Unmanned aerial vehicle (UAV) formations for bearing-only passive detection are increasingly important in modern military confrontations, and the array of the formation is one of the decisive factors affecting the detection accuracy of the system. How to plan the optimal geometric array in bearing-only detection is a complex nondeterministic polynomial problem, and this paper proposed the distributed stochastic subgradient projection algorithm (DSSPA) with layered constraints to solve this challenge. Firstly, based on the constraints of safe flight altitude and fixed baseline, the UAV formation is layered, and the system model for bearing-only cooperative localisation is constructed and analysed. Then, the calculation formula for geometric dilution of precision (GDOP) in the observation plane is provided, this nonlinear objective function is appropriately simplified to obtain its quadratic form, ensuring that it can be adapted and used efficiently in the system model. Finally, the proposed distributed stochastic subgradient projection algorithm (DSSPA) combines the idea of stochastic gradient descent with the projection method. By performing a projection operation on each feasible solution, it ensures that the updated parameters can satisfy the constraints while efficiently solving the convex optimisation problem of array planning. In addition to theoretical proof, this paper also conducts three simulation experiments of different scales, validating the effectiveness and superiority of the proposed method for bearing-only detection array planning in UAV formations. This research provides essential guidance and technical reference for the deployment of UAV formations and path planning of detection platforms.

This paper proposes a cooperative midcourse guidance law with target changing and topology switching for multiple interceptors intercepting targets in the case of target loss and communication topology switching. Firstly, a three-dimensional guidance model is established and a cooperative trajectory shaping guidance law is given. Secondly, the average position consistency protocol of virtual interception points is designed for communication topology switching, and the convergence of the average position of virtual interception points under communication topology switching is proved by Lyapunov stability theory. Then, in the case of the target changing, the target handover law and the handover phase guidance law are designed to ensure the acceleration smoothing, at last, the whole cooperative midcourse guidance law is given based on the combination of the above guidance laws. Finally, numerical simulation results show the effectiveness and the superiority of the proposed cooperative midcourse guidance law.

Background: Cerebral venous thrombosis (CVT) is a rare cause of stroke, with 10–15% of patients experiencing dependence or death. The role of endovascular therapy (EVT) in the management of CVT remains controversial and practice patterns are not well-known. Methods: We distributed a comprehensive 53-question survey to neurologists, neuro-interventionalists, neurosurgeons and other relevant clinicians globally from May 2023 to October 2023. The survey asked about practice patterns and perspectives on EVT for CVT and assessed opinions regarding future clinical trials. Results: The overall response rate was 31% (863 respondents from 2744 invited participants) across 61 countries. A majority (74%) supported use of EVT for certain CVT cases. Key considerations for EVT included worsening level of consciousness (86%) and other clinical deficits (76%). Mechanical thrombectomy with aspiration (22%) and stent retriever (19%) were the most utilized techniques, with regional variations. Post-procedurally, low molecular weight heparin was the predominant anticoagulant administered (40%), although North American respondents favored unfractionated heparin. Most respondents supported future trials of EVT (90%). Conclusions: Our survey reveals significant heterogeneity in approaches to EVT for CVT, highlighting the necessity for adequately powered clinical trials to guide standard-of-care practices.

Polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by particle-in-cell simulations. The evolution of the electron beam polarization is studied based on the Thomas–Bargmann–Michel–Telegdi equation for the transverse and longitudinal self-injection, and the depolarization process is found to be influenced by the injection schemes. In the case of transverse self-injection, as found typically in the bubble regime, the spin precession of the accelerated electrons is mainly influenced by the wakefield. However, in the case of longitudinal injection in the quasi-1D regime (for example, F. Y. Li et al., Phys. Rev. Lett. 110, 135002 (2013)), the direction of electron spin oscillates in the laser field. Since the electrons move around the laser axis, the net influence of the laser field is nearly zero and the contribution of the wakefield can be ignored. Finally, an ultra-short electron beam with polarization of $99\%$ can be obtained using longitudinal self-injection.

Echinococcosis poses a significant threat to public health. The Chinese government has implemented prevention and control measures to mitigate the impact of the disease. By analyzing data from the Chinese Center for Disease Control and Prevention and the State Council of the People’s Republic of China, we found that implementation of these measures has reduced the infection rate by nearly 50% between 2004 to 2022 (from 0.3975 to 0.1944 per 100,000 person-years). Nonetheless, some regions still bear a significant disease burden, and lack of detailed information limites further evaluation of the effects on both alveolar and cystic echinococcosis. Our analysis supports the continuing implementation of these measures and suggests that enhanced wildlife management, case-based strategies, and surveillance systems will facilitate disease control.

