To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The Statute of Uses enacted radical reform which can still be felt across the common law world. It was from exceptions to the statute’s execution of uses to perform last wills that the modern trust emerged. Our understanding of the passage of the statute has been shaped by the survival of several draft bills and ancillary documents. It has been argued that a draft bill introduced in 1529 was rejected by the Commons in March 1532. This in turn inspired the landmark litigation in Dacre’s Case (1533–35), which paved the way for the subsequent enactment of the Statute of Uses. This chapter challenges that orthodox position by demonstrating that there were in fact three early drafts which were considered. It then considers what this tells us about the role of the crown, parliament and the courts during this pivotal period in our legal history.
Palmyra is usually studied for one of three reasons, either its role in the long-distance trade between Indian Ocean and Mediterranean, its distinctive cultural identity as visible in the epigraphic and material record from the city or its rise as an independent regional power in the Near East in the third quarter of the third century AD. While Palmyra was indeed a special place, with a private sorte, or destiny of its own, as Pliny famously expressed it (HN 5.88), the city’s ability to maintain its distinctiveness arguably rested on deep entanglements with her local and regional surroundings. This chapter addresses how the city engaged with its neighbours and its Roman imperial overlords. Actions, events and policies attested in the epigraphic record from the city and from the Palmyrene diaspora in the Roman Empire are discussed in light of theoretical insights from archaeology, sociology and economics. It is argued that Palmyra’s remarkable success built on the city’s ability to connect with the range of social networks that constituted the Roman Empire.
This scoping review aims to synthesize the literature on pediatric health technology assessments (HTAs) and map out the challenges of assessing new technologies for use in children, with a particular focus on pharmaceutical interventions.
Methods
Conducted in accordance with the Joanna Briggs Institute Methodology, this scoping review addressed HTAs in the pediatric domain through searches of PubMed, Embase, Web of Science Core Collection, and EconLit through 22 January 2024, as well as the gray literature. Sources were excluded if they (i) were a clinical trial investigating a specific technology or an HTA of that technology, (ii) did not address the challenges of HTAs, or (iii) had no relevance to pediatrics. Two authors performed screening and data extraction independently and in duplicate.
Results
One hundred and three reports were included. Of these, sixty were full journal articles, twenty-three were conference abstracts, and twenty were guidelines, reports, and other documents. Two important themes emerged from this work. The first was the unique position of children within society and the resulting difficulty of incorporating them within a population-wide HTA system. The second was the uncertainty that characterized pediatric HTAs due to data constraints and either a lack of guidance by HTA bodies or variations in guidance between bodies.
Conclusions
Many factors inherent to children, including the heterogeneity of pediatric disease populations, long-term outcomes, and children’s distinct social positions, render conducting pediatric HTAs challenging. Innovative approaches are required to address these challenges and respond to the needs of pediatric populations.
This chapter critiques private property on four grounds. First, private property pushes resources into the hands of those who have more at the expense of those who have less. This arises because wealthier people are willing to pay more for normal goods so they tend to bid successfully for them, and because their wealth allows them to hold out for a larger share of the gains from trade. Second, private property is, in fact, allocatively inefficient. This is because the use of willingness to pay as an allocational technology means that the allocation of property is partially driven by ability to pay rather than a purchaser’s greater productive efficiency. Private property is also allocatively inefficient due to the monopoly power that it places in the hands of owners. Third, the regressivity of private property creates a powerful propertied class that can come to dominate the political system. Finally, both the regressivity and the inefficiency of private property have become even more stark in the internet era because markets which already have strong network effects and are vulnerable to domination by monopolists exacerbate both features.
In 1974 Geoffrey Chew, building on work by H. C. Robbins Landon, established that Haydn quoted a melody that has come to be known as the ‘night watchman’s song’ on at least seven occasions. Most of these works date from the earlier part of the composer’s career – divertimentos and pieces with baryton, as well as Symphony No. 60, ‘Il Distratto’, of 1774. A canon from the 1790s, ‘Wunsch’, represents a late engagement with the tune, while it is also used in the minuet-finale of the Sonata in C Sharp Minor, one of a set of six sonatas published in 1780. The melody has been found in many sources dispersed over a wide area of central Europe, principally Austria, Bohemia, and Moravia, dating at the least comfortably back into the seventeenth century.
