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The operating goals of family firms (FFs) typically include building both economic and socioemotional wealth. Innovation is increasingly recognized as a key source for the development and growth of family firms. From the multiple dimensions of socioemotional wealth (SEW), this research has focused on how family influences a particular type of innovation – green innovation – in family firms. Using 5,071 observations from among the listed firms in Taiwan over an eight-year period (2014–2021), we examined the relationships between FFs and green innovation. The results indicate that FFs are more likely to develop green innovation than their nonfamily counterparts. In particular, there are complicated effects within different types of FFs – control deviation family firms (CDFFs).
Malnutrition is a key factor in metabolic syndrome (MS) and sarcopenia, assessing the nutritional status of these patients is a pressing issue. The purpose of this study was to clarify sarcopenia and sarcopenic obesity in patients with MS based on nutritional status. This was a case–control study between MS/non-MS. Body composition was measured by dual-energy X-ray absorptiometry. Muscle function was assessed by handgrip strength, five times sit-to-stand test, gait speed test and short physical performance battery (SPPB). The Mini Nutritional Assessment (MNA) was performed to assess the nutritional status in the participants in this study. Overall, a total of 56 % and 13 % of participants suffered from possible sarcopenia and sarcopenia, respectively. There was a higher rate of possible sarcopenic obesity in the MS group than in the non-MS group (48·9 % v. 24·7 %, P < 0·01), and all the sarcopenia participants in the MS group had sarcopenic obesity. MNA score was significantly associated with sarcopenia status (P < 0·01). The MNA combined with body fat score showed better acceptable discrimination for detecting sarcopenic obesity and sarcopenia in MS (AUC = 0·70, 95 % CI 0·53, 0·86). In summary, there was a higher prevalence of possible sarcopenic obesity in MS, and all the MS patients with sarcopenia had sarcopenic obesity in the present study. We suggest that the MNA should be combined with body fat percentage to assess the nutritional status of MS participants, and it also serves as a good indicator for sarcopenia and sarcopenic obesity in MS.
The present study investigated the association between fibre degradation and the concentration of dissolved molecular hydrogen (H2) in the rumen. Napier grass (NG) silage and corn stover (CS) silage were compared as forages with contrasting structures and degradation patterns. In the first experiment, CS silage had greater 48-h DM, neutral-detergent fibre (NDF) and acid-detergent fibre degradation, and total gas and methane (CH4) volumes, and lower 48-h H2 volume than NG silage in 48-h in vitro incubations. In the second experiment, twenty-four growing beef bulls were fed diets including 55 % (DM basis) NG or CS silages. Bulls fed the CS diet had greater DM intake (DMI), average daily gain, total-tract digestibility of OM and NDF, ruminal dissolved methane (dCH4) concentration and gene copies of protozoa, methanogens, Ruminococcus albus and R. flavefaciens, and had lower ruminal dH2 concentration, and molar proportions of valerate and isovalerate, in comparison with those fed the NG diet. There was a negative correlation between dH2 concentration and NDF digestibility in bulls fed the CS diet, and a lack of relationship between dH2 concentration and NDF digestibility with the NG diet. In summary, the fibre of CS silage was more easily degraded by rumen microorganisms than that of NG silage. Increased dCH4 concentration with the CS diet presumably led to the decreased ruminal dH2 concentration, which may be helpful for fibre degradation and growth of fibrolytic micro-organisms in the rumen.
Attention-deficit hyperactivity disorder (ADHD) increases the risk of suicidal behaviours through psychiatric comorbidities; however, a significant direct association has not been observed between ADHD and suicide attempts.
Aims
To evaluate the risk of suicide attempt in adolescents and young adults with ADHD.
Method
Using a nationwide, population-based insurance claims database, this longitudinal cohort study enrolled 20 574 adolescents and young adults with ADHD and 61 722 age- and gender-matched controls between 2001 and 2009. Any suicide attempt was identified from enrolment to 31 December 2011. The association between ADHD medications and the likelihood of suicide attempt was assessed.
Results
ADHD was an independent risk factor for any suicide attempt (hazard ratio = 3.84, 95% CI = 3.19–4.62) and repeated suicide attempts (hazard ratio = 6.52, 95% CI = 4.46–9.53). Subgroup analyses of men, women, adolescents and young adults demonstrated the same trend. Methylphenidate or atomoxetine treatment did not increase the risk of suicide attempt or repeated suicide attempts. Long-term methylphenidate treatment was associated with a significantly decreased risk of repeated suicide attempts in men (hazard ratio = 0.46, 95% CI = 0.22–0.97).
