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The book’s introduction explains the history of thought experiments in philosophy. It also describes Hans Christian Ørsted’s interactions with Kierkegaard and his influence on Kierkegaard’s concept of Tankeexperiment. The introduction outlines the ways in which thought experiments make thoughts meaningful by providing immediate presentations.
This chapter distinguishes the work of thought experiments in exemplifying concepts from their role in aiding cognition of regulative ideas. Contemporary interest in thought experiments as a “method of cases” treats thought experiments as providing instances or exemplars. For regulative ideas as Kant understands them, however, no observable instances or exemplars are possible. Nevertheless, thought experiments can direct attention toward regulative ideas negatively (by distinguishing them from what is observable) or positively by indicating a direction for extrapolation or ongoing inquiry. These positive uses are forms of cognition. The distinction between regulative and constitutive concepts matters for thought experiments that deal with regulative ideas such as the self – for example, for thought experiments about personal identity, where a number of objections to the use of thought experiments have been raised. I argue in this chapter that some of these objections can be answered by distinguishing regulative from constitutive concepts.
This chapter proposes that thought experiments are a cognitive apparatus and situates this view among contemporary accounts of thought experiment. I set forward the project of the book, which is to (1) propose a new account of thought experiments as a method and (2) trace the historical foundations of the term and concept of “thought experiment” from Kant through Ørsted to Kierkegaard. I define “cognition” [Erkenntnis] for Kant as a synthesis of concepts with intuitions and propose that Kierkegaard, like Kant and Ørsted, views thought experiments as useful for achieving cognitions. I introduce the term Tanke-experiment in Kierkegaard and suggest why it has been little emphasized by Kierkegaard scholars and remains widely unacknowledged in contemporary descriptions of the history of thought experiment.
The conclusion outlines key points in the book. On a Kantian-Kierkegaardian account, thought experiments lead to presentations that justify calling a thought experiment an experience, though not an empirical or sensory one. Without a sensible object, we can nevertheless have givenness, or presence, but not existence. Cognition, for that reason, is not necessarily truthful: although object-directed, cognition on its own does not justify belief in any particular object’s existence. My conclusion that thought experiments provide cognition rather than knowledge echoes Michael Stuart’s claim that thought experiments increase understanding. Cognition is a common basis for knowledge in Kant, but it is not the same thing as knowledge. The conclusion also draws implications for how we understand faith (religious belief) in Kierkegaard and how thought experiments make sense of the complexity of reality.
Rationalist accounts of thought experiment in epistemology offer an alternative to the more predominantly empiricist approaches in philosophy of science. In this chapter, I will pose a Kantian critique of recent rationalist accounts of intellectual intuition. Some epistemologists have recently argued that intellectual intuitions can provide prima facie justification for judgments. In this chapter, I highlight some promising elements of recent rationalist accounts, especially the proposal that there can be nonsensory presentations analogous to empirical perceptions. If they are right, then thought experiments can provide new experiential content even without empirical confirmation. However, I also draw attention to Kant’s objections to the possibility of purely intellectual intuitions.
Kierkegaard and Ørsted were not just contemporaries but personally knew each other. In this chapter, I argue that Kierkegaard probably learned the term Tankeexperiment from Ørsted. This chapter contextualizes Kierkegaard’s use of “imaginary construction” (Experiment) in his work as a whole, including his well-known uses of paradoxes. I will show how the core elements of Ørsted’s account – thought experiment as a method of variation, the need for free and active constitution, and the use of thought experiments for facilitating genuine thought – are echoed in Kierkegaard’s discussions. Along the way, I will describe some decisions on how to translate Experiment and Tankeexperiment that are unfortunate in some ways and fortuitous in others, as I will explain. In these ways, Kierkegaard indirectly takes up Kant’s proposal that “construction” (i.e., Experiment in Danish) is a means of achieving cognition.