Unmanned aerial vehicles (UAVs) have recently been widely applied in a comprehensive realm. By enhancing computer photography and artificial intelligence, UAVs can automatically discriminate against environmental objectives and detect events that occur in the real scene. The application of collaborative UAVs will offer diverse interpretations which support a multiperspective view of the scene. Due to the diverse interpretations of UAVs usually deviating, UAVs require a consensus interpretation for the scenario. This study presents an original consensus-based method to pilot multi-UAV systems for achieving consensus on their observation as well as constructing a group situation-based depiction of the scenario. Taylor series are used to describe the fuzzy nonlinear plant and derive the stability analysis using polynomial functions, which have the representations $V(x )={m_{\textrm{1} \le l \le N}}({{V_\textrm{l}}(x )} )$ and ${V_l}(x )={x^T}{P_l}(x )x$. Due to the fact that the ${\dot{P}_l}(x )$ in ${\dot{V}_l}(x )={\dot{x}^T}{P_l}(x )x + {x^T}{\dot{P}_l}(x )x + {x^T}{P_l}(x )\dot{x}$ will yield intricate terms to ensure a stability criterion, we aim to avoid these kinds of issues by proposing a polynomial homogeneous framework and using Euler's functions for homogeneous systems. First, this method permits each UAV to establish high-level conditions from the probed events via a fuzzy-based aggregation event. The evaluated consensus indicates how suitable is the scenario collective interpretation for every UAV perspective.

There has been limited research on clay mineral transformation in serpentinitic soils under humid tropical conditions. In this study, four soil pedons were selected along a toposequence from the summit (Entisol), shoulder (Vertisol), backslope (Alfisol) to footslope (Ultisol) positions to explore the contributions and the significance of landscape and weathering status of serpentinitic rock with regard to clay mineral transformations in eastern Taiwan. Experimental results indicated that the large amount of dithionite-citrate-bicarbonate-extractable Fe (Fed) and clay in the subsurface horizon were mainly caused by the strong leaching potential from intensive rainfall and weathering of the fine-grained parent rocks. The clay mineralogy reflected the clear weathering trend of the soils along the toposequence: (1) the soils on the summit and shoulder contained smectite and serpentine, which are predominant in the young soils derived from serpentinitic rocks; and (2) vermiculite gradually increased in the relatively old soils on backslope and footslope. The mineralogical transformations observed along the toposequence indicated that chlorite and serpentine, initially present in the Entisol on the summit, weather into smectite and interstratified chlorite-vermiculite in the intermediate soil on the shoulder under strong leaching and oxidizing conditions. Furthermore, vermiculite formed as the major weathering product of chlorite and smectite in the soil developed on the backslope. In addition to vermiculite, kaolinite and quartz formed in the soils on the footslope with the greatest concentration of Fed along the toposequence.

Effects of plasma non-uniformities and kinetic dispersiveness on the spontaneous excitation of geodesic acoustic mode (GAM) by reversed shear Alfvén eigenmode (RSAE) are investigated numerically. It is found that, due to the turning points induced by the shear Alfvén continuum structure, the nonlinear excitation of GAM is a quasiexponentially growing absolute instability. As the radial dependence of GAM frequency and pump RSAE mode structure are accounted for, the radially inward propagating GAM is preferentially excited, leading to core localized thermal plasma heating by GAM collisionless damping. Our work, thus, suggests that GAM excitation plays a crucial role in not only RSAE nonlinear saturation, but also anomalous fuel ion heating in future reactors.

The great demographic pressure brings tremendous volume of beef demand. The key to solve this problem is the growth and development of Chinese cattle. In order to find molecular markers conducive to the growth and development of Chinese cattle, sequencing was used to determine the position of copy number variations (CNVs), bioinformatics analysis was used to predict the function of ZNF146 gene, real-time fluorescent quantitative polymerase chain reaction (qPCR) was used for CNV genotyping and one-way analysis of variance was used for association analysis. The results showed that there exists CNV in Chr 18: 47225201-47229600 (5.0.1 version) of ZNF146 gene through the early sequencing results in the laboratory and predicted ZNF146 gene was expressed in liver, skeletal muscle and breast cells, and was amplified or overexpressed in pancreatic cancer, which promoted the development of tumour through bioinformatics. Therefore, it is predicted that ZNF146 gene affects the proliferation of muscle cells, and then affects the growth and development of cattle. Furthermore, CNV genotyping of ZNF146 gene was three types (deletion type, normal type and duplication type) by Real-time fluorescent quantitative PCR (qPCR). The association analysis results showed that ZNF146-CNV was significantly correlated with rump length of Qinchuan cattle, hucklebone width of Jiaxian red cattle and heart girth of Yunling cattle. From the above results, ZNF146-CNV had a significant effect on growth traits, which provided an important candidate molecular marker for growth and development of Chinese cattle.