Conclusion
ADHD was a risk factor for suicide attempt and a stronger predictor of repeated suicide attempts, independent of comorbidities. Further investigation is warranted to explore the mechanism underlying the association between ADHD and suicidal behaviours.
A 0.18 µm CMOS Binary Frequency Shift Keying Modulator with a novel frequency synthesizer structure is proposed in this paper. Based on an analog adder technique being the backbone of the synthesizer, this prototype demonstrates a compact modulator with low complexity, which achieves 1 Mbps at 400 MHz while dissipating 3.1 mW at 1.5 V supply. The proposed design is ideal for biomedical sensor network systems including distributed wearable body area network.
Biomolecular detection is crucial from various perspectives, such as qualitycontrol of our food and water, identification of biological terroristagents, and diagnosis of diseases. Early detection of disease is importantfor effective treatment and for prognostic assessment of diseaseprogression; in addition, the trend of ageing societies leads to anincreasing requirement for biomarker diagnoses for personalized healthcaremonitoring. This results in more stress on the social healthcare system [1,2]. As a consequence, researchers have focused on developing biomoleculardetection devices and systems. Over the past decade, emerging methods toaddress the above needs have bloomed because of developments inmicro/nanotechnologies. To enhance throughputs and reduce costs,moreover, these detection devices and systems are evolving from label-basedto label-free technologies.
Traditionally, label-based molecular diagnosis techniques have been used as auseful fundamental concept for the detection of potential disease biomarkersor pathogen nucleic acids. In general, the detection signal comes from theusage of a specific tag for a target molecule. The tags can be conventionalfluorescent dyes or radioisotopes. To fulfill the requirements of differentapplications, a number of conventional label-based techniques, such aspolymerase chain reaction (PCR), DNA or protein microarrays, andenzyme-linked immunosorbent assay (ELISA), have been developed andimplemented. Some of them have been used to form a versatile platform formany diverse applications with promising results and represent the goldstandards of biomedical diagnosis [3–5]. However, these techniquesrequire trained staff and expensive equipment, and are time-consuming.Moreover, the detection of such low-abundance biomarkers in biologicalfluids (e.g. blood, urine, saliva) requires large quantities of the sampleand complicated sample preparation. Consequently, these label-basedtechniques encounter problems of cost-effectiveness and throughput undermodern circumstances.
This study examined the combined effect of family ownership and high-discretion organizational slack on the international involvement of Taiwanese firms. Employing a sample of 179 publicly listed high-tech firms in Taiwan over a period of 6 years (2000–2005), we found that firms with high levels of international involvement, that is, a higher degree of internationalization, (i) were not closely held, and (ii) were not excessively controlled by the family. Further, high-discretion organizational slack (indicated by resources that can be deployed in a flexible fashion such as in cash and receivables) moderated the negative relationship between family control and international involvement. This relationship is stronger with a higher level of high-discretion slack. The results support the hypothesis that family control and high-discretion organizational slack negatively influence the decision to internationalize.
Our study examines the relationship among successor characteristics, post-succession firm change in the degree of internationalization, and firm performance. We use the upper echelon, organization change, and contingency perspectives to frame our conceptual arguments. Based on data from 187 succession observations for listed companies in Taiwan between 2000 and 2005, we find that firms will opt for higher levels of change in their degree of internationalization when they experience outside succession and that the negative impact of change in the degree of firm internationalization on subsequent firm performance is relatively low. We extend the industrial environment, explaining the moderating effect of chief executive officer succession on change in the international strategy model. Outsider successors foster a greater degree of change in the level of firm internationalization when the industrial environment is munificent or complex.
Optical control is a reversible and convenient technology, able to be measured in real-time, which makes it excellent for application to microfluidic, biomechanical, and electro-mechanical devices. These advantages are especially attractive for photo-responsive materials. In this study, we developed a new photo-responsive, electrostrictive material from a composite material made by mixing a dielectric polymer P(VDF-TrFE-CFE) and an organic photoconductive material TiOPc. The photo-responsibility of the material has been validated by corresponding actuators. We found that under white light illumination, deformation will increase which can be attributed to a decrease in the TiOPc impedance. We identified that the optimal TiOPc concentration for actuator applications is 10% P(VDF-TrFE-CFE)/TiOPc. Moreover, controlling the fluid flow within the capillary tube through light illumination also validated the photo-responsive actuator. Our results show that the mechanism and the photo-responsive material can be used to pursue further study on light controlling microfluidic, and related electro-mechanical devices.