This chapter explains why cognition (Erkenntnis) is its own kind of cognitive good, apart from questions of justification. I argue against reducing the work of thought experiments to their epistemological results, such as their potential to provide prima facie justification. As an apparatus for cognition, a thought experiment enacts the three core elements of Ørsted’s Kantian account: (1) it is a tool for variation; (2) it proceeds from concepts, and (3) its goal is the genuine activation or reactivation of mental processes. Cognition has two components: givenness and thought. I will show in this chapter how givenness and thought are both achieved through thought experiments.
Psychiatric disorders lead to disability, premature mortality and economic burden, highlighting the urgent need for more effective treatments. The understanding of psychiatric disorders as conditions of large-scale brain networks has created new opportunities for developing targeted, personalised, and mechanism-based therapeutic interventions. Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), can directly modulate dysfunctional neural networks, enabling treatments tailored to the individual’s unique functional network patterns.
As NIBS techniques depend on our understanding of the neural networks involved in psychiatric disorders, this review offers a neural network-informed perspective on their applications. We focus on key disorders, including depression, schizophrenia, and obsessive-compulsive disorder, and examine the role of NIBS on cognitive impairment, a transdiagnostic feature that does not respond to conventional treatments. We discuss the advancements in identifying NIBS response biomarkers with the use of electrophysiology and neuroimaging, which can inform the development of optimised, mechanism-based, personalised NIBS treatment protocols.
We address key challenges, including the need for more precise, individualised targeting of dysfunctional networks through integration of neurophysiological, neuroimaging and genetic data and the use of emerging techniques, such as low- intensity focused ultrasound, which has the potential to improve spatial precision and target access. We finally explore future directions to improve treatment protocols and promote widespread clinical use of NIBS as a safe, effective and patient-centred treatment for psychiatric disorders.
As the global population ages, the prevalence of cognitive decline is rising, creating urgent demand for proactive strategies that support brain health and healthy aging. Ergothioneine, a unique dietary amino-thione absorbed via the OCTN1 transporter, has recently gained attention for its potential as a neuroprotective, longevity-promoting compound. This review synthesizes growing evidence from observational, interventional, and mechanistic studies. Observational data consistently associate low blood ergothioneine levels with cognitive impairment, neurodegenerative diseases, cardiovascular disorders, frailty, and mortality. Interventional trials in older adults suggest that ergothioneine supplementation may improve cognition, memory, sleep quality, and stabilize neurodegeneration biomarkers, with no safety concerns at doses up to 25 mg/day. Mechanistic studies reveal that ergothioneine acts through multiple pathways: mitigating oxidative stress, reducing neuroinflammation, preserving mitochondrial function, and potentially modulating neurogenesis and NAD⁺ metabolism, although some mechanisms require further investigation. Beyond cognition, ergothioneine shows promise in supporting other physiological systems relevant to aging, including cardiovascular, metabolic, gut, eye, auditory, liver, kidney, immune, skin, and lung health. Together, current evidence positions ergothioneine as a promising nutritional intervention for promoting cognitive resilience and systemic health in aging, although larger, long-term interventional trials are needed to confirm causality and optimize use.
The prevalence of prolonged symptoms following a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represents a significant health challenge with potentially severe individual and societal costs. Our study investigates the long-term cognitive and mental health consequences associated with post-coronavirus disease 2019 (COVID-19) condition (PCC) following a mild SARS-CoV-2 infection.
Methods
We conducted longitudinal assessments of cognitive performance and mental health in 50 post-COVID-19 patients and 48 matched healthy controls across 10 months, starting on average 2 years after infection. Cognitive function was evaluated using a comprehensive neuropsychological battery of standardized tests, while mental health was assessed via self-reported questionnaires. Data were analyzed with linear mixed models.
Results
Initial group differences in cognitive performance were observed for memory, executive functioning, and perceptual speed, with worse performance in patients. Improvement across the follow-up period occurred for most tasks, with PCC patients displaying greater improvement compared to healthy controls for some memory and executive function tasks, reaching performance levels of the control group. Fatigue and mental health measures remained elevated in the patient group, with worsening in general fatigue and a small improvement in fatigue after cognitive testing. Factors such as male sex, absence of burnout history, and lower depression scores at baseline predicted cognitive recovery in the patient group.