This study investigates the influence of multiple jet parameters on the flow field of translating impinging inclined water jets. We conducted full-scale stereoscopic particle image velocimetry and pressure measurements and three-dimensional computational fluid dynamics simulations for Reynolds numbers in the range of $Re = 23{,}000{-}43{,}750$. Considering the complex mechanism of a translating impinging jet, a good concordance is observed between the experimental and numerical results. The translation-to-jet velocity ratio ($R$) is identified as a critical parameter in determining whether the jet flow predominantly exhibits impinging characteristics or behaves as a jet in cross-flow. It is found that, for $R \gt 0.22$, jet impingement is minimal. The stand-off distance to nozzle diameter ratio ($H/D$) determines the relative influence of the cross-flow on the jet flow. The effect of $H/D$ is similar to a stationary impinging jet, with the potential core extending up to $H/D \approx 4$, but entrainment is enhanced by the relative cross-flow. For an inclined jet, i.e. jet angle $\theta \neq 90^{\circ}$, the direction of the jet, either backward or forward, governs the deflection of the flow. Higher pressures are recorded for a backward directed jet compared with a forward directed jet for supplementary angles.
The book’s introduction explains the history of thought experiments in philosophy. It also describes Hans Christian Ørsted’s interactions with Kierkegaard and his influence on Kierkegaard’s concept of Tankeexperiment. The introduction outlines the ways in which thought experiments make thoughts meaningful by providing immediate presentations.
This chapter provides economic explanations of the level of total national health expenditures in the US and of population health outcomes. It helps managers explain the role of wage differences with other countries and the impact of income inequality and racism on spending and outcomes. Wages of healthcare workers are much higher in the US than abroad. The healthcare GDP share has stabilized after growing for many years, but beneficial yet costly new technology still matters for cost and health growth. Metrics of relative health spending are distorted by exchange rate mismeasurement. Evidence on the fraction of total spending that is wasteful is very uncertain because no managerial or policy actions as yet have been proven to reduce waste in ways that do more good than harm. Changes in insurance and pricing policy have the highest promise for improvement.
A prevalent idea in scholarship on Athenian politics of the classical period is the assumption, based on figures like Pericles and Demosthenes, that political leadership depended on the ability to give good advice and communicate well with fellow citizens in the Council and Assembly. Without necessarily challenging this assumption, the present chapter focuses on a mechanism for attaining political leadership that has received less attention: gift-giving to both individual citizens and the entire community. Athenians with political ambitions built networks of followers (clients) through private gifts, but the phenomenon has not been fully appreciated because of the supposition that nothing comparable to the Roman patron/client relationship existed in the Greek polis. This chapter focuses on the case of Demosthenes.
10.1 [675] We have, I believe, given an account of the shadow in the law that is precise, since the enemy of the truth attempted – I do not know how – to persecute us and bizarrely brings the indictment of lawlessness against people who, more than anyone else, have made a firm determination to fulfill those divine laws in a more rational and precise manner than those who are conversant with the bare types alone. But since he takes us to task for absolutely everything we say and do, observe how he plunges us, so to speak, into yet more accusations, and says we stand in opposition even to the holy mystagogues themselves and have given no regard to the apostolic tradition, but instead have turned wherever our whim might carry us – and what’s more, without being taken to task for it! For he again writes as follows:1 [676]
This chapter explores the roles of different generations of lawyers in Estonia’s post-1991 democratic transformation. Focused on young, progressive lawyers familiar with Western legal culture and established leaders educated under the Soviet regime, the study draws on extensive interviews and document analysis to trace how these actors shaped the nation’s transition from Soviet legal structures to a contemporary democratic framework. The findings highlight the critical importance of individual efforts in redefining legal practices, emphasising the dual impact of innovative youth and experienced mentors in driving significant legal and institutional reforms. The study enhances understanding of the dynamics of legal transitions in post-Soviet states, highlighting the essential blend of innovation and experience necessary for successful legal reform.