Background: Executive dysfunction is not uncommon in patients with amnestic mild cognitive impairment (aMCI). This study aimed to investigate the applicability of executive function tests (EFTs) in aMCI as an aid in establishing the diagnosis of multi-domain MCI.
Methods: One hundred and twenty (120) aMCI patients, 126 Alzheimer's disease (AD) patients, and 100 normal controls were enrolled. The EFTs evaluated included the trail making test, digit backward span, Stroop color–word test, and design fluency and category fluency tests.
Results: Of the aMCI participants, 66% exhibited impairment in at least one EFT. Among the five selected EFTs, the category fluency test was the most discriminative in detecting executive dysfunction between patients with aMCI (standardized β = 0.264) or AD (standardized β = 0.361) with the controls, followed by the Stroop test. The performance of aMCI patients with two or more impaired EFTs was significantly different from those of controls but not from those of AD patients.
Conclusion: In the clinical setting, aMCI patients who fail in two or more EFTs may represent a unique population with multi-domain MCI that require close follow-up.
The present study evaluated the prebiotic effect of a standardised aqueous extract of Anoectochilus formosanus (SAEAF) and its effects on osteoporosis in ovariectomised (OVX) rats. The OVX rats were randomly divided into five groups and orally treated with water, SAEAF (200 and 400 mg/kg daily) and inulin (400 mg/kg daily) for 12 weeks. The sham group was orally treated with water. The SAEAF treatment enhanced the number of faecal bifidobacteria in OVX rats. The results of a Ca-balance experiment showed that SAEAF increased apparent Ca absorption and retention. The OVX rats were killed after SAEAF treatment lasting 12 weeks. The SAEAF decreased the caecal pH values and increased the caecal wall weight, caecal mucosa calbindin-D9k mRNA expression, free-Ca concentration and levels of SCFA in the caecum. The mineral content, density and biomechanical strength of bones were lower in OVX rats than the sham group, but these bone losses were prevented by SAEAF administration. Microtomography scanning showed that the SAEAF-treated rats had higher trabecular bone volume than the OVX rats. These results suggest that SAEAF prevented bone loss associated with ovarian hormone deficiency in the rats.
Episodic memory tasks are one of the most sensitive tools to discriminate Alzheimer’s disease (AD). This study aimed to validate a shorter version verbal memory test that will efficiently assess Chinese elderly with memory complaints. One hundred and eighty-five elderly with normal cognition (NC) and 217 AD patients were evaluated. Each participant received the Chinese Version Verbal Learning Test (CVVLT) consisting of 9 two-character nouns with 4 learning trials, 2 delayed recalls in 30 seconds and 10 minutes, and a word recognition test. In the NC elderly, age and sex had significant effects on recall scores in CVVLT, while education level showed an inverse correlation with 3 different patterns of errors made during the learning, recall, and recognition trials. AD patients had lower scores across all recall tests. In those with lower educational level, NC elderly had higher perseveration errors than AD patients. The cutoff value between the AD and NC groups in the 10-minute recall was 4/5 for those aged >75 years and 5/6 for those aged <75 years. This study has good validity in discriminating AD participants and the data here can help in diagnosing AD and mild cognitive impairment using the CVVLT. (JINS, 2010, 16, 244–251.)
Type 2 QSOs (QSO2s) are intrinsically luminous QSOs embedded in dusty environments. In this work, we study the radio, optical, and soft X-ray properties of 887 optically selected [O III]-based QSO2s (Reyes et al. 2008) at z<0.83 to investigate the connection between QSO2s and their environments. We use SDSS data to measure the luminosity-limited galaxy counts in a volume centered on each QSO2 and defined by Δ z<0.1 (based on photometric redshifts) and within a projected distance of 1.5 Mpc of the QSO2 (δ1.5Mpc). We used ROSAT All Sky Survey (RASS) data to estimate the X-ray excess. Hsu & Chen (2010), after correcting for Galactic absorption, obtain a lower limit for the intrinsic neutral hydrogen column density (NH) toward each of the QSO2s. About 50% of these sources have NH > 1022 cm−2. We take this value as a threshold to subdivide QSO2s into high- and low-NH groups, and compare their environments. The distributions δ1.5Mpc of the two populations show that, in regions of higher galaxy density, QSO2s are dominated by the high-NH population (Figure 1), suggesting a closer connection between more obscured QSO2s and surrounding galaxies.
