for local and statewide initiatives. The organization has evolved into an independent coalition seeking 501(c)3 status and is planning to expand its scope to 5 counties. REACH thus serves as model for successful replication across applicable CTSA hubs.

There is recent scholarship suggesting that the Responsibility to Protect (R2P) has now emerged as a master concept in relation to responding to mass atrocity crimes and that the R2P can further be seen as representative of an emerging global constitutional norm. In critical response, this article provides the first attempt to systematically investigate R2P’s relationship with global constitutionalisation as well as to explore its wider implication with regard to global constitutionalism. In doing so, the article examines existing discussions of R2P and global constitutionalism, tracks the normative evolution of R2P in order to determine its current ‘stage’ of norm diffusion, and further attempts to locate the extent to which the R2P can be perceived as also part of a process of global constitutionalisation. From this analysis the article concludes that although the R2P could be labelled as, at best, a weak emerging norm, it fails to meet the more demanding signifier of an emerging constitutional norm and that there is further evidence to suggest that the R2P might be better understood as a stalled or degenerating norm.

Academics and policymakers often argue that global health policy greatly affects and influences national health systems because these policies transfer and implant ‘best practice’ norms and accountability techniques into local health systems. On the whole these arguments about the ‘diffusion of norms’ have merit since there is considerable evidence to suggest the existence of a positive correlation between global norms and national behaviour. Nevertheless, this article argues that traditional analytical frameworks to explain norm diffusion underplay the fact that norms are significantly ‘glocalised’ by national actors and further discount the role that national leadership plays in strengthening health systems. In response, this article presents a ten-year comparative paired study of the participatory governance mechanisms of the South African health system and its health strengthening measures. In doing so, the role of the national government in their relations with the Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM) will be examined and how key ‘partnership’ norms were amalgamated into health governance mechanisms. It will be argued that although global policy plays an important guiding role, health norms are never transcribed straightforwardly and a central element to successful health governance remains vested in the nation and the leadership role it exerts.

Imidazoles present a tunable, versatile and economical platform for the development of novel liquid solvents and polymer membranes for CO2 capture. An overview of our studies in this area is presented, with emphasis on characterization of structure-property relationships in imidazole-based materials through both experimental and computational studies. To this end, a growing library of systematically varied imidazole compounds has been synthesized using only commercial available starting materials and straightforward reactions. Using this library of compounds, we have sought to understand and develop predictive models for thermophysical properties relating to process design, including: density, viscosity, vapor pressure, pKa and CO2 absorption capacity. Furthermore, we have discovered that imidazoles are stable in the presence of SO2 and can form reversible 1:1 adducts, which can be beneficial as SO2 is typically present at ppm levels alongside CO2 in flue gas from coal-fired power plants.

We describe an investigation of 3 postoperative Gordonia bronchialis sternal infections. A nurse anesthetist was identified as the source of the outbreak, her scrubs likely becoming contaminated by her home washing machine. The outbreak ended after disposal of the implicated washing machine. Domestic laundering of surgical scrubs may need reevaluation.

A series of editorials in this Journal have argued that psychiatry is in the midst of a crisis. The various solutions proposed would all involve a strengthening of psychiatry's identity as essentially ‘applied neuroscience’. Although not discounting the importance of the brain sciences and psychopharmacology, we argue that psychiatry needs to move beyond the dominance of the current, technological paradigm. This would be more in keeping with the evidence about how positive outcomes are achieved and could also serve to foster more meaningful collaboration with the growing service user movement.

There are difficult global challenges that need to be addressed. In response, many have argued for the increased constitutionalization of international law. An argument is often also made that the international order is already constitutionalized in some meaningful sense and that there are founding conditions within the international order that represent something like a global constitution. Nevertheless, when surveying the literature on constitutionalization one is often struck by a general ambiguity about what the term means and with how constitutionalization is meant to operate between theory and institutional practice. In particular, there seems to be an overall ambiguity regarding what is being constituted by the processes of constitutionalization, about how these processes operate, and with whether this legal order is in fact creating the type of progressive cosmopolitanism that is often assumed. To address these ambiguities, this article will seek to better understand what appeals to constitutionalization generally mean and to expose key conceptual problems. The goal in doing so is to highlight areas that need greater conceptual attention and to recommend potential solutions, so that more cosmopolitan minded scholars can feel more confident in prescribing constitutionalization as part of their normative catalogue.