Cinema as a mirror of postrevolutionary cultural negotiations. After the revolution, Iranian cinema becomes a shared format for national self-representation. Despite censorship and practical constraints, filmmaking developed a coded but locally recognizable language to explore tensions around class, region, gender, history, and politics. Acquiescing to censorship requirement that women actors never unveil, even when represented in private alone or with other women, filmmakers and audiences found themselves undermining the dramatic artifice of the cinematic fourth wall, the convention of invisible, passive dramatic observation taken for granted in modern filmmaking. Instead, audiences became collaborators of cultural meaning, acknowledging cinematic artifice and the possibilities of symbolic representation. Canny directors involved their viewers as conscious partners in a community of interpretation, pushing the limits of cultural critique. These self-reflexive Iranian films provide the most accurate format for reflecting on postrevolutionary national and political developments, making postrevolutionary Iranian cinema a mirror for national subjectivity and society.
We investigate the energetics of mixing induced by a continuously supplied dense current (density $\rho _0$) propagating beneath a lighter ambient fluid (density $\rho _a$) along a horizontal rigid boundary within a rectangular domain. The flow fields are computed using direct numerical simulations (DNS) performed with the Nek5000 spectral element solver. Mixing is quantified through the temporal evolution of the background potential energy, which exhibits a linear increase over time. This linear trend enables the definition of a dimensionless mixing parameter $\gamma$, representing the rate of background potential energy growth. The value of $\gamma$ depends on the initial density contrast for a fixed volumetric discharge at the source, characterised by the dimensionless source Froude number. The results reveal a non-monotonic dependence of $\gamma$ on the source Froude number, highlighting a complex interaction between flow forcing and mixing efficiency. We find that, under the assumption of uniform mixing along the current’s length, a fraction $\gamma /2$ of the total supplied energy is invested in mixing along a horizontal distance equal to the height of the inlet.
Dietary phytosterols exert hypocholesterolemic effects by inhibiting cholesterol absorption in the small intestine. However, oxidised phytosterols exert harmful effects. In this study, we compared the effects of dietary stigmasterol or oxidised stigmasterol (OS) on cholesterol absorption and metabolism in mice. Institute of Cancer Research (ICR) male mice were fed one of the following diets: a standard American Institute of Nutrition (AIN) diet; the standard diet plus 0·25 % cholesterol; the standard diet plus 0·25 % cholesterol and 0·25 % stigmasterol or the standard diet plus 0·25 % cholesterol and 0·25 % OS. Stigmasterol, but not OS, decreased plasma total cholesterol levels. Unlike stigmasterol, dietary OS increased the cholesterol levels in micellar solutions. Thus, OS could not exert hypocholesterolemic effects as it could not displace cholesterol in micellar solutions. In contrast, dietary OS downregulates the mRNA expression of genes involved in cholesterol synthesis and upregulates the mRNA expression of genes involved in cholesterol catabolism in mice fed cholesterol. In addition, dietary stigmasterol and OS increased the levels of faecal-neutral steroids by downregulating the mRNA expression of Niemann-Pick C1-like 1 protein (NPC1L1) in the small intestine. Dietary stigmasterol may directly regulate the mRNA expression of NPC1L1, whereas dietary OS may reduce the mRNA expression of sterol regulatory element-binding protein 2 and act as a Liver X receptor α agonist, reducing the mRNA expression of NPC1L1. Therefore, OS may affect cholesterol absorption and metabolism through a mechanism different from that of stigmasterol.
A theoretical intervention into the challenge of thinking through the complexities of life, in Iran or elsewhere. Hannah Arendt and Michel Foucault offer us a model of thinking as a practice. Each attempted one project in which they were thinking systematically about ongoing events, and offering that thinking as a contribution to public understanding. Arendt traveled to Jerusalem to observe the Adolf Eichmann trial, and her contemporaneous writing was published in The New Yorker magazine. Foucault traveled to Iran to observe the early stages of the revolution, and his contemporaneous writing was published (mostly) in the Corriere della Sera newspaper. These two projects have commonly been regarded as their author’s most controversial and have often been ignored or used to denigrate the writer’s entire theoretical oeuvre. Yet they offer compelling models of thinking as a practice that critically links the self and the world. Rescuing theory from the confines of academic specialization restores it, and us, to the possibility of thinking as a practice of freedom, and freedom as the daily possibility of beginning anew.