Customer survey data is critical to supporting customer preference modeling in engineering design. We present a framework of information retrieval and survey design to ensure the collection of quality customer survey data for analyzing customers’ preferences in their consideration-then-choice decision-making and the related social impact. The utility of our approach is demonstrated through the survey design for customers in the vacuum cleaner market. Based on the data, we performed descriptive analysis and network-based modeling to understand customers’ preferences in consideration and choice.

Pneumatic launch systems for Unmanned Aerial Vehicles (UAVs), including mechanical and pneumatic systems, are complex and non-linear. They are subjected to system parameters during launch, which leads to difficulty in engineering research analysis. For example, the mismatch between the UAV parameters and the parameter design indices of the launch system as well as the unclear design indices of the launching speed and overload of UAVs have a great impact on launch safety. Considering this situation, some studies are presented in this paper. Taking the pneumatic launch system as a research object, a pneumatic launcher dynamic simulation model is built based on co-simulation considering the coupling characteristics of the mechanical structure and transmission system. Its accuracy was verified by laboratory test results. Based on this model, the paper shows the effects of the key parameters, including the mass of the UAV, cylinder volume, pressure and moment of inertia of the pulley block, on the performance of the dynamic characteristics of the launch process. Then, a method for matching the parameter characteristics between the UAV and launch system based on batch simulation is proposed. The set of matching parameter values of the UAV and launch system that satisfy the launch take-off safety criteria are calculated. Finally, the influence of the system parameters of the launch process on the launch performance was analysed in detail, and the design optimised. Meaningful conclusions were obtained. The analysis method and its results can provide a reference for engineering and theoretical research and development of pneumatic launch systems.

Considering the shortcomings of current methods for real-time resolution of two-aircraft flight conflicts, a geometric optimal conflict resolution and recovery method based on the velocity obstacle method for two aircraft and a cooperative conflict resolution method for multiple aircraft are proposed. The conflict type was determined according to the relative position and velocity of the aircraft, and a corresponding conflict mitigation strategy was selected. A resolution manoeuvre and a recovery manoeuvre were performed. On the basis of a two-aircraft conflict resolution model, a multi-aircraft cooperative conflict resolution game was constructed to identify an optimal solution for maximising group welfare. The solution and recovery method is simple and effective, and no new flight conflicts are introduced during track recovery. For multi-aircraft conflict resolution, an equilibrium point that maximises the welfare function of the group was identified, and thus, an optimal strategy for multi-aircraft conflict resolution was obtained.

An acute gastroenteritis (AGE) outbreak caused by a norovirus occurred at a hospital in Shanghai, China, was studied for molecular epidemiology, host susceptibility and serological roles. Rectal and environmental swabs, paired serum samples and saliva specimens were collected. Pathogens were detected by real-time polymerase chain reaction and DNA sequencing. Histo-blood group antigens (HBGA) phenotypes of saliva samples and their binding to norovirus protruding proteins were determined by enzyme-linked immunosorbent assay. The HBGA-binding interfaces and the surrounding region were analysed by the MegAlign program of DNAstar 7.1. Twenty-seven individuals in two care units were attacked with AGE at attack rates of 9.02 and 11.68%. Eighteen (78.2%) symptomatic and five (38.4%) asymptomatic individuals were GII.6/b norovirus positive. Saliva-based HBGA phenotyping showed that all symptomatic and asymptomatic cases belonged to A, B, AB or O secretors. Only four (16.7%) out of the 24 tested serum samples showed low blockade activity against HBGA-norovirus binding at the acute phase, whereas 11 (45.8%) samples at the convalescence stage showed seroconversion of such blockade. Specific blockade antibody in the population played an essential role in this norovirus epidemic. A wide HBGA-binding spectrum of GII.6 supports a need for continuous health attention and surveillance in different settings.

Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.