Ternary Sn-In-Cu alloys are prepared and equilibrated at 250 °C for 2 to 20 weeks. The phases formed in these alloys are experimentally determined. The 250 °C Sn-In-Cu isothermal section is established according to the phase equilibrium information obtained in this study and that of the three constituent binary systems. It has eight single-phase regions, namely liquid, δ1-Cu41Sn11, ε-Cu3Sn, δ2-Cu7In3, η-(Cu6Sn5, Cu2In), Cu11In9, Cu2In3Sn, and α-(Cu) phases, 14 two-phase regions, and seven three-phase regions. In the Sn-In-Cu system at 250 °C, the η-Cu6Sn5 and η-Cu2In phases form a continuous solid solution and the ternary Cu2In3Sn compound is observed. The δ1-Cu41Sn11 phase is stabilized at 250 °C with the introduction of indium although it transforms into α-(Cu) and ε-Cu3Sn phases via a eutectoid reaction around 350 °C in the binary Sn-Cu system. Except for the Cu11In9 phase and the Cu2In3Sn ternary compound, the other binary compounds all have significant indium and tin mutual solubilities.
The expression of the YUCAA1 gene and the amount of endogenous indole acetic acid (IAA) in rice (Oryza sativa subsp. japonica) plants and rice suspension cells infected by Rice stripe virus (RSV) were investigated by real-time reverse transcriptase–polymerase chain reaction (RT-PCR) and high-performance liquid chromatography, respectively. The results showed that the expression of the YUCAA1 gene and the amount of endogenous IAA increased at various times (16, 32, 48 and 64 h) after infection of rice suspension cells by RSV. In rice plants infected with RSV, the expression of the YUCAA1 gene and the amount of endogenous IAA increased, in comparison with healthy rice plants, at 4–8 days after infection, and decreased at 12 and 16 days. These results indicated that RSV infection could regulate auxin biosynthesis in rice. Additionally, the expression of the RSV gene CP increased 2.9 times in rice plants after they were treated with a KPSC buffer to deplete the endogenous auxins, and decreased 45% after treatment with 30 μmol/l IAA. All of these results suggest that auxin may play a role in RSV replication in rice plants.
Si1−xGexOynanowire (SiGeONW) assemblies with cord-, chain-, and tubelike morphologies were grown on a Si substrate via the carbothermal reduction of GeO2/CuO powders at 1100 °C in Ar. The growth of various SiGeONWs assemblies follows the vapor-liquid-solid process. The CuSiGe droplets formed during the growth of SiGeONWs simultaneously play the roles of catalyst and reactant. The morphology of SiGeONWs assemblies is not temperature controlled but dependent on the Cu concentration and the size of CuSiGe catalysts. This phenomenon is unlike the Ge- and Ga-catalyzed growth of SiOxnanowire assemblies. In addition, the processing parameters and the mechanisms for the growth of SiGeONWs assemblies with various morphologies are discussed.
In this work, high quality silicon dioxide (SiO2) films were prepared by large-area plasmaenhanced chemical vapor deposition (LA-PECVD) using tetraethylorthosilicate(TEOS)-oxygen based chemistry. The effects of various short-time plasma treatments on these as-deposited TEOS oxide were also investigated. Different plasma treatments such as O2, N2O, and NH3 were used in our experiments. Electrical characteristics were exploited to examine the effects of plasma treatments. It was shown that after N2O, and NH3 plasma treatments, the electrical strength of oxide was enhanced. Besides, NH3 plasma treatment exhibited the highest enhancement efficiency. O2- plasma treatment, however, showed some harmful effects on the electrical properties of the TEOS oxide. The reliability tests including charge to breakdown (Qbd) and bias temperature stress (BTS) were also analyzed in these samples. Although better pre-stress characteristics were observed in those samples treated by NH3-plasma, samples with N2O plasma treatment showed superior stress endurance. Consequently, N2O plasma treatment seems to be the best candidate for future TFTs under the consideration of long-term reliability.
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