Conclusions
Our study underscores the importance of addressing cognitive and psychological effects following mild SARS-CoV-2 infection, as persistent fatigue, low mental health, and cognitive impairments significantly impact individuals’ ability to return to their pre-COVID professional and personal lives.
The chapter explains the process of building Meaning Networks and Systemic Networks, as described in chapter 6, for two semantic fields: Cognition and Communication. The identification of these fields is inspired by the Systemic Function Grammar processes: mental and verbal. The Cognition field is divided into Emotion (53 constructions), Perception (9 constructions) and Thought (92 constructions). Following an overview, the Communication field is divided into communication about a future action (Communication: Action) (21 constructions) and communication about information (Communication: Information) (82 constructions). For each semantic field, the constructions are described as they relate to one another. Their significant features are identified and expressed in Systemic Networks. The distinctions or choices between the constructions are modelled in taxonomies or Meaning Networks.
We evaluated performance-based differences in neuropsychological functioning in older adults (age 65+) across the dementia continuum (cognitively intact, mild cognitive impairment, and dementia) according to recent cannabis use (past six months).
Method:
A sample of 540 older adults from a well-characterized observational cohort was included for analysis. Participants completed a standardized questionnaire assessing cannabis use in the six months prior to the study visit and completed a comprehensive neuropsychological assessment. We used traditional cross-sectional analyses (multivariate, univariate) alongside causal inference techniques (propensity score matching [PSM]) to evaluate group differences according to recent cannabis use status. We also examined whether cannabis-related problem severity, a risk factor for cannabis use disorder (CUD), was associated with cognitive outcomes among those reporting recent cannabis use.
Results:
Approximately 11% of participants reported using cannabis in the prior six months, with the median user consuming cannabis two to four times per month. Participants with recent cannabis use performed similarly across all five domains of neuropsychological functioning compared to those with no cannabis use. Among older adults reporting recent cannabis use, those with elevated risk for CUD demonstrated lower memory performance.
Conclusions:
These preliminary results are broadly consistent with other findings indicating that low-frequency cannabis use among older adults, including those along the dementia continuum, is generally well tolerated from a cognitive perspective. However, among older adults who used cannabis, elevated symptoms of CUD may negatively impact memory performance. Future research should explore how variations in cannabis use patterns, individual characteristics, and clinical phenotypes influence cognitive outcomes.
The ability to efficiently complete everyday tasks was evaluated with a novel, performance-based test called the Virtual Kitchen Challenge (VKC) in college athletes. Analyses focused on the effect of practice and associations between the VKC and conventional measures of cognition.
Method:
81 college athletes with and without self-reported concussion completed conventional cognitive tests and the VKC, a nonimmersive virtual-reality task that requires manipulating virtual objects on a touch screen to prepare a breakfast and lunch under two conditions: 1) Training condition with feedback and 2) Test condition without feedback. VKC performance was scored for completion time, percent of time working on-screen, number of interactions with target and distractor objects. Paired t-tests compared VKC Training and Test conditions, correlations examined relations between VKC performance and cognitive tests.
Results:
VKC performance was significantly better after practice, as noted by faster completion time, fewer screen interactions, and a higher proportion of time spent on-screen during Test vs. Training conditions. Interactions with distractors were too infrequent for analyses. Correlations showed VKC Training was associated with episodic memory abilities whereas VKC Test scores were associated with executive function. VKC scores did not differ between participants with versus without concussion.
Conclusions:
The VKC is a promising portable performance-based measure of subtle functional difficulties for young, high-functioning participants. The VKC automated scoring makes it highly efficient for large studies and clinical settings.
