This study presents a framework for assessing the scalability of innovations aimed at achieving low-emission development, using a case study of Nandi County, Kenya. Food system emissions make up a significant portion of Kenya’s total greenhouse gas emissions. Reducing these emissions is crucial for lowering the country’s overall emissions, supporting Kenya’s commitment to the Paris Agreement. To achieve this, Kenya must scale innovations that can transform the food system toward low emissions while meeting national development targets. The framework was thus tested, in the scope of two participatory workshops, on three CGIAR innovations with relevance to Nandi County: Improved Livestock Breeds and Feeds (ILBF), Integrated Aquaculture Practices (IAP), and Biogas Technology (BT). Stakeholders evaluated these innovations in a two-day participatory workshop using a multi-criteria scoring process. Based on established criteria, the participants developed scores that reflected an innovations’ potential for scaling. ILBF scored 24 out of 33 points (75%), IAP scored 27 (81%), and BT scored 26 (76%). The results indicate varying potential for scaling among the innovations, highlighting the importance of context-specific and systemic enabling factors, beyond technical performance. These include institutional, social, and biophysical contexts, adoption barriers, market potential, costs of innovation, financial opportunities for scaling, environmental and social co-benefits and trade-offs as well as economic benefits, all of which are critical in creating an enabling environment for scaling. The framework serves as a support tool for evaluating potential opportunities, barriers, bottlenecks, and trade-offs to inform scaling strategies in a more systematic and responsible manner. Beyond its empirical findings, the study contributes methodologically by illustrating how participatory multi-criteria assessment can strengthen strategic decision-making for Agricultural Research for Development programs.