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VIII.116 - Relapsing Fever

from Part VIII - Major Human Diseases Past and Present

Published online by Cambridge University Press:  28 March 2008

Kenneth F. Kiple
Affiliation:
Bowling Green State University, Ohio
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Summary

Relapsing fever is a disease characterized by the occurrence of one or more relapses after the primary febrile paroxysm has subsided. Various types of relapsing fever are caused by blood parasites of the Borrelia group. There are two chief forms of the disease: the endemic, transmitted to humans by various ticks of the genus Ornithodoros, and maintained among a variety of rodents; and the epidemic, caused by a parasitic spirochete, Borrelia recurrentis, which is transmitted by human head and body lice. B. recurrentis is less virulent than the tick-borne forms. Under favorable conditions, mortality is about 5 percent, but in times of distress, as in war or famine, it can reach 60 to 70 percent.

It is also known as famine fever and tick fever, and in the past as yellow fever, because of associated jaundice. The term “relapsing fever” was first used by David Craigie of Edinburgh in 1843. The disease was often, and frequently is still, confused with malaria and typhus, whose symptoms are similar.

Etiology and Epidemiology

Tick-borne relapsing fever is normally contained within the relationship between tick and rodent host; human beings become affected only when they accidentally become involved in that relationship. For example, if human shelters such as log cabins attract rodents, they may in turn become tick habitats. Transmission of relapsing fever is through the infected saliva or coxal fluid of the tick, making it essentially a disease of locality. In the case of louse-borne relapsing fever, the only reservoir of B. recurrentis is human beings, despite the fact that the disease is spread by lice, either in the bite, or by contact with the body fluids of the louse through scratching.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 1993

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References

Bryceson, A. D. M., et al. 1970. Louse-borne relapsing fever. Quarterly Journal of Medicine 153.Google Scholar
Burgdorfer, Willy. 1976. The epidemiology of relapsing fevers. In The biology of parasitic spirochaetes, ed. Johnson, Russell C.. London.Google Scholar
Collie, Alex. 1887. On fevers. London.Google Scholar
Edell, Timm A., et al. 1979. Tick-borne relapsing fever in Colorado. Journal of the American Medical Association 249, No. 21.Google Scholar
Felsenfeld, Oscar. 1971. Borrelia. St Louis, Mo..Google Scholar
MacArthur, William P. 1957. Medical history of the famine. In The Great Famine, ed. Edwards, R. Dudley and Williams, T. Desmond. New York.Google Scholar
Mackie, F. P. 1907. The part played by Pediculus corporis in the transmission of relapsing fever. British Medical Journal ii.Google Scholar
Mackie, F. P. 1920. The transmission of relapsing fever. British Medical Journal i.Google Scholar
Murchison, Charles. 1884. Continued fevers of Great Britain and Ireland, 3d edition. London.Google Scholar
Topley, William, and Wilson, Graham S., eds. 1984. Principles of bacteriology, virology and immunity, 7th edition, Vol. 3. London.Google Scholar

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  • Relapsing Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.178
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  • Relapsing Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.178
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Relapsing Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.178
Available formats
×