To evaluate the impacts of guanidinoacetic acid (GAA) and coated folic acid (CFA) on growth performance, nutrient digestion and hepatic gene expression, fifty-two Angus bulls were assigned to four groups in a 2 × 2 factor experimental design. The CFA of 0 or 6 mg/kg dietary DM folic acid was supplemented in diets with GAA of 0 (GAA−) or 0·6 g/kg DM (GAA+), respectively. Average daily gain (ADG), feed efficiency and hepatic creatine concentration increased with GAA or CFA addition, and the increased magnitude of these parameters was greater for addition of CFA in GAA− diets than in GAA+ diets. Blood creatine concentration increased with GAA or CFA addition, and greater increase was observed when CFA was supplemented in GAA+ diets than in GAA− diets. DM intake was unchanged, but rumen total SCFA concentration and digestibilities of DM, crude protein, neutral-detergent fibre and acid-detergent fibre increased with the addition of GAA or CFA. Acetate:propionate ratio was unaffected by GAA, but increased for CFA addition. Increase in blood concentrations of albumin, total protein and insulin-like growth factor-1 (IGF-1) was observed for GAA or CFA addition. Blood folate concentration was decreased by GAA, but increased with CFA addition. Hepatic expressions of IGF-1, phosphoinositide 3-kinase, protein kinase B, mammalian target of rapamycin and ribosomal protein S6 kinase increased with GAA or CFA addition. Results indicated that the combined supplementation of GAA and CFA could not cause ADG increase more when compared with GAA or CFA addition alone.

‘Recurrence’ of coronavirus disease 2019 (COVID-19) has triggered numerous discussions of scholars at home and abroad. A total of 44 recurrent cases of COVID-19 and 32 control cases admitted from 11 February to 29 March 2020 to Guanggu Campus of Tongji Hospital affiliated to Tongji Medical College Huazhong University of Science and Technology were enrolled in this study. All the 44 recurrent cases were classified as mild to moderate when the patients were admitted for the second time. The gender and mean age in both cases (recurrent and control) were similar. At least one concomitant disease was observed in 52.27% recurrent cases and 34.38% control cases. The most prevalent comorbidity among them was hypertension. Fever and cough being the most prevalent clinical symptoms in both cases. On comparing both the cases, recurrent cases had markedly elevated concentrations of alanine aminotransferase (ALT) (P = 0.020) and aspartate aminotransferase (AST) (P = 0.007). Moreover, subgroup analysis showed mild to moderate abnormal concentrations of ALT and AST in recurrent cases. The elevated concentrations of ALT and AST may be recognised as predictive markers for the risk of ‘recurrence’ of COVID-19, which may provide insights into the prevention and control of COVID-19 in the future.

Guanidinoacetic acid (GAA) can improve the growth performance of bulls. This study investigated the influences of GAA addition on growth, nutrient digestion, ruminal fermentation and serum metabolites in bulls. Forty-eight Angus bulls were randomly allocated to experimental treatments, that is, control, low-GAA (LGAA), medium-GAA (MGAA) and high-GAA (HGAA), with GAA supplementation at 0, 0.3, 0.6 and 0.9 g/kg DM, respectively. Bulls were fed a basal diet containing 500 g/kg DM concentrate and 500 g/kg DM roughage. The experimental period was 104 days, with 14 days for adaptation and 90 days for data collection. Bulls in the MGAA and HGAA groups had higher DM intake and average daily gain than bulls in the LGAA and control groups. The feed conversion ratio was lowest in MGAA and highest in the control. Bulls receiving 0.9 g/kg DM GAA addition had higher digestibility of DM, organic matter, NDF and ADF than bulls in other groups. The digestibility of CP was higher for HGAA than for LGAA and control. The ruminal pH was lower for MGAA, and the total volatile fatty acid concentration was greater for MGAA and HGAA than for the control. The acetate proportion and acetate-to-propionate ratio were lower for MGAA than for LGAA and control. The propionate proportion was higher for MGAA than for control. Bulls receiving GAA addition showed decreased ruminal ammonia N. Bulls in MGAA and HGAA had higher cellobiase, pectinase and protease activities and Butyrivibrio fibrisolvens, Prevotella ruminicola and Ruminobacter amylophilus populations than bulls in LGAA and control. However, the total protozoan population was lower for MGAA and HGAA than for LGAA and control. The total bacterial and Ruminococcus flavefaciens populations increased with GAA addition. The blood level of creatine was higher for HGAA, and the activity of l-arginine glycine amidine transferase was lower for MGAA and HGAA, than for control. The blood activity of guanidine acetate N-methyltransferase and the level of folate decreased in the GAA addition groups. The results indicated that dietary addition of 0.6 or 0.9 g/kg DM GAA improved growth performance, nutrient digestion and ruminal fermentation in bulls.