It is often argued that multilateralism is no longer an effective mechanism to respond to global priorities and that more deliberative and multisectoral governance is needed. To explore this, the purpose of this article is to examine the practice of mutlisectoral deliberation within the Global Fund to Fight AIDS, Tuberculosis and Malaria and to determine whether it has resulted in providing a more deliberative response to global health priorities. To do so, this article will apply various theoretical arguments for deliberative democracy to the results of a four year study on the multisectoral organisation the Global Fund. By making links between theory and practice, the article will argue that the multisectoralism practiced by the Global Fund continues to suffer from a deliberative deficit and that it has not safeguarded equal stakeholder participation, equal deliberation between stakeholders or alleviate the asymmetric power relationships which are representative of current forms of multilateral governance. Nevertheless, by locating these gaps between theory and practice, it is possible to outline deliberative safeguards that might, if constitutionally enhanced, pull the Global Fund closer to its own normative values of multisectoral deliberative decision-making.

The fast ignitor concept for inertial confinement fusion relies on the generation of hot electrons, produced by a short-pulse ultrahigh intensity laser, which propagate through high-density plasma to deposit their energy in the compressed fuel core and heat it to ignition. In preliminary experiments designed to investigate deep heating of high-density matter, we used a 20 joule, 0.5–30 ps laser to heat solid targets, and used emission spectroscopy to measure plasma temperatures and densities achieved at large depths (2–20 microns) away from the initial target surface. The targets consisted of an Al tracer layer buried within a massive CH slab; H-like and He-like line emission was then used to diagnose plasma conditions. We observe spectra from tracer layers buried up to 20 microns deep, measure emission durations of up to 200 ps, measure plasma temperatures up to Te=650 eV, and measure electron densities above 1023 cm−3. Analysis is in progress, but the data are in reasonable agreement with heating simulations when space-charge induced inhibition is included in hot-electron transport, and this supports the conclusion that the deep heating is initiated by hot electrons.

Rumen fluid was removed from four sheep 6 h after feeding, and the fluid was centrifuged to remove the micro-organisms. Perchloric acid (PCA) was added to the supernatant fluid to precipitate soluble proteins, which were again removed by centrifugation. The PCA extract was neutralized with KOH and the precipitate was removed by centrifugation. The supernatant fluid was hydrolysed with 6 MHC1 at 110 °C for 24 h, then dried by rotary evaporation, and the amino acid composition of each extract was analysed by ion-exchange chromatography. The recovery of amino acids was 98%, except for methionine, cysteine and tryptophan, which were destroyed. The recovery of amino acids from added Trypticase was 92% of the peptide mixture as amino acids. The free amino acid composition of extracellular rumen fluid was low and variable in both amount and composition (0·36, S.D. 0·49, μmol/ml). The concentration of amino acids released by acid hydrolysis of the PCA extract, presumed to be derived from peptides, was larger and its composition was less variable (1 ·02, S.D. 0·30, μmol/ml). Aspartic acid and histidine were enriched in peptides in comparison with the amino acids present in the feed or in rumen particulate material. Glycine and proline contents were higher in peptides that in particulate material. In contrast, the contents of isoleucine, leucine, tyrosine and phenylalanine tended to be lower in peptides than in the other materials. It was concluded that extracellular degradation-resistant peptides had a composition that was different to microbial protein and to the feed. The peptides appeared to be enriched for amino acids which previous studies with pure peptides had shown tend to make peptides more resistant to degradation.

There has been considerable debate about how it would be possible to move from cosmopolitan normative theory to cosmopolitan legal practice. These debates range from an uncertainty about what specific moral and normative principles should underwrite cosmopolitan law, to how those requirements should be institutionalised at the global level. In addition, many cosmopolitan theorists rest their more elaborate institutional models on the assumption of an already existing and thoroughgoing practice of cosmopolitan law, without detailed considerations regarding applied theory. The purpose of this paper is to examine the concept of cosmopolitan law and to argue how legal cosmopolitanism provides a necessary linchpin and transitional conduit between cosmopolitan theory and more institutionally based forms of cosmopolitanism. The paper examines the historical development of legal cosmopolitanism, the uniqueness of contemporary cosmopolitan legal theory within international legal debates, and maps the various approaches for moving cosmopolitan legal theory to legal practice. Through mapping the discipline, it is argued that Kantian legal cosmopolitanism represents the most coherent attempt to move from cosmopolitan legal theory to global institutional practice. This is due to the fact that it represents a minimal and moderate form of legal cosmopolitanism that accepts that any move to a cosmopolitan order would need to evolve from our current legal order. In this regard, it is argued that Kantian legal cosmopolitanism can occupy a transitional position, that not only satisfies the cosmopolitan concern for human worth, but that is also not guilty of being grossly utopian in its quest toward global justice.