Schizophrenia is known to be a disabling psychiatric condition with wide reaching impact on everyday functioning and outcomes. These functional outcomes include increases in all-cause mortality (especially suicide and injury), cognitive and functional capacity deficits, lower reported levels of quality of life (QoL), increased incarceration, higher risk for violence and victimization, and homelessness. Studies have shown that medications and outpatient services can improve each of these functional outcomes in individuals with schizophrenia. However, most studies of pharmacological treatment utilize rating scales that do not reflect these real-world outcomes. This review looks at available studies focused on real-world outcomes and argues for an expansion of this body of research.
Cognitive intra-individual variability (IIV) is a neuropsychological marker reflecting divergent performance across cognitive domains. In this brief communication, we examined whether clinical severity, apolipoprotein E (APOE) ε4 carriers, and higher polygenic risk were associated with higher cognitive IIV, and whether higher polygenic risk and cognitive IIV synergistically influence clinical severity.
Method:
This large study involved up to 24,248 participants (mean age = 72) from the National Alzheimer’s Coordinating Center (NACC) and multiple regression controlling for age, sex, and education was used to analyze the data.
Results:
We found that disease severity (B = 0.055, SE = 0.001, P < 0.001), APOE ε4 carriers (B = 0.02, SE = 0.003, P < 0.001), and higher polygenic risk (B = 0.02, SE = 0.004, P < 0.001) were associated with higher cognitive IIV. Polygenic risk and cognitive IIV also interacted to influence clinical severity, beyond APOE ε4 (B = 0.11, SE = 0.05, P = 0.02), such that individuals with high polygenic risk and cognitive IIV had the greatest clinical severity.
Conclusions:
Heightened polygenic risk and increased cross-domain cognitive variation are implicated in dementia and may impact clinical decline in tandem.
We investigated differences in cognition between variants of progressive supranuclear palsy (PSP) including PSP-Richardson (PSP-RS) and subcortical and cortical variants using updated diagnostic criteria and comprehensive neuropsychological assessment.
Method:
We recruited 140 participants with PSP (age = 71.3 ± 6.9 years; education = 15.0 ± 2.8 years; 49.3% female) who completed neurological and neuropsychological assessment. Participants received diagnoses of PSP clinical variants at their evaluation (or retrospectively if evaluated before 2017) according to the Movement Disorder Society PSP criteria. We grouped variants as PSP-RS (62 participants), PSP-Cortical (25 with PSP-speech/language and 9 with PSP-corticobasal syndrome), and PSP-Subcortical (27 with PSP-parkinsonism, 11 with PSP-progressive gait freezing, and 6 with PSP-postural instability). Analysis of covariance adjusted for age assessed for differences in neuropsychological performance between variants across cognitive domains.
Results:
PSP-Cortical participants performed worst on measures of visual attention/working memory (Spatial Span Forward/Backward/Total), executive function (Frontal Assessment Battery), and language (Letter Fluency). PSP-RS participants performed worst on verbal memory (Camden Words). There were no significant group differences for the MoCA or indices of visuospatial function. There were no sex or education differences between PSP groups; however, there were differences in age at visit and disease duration.
Conclusions:
In a large sample of participants with PSP, there were differences in cognition across PSP-RS, PSP-Subcortical, and PSP-Cortical variants, with PSP-Cortical and, to a lesser extent, PSP-RS, performing worse on tests of attention and executive function. These findings suggest cognitive distinctions among PSP clinical variants and highlight the value of neuropsychological assessment in differential diagnosis of PSP subtypes for more accurate and timely clinical classification.
This study examined three neurocognitive patterns or “clinical pearls” historically viewed as evidence for executive dysfunction in Parkinson disease (PD): 1) letter < category fluency; 2) word list < story delayed recall; 3) word list delayed recall < recognition. The association between intraindividual magnitudes of each neuropsychological pattern and individual performance on traditional executive function tests was examined.
Methods:
A clinical sample of 772 individuals with PD underwent neuropsychological testing including tests of verbal fluency, word list/story recall, recognition memory, and executive function. Raw scores were demographically normed (Heaton) and converted to z-scores for group-level analyses.
Results:
Letter fluency performance was worse than category fluency (d = −0.12), with 28% of participants showing a discrepancy of ≥ −1.0 SD. Delayed recall of a list was markedly poorer than story recall (d = −0.86), with 52% of the sample exhibiting ≥ −1.0 SD deficits. Lastly, delayed free recall was worse than recognition memory (d = −0.25), with 24% showing a discrepancy of ≥ −1.0 SD. These patterns did not consistently correlate with executive function scores. The word list < story recall pattern was more common in earlier than later PD stages and durations.
Conclusion:
Among the three pearls, the most pronounced was stronger memory performance on story recall than word lists, observed in more than half the sample. Only ¼ the participants exhibited all three neurocognitive patterns simultaneously. The variability in patterns across individuals highlights the heterogeneity of cognitive impairment in PD and suggests that intra-individual comparisons may offer a more nuanced insight into cognitive functioning.
Social role theory and evolutionary neuroandrogenic (ENA) theory are compared regarding how well they can explain 15 cognitive and behavioral sex differences that appear to be present in all human cultures. In essence, social role theory argues that, except for males being larger and more muscular and only females being able to bear children, cognitive and behavioral differences between the sexes result from sociocultural training and expectations. On the other hand, ENA theory attributes sex differences in cognition and behavior to evolved differential exposure of male and female brains to sex hormones, especially testosterone. The existence of 15 nearly certain universal sex differences in cognitive and behavioral traits was documented in a recently published book based on findings from over 40,000 empirical studies. This Element documents that, while both theories have explanatory power, ENA theory surpasses social role theory in explaining the universality of most of the 15 traits.
Language is known to interact flexibly with non-verbal representations, but the processing mechanisms governing these interactions remain unclear. This article reviews general cognitive processes that operate across various tasks and stimulus types and argues that these processes may drive the interactions between language and cognition, regardless of whether these interactions occur cross-linguistically or within a language. These general processes include goal-directed behaviour, reliance on context-relevant semantic knowledge and attuning to task demands. An overview of existing findings suggests that resorting to language in non-verbal or multi-modal tasks may depend on how linguistic representations align with current task goals and demands. Progress in understanding these mechanisms requires theories that make specific processing predictions about how tasks and experimental contexts encourage or discourage access to linguistic knowledge. Systematic testing of alternative mechanisms is necessary to explain how and why linguistic information influences some cognitive tasks but not others.
Cognitive impairment represents a central component of major depressive disorder (MDD), affecting a large proportion of people living with MDD and showing a consistent negative impact on social, interpersonal, and occupational functioning and subjective quality of life. Cognitive remediation (CR) is a training-based psychosocial intervention targeting cognitive performance and psychosocial functioning that has shown consistent evidence of effectiveness in individuals with schizophrenia and that could provide significant benefits also in people with MDD: this study aimed to assess the effects of a computerized CR intervention in adults living with MDD.
Methods
Participants recruited in this single blind multicentric randomized controlled trial were allocated to receive a computerized CR intervention delivered by an active and trained therapist or to an active control condition (computer games – CG). Outcomes were measured with validated instruments by blind assessors and included cognitive performance, depressive symptoms, and psychosocial functioning. Outcomes were assessed using mixed models for repeated measures, considering baseline and end-of-treatment scores.
Results
Hundred and one participants (CR=52 and CG=49) were included and 81 (CR=45 and CG=36) completed the study. CR produced superior results in clinician-rated depressive symptoms (p=0.023, d=042), global clinical severity (p=0.025, d=0.39), subjective depressive symptoms (p=0.005, d=0.45), working memory performance (p=0.004, d=0.34), executive functions/cognitive flexibility (p=0.020, d=0.43), and subjective cognitive impairment (p=0.006, d=0.48).
Conclusions
CR represents an effective intervention in MDD, improving clinical outcomes and cognitive performance in a clinician-rated and in a subjective manner, which should be more consistently implemented in clinical practice and included in MDD treatment